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Early Rectal Cancer: Definition and Management

Emanuele Lezoche, Maddalena Baldarelli, Angelo De Sanctis, Giovanni Lezoche, Mario Guerrieri
2007 Digestive Diseases  
treated with transanal endoscopic microsurgery were similar to those reported in the literature after conventional surgery (total mesorectal excision). Colorectal cancer is the second most common cause of cancer deaths in the Western world. More than 35,000 new rectal cancers are diagnosed every year in the USA and 25% are stage I disease. Fewer than half of these cases are lesions confined to the mucosa and submucosa [1] . In the past the gold standard of treatment for all low rectal cancers
more » ... ow rectal cancers was anterior resection with coloanal or low rectal anastomosis and abdominoperinal resection. These procedures led to good results in terms of local recurrence and 5-year survival rate [1-4] . Unfortunately, resection of the rectum is a major surgery procedure associated with significant morbidity (7-68%), mortality (0-6.5%), alteration in body image and sometimes distressing functional consequences for the patients [2] . In the past the use of local excision was limited to highrisk patients for major surgery, especially in the elderly and those who refused radical surgery because of permanent colostomy. However, the high number of complications, functional sequels and sphincter sacrifice rates associated with radical resection prompted researchers to reevaluate local excision for distal rectal cancer as an al- Key Words Rectal cancer ؒ Preoperative staging ؒ Preoperative radiotherapy and chemotherapy ؒ Transanal endoscopic microsurgery Abstract Background: Local excision of rectal cancer is an alternative to radical resection but today its role surrounding the management of patients with early stage rectal cancer (T1-T2-N0) represents an important surgical issue. Aim: To analyze the results of 135 patients with early stage low rectal cancer treated with local excision by transanal endoscopic microsurgery and in the case of T2 also by neoadjuvant therapy. Study Design: 135 patients with T1-T2-N0-M0 rectal cancer were enrolled in the study. Staging according to the definitive histological findings was as follows: pT0 in 24 patients (17.8%), pT1 in 66 patients (48.8%) and pT2 in 45 patients (33.4%). Results: Minor complications were observed in 12 patients (8.8%) whereas major complications were seen only in 2 patients (1.5%). At a median follow-up of 78 (36-125) months, local recurrences occurred in 4 patients and distal metastasis in 2 patients (all patients were staged preoperatively T2). Disease-free survival rates in T1 and T2 patients were 100 and 93% respectively at the end of follow-up. Conclusions: With respect to local recurrence and survival rate, the long-term results of early stage rectal cancer in patients
doi:10.1159/000099173 pmid:17384511 fatcat:ob5bldvq2rflvcwvxtx6x3cscu

Knowledge extraction, modeling and formalization: EEG case study [article]

Dmitry Morozov, Mario Lezoche, Hervé Panetto
2018 arXiv   pre-print
Formal Concept Analysis (FCA) is a well-established method for data analysis which finds many applications in data mining. Its extension on complex data representation formats brought a wave of new applications to the problems such as gene expression mining, prediction of toxicity of chemical compounds or clustering of sequences in process event logs. Insipired from this work our research inherits their model and designs an experiment for mining electroencephalographic recordings for patterns
more » ... ings for patterns of sleep spindles. The contribution of this paper lies in the specification of desritizition procedure and the architecture of FCA experiment. We also provide some reflection on the related research papers.
arXiv:1809.09955v1 fatcat:mhindvmz2rg5jfi6xlkcjgmx74

Cyber-Physical Systems, a new formal paradigm to model redundancy and resiliency [article]

Mario Lezoche
2018 arXiv   pre-print
The actual investigation is about the application of an approach named Formal Concept Analysis (FCA) for modelling and analysing a large-scale set of collaborative systems (Lezoche et al., 2012) , specifically  ... 
arXiv:1810.06911v1 fatcat:uetlvu2a4zaefcj4kluaogo2ji

