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Sex differences in antidepressant efficacy
2018
Neuropsychopharmacology
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These results suggest that hormones may have activational effects on activity changes induced by OBX and organizational effects in the marked anhedonia exhibited by female OBX mice. ...
In data from the STAR*D trial, 66% of women reported premenstrual exacerbations in their symptoms [38] . Of note, this was associated with longer depressive episodes and shorter latency to relapse. ...
doi:10.1038/s41386-018-0156-z
pmid:30082889
pmcid:PMC6235879
fatcat:vvfaberi6bfsffjt4j5q3d7hpm
An excitatory synapse hypothesis of depression
2015
Trends in Neurosciences
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D. Pharmacological inhibition of proteosomal degradation prevented decreases in AMPAR-mediated synaptic currents in response to chronic stress, but had no effect in unstressed animals. ...
doi:10.1016/j.tins.2015.03.003
pmid:25887240
pmcid:PMC4417609
fatcat:vdtc3i6vgvewbo3ebbnnmda65u
Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network
2012
Journal of Neurophysiology
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Kvarta MD, Harris-Warrick RM, Johnson BR. Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network. ...
Gray horizontal lines mark the amplitude of the initial peak gIPSP. ...
D: 5-HT increases synaptic depression. ...
doi:10.1152/jn.00586.2012
pmid:22933725
pmcid:PMC3545119
fatcat:gie3l3u2prguhn4oxzimtixe2m
Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses
2015
Journal of Neurophysiology
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Kvarta MD, Bradbrook KE, Dantrassy HM, Bailey AM, Thompson SM. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses. ...
Marked morphological, functional, and volumetric brain changes correlate with stress load, depressive episode duration, and response to antidepressants (Sheline 2000; Sheline et al. 2003; Koolschijn et ...
D: survival plot illustrating the proportion of rats that remained unfed vs. time in the noveltysuppressed feeding task. ...
doi:10.1152/jn.00359.2015
pmid:26180121
pmcid:PMC4567614
fatcat:g3u43rhyo5dezpay5rmuc23hoy
Mapping Local and Long-Distance Resting Connectivity Markers of TMS-Related Inhibition Reduction in Schizophrenia
2021
NeuroImage: Clinical
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Mark D. Kvarta: Writing -review & editing. Laura Garcia: Project administration, Writing -review & editing. Peter Kochunov: Funding acquisition, Methodology, Resources, Writingreview & editing. L. ...
doi:10.1016/j.nicl.2021.102688
pmid:33991855
fatcat:zrrxulrsmnhw7he6i5se3o6bei
Multiple dimensions of stress vs. genetic effects on depression
2021
Translational Psychiatry
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From left to right: (A) Beck Depression Inventory (BDI), (B) number of life stressors, and (C) Perceived Stress Scale (PSS) were all significantly higher in DRD cases compared to controls, while (D) community ...
doi:10.1038/s41398-021-01369-9
pmid:33927182
pmcid:PMC8085217
fatcat:n4urkrchubgxlmnqsby6rlkzs4
Differential Modulation of Synaptic Strength and Timing Regulate Synaptic Efficacy in a Motor Network
2011
Journal of Neurophysiology
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B, D, and F: summary of DA (B), Oct (D), and 5HT (F) effects at the LP¡PD synapse, showing the mean amplitude of the PD graded inhibitory postsynaptic potentials (gIPSPs) to LP control waveform under control ...
Thus we show our results with Oct application using only the control LP waveform (Fig. 2, D and E) . ...
doi:10.1152/jn.00809.2010
pmid:21047938
pmcid:PMC3023374
fatcat:thlemxz4vvhkzc4bc6glapk2vi
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
2015
Neuropsychopharmacology
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AM Van Dyke and MD Kvarta are shareholders in Asulon Therapeutics, Inc. ...
AM Van Dyke, MD Kvarta, and SM Thompson have filed a patent application covering the use of alpha5-selective negative allosteric modulators as fast acting antidepressants. ...
Neither injection produced a significant change in social interaction (c) or sucrose preference (d). ...
doi:10.1038/npp.2015.112
pmid:25900119
pmcid:PMC4569955
fatcat:e4v45l6nlbb5tcquqgbcvugi3a
Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression
2013
Nature Neuroscience
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(d) Anpirtoline neither enhanced SC-CA1 fEPSPs nor occluded LTP of SC-CA1 synapses (red; n=7 slices). LTP of SC-CA1 fEPSPs in control slices shown in black (n=5 slices). ...
