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Sex differences in antidepressant efficacy

Tara A. LeGates, Mark D. Kvarta, Scott M. Thompson
2018 Neuropsychopharmacology  
These results suggest that hormones may have activational effects on activity changes induced by OBX and organizational effects in the marked anhedonia exhibited by female OBX mice.  ...  In data from the STAR*D trial, 66% of women reported premenstrual exacerbations in their symptoms [38] . Of note, this was associated with longer depressive episodes and shorter latency to relapse.  ... 
doi:10.1038/s41386-018-0156-z pmid:30082889 pmcid:PMC6235879 fatcat:vvfaberi6bfsffjt4j5q3d7hpm

An excitatory synapse hypothesis of depression

Scott M. Thompson, Angy J. Kallarackal, Mark D. Kvarta, Adam M. Van Dyke, Tara A. LeGates, Xiang Cai
2015 Trends in Neurosciences  
D. Pharmacological inhibition of proteosomal degradation prevented decreases in AMPAR-mediated synaptic currents in response to chronic stress, but had no effect in unstressed animals.  ... 
doi:10.1016/j.tins.2015.03.003 pmid:25887240 pmcid:PMC4417609 fatcat:vdtc3i6vgvewbo3ebbnnmda65u

Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network

Mark D. Kvarta, Ronald M. Harris-Warrick, Bruce R. Johnson
2012 Journal of Neurophysiology  
Kvarta MD, Harris-Warrick RM, Johnson BR. Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.  ...  Gray horizontal lines mark the amplitude of the initial peak gIPSP.  ...  D: 5-HT increases synaptic depression.  ... 
doi:10.1152/jn.00586.2012 pmid:22933725 pmcid:PMC3545119 fatcat:gie3l3u2prguhn4oxzimtixe2m

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

Mark D. Kvarta, Keighly E. Bradbrook, Hannah M. Dantrassy, Aileen M. Bailey, Scott M. Thompson
2015 Journal of Neurophysiology  
Kvarta MD, Bradbrook KE, Dantrassy HM, Bailey AM, Thompson SM. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses.  ...  Marked morphological, functional, and volumetric brain changes correlate with stress load, depressive episode duration, and response to antidepressants (Sheline 2000; Sheline et al. 2003; Koolschijn et  ...  D: survival plot illustrating the proportion of rats that remained unfed vs. time in the noveltysuppressed feeding task.  ... 
doi:10.1152/jn.00359.2015 pmid:26180121 pmcid:PMC4567614 fatcat:g3u43rhyo5dezpay5rmuc23hoy

Mapping Local and Long-Distance Resting Connectivity Markers of TMS-Related Inhibition Reduction in Schizophrenia

Stephanie M. Hare, Xiaoming Du, Bhim M. Adhikari, Shuo Chen, Chen Mo, Ann Summerfelt, Mark D. Kvarta, Laura Garcia, Peter Kochunov, L. Elliot Hong
2021 NeuroImage: Clinical  
Mark D. Kvarta: Writing -review & editing. Laura Garcia: Project administration, Writing -review & editing. Peter Kochunov: Funding acquisition, Methodology, Resources, Writingreview & editing. L.  ... 
doi:10.1016/j.nicl.2021.102688 pmid:33991855 fatcat:zrrxulrsmnhw7he6i5se3o6bei

Multiple dimensions of stress vs. genetic effects on depression

Mark D. Kvarta, Heather A. Bruce, Joshua Chiappelli, Stephanie M. Hare, Eric L. Goldwaser, Jessica Sewell, Hemalatha Sampath, Samantha Lightner, Wyatt Marshall, Kathryn Hatch, Elizabeth Humphries, Seth Ament (+5 others)
2021 Translational Psychiatry  
From left to right: (A) Beck Depression Inventory (BDI), (B) number of life stressors, and (C) Perceived Stress Scale (PSS) were all significantly higher in DRD cases compared to controls, while (D) community  ... 
doi:10.1038/s41398-021-01369-9 pmid:33927182 pmcid:PMC8085217 fatcat:n4urkrchubgxlmnqsby6rlkzs4

Differential Modulation of Synaptic Strength and Timing Regulate Synaptic Efficacy in a Motor Network

Bruce R. Johnson, Jessica M. Brown, Mark D. Kvarta, Jay Y. J. Lu, Lauren R. Schneider, Farzan Nadim, Ronald M. Harris-Warrick
2011 Journal of Neurophysiology  
B, D, and F: summary of DA (B), Oct (D), and 5HT (F) effects at the LP¡PD synapse, showing the mean amplitude of the PD graded inhibitory postsynaptic potentials (gIPSPs) to LP control waveform under control  ...  Thus we show our results with Oct application using only the control LP waveform (Fig. 2, D and E) .  ... 
doi:10.1152/jn.00809.2010 pmid:21047938 pmcid:PMC3023374 fatcat:thlemxz4vvhkzc4bc6glapk2vi

Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors

Jonathan Fischell, Adam M Van Dyke, Mark D Kvarta, Tara A LeGates, Scott M Thompson
2015 Neuropsychopharmacology  
AM Van Dyke and MD Kvarta are shareholders in Asulon Therapeutics, Inc.  ...  AM Van Dyke, MD Kvarta, and SM Thompson have filed a patent application covering the use of alpha5-selective negative allosteric modulators as fast acting antidepressants.  ...  Neither injection produced a significant change in social interaction (c) or sucrose preference (d).  ... 
doi:10.1038/npp.2015.112 pmid:25900119 pmcid:PMC4569955 fatcat:e4v45l6nlbb5tcquqgbcvugi3a

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

Xiang Cai, Angy J Kallarackal, Mark D Kvarta, Sasha Goluskin, Kaitlin Gaylor, Aileen M Bailey, Hey-Kyoung Lee, Richard L Huganir, Scott M Thompson
2013 Nature Neuroscience  
(d) Anpirtoline neither enhanced SC-CA1 fEPSPs nor occluded LTP of SC-CA1 synapses (red; n=7 slices). LTP of SC-CA1 fEPSPs in control slices shown in black (n=5 slices).  ...  (d) Anpirtoline selectively enhanced TA-CA1 EPSCs recorded in whole-cell voltage-clamp mode, but not simultaneously evoked SC-CA1 EPSCs in a two-pathway experimental design (n=9 cells).  ... 
doi:10.1038/nn.3355 pmid:23502536 pmcid:PMC3609911 fatcat:td3paijaa5genphztgdywblyj4

Clinical and genetic validity of quantitative bipolarity

Heather A. Bruce, Peter Kochunov, Braxton Mitchell, Kevin A. Strauss, Seth A. Ament, Laura M. Rowland, Xiaoming Du, Feven Fisseha, Thangavelu Kavita, Joshua Chiappelli, Krista Wisner, Hemalatha Sampath (+8 others)
2019 Translational Psychiatry  
Research has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. The Quantitative Bipolarity Scale (QBS) was administered to 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110
more » ... uals had psychiatric diagnoses (20 BP, 61 major depressive disorders (MDD), 3 psychotic disorders, 26 other psychiatric disorders). Familial aggregation of QBS was calculated using the variance components method to derive heritability and shared household effects. The QBS score was significantly higher in BP subjects (31.5 ± 3.6) compared to MDD (16.7 ± 2.0), other psychiatric diagnoses (7.0 ± 1.9), and no psychiatric diagnosis (6.0 ± 0.65) (all p < 0.001). QBS in the whole sample was significantly heritable (h2 = 0.46 ± 0.15, p < 0.001) while the variance attributed to the shared household effect was not significant (p = 0.073). When subjects with psychiatric illness were removed, the QBS heritability was similar (h2 = 0.59 ± 0.18, p < 0.001). These findings suggest that quantitative bipolarity as measured by QBS can separate BP from other psychiatric illnesses yet is significantly heritable with and without BP included in the pedigrees suggesting that the quantitative bipolarity describes a continuous heritable trait that is not driven by a discrete psychiatric diagnosis. Bipolarity trait assessment may be used to supplement the diagnosis of BP in future genetic studies and could be especially useful for capturing subclinical genetic contributions to a BP phenotype.
doi:10.1038/s41398-019-0561-z pmid:31527585 pmcid:PMC6746871 fatcat:nfl35ftpmrchvne72nx24t75vu

Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination

Mark D. Kvarta, Deva Sharma, Rudolph J. Castellani, Robert E. Morales, Stephen G. Reich, Amy S. Kimball, Robert K. Shin
2016 BMC Neurology  
Primary central nervous system lymphoma (PCNSL) may rarely be preceded by "sentinel demyelination," a pathologic entity characterized by histologically confirmed demyelinating inflammatory brain lesions that mimic multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Interpreting the overlapping radiologic and clinical characteristics associated with each of these conditions-contrast-enhancing demyelination of white matter and relapsing and remitting steroid-responsive
more » ... respectively-can be a significant diagnostic challenge. Case presentation: We describe a 57-year-old woman with an unusual clinical course who presented with multi-focal enhancing white matter lesions demonstrated to be inflammatory demyelination by brain biopsy. Despite a good initial response to steroids and rituximab for treatment of presumed tumefactive multiple sclerosis, the patient's condition rapidly deteriorated, and a repeat brain biopsy six months later was consistent with a diagnosis of diffuse large B-cell lymphoma. Conclusions: Early clinical suspicion for PCNSL and awareness that biopsied lesions may initially show sentinel demyelination suggestive of alternate diagnoses may be essential for early initiation of appropriate therapies and mitigation of disease progression. Clinical, pathophysiological, and diagnostic aspects of sentinel demyelination and PCNSL are discussed.
doi:10.1186/s12883-016-0596-1 pmid:27206499 pmcid:PMC4875602 fatcat:35vky2bqw5gopk3mus2f7vooky

