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Structural Implications of Siglec-5-Mediated Sialoglycan Recognition
2008
Journal of Molecular Biology
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Sialic acid Ig-like binding lectins are important mediators of recognition and signaling events among myeloid cells. To investigate the molecular mechanism underlying Siglec functions, we have determined the crystal structure of the two N-terminal extracellular domains of a human myeloid cell inhibitory receptor Siglec-5 (CD170) and its complexes with two sialylated carbohydrates. The native structure revealed an unusual conformation of the CC′ ligand specificity loop and a unique interdomain
doi:10.1016/j.jmb.2007.10.009
pmid:18022638
pmcid:PMC2245879
fatcat:vlh5jcmh6jchpp2tqnvo2xu2xq
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... sulfide bond. The α(2,3)-sialyllactose and α(2,6)-sialyllactose complexed structures showed a conserved sialic acid recognition motif that involves both Arg 124 and a portion of the Gstrand in the V-set domain forming β-sheet-like hydrogen bonds with the glycerol side chain of the sialic acid. Only few direct protein contacts to the sub-terminal sugars are observed and mediated by the highly variable GG′ linker and CC′ loop. These structural observations in conjunction with surface plasmon resonance binding assays provide mechanistic insights into the linkage-dependent Siglec carbohydrate recognition and suggest that Siglec-5 and other CD33-related Siglec receptors are more promiscuous in sialo-glycan recognition than previously understood.
Training research through EFL
2016
SHS Web of Conferences
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In a globalized research market, developing students' research skills by means of a foreign language is of particular importance. Students' research work within the framework of the syllabus and extracurricular activities constitute the system of scientific work of students in a higher education institution. The potential of a foreign language in shaping the academic and research competence of students of Economics is revealed in the content and process aspects. Linguistics and economics as
doi:10.1051/shsconf/20162601097
fatcat:wvzqpkjlkja7bc4a4w766r655u
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... ds of scientific knowledge are reflected in the content aspect. Regarding the mode of training research, the emphasis is on reading strategies and activities aimed at fluent comprehension and handling professional and scientific information. Students' scientific conference survey proves the potential of EFL in research activities and sheds the light on the new ways to develop research competence. 26 shs SHS Web of Conferences 1097 E PA R 5 4 The following survey results may be noted as positive ones: the main motive of participation in the conference of the students of all levels of education (those undertaking bachelor's and master's degreeprograms, and additional education program) is their interest to the topic chosen and their attitude to the foreign language they study -80 % of respondents respectively; 70 % of the participants were senior undergraduates, although English is taught for the first-and second-year students doing Bachelor's degree; English and Russian sources were used in almost equal propotion, and the usage of Russian materials means that translation as one of the main types of written communication was implemented; more than 50 % of the participants showed their intention to continue their research on the topic chosen. The number of sources adapted varied between 2 and 3, and it is not enough especially for graduate students. With regard to the composition of the rest of the participants, it was distributed as follows: 20% were first-year students, and only 10 %were students undertaking Master's degree programsfor whom research work is, in fact, the main focus of study.
Development of prospective engineers' readiness for international partnership in oil and gas production
2020
Samara Journal of Science
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This paper deals with the development of prospective engineers readiness for international partnership in oil and gas industries. The directions of international technological cooperation of integrated corporations are described. The paper presents approaches and principles (advanced learning, efficiency of technological knowledge, global technological imperative, motivation for competitiveness, internationalization, social partnership, interdisciplinarity) used for readiness development
doi:10.17816/snv202094305
fatcat:ti7gwxq5bnadjaxyzhpp34hln4
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... modeling. The conditions for the activity of a prospective engineer in internationally integrated companies and the possibilities of the international polypartner educational environment for engineering activity modeling in internationally integrated companies are correlated. The development of prospective engineers readiness for international technological partnership in oil and gas production is carried out in the course of a phased continuous training and divided into the following stages: introduction-technological, adaptation-technological and initiative-technological. To assess the effectiveness of the development of prospective engineers readiness for international partnership in oil and gas industries, motivational, professional-activity (scientific and technological, organizational and managerial, communicative) and personal resource criteria are used. The paper defines a number of performance indicators for each of the three stages: development of additional competencies, knowledge in the field of intellectualization, technology commercialization, research activities during academic mobility, scientific publications in international journals, work experience in an international company.