Results of Medium Seventeen Years' Follow-Up after Laparoscopic Choledochotomy for Ductal Stones

Silvia Quaresima, Andrea Balla, Mario Guerrieri, Giovanni Lezoche, Roberto Campagnacci, Giancarlo D'Ambrosio, Emanuele Lezoche, Alessandro M. Paganini
2016 Gastroenterology Research and Practice  
Conflict of Interests Silvia Quaresima, Andrea Balla, Mario Guerrieri, Giovanni Lezoche, Roberto Campagnacci, Giancarlo D' Ambrosio, Emanuele Lezoche, and Alessandro M.  ... 
doi:10.1155/2016/9506406 pmid:26880900 pmcid:PMC4735927 fatcat:mvrqxqp3urfcxetrmdfomwwfzm

Multi-paradigm modelling of Cyber-Physical Systems

Dmitry Morozov, Mario Lezoche, Hervé Panetto
2018 IFAC-PapersOnLine  
Cyber-Physical Systems (CPS) lead to the 4-th Industrial Revolution (Industry 4.0) that will have benefits from high flexibility of production, easy and so more accessible participation of all involved parties of business processes. The Industry 4.0 production paradigm is characterized by autonomous behaviour and intercommunicating properties of its production elements across all levels of manufacturing processes so one of the key concept in this domain will be the semantic interoperability of
more » ... nteroperability of systems. This goal can benefit from formal methods well known in various scientific domains such as artificial intelligence, and machine learning. So, the current research concerns the adaptation of the approach named Formal Concept Analysis (FCA) for structuring knowledge and for optimizing CPS interoperability.
doi:10.1016/j.ifacol.2018.08.334 fatcat:a2blkmkuazeirgynbbvpyl5xni

Robot-Assisted Colonic Resections for Cancer [chapter]

Monica Ortenzi, Giovanni Lezoche, Roberto Ghiselli, Mario Guerrieri
2016 Colorectal Cancer - From Pathogenesis to Treatment  
Author details Monica Ortenzi * , Giovanni Lezoche, Roberto Ghiselli and Mario Guerrieri *Address all correspondence to: monica.ortenzi@gmail.com Polytechnic University of Marche, Surgical Clinic, United  ... 
doi:10.5772/62416 fatcat:amxt2f2vevhdhp7xn6vbe7piba

Semantics enactment in Enterprise Information Systems

Esma Yahia, Mario Lezoche, Alexis Aubry, Hervé Panetto
2011 IFAC Proceedings Volumes  
The grown complexity of the modern enterprise poses a series of challenges, among them keeping competitiveness in the fast changing environment in which the enterprise evolves. Addressing Enterprise Integration is considered as a key to achieve the goal of any enterprise either it is a single or a networked enterprise. Enterprise Modelling is a prerequisite to enable the common understanding of the enterprises and its various interactions in order to "provide the right information, at the right
more » ... ation, at the right time, at the right place". However, problems often emerge from a lack of understanding of the semantics of the elaborated models resulting from various modelling experience based on different methods and tools. In this paper, we describe the challenges associated to semantics enactment in Information Systems models. To facilitate this enactment, we propose an approach based on a fact-oriented modelling perspective. Then, we also provide an algorithm to automatically build semantic aggregates that help in highlighting Enterprise Models core embedded semantics. A case study on the field of B2M interoperability is performed in order to illustrate the application of the presented approach.
doi:10.3182/20110828-6-it-1002.03597 fatcat:vfplrhzw45bztiyyygrkamiwbm

Semantic Annotation Model Definition for Systems Interoperability [chapter]