(d) Anpirtoline selectively enhanced TA-CA1 EPSCs recorded in whole-cell voltage-clamp mode, but not simultaneously evoked SC-CA1 EPSCs in a two-pathway experimental design (n=9 cells). ...
doi:10.1038/nn.3355
pmid:23502536
pmcid:PMC3609911
fatcat:td3paijaa5genphztgdywblyj4
Clinical and genetic validity of quantitative bipolarity
2019
Translational Psychiatry
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Research has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. The Quantitative Bipolarity Scale (QBS) was administered to 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110
doi:10.1038/s41398-019-0561-z
pmid:31527585
pmcid:PMC6746871
fatcat:nfl35ftpmrchvne72nx24t75vu
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... uals had psychiatric diagnoses (20 BP, 61 major depressive disorders (MDD), 3 psychotic disorders, 26 other psychiatric disorders). Familial aggregation of QBS was calculated using the variance components method to derive heritability and shared household effects. The QBS score was significantly higher in BP subjects (31.5 ± 3.6) compared to MDD (16.7 ± 2.0), other psychiatric diagnoses (7.0 ± 1.9), and no psychiatric diagnosis (6.0 ± 0.65) (all p < 0.001). QBS in the whole sample was significantly heritable (h2 = 0.46 ± 0.15, p < 0.001) while the variance attributed to the shared household effect was not significant (p = 0.073). When subjects with psychiatric illness were removed, the QBS heritability was similar (h2 = 0.59 ± 0.18, p < 0.001). These findings suggest that quantitative bipolarity as measured by QBS can separate BP from other psychiatric illnesses yet is significantly heritable with and without BP included in the pedigrees suggesting that the quantitative bipolarity describes a continuous heritable trait that is not driven by a discrete psychiatric diagnosis. Bipolarity trait assessment may be used to supplement the diagnosis of BP in future genetic studies and could be especially useful for capturing subclinical genetic contributions to a BP phenotype.
Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination
2016
BMC Neurology
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Primary central nervous system lymphoma (PCNSL) may rarely be preceded by "sentinel demyelination," a pathologic entity characterized by histologically confirmed demyelinating inflammatory brain lesions that mimic multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Interpreting the overlapping radiologic and clinical characteristics associated with each of these conditions-contrast-enhancing demyelination of white matter and relapsing and remitting steroid-responsive
doi:10.1186/s12883-016-0596-1
pmid:27206499
pmcid:PMC4875602
fatcat:35vky2bqw5gopk3mus2f7vooky
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... respectively-can be a significant diagnostic challenge. Case presentation: We describe a 57-year-old woman with an unusual clinical course who presented with multi-focal enhancing white matter lesions demonstrated to be inflammatory demyelination by brain biopsy. Despite a good initial response to steroids and rituximab for treatment of presumed tumefactive multiple sclerosis, the patient's condition rapidly deteriorated, and a repeat brain biopsy six months later was consistent with a diagnosis of diffuse large B-cell lymphoma. Conclusions: Early clinical suspicion for PCNSL and awareness that biopsied lesions may initially show sentinel demyelination suggestive of alternate diagnoses may be essential for early initiation of appropriate therapies and mitigation of disease progression. Clinical, pathophysiological, and diagnostic aspects of sentinel demyelination and PCNSL are discussed.
Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linkedUBQLN2mutations
2016
Proceedings of the National Academy of Sciences of the United States of America
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S8 B-D) . ...
S8 A and D) . ...
doi:10.1073/pnas.1608432113
pmid:27834214
pmcid:PMC5127348
fatcat:36lp4yh3pjc45nw4qzrttpwjwm
Comparison of Regional Brain Deficit Patterns in Common Psychiatric and Neurological Disorders as Revealed by Big Data
2021
NeuroImage: Clinical
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Mark D. Kvarta: Writing -review & editing. Thomas E. Nichols: Funding acquisition, Writing -review & editing. L. ...
Whole-brain RVI-AD was elevated in patients with AD (d = 1.4, t = 4.2, p = 10 − 5 , same data as above), PD (d = 0.50, t = 2.4p = 0.004) but not stroke (d = 0.10, t = 1.1, p = 0.3) (Fig. 3C) . ...
doi:10.1016/j.nicl.2021.102574
pmid:33530016
pmcid:PMC7851406
fatcat:46ftuwiovjef7nk3u66hwoekwu
Comparing Empirical Kinship Derived Heritability for Imaging Genetics Traits in the UK Biobank and Human Connectome Project
2021
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D. Scatter plot of the UKBB GCTA estimates calculated using GREML versus the HCP GCTA estimates calculated using GREML for 60 neuroimaging phenotypes. ...
Regional and voxel-wise heritability in the HCP versus UKBB The regional heritability analyses showed good agreement between HCP and UKBB ( Fig. 2 C and D ) when calculated using FPHI (overall linear ...
doi:10.1016/j.neuroimage.2021.118700
pmid:34740793
pmcid:PMC8771206
fatcat:oq55xygyenajvjzyoag2wchh2q
The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging
2022
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SSD had the largest effect (Cohen's d = 1.42) then BD (d = 0.55), and MDD (d = 0.15). Hypertension had a significant effect on SMI+ (d = 0.19) and SMI- (d = 0.14). ...
, Cohen's d = 1.42; 95% CI: [0.54, 2.30]) followed by BD (d = 0.55; 95% CI: [0.26, 0.84]) and MDD (d = 0.15; 95% CI: [0.10, 0.21]).
Figure 5b-d and TableS4. ...
We observed significant and similar effect sizes for hypertension for the whole-brain (d = 0.19, 0.14) and white matter (d = 0.22, 0.21) QRIs in subjects with SMI and controls. ...
doi:10.1002/hbm.25769
pmid:35112422
pmcid:PMC8933252
fatcat:wsseunmajzc2hjhvhnvemetgtu
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