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The role of vitamin D in osteoporosis

Mark Brincat, Max Brincat, Jeanine Gambin, Jean Calleja-Agius
2015 Maturitas  
Calleja-Agius).  ...  Clinical studies have demonstrated that only when 25(OH)D3 levels fall below 20 nmol/L does marked secondary hyperparathyroidism develop as a consequence of impaired 1,25(OH)2D3 synthesis and intestinal  ... 
doi:10.1016/j.maturitas.2015.02.193 fatcat:e75qi4bca5e65lgw6fjslfcu7a

The role of vitamin D in osteoporosis

Max Brincat, Jeannine Gambin, Mark Brincat, Jean Calleja-Agius
2015 Maturitas  
Calleja-Agius).  ...  Clinical studies have demonstrated that only when 25(OH)D3 levels fall below 20 nmol/L does marked secondary hyperparathyroidism develop as a consequence of impaired 1,25(OH)2D3 synthesis and intestinal  ... 
doi:10.1016/j.maturitas.2014.12.018 pmid:25660912 fatcat:wvkginzhxvhgnbsd5a7mchjeym

The role of prostaglandin E2in endometriosis

Keith Sacco, Mark Portelli, Joël Pollacco, Pierre Schembri-Wismayer, Jean Calleja-Agius
2011 Gynecological Endocrinology  
Endometriosis is a leading cause of infertility in women of reproductive age. It involves the occurrence of endometrial tissue outside the uterine endometrium, mainly in the peritoneal cavity. Prostaglandin E 2 is up regulated in the peritoneal cavity in endometriosis and is produced by macrophages and ectopic endometrial cells. This prostaglandin is involved in the pathophysiology of the disease and elicits cell signals via four receptor types. Prostaglandin E 2 increases estrogen synthesis by
more » ... up regulating steroidogenic acute regulatory protein (StAR) and aromatase. It inhibits apoptosis and up regulates fibroblast growth factor-9 (FGF-9) promoting cell proliferation. Prostaglandin E 2 affects leukocyte populations and promotes angiogenesis through its effect on estrogen and up regulation of vascular endothelial growth factor (VEGF). Dienogest is a synthetic progestin targeting expression of genes involved in prostaglandin synthesis.
doi:10.3109/09513590.2011.588753 pmid:22003899 fatcat:hbz5cxyk5rgsrbw6b365lylopy

Backsliding and Reversal: The J Curve Revisited

David Carment, Peter Tikuisis, Rachael Calleja, Mark Haichin
2018 Democracy and Security  
Standard-Nutzungsbedingungen: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen
more » ... bedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Abstract: Ian Bremmer published a treatise on the stability of states built on the notion that states fall along a curve resembling a slanted "J" when plotting their stability against openness. States in the turnover process are considered unstable, and are at risk of either reversing to a closed and stable system or even collapsing. Our paper shifts the J curve's associated conditions to a model to more accurately specify the causes of reversal in which crises of instability and backsliding occur. We define stability as a function of two state dimensions: authority and capacity, and apply the remaining state dimension of legitimacy as a proxy for openness. We find that transitions can reverse, oscillate, or simply stall, which are exemplified in the different types of states we categorize. The paper concludes with implications for policy and the application of the model to conflict prediction.
doi:10.1080/17419166.2018.1517334 fatcat:m2nbt2qf3zh33htp7m27bnk3tm

Performance prediction for running workflows under role-based authorization mechanisms

Ligang He, Mark Calleja, Mark Hayes, Stephen A. Jarvis
2009 2009 IEEE International Symposium on Parallel & Distributed Processing  
A tangible marking can be reached from another tangible marking by firing one timed transition and a (possibly empty) sequence of immediate transitions, until there are no more immediate transitions enabled  ...  A marking in the GSPN is called tangible when there are no immediate transitions enabled.  ... 
doi:10.1109/ipdps.2009.5161190 dblp:conf/ipps/HeCHJ09 fatcat:dbtrv2hesnaq5npg47mmq5s43a

Intervertebral disc height in treated and untreated overweight post-menopausal women