Yongxin Liao, Mario Lezoche, Hervé Panetto, Nacer Boudjlida
2011 Lecture Notes in Computer Science  
Semantic annotation is one of the useful solutions to enrich target's (systems, models, meta-models, etc.) information. There are some papers which use semantic enrichment for different purposes (integration, composition, sharing and reuse, etc.) in several domains, but none of them provides a complete process of how to use semantic annotations. This paper identifies three main components of semantic annotation, proposes for it a formal definition and presents a survey of current semantic
more » ... rent semantic annotation methods. At the end, we present a simple case study to explain how our semantic annotation proposition can be applied.The survey presented in this paper will be the basis of our future research on models, semantics and architecture for enterprises systems interoperability during the product lifecycle.
doi:10.1007/978-3-642-25126-9_14 fatcat:izu6yqa23zcvlccvt5khdpja7a

Cyber-Physical Systems, a new formal paradigm to model redundancy and resiliency

Mario Lezoche, Hervé Panetto
2018 Enterprise Information Systems  
The actual investigation is about the application of an approach named Formal Concept Analysis (FCA) for modelling and analysing a large-scale set of collaborative systems (Lezoche et al., 2012) , specifically  ... 
doi:10.1080/17517575.2018.1536807 fatcat:pfnyrgbtejb6xgretp7svkdqwq

Sustainability Assessment of Manufacturing Organizations Based on Indicator Sets: A Formal Concept Analysis [chapter]

Yasamin Eslami, Michele Dassisti, Hervé Panetto, Mario Lezoche
2019 Msphere  
Organizations are struggling to survive in today's competitive market. They are mostly obliged to meet customers' expectations and demand for sustainable products from one side and comply with governmental rules and regulations regarding energy, resources, materials, etc. on the other side. Therefore, measuring their sustainability performance and trying to keep up with the competitors is essential for their future development. Consequently, organizations' perception of operational
more » ... tional sustainability can reveal their strategies on how to be sustainable, endeavouring the three pillars of economic, environmental and social. The present work investigates the role of indicators' choice and their meaning for sustainability assessment of manufacturing organizations. To this point, an analysis is conducted on the sustainability assessment of 100 manufacturing organizations using GRI indicators for assessing their sustainability state. A Formal Concept Analysis was run to look over the indicators and their interpretations to reach a given degree of sustainability of the organization.
doi:10.1007/978-3-030-11683-5_4 fatcat:fkmzksc5rzdtlk7ls344f4qdgq

CONFIGURING PROCESS VARIANTS THROUGH SEMANTIC REASONING IN SYSTEMS ENGINEERING

Silvana Pereira Detro, Edoardo Portela, Eduardo Loures Rocha, Hervé Panetto, Mario Lezoche
2017 Insight  
Lezoche, (mario.lezoche@univlorraine.fr) Organizations faces the challenge to adapt their business process according changes that may occur in the dynamic environment in which they operate.  ...  (silvana.detro@pucpr.edu.br); Eduardo Alves Portela Santos, (eduardo.portela@pucpr.br); Hervé Panetto, (herve.panetto@univ-lorraine.fr); Eduardo de Freitas Rocha Loures, (eduardo.loures@pucpr.br) and Mario  ... 
doi:10.1002/inst.12179 fatcat:bfnaartnx5hu3puux4nq5fhazu

Semantic Lifting of Business Process Models

Antonio De Nicola, Tania Di Mascio, Mario Lezoche, Francesco Tagliano
2008 2008 12th Enterprise Distributed Object Computing Conference Workshops  
Business Process modeling is constantly acquiring attention in modern enterprises. Today, BP editor tools support modelers in building correct diagrams only from the syntactic point of view. Enriching them with ontologies may bring many advantages, that go from the possibility of applying advanced reasoning techniques, aimed at the identification of contradictions and mistakes in the model specification, to the possibility of organizing BP models repositories, with advanced search and retrieval
more » ... earch and retrieval facilities. Finally, semantic technologies can substantially help the solution of the Business/IT alignment problem. Semantic enrichment of a BP can be achieved by representing a BP, or part of it, with an ontology-oriented formalism (semantic lifting) and mapping it to a reference ontology. In this paper, we present the basic elements of a Business Process Ontology framework (OPAL+BPAL) and its concrete representation according to an OWL syntax. Finally, we show how it is possible to generate an OWL representation of a BPMN diagram.
doi:10.1109/edocw.2008.55 dblp:conf/edoc/NicolaMLT08 fatcat:6d2bxbrjkbgmrksyuerzzejlie