Angiogenic activity of cytochalasin B-induced membrane vesicles of human mesenchymal stem cells
[article]
2019
bioRxiv
pre-print
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The cytochalasin B-induced membrane vesicles (CIMVs) are suggested to be used as a vehicle for the delivery of therapeutics. However, the angiogenic activity and therapeutic potential of human mesenchymal stem cells (MSCs) derived CIMVs (CIMVs-MSCs) remains unknown. Objectives: The objectives of this study were to analyzed the morphology, size distribution, molecular composition and angiogenic properties of CIMVs-MSCs. Methods: The morphology of CIMVs-MSC was analyzed by scanning electron
doi:10.1101/646398
fatcat:uca3pinrx5expc6mil4kxiwoti
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... copy. The proteomic analysis, multiplex analysis and immunostaining were used to characterize the molecular composition of the CIMVs-MSCs. The transfer of surface proteins from a donor to a recipient cell mediated by CIMVs-MSCs was demonstrated using immunostaining and confocal microscopy. The angiogenic potential of CIMVs-MSCs was evaluated using in vivo approach of subcutaneous implantation of CIMVs-MSCs in mixture with Matrigel matrix. Results: Human CIMVs-MSCs retain parental MSCs content such as growth factors, cytokines, chemokines: EGF, FGF-2, Eotaxin, TGF-α, G-CSF, Flt-3L, GM-CSF, Fractalkine, IFNα2, IFN-γ, GRO, IL-10, MCP-3, IL-12p40, MDC, IL-12p70, IL-15, sCD40L, IL-17A, IL-1RA, IL-1a, IL-9, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, MCP-1, MIP_1a, MIP-1b, TNF-α, TNF-β, VEGF. CIMVs-MSCs also have the expression of surface receptors similar to those in parental human MSCs (CD90+, CD29+, CD44+, CD73+). Additionally, CIMVs-MSCs could transfer membrane receptors to the surfaces of target cells in vitro. Finally, CIMVs-MSCs can induce angiogenesis in vivo after subcutaneous injection into adult rats. Conclusions: Human CIMVs-MSCs have similar content, immunophenotype and angiogenic activity to those of the parental MSCs. Therefore, we believe that human CIMVs-MSCs could be used for cell free therapy of degenerative diseases.
On Assignment of the Upper Bohl Exponent for Linear Time-Invariant Control Systems in a Hilbert Space by State Feedback
2020
Mathematics
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We consider a linear continuous-time control system with time-invariant linear bounded operator coefficients in a Hilbert space. The controller in the system has the form of linear state feedback with a time-varying linear bounded gain operator function. We study the problem of arbitrary assignment for the upper Bohl exponent by state feedback control. We prove that if the open-loop system is exactly controllable then one can shift the upper Bohl exponent of the closed-loop system by any
doi:10.3390/math8060992
fatcat:6dixrblfzvglbitmbgct6ye3hu
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... n number with respect to the upper Bohl exponent of the free system. This implies arbitrary assignability of the upper Bohl exponent by linear state feedback. Finally, an illustrative example is presented.
Extension activities of Kazan Imperial University in the 19th century
2017
SHS Web of Conferences
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WHQVLRQ DFWLYLWLHV RI .D]DQ ,PSHULDO 8QLYHUVLW\ LQ WKH WK FHQWXU\ (YJHQLD =KXUDYOHYD 5LPPD 0DUGDQVKLQD D 0DULQD .XGU\DYWVHYD DQG $QLVD .KXVDLQRYD .D]DQ )HGHUDO 8QLYHUVLW\ ,QVWLWXWH RI 0DQDJHPHQW (FRQRPLFV DQG )LQDQFH 5XVVLD $EVWUDFW %DVHG SULPDULO\ RQ DUFKLYDO GRFXPHQWV WKLV DUWLFOH H[SORUHV WKH GHYHORSPHQW RI DGGLWLRQDO HGXFDWLRQ LQ .D]DQ SURYLQFH 5XVVLD LQ WKH WK FHQWXU\ ,WV JHQHVLV LV IRXQG LQ WKH YDU\LQJ RUGHU RI .D]DQ ,PSHULDO 8QLYHUVLW\ H[WHQVLRQ DFWLYLWLHV ZKLFK WDNH WKH IRUP RI IRUHLJQ
doi:10.1051/shsconf/20173701068
fatcat:qa7rlxcu5fegtkjiuwe4dn7cbm
