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MATERIALS AND METHODS Transgenic mice B6CBAF1/J mice were obtained from the Jackson Laboratories (Bar Harbor, ME). ... Transgenic mice were prepared by injecting fertilized single cell embryos from B6CBAFI/J mice with approximately 200 copies of cos ligated lambda DNA, essentially as described by Hogan Table II ...doi:10.1093/nar/18.10.3007 pmid:1693420 pmcid:PMC330831 fatcat:x4mh3tni5vfhvebahvrkevin6i
The numbers on the top of the bars represent copy numbers of the transgenes; the transgenes in the sublines marked with an asterisk are integrated in complex patterns of single or multiple loci. ... The germline mutation frequency in transgenic rodents, as calculated for a single transgene copy, was~10 ±9 per base pair (Kohler et al., 1991; Dycaico et al., 1994) . ...doi:10.1093/emboj/19.17.4431 pmid:10970837 pmcid:PMC302052 fatcat:qzuza4b7mrho3g7aih4nwcnxly
We constructed pEF-AAT by cloning a 19-kb SalI fragment from phage clone ␣NN (a gift from Mark Dycaico, Stratagene) carrying the complete human SERPINA1 into pEF. ...doi:10.1006/mthe.2001.0429 pmid:11482983 fatcat:bkfrbsbh2vgz3juabhfwepzdcu
(By J. Pendola in http://jaxmice.jax.org). TRANSGENIC ANIMAL MODELS IN TOXICOLOGY 209 Downloaded from https://academic.oup.com/toxsci/article-abstract/121/2/ ... Subsequently, a lacI transgenic rat was developed in a Fischer 344 background (Dycaico et al., 1994) containing 30 copies of the shuttle vector per diploid genome. ... The transgene is present in approximately 40 copies per chromosome with integration occurring in a head-to-tail fashion at a single locus on chromosome 4 (Dycaico et al., 1994) . ...doi:10.1093/toxsci/kfr075 pmid:21447610 fatcat:esy25m3apfej7h46h6wcelevpy
Product identities were confirmed by size and restriction Allison, J., Campbell, I.L., Morahan, G., Mandel, T.E., Harrison, L.C., enzyme mapping. ... Debris surrounding the cell body marks the locations of cell processes likely re-spinal cord %01ف( of total cells). ... The interpretatations cause emphysema and missense mutations action from these data and additional mutations (A.G., cumulating in the ER cause hepatitis (Dycaico et al., unpublished data) is illustrated ...doi:10.1016/s0896-6273(02)01045-0 pmid:12441049 pmcid:PMC4603660 fatcat:awjmuqhklfbdzjsh3mitvb7eky
In contrast, in the pep4D strain, there was a marked increase in higher-molecular-weight AT species over time. ... Live-cell fluorescence imaging of yeast expressing AT-GFP (pATM-2 or pATZ-2) and a Sec63-mCherry fusion (pBK177, obtained from J. ...doi:10.1534/genetics.112.143487 pmid:22923381 pmcid:PMC3522165 fatcat:xtd2n36eq5bblfqc5p5x4fzrf4