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A tombstone in Alzheimer's?

Mark P. Mattson, John W. Carney, D. Allan Butterfield
1995 Nature  
_-I-I,-- Mark P. Mattson*. John W. Carneyt. D.  ... 
doi:10.1038/373481a0 pmid:7845457 fatcat:xlcvimdqpremjeifg2svdfgj7e

Sintering and Densification of Fibre Reinforcement in Polymers during Rotational Moulding

David Castellanos, Peter J. Martin, Joseph Butterfield, Mark McCourt, Mark Kearns, Patrick Cassidy
2020 Procedia Manufacturing  
Butterfield a , Mark McCourt a , Mark Kearns a and Patrick Cassidy b a Polymer Processing Research Centre, School of Mechanical and Aerospace Engineering, Queen's University of Belfast, Ashby Building  ...  Butterfield a , Mark McCourt a , Mark Kearns a and Patrick Cassidy b a Polymer Processing Research Centre, School of Mechanical and Aerospace Engineering, Queen's University of Belfast, Ashby Building  ... 
doi:10.1016/j.promfg.2020.04.301 fatcat:ka6bbhrffna2dklempyznywwcm

Player Positioning in the Four-Legged League [chapter]

Henry Work, Eric Chown, Tucker Hermans, Jesse Butterfield, Mark McGranaghan
2009 Lecture Notes in Computer Science  
As RoboCup continues its march towards the day when robots play soccer against people, the focus of researchers' efforts is slowly shifting from low-level systems (vision, motion, self-localization, etc) to high-level systems such as strategy and cooperation. In the Four-Legged League (recently renamed to the Standard Platform League), teams are still struggling with this transition. While the level of play has consistently risen each year, teams continue to remain focused on low-level tasks.
more » ... rprisingly few of the 24 Four-Legged teams that competed at RoboCup 2007 were able to self-position at the beginning of the game, despite penalties incurred for not doing so. Things considered to be standard in 'real' soccer -positioning, passing, overall strategies -are still, after 10 years of research, far from a given within the league, and are arguably in their infancy compared to other RoboCup leagues (Small-Sized, Mid-Sized, Simulation). Conversely, for the top teams, many of these low-level systems have been pushed far enough that there is little to be gained in soccer performance from further low-level system work. In this paper we present a robust and successful player positioning system for the Four-Legged League.
doi:10.1007/978-3-642-02921-9_34 fatcat:32q6xx5etbdvhaffxqqzcacria

Motion control for uniaxial rotational molding

Jonathan Adams, Yan Jin, David Barnes, Joseph Butterfield, Mark Kearnes
2020 Journal of Applied Polymer Science  
As per the markings shown in Figure 3a , each molded cylinder was cut longitudinally into four parts with three of the parts measuring 60 mm in width.  ... 
doi:10.1002/app.49879 fatcat:evo6xtn7nbf3rb6poajtyc27km

6.7 GHz CH3OH absorption towards the N3 Galactic Center point-source [article]

Natalie Butterfield, Adam Ginsburg, Dominic Ludovici, Ashley Barnes, Riley Dunnagan, Cornelia C. Lang, Mark R. Morris
2019 arXiv   pre-print
Most of the recent measurements of GC cloud kinematics, across mul- Butterfield et al. 2018) . Several prominent radio continuum features are labeled in the figure.  ...  H II region, or a micro-quasar are all ruled out. 1 The N3 source has associated molecular emission (the 'N3 molecular cloud') that appears to wrap around the compact source (Ludovici et al. 2016; Butterfield  ... 
arXiv:1911.10997v1 fatcat:yfetn6uzbfgjxaojiuwmkpmm5u

Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

D. Allan Butterfield, Mark P. Mattson
2020 Neurobiology of Disease  
also contribute to neuronal death in AD and MCI brains(Butterfield et al., 2006; Sultana et al., 2013; Di Domenico et al., 2017b; Butterfield and Halliwell, 2019; Butterfield and Boyd-Kimball, 2019; ).  ...  opening of voltage-gated ion channels, including Ca 2+ channels and decreased function of ion-motive ATPases that would otherwise normally pump Ca 2+ back out of neurons and maintain cell potentials (Mark  ... 
doi:10.1016/j.nbd.2020.104795 pmid:32036033 pmcid:PMC7085980 fatcat:hhgiyvhgi5fxxpuowppiqpg6iq