Semantics enactment for interoperability assessment in enterprise information systems

Esma Yahia, Mario Lezoche, Alexis Aubry, Hervé Panetto
2012 Annual Reviews in Control  
The grown complexity of the modern enterprise poses a series of challenges, among them keeping competitiveness in the fast changing environment in which the enterprise evolves. Addressing Enterprise Integration is considered as a key to achieve the goal of any enterprise either it is a single or a networked enterprise. Enterprise Modelling is a prerequisite to enable the common understanding of the enterprises and its various interactions in order to "provide the right information, at the right
more » ... ation, at the right time, at the right place". However, problems often emerge from a lack of understanding of the semantics of the elaborated models resulting from various modelling experience based on different methods and tools. This paper describes the challenges associated to semantics enactment in Information Systems models. To facilitate this enactment, it proposes an approach based on a fact-oriented modelling perspective. Then, it also provides an algorithm to automatically build semantic aggregates that help in highlighting Enterprise Models core embedded semantics. A case study on the field of B2M interoperability is performed in order to illustrate the application of the presented approach.
doi:10.1016/j.arcontrol.2012.03.008 fatcat:3rsup6azorfyvdqyspcfabnrpa

Formal Fact-Oriented Model Transformations for Cooperative Information Systems Semantic Conceptualisation [chapter]

Mario Lezoche, Alexis Aubry, Hervé Panetto
2012 Lecture Notes in Business Information Processing  
Information in enterprise is, now more than ever, a fundamental resource. In order to increase enterprise performance, economics paradigms focus on how to better manage it. Information Systems (IS) are systems whose activities are devoted to capture and to store data, to process them and produce knowledge, used by any stakeholders within an enterprise or among different networked enterprises. The modern architecture of information systems is based on distributed networks. An important
more » ... important challenge, to reach higher performance, is to represent and share knowledge managed by those ISs. One of the main issues in making such heterogeneous Cooperative Information Systems (CIS) working together is to remove semantics interoperability barriers. This paper firstly analyses interoperability issues between CISs and then proposes a systematic approach for data models conceptualisation for knowledge explicitation, based on initial conceptual model cleaning rules, expert knowledge injection rules and finally fact-oriented transformation rules. A case study is proposed, related to a work order process in an Enterprise Resource Planning application, Sage X3.
doi:10.1007/978-3-642-29958-2_8 fatcat:etu2vsxbi5cudiey6nkhph5a2i

Formalization of Semantic Annotation for Systems Interoperability in a PLM Environment [chapter]

Yongxin Liao, Mario Lezoche, Eduardo Loures, Hervé Panetto, Nacer Boudjlida
2012 Lecture Notes in Computer Science  
Nowadays, the need for systems collaboration across enterprises and through different domains has become more and more ubiquitous. Due to the lack of standardized models or architecture, as well as semantic mismatching and inconsistencies, research works on information and model exchange, transformation, discovery and reuse are carried out in recent years. One of the main challenges in these researches is to overcome the semantic gap between enterprise applications along any product lifecycle,
more » ... product lifecycle, involving many distributed and heterogeneous enterprise applications. We propose, in this paper, an approach for semantically annotating different knowledge views (business process models, business rules, conceptual models, and etc.) in the Product Lifecycle Management (PLM) environment. These formal semantic annotations will make explicit the tacit knowledge generally engraved in application models and act as bridges to support all actors in along the product lifecycle. A case study based on a specific manufacturing process will be presented for demonstrating how our semantic annotations can be applied in a Business to Manufacturing (B2M) interoperability context.
doi:10.1007/978-3-642-33618-8_29 fatcat:j23gi73gsvaf3bkbmtjjqusare
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