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linkedUBQLN2mutations

Nhat T. T. Le, Lydia Chang, Irina Kovlyagina, Polymnia Georgiou, Nathaniel Safren, Kerstin E. Braunstein, Mark D. Kvarta, Adam M. Van Dyke, Tara A. LeGates, Thomas Philips, Brett M. Morrison, Scott M. Thompson (+5 others)
2016 Proceedings of the National Academy of Sciences of the United States of America  
S8 B-D) .  ...  S8 A and D) .  ... 
doi:10.1073/pnas.1608432113 pmid:27834214 pmcid:PMC5127348 fatcat:36lp4yh3pjc45nw4qzrttpwjwm

Comparison of Regional Brain Deficit Patterns in Common Psychiatric and Neurological Disorders as Revealed by Big Data

Peter Kochunov, Meghann C. Ryan, Qifan Yang, Kathryn S. Hatch, Alyssa Zhu, Sophia I. Thomopoulos, Neda Jahanshad, Lianne Schmaal, Paul M. Thompson, Shuo Chen, Xiaoming Du, Bhim M. Adhikari (+6 others)
2021 NeuroImage: Clinical  
Mark D. Kvarta: Writing -review & editing. Thomas E. Nichols: Funding acquisition, Writing -review & editing. L.  ...  Whole-brain RVI-AD was elevated in patients with AD (d = 1.4, t = 4.2, p = 10 − 5 , same data as above), PD (d = 0.50, t = 2.4p = 0.004) but not stroke (d = 0.10, t = 1.1, p = 0.3) (Fig. 3C) .  ... 
doi:10.1016/j.nicl.2021.102574 pmid:33530016 pmcid:PMC7851406 fatcat:46ftuwiovjef7nk3u66hwoekwu

Comparing Empirical Kinship Derived Heritability for Imaging Genetics Traits in the UK Biobank and Human Connectome Project

Si Gao, Brian Donohue, Kathryn S Hatch, Shuo Chen, Tianzhou Ma, Yizhou Ma, Mark D Kvarta, Heather Bruce, Bhim M Adhikari, Neda Jahanshad, Paul M Thompson, John Blangero (+5 others)
2021
D. Scatter plot of the UKBB GCTA estimates calculated using GREML versus the HCP GCTA estimates calculated using GREML for 60 neuroimaging phenotypes.  ...  Regional and voxel-wise heritability in the HCP versus UKBB The regional heritability analyses showed good agreement between HCP and UKBB ( Fig. 2 C and D ) when calculated using FPHI (overall linear  ... 
doi:10.1016/j.neuroimage.2021.118700 pmid:34740793 pmcid:PMC8771206 fatcat:oq55xygyenajvjzyoag2wchh2q

The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging

Meghann C Ryan, L Elliot Hong, Kathryn S Hatch, Si Gao, Shuo Chen, Krystl Haerian, Jingtao Wang, Eric L Goldwaser, Xiaoming Du, Bhim M Adhikari, Heather Bruce, Stephanie Hare (+5 others)
2022
SSD had the largest effect (Cohen's d = 1.42) then BD (d = 0.55), and MDD (d = 0.15). Hypertension had a significant effect on SMI+ (d = 0.19) and SMI- (d = 0.14).  ...  , Cohen's d = 1.42; 95% CI: [0.54, 2.30]) followed by BD (d = 0.55; 95% CI: [0.26, 0.84]) and MDD (d = 0.15; 95% CI: [0.10, 0.21]). Figure 5b-d and TableS4.  ...  We observed significant and similar effect sizes for hypertension for the whole-brain (d = 0.19, 0.14) and white matter (d = 0.22, 0.21) QRIs in subjects with SMI and controls.  ... 
doi:10.1002/hbm.25769 pmid:35112422 pmcid:PMC8933252 fatcat:wsseunmajzc2hjhvhnvemetgtu
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