Evolution and diversification of the nuclear envelope

Norma E Padilla-Mejia, Alexandr A Makarov, Lael D Barlow, Erin R Butterfield, Mark C Field
2021 Nucleus (Austin, Tex.)  
Funding ORCID Mark C. Field http://orcid.org/0000-0002-4866-2885  ... 
doi:10.1080/19491034.2021.1874135 pmid:33435791 pmcid:PMC7889174 fatcat:gyeazt62sfez3oba5k3y23k3a4

Role of Oxidative Stress in the Progression of Alzheimer's Disease

Rukhsana Sultana, D. Allan Butterfield, Mark A. Lovell
2010 Journal of Alzheimer's Disease  
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized pathologically by the presence of senile plaques, neurofibrillary tangles, and synapse loss. Increasing evidence supports a role of amyloid β-peptide (Aβ)-induced oxidative stress in the progression and pathogenesis of AD. In this review, we summarize evidence for a role of oxidative stress in the progression of AD by comparing the appearance of the same oxidized brain proteins from subjects with mild
more » ... itive impairment (MCI), early AD (EAD), and late-stage AD, and relating these findings to the reported AD pathology. The identification of oxidized brain proteins in common in MCI, EAD, and AD brain suggest that certain key pathways are triggered and may be involved in the progression of AD. Exploring these pathways in detail may provide clues for better understanding the pathogenesis and progression of AD and also for the development of effective therapies to treat or delay this dementing disorder.
doi:10.3233/jad-2010-1222 pmid:20061649 fatcat:sci3u2ewmrcfbfihldchfsqrfi

Inhibition of tumor angiogenesis by oral etoposide

DIPAK PANIGRAHY, ARJA KAIPAINEN, CATHERINE E. BUTTERFIELD, DEVINEY M. CHAPONIS, ANDREA M. LAFORME, JUDAH FOLKMAN, MARK W. KIERAN
2010 Experimental and Therapeutic Medicine  
vehicle after removal of the primary llc. in mice treated with vehicle, growing invasive metastasis almost entirely replaced the normal lung tissue, leading to lung weights in these mice of 505±42 mg. in marked  ... 
doi:10.3892/etm.2010.127 pmid:22993597 pmcid:PMC3445956 fatcat:rlapyautwverbaq3oa4wc7vjzm

Microbial Population Structures in the Deep Marine Biosphere

J. A. Huber, D. B. Mark Welch, H. G. Morrison, S. M. Huse, P. R. Neal, D. A. Butterfield, M. L. Sogin
2007 Science  
The point at generation 0 represents wild fish as a control (marked as a cross). Estimates of the RRS of C[WxW] are plotted at generation 1 and C[CxW] at generation 2.  ...  Mark Welch, Genome Biol. 8, R143 (2007). 21. C. Pedros-Alio, Trends Microbiol. 14, 257 (2006). 22. P. D. Schloss, J. Handelsman, PLoS Comput. Biol. 2, e92 (2006). 23. R. E. Ley et al., Appl. Environ.  ... 
doi:10.1126/science.1146689 pmid:17916733 fatcat:a3fwiu7twzc2hlef3zk56lmuie

4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease

Jennifer Drake, Robin Petroze, Alessandra Castegna, Qunxing Ding, Jeffrey N. Keller, William R. Markesbery, Mark A. Lovell, D.Allan Butterfield
2004 Neuroscience Letters  
There is increasing evidence of DNA oxidation and altered DNA repair mechanisms in Alzheimer's disease (AD) brain. Histones, which interact with DNA, conceivably could provide a protective shield for DNA against oxidative stress. However, because of their abundant lysine residues, histones may be a target for 4-hydroxynonenal (HNE) modification. In this study, we have shown that HNE binds to histones and that this binding affects the conformation of the histone, measured by electron
more » ... resonance in conjunction with a proteinspecific spin label. The covalent modification to the histone by HNE affects the ability of the histone to bind DNA. Interestingly, acetylated histones appear to be more susceptible to HNE modifications than control histones. Conceivably, altered DNA-histone interactions, subsequent to oxidative modification of histones by the lipid peroxidation product HNE, may contribute to the vulnerability of DNA to oxidation in AD brain. q
doi:10.1016/j.neulet.2003.11.047 pmid:15036618 fatcat:45zcphczjbdkfi3omp6jl4s6jm