Yves Muscat Baron, Mark P. Brincat, Raymond Galea, Neville Calleja
2005 Human Reproduction  
BACKGROUND: The effect of the menopause and HRT on the intervertebral discs has not been investigated. METHODS: One hundred women were recruited, comprising of 44 post-menopausal women on HRT, 33 untreated post-menopausal women and 23 pre-menopausal women. The height of the intervertebral discs between the 12th thoracic vertebra and the 3rd lumbar vertebra was measured by utilizing the bone densitometer height cursors. RESULTS: The untreated menopausal group of women had the lowest total disc
more » ... ight (D1-D3: 1.95 ± 0.31 cm). This was significantly lower than the pre-menopausal group D1-D3: 2.16 ± 0.24 cm) and the hormone-treated group (2.2 ± 0.26 cm) (P > 0.02). The 2nd intervertebral disc consistently maintained a significant difference between the untreated menopausal group (D2: 0.63 ± 0.13) and the other two groups (pre-menopausal group (D2: 0.72 ± 0.09 cm) and treated menopausal group (D2: 0.73 ± 0.12 cm) (P > 0.02). CONCLUSIONS: Estrogen-replete women appear to maintain higher intervertebral discs compared to untreated post-menopausal women. The estrogenic milieu may be relevant because of the significant impact it has on the hydrophilic glycosaminoglycans, the water content, collagen and elastin of the intervertebral discs. The maintenance of adequate disc height may allow the intervertebral discs to retain their discoid shape and viscoelastic function, containing vertical forces which may threaten spinal architecture leading to vertebral body compression fractures.
doi:10.1093/humrep/dei251 pmid:16113041 fatcat:yaxllc267zcijah2myp2gfeeo4

Computational pattern making from 3D garment models

Nico Pietroni, Corentin Dumery, Raphael Falque, Mark Liu, Teresa Vidal-Calleja, Olga Sorkine-Hornung
2022 ACM Transactions on Graphics  
In a preprocessing step, we mark each boundary node with a label to determine if it is an exit or an entrance node.  ...  We keep the complete patch layout updated at every insertion step, and we mark all the patches that do not satisfy the goals specified in Sec. 3.1.  ... 
doi:10.1145/3528223.3530145 fatcat:idkmofaprzdgtal32bh3czahye

Anisotropic ionic transport in quartz: the effect of twin boundaries

Mark Calleja, Martin T Dove, Ekhard K H Salje
2001 Journal of Physics: Condensed Matter  
Transport of Na + and Li + under the influence of an electric field in twinned quartz is simulated using molecular dynamics techniques. Comparison between bulk transport and transport along twin boundaries shows that the cations are trapped inside twin walls for weak fields along the crystallographic c-axis. Stronger fields lead to transport along twin walls with significantly lower mobility than in the bulk. With E along [110], transport in the wall is faster than in the bulk. We observe
more » ... trapping preferentially in the twin walls when E is applied out of the plane of the wall.
doi:10.1088/0953-8984/13/42/305 fatcat:dmvwrx733bfnda2oxrbrtnhjnu

Multicast Application Sharing Tool – Facilitating the eMinerals Virtual Organisation [chapter]

Gareth J. Lewis, S. Mehmood Hasan, Vassil N. Alexandrov, Martin T. Dove, Mark Calleja
2005 Lecture Notes in Computer Science  
The eMinerals Virtual Organisation consists of a consortium of individuals affiliated to geographically distributed academic institutions. Collaborative tools are essential in order to facilitate cooperative work within this Virtual Organisation. The Access Grid Toolkit has been widely adopted for this purpose, delivering high quality group-to-group video and audio conferencing. We briefly mention this technology and describe the development of a Multicast Application Sharing Tool designed specifically for this environment.
doi:10.1007/11428862_50 fatcat:4gb7maluyfbsjjkkg7cnuw26um

Calculating Activation Energies in Diffusion Processes Using a Monte Carlo Approach in a Grid Environment [chapter]

Mark Calleja, Martin T. Dove
2004 Lecture Notes in Computer Science  
We would like to thank Mark Hayes (CeSC) and Rik Tyer (CCLRC) for useful discussions and the NERC (UK) (grant: Environment from the molecular level) for funding this work.  ... 
doi:10.1007/978-3-540-25944-2_63 fatcat:dxorbmjcsbgrtc54modvhb6ak4

Influence of the Type of Marking and the Number of Players on Physiological and Physical Demands During Sided Games in Soccer

David Casamichana, Jaime San Román-Quintana, Julen Castellano, Julio Calleja-González
2015 Journal of Human Kinetics  
The aim of this research was to examine the influence of two variables, the type of marking (with or without man-marking) and the number of players per team (3, 6, or 9) on the physical and physiological  ...  The results showed that the type of marking influenced the physical demands of players, with greater total distance, a player load and a work:rest ratio when man-marking was used in the 3 vs. 3 (737 m,  ...  Aroso et al. (2004) compared games with (man-marking; MM) and without man-marking (no man-marking; NMM) and found an increase in blood lactate concentration when MM was used.  ... 
doi:10.1515/hukin-2015-0081 pmid:26557209 pmcid:PMC4633261 fatcat:25ya7xoovbfbrfqczhef47cl5q

Long-Term Survival After Acute Myocardial Infarction and Relation to Type 2 Diabetes and Other Risk Factors

Mark Gruppetta, Neville Calleja, Stephen Fava
2010 Clinical Cardiology  
Diabetes mellitus (DM) is well established as a short-term prognostic indicator after myocardial infarction (MI), but little long-term data are available. Hypothesis: The objective of the study was to assess the impact of DM and other patient characteristics at baseline on long-term mortality after acute MI. Methods: Patients who were hospitalized with MI from December 1990 to November 1992 were recruited. Baseline data were recorded and patients were followed up through January 31, 2008, to
more » ... ess their survival rates. Survival curves were generated by the Kaplan-Meier method. The main outcome measure was long-term survival (median 16.6 y). Results: The study followed 337 patients (mean age 66.4 y, 61.1% men) for a median of 16.6 years. Using Cox regression analysis, survival was associated with history of MI (hazard ratio [HR]: 1.47, P = 0.016), DM at baseline (HR: 1.31, P = 0.038), and age (HR: 1.061 for each additional year, P < 0.001). By multivariable regression, cardiovascular mortality was also associated with previous MI (HR: 1.58, P = 0.017), DM at baseline (HR: 1.69, P = 0.001), and age (HR: 1.075 for each additional year, P < 0.001). There was no statistically significant difference between the HRs for history of MI and history of DM. Conclusions: Diabetic patients with MI have a higher long-term all-cause and cardiovascular mortality. Our data also show that in patients with MI, DM confers the same level of risk as a previous MI. This extends to patients with documented MI, our concept of diabetes being a coronary heart disease equivalent. Based on this and on data from the literature, we propose that it would be more accurate to consider DM as an MI equivalent rather than a coronary heart disease equivalent. The authors have no funding, financial relationships, or conflicts of interest to disclose. mortality during long-term follow-up (median 16.6 y; range, 15.3-17.2 y) of a cohort of patients who had had an MI.
doi:10.1002/clc.20776 pmid:20641120 fatcat:fq2nkdipf5h25aufb2wr43az74

Trapping of oxygen vacancies on twin walls of CaTiO3: a computer simulation study

Mark Calleja, Martin T Dove, Ekhard K H Salje
2003 Journal of Physics: Condensed Matter  
We have studied the atomic structure of [001]90 • rotation twin walls in orthorhombic CaTiO 3 (symmetry Pbnm) at low temperature (10 K) and their effects on oxygen vacancies. The wall thickness was found to be 2.3 nm at T T c and it was found that it is energetically favourable for such vacancies to reside in the wall, particularly when bridging titania ions in the (001) plane. The binding energy of an oxygen vacancy in the wall with respect to the bulk is calculated to be 1.2 eV. 1 www.esc.cam.ac.uk/minsci
doi:10.1088/0953-8984/15/14/305 fatcat:ew6raeznpbfahkvm6ctv4m4lyy

(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

Maja Sabol, Jean Calleja-Agius, Riccardo Di Di Fiore, Sherif Suleiman, Sureyya Ozcan, Mark P. Ward, Petar Ozretić
2021 Cancers  
Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100,000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints.
more » ... ion of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expression through several mechanisms and therefore add another level of complexity to the regulatory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an emphasis on ROCs.
doi:10.3390/cancers13205040 pmid:34680193 fatcat:nn6t4l6rljdp7gcnqyp4cx6yv4

A High-Throughput Computational Framework for Identifying Significant Copy Number Aberrations from Array Comparative Genomic Hybridisation Data

Ian Roberts, Stephanie A. Carter, Cinzia G. Scarpini, Konstantina Karagavriilidou, Jenny C. J. Barna, Mark Calleja, Nicholas Coleman
2012 Advances in Bioinformatics  
Reliable identification of copy number aberrations (CNA) from comparative genomic hybridization data would be improved by the availability of a generalised method for processing large datasets. To this end, we developed swatCGH, a data analysis framework and region detection heuristic for computational grids. swatCGH analyses sequentially displaced (sliding) windows of neighbouring probes and applies adaptive thresholds of varying stringency to identify the 10% of each chromosome that contains
more » ... he most frequently occurring CNAs. We used the method to analyse a published dataset, comparing data preprocessed using four different DNA segmentation algorithms, and two methods for prioritising the detected CNAs. The consolidated list of the most commonly detected aberrations confirmed the value of swatCGH as a simplified high-throughput method for identifying biologically significant CNA regions of interest.
doi:10.1155/2012/876976 pmid:23008709 pmcid:PMC3449101 fatcat:drqvimfhifeopg3ttopah2ml74
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