Predictive Ecological Land Classification From Multi-Decadal Satellite Imagery

Daniel Sousa, Frank W. Davis, Kelly Easterday, Mark Reynolds, Laura Riege, H. Scott Butterfield, Moses Katkowski
2022 Frontiers in Forests and Global Change  
Owned and managed by The Nature Conservancy, JLDP has global significance for coastal, marine, and terrestrial biodiversity conservation (Butterfield et al., 2019 ; Figure 1 ).  ... 
doi:10.3389/ffgc.2022.867369 doaj:9bebc5b9d61e4e3990dab210dc254e05 fatcat:vsadiqfqbjhj3maqyqi24wmvcu

PPARα Deficiency in Inflammatory Cells Suppresses Tumor Growth

Arja Kaipainen, Mark W. Kieran, Sui Huang, Catherine Butterfield, Diane Bielenberg, Gustavo Mostoslavsky, Richard Mulligan, Judah Folkman, Dipak Panigrahy, Mikhail Blagosklonny
2007 PLoS ONE  
2007. PPAR\(\alpha\) deficiency in inflammatory cells suppresses tumor growth. PLoS ONE 2(2): e260. Published Version
doi:10.1371/journal.pone.0000260 pmid:17327920 pmcid:PMC1800345 fatcat:mhugqrmz4zdevno4qvc3qlklfe

Penetration of Vancomycin into Epithelial Lining Fluid in Healthy Volunteers

Thomas P. Lodise, George L. Drusano, Jill M. Butterfield, Joshua Scoville, Mark Gotfried, Keith A. Rodvold
2011 Antimicrobial Agents and Chemotherapy  
ABSTRACTAlthough vancomycin is often regarded as an agent that concentrates poorly in the lower respiratory tract, as determined from concentrations in epithelial lining fluid (ELF), few data are available. This study sought to determine the profile of vancomycin exposure in the ELF relative to plasma. Population modeling and Monte Carlo simulation were employed to estimate the penetration of vancomycin into ELF. Plasma and ELF pharmacokinetic (PK) data were obtained from 10 healthy volunteers.
more » ... Concentration-time profiles in plasma and ELF were simultaneously modeled using a three-compartment model with zero-order infusion and first-order elimination and transfer using the big nonparametric adaptive grid (BigNPAG) program. Monte Carlo simulation with 9,999 subjects was performed to calculate the ELF/plasma penetration ratios by estimating the area under the concentration-time curve (AUC) in ELF (AUCELF) and plasma (AUCplasma) after a single simulated 1,000-mg dose. The mean (standard deviation) AUCELF/AUCplasmapenetration ratio was 0.675 (0.677), and the 25th, 50th, and 75th percentile penetration ratios were 0.265, 0.474, and 0.842, respectively. Our results indicate that vancomycin penetrates ELF at approximately 50% of plasma levels. To properly judge the adequacy of current doses and schedules employed in practice, future studies are needed to delineate the PK/PD (pharmacodynamics) target for vancomycin in ELF. If the PK/PD target in ELF is found to be consistent with the currently proposed target of an AUC/MIC of ≥400, suboptimal probability of target attainment would be expected when vancomycin is utilized for pneumonias due to MRSA (methicillin-resistantStaphylococcus aureus) with MICs in excess of 1 mg/liter.
doi:10.1128/aac.00712-11 pmid:21911567 pmcid:PMC3232765 fatcat:63bdotolnva2xbqlz4wyxe6ms4

Isolated communities of Epsilonproteobacteria in hydrothermal vent fluids of the Mariana Arc seamounts

Julie A. Huber, Holly V. Cantin, Susan M. Huse, David B. Mark Welch, Mitchell L. Sogin, David A. Butterfield
2010 FEMS Microbiology Ecology  
Whole unfiltered fluids for chemical analyses were also collected and analyzed according to Butterfield et al. (2004) .  ...  Diffuse vents represent a mixture of seawater and vent fluids that mix in the crust before venting on the seafloor (Butterfield et al., 2004) .  ... 
doi:10.1111/j.1574-6941.2010.00910.x pmid:20533947 fatcat:njlvxl3lyzffrdo3egc2y2pjhq
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