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... FDGHPLF DQG VFLHQWLILF PRELOLW\ LQGLYLGXDO PHQWRULQJ SUDFWLFH RI UHFRJQLVHG VFKRODUV PDVWHUV ¶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additional LV XVHG WR UHIHU WR HGXFDWLRQ UHFHLYHG LQ DGGLWLRQ WR IRUPDO LQVWUXFWLRQ 5HVHDUFK PHWKRGV FRYHU WKH DQDO\VLV RI DUFKLYDO GRFXPHQWV .D]DQ ,PSHULDO 8QLYHUVLW\ SURIHVVRUV ¶ VSHHFKHV UHSRUWV DQG PRQRJUDSKV 8QLYHUVLW\ &KDUWHU WKH 3HGDJRJLFDO 6RFLHW\ &KDUWHU DQG &LUFXODU /HWWHUV RI 0LQLVWU\ RI (GXFDWLRQ HWF DQG JHQHUDOL]DWLRQ RI WKH GDWD REWDLQHG 7KLV PDGH LW SRVVLEOH WR LGHQWLI\ 8QLYHUVLW\ ZLGHQLQJ DFWLYLWLHV DV WKH IRXQGDWLRQ IRU DGGLWLRQDO HGXFDWLRQ IRUPDWLRQ LQ WKH WK DQG HDUO\ WK FHQWXULHV D &RUUHVSRQGLQJ DXWKRU ULP\OMD#PDLOUX
Information Competence Structure and Content of the Higher School Students
2015
Mediterranean Journal of Social Sciences
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For free orientation in the flow of information people should possess information competence as one of the components of professionalism. In this regard, the article reveals the structure and content of the information competence of students, including motivational and values, cognitive, activity, communicative and health saving components that are in relationships and are aimed at ensuring the integrity and continuity of the process of students' information competence forming in conditions of
doi:10.5901/mjss.2015.v6n2s3p254
fatcat:mzfg55ybgbff7hhzrs5n7juvay
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... odern high school.The article also describes the problem of the teachers' functions' expansion involved in this process. The article can be recommended for use in modern practice of educational institutions, as well as in the system of teacher training.
COMMUNITY-ACQUIRED PNEUMONIA IN INFECTIOUS HOSPITAL PATIENTS: THE DEVELOPMENT OF RESISTANCE TO ANTIMICROBIALS
2018
Epidemiology and Infectious Diseases (Russian Journal)
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, Zhuravleva E.V. ...
Антимикробный препарат Streptoccocus pneumoniaе
Staphylococcus aureus Пенициллин (скрининг) 0,76% For correspondence: Marina G Avdeeva, Doctor of For citation: Avdeevа M.G., Shubina G.V., Ganzha A.A. ...
doi:10.18821/1560-9529-2018-23-3-108-113
fatcat:xjeyhevcmndhdaf6hdyoanlw5a
Pharmacokinetics of enalapril in patients with arterial hypertension depending on the glomerular filtration rate
2019
КардиоСоматика
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Литература/References For citation: Zhuravleva M.V., Prokofiev A.B., Dmitriev A.I. et al. ...
doi:10.26442/22217185.2019.3.190409
fatcat:aqicr5qlljdbxnzwpug7fugnzm
TOOLS AND TECHNOLOGIES OF INFLUENCE ON THE READER (BASING ON THE BRITISH NEWSPAPERS)
ИНСТРУМЕНТЫ И ТЕХНОЛОГИИ ВОЗДЕЙСТВИЯ НА ЧИТАТЕЛЯ (НА МАТЕРИАЛЕ БРИТАНСКИХ ГАЗЕТ)
2019
Philological Sciences Issues of Theory and Practice
ИНСТРУМЕНТЫ И ТЕХНОЛОГИИ ВОЗДЕЙСТВИЯ НА ЧИТАТЕЛЯ (НА МАТЕРИАЛЕ БРИТАНСКИХ ГАЗЕТ)
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TOOLS AND TECHNOLOGIES OF INFLUENCE ON THE READER (BASING ON THE BRITISH NEWSPAPERS) Zhuravleva Ol'ga Alekseevna, Ph. D. in Philology Pivovarova Marina Olegovna, Ph. ...
doi:10.30853/filnauki.2019.4.9
fatcat:adv3xu535rg3faepfyjhjuwlrq
Improving the representation of peptide-like inhibitor and antibiotic molecules in the Protein Data Bank
2014
Biopolymers
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With the accumulation of a large number and variety of molecules in the Protein Data Bank (PDB) comes the need on occasion to review and improve their representation. The Worldwide PDB (wwPDB) partners have periodically updated various aspects of structural data representation to improve the integrity and consistency of the archive. The remediation effort described here was focused on improving the representation of peptidelike inhibitor and antibiotic molecules so that they can be easily
doi:10.1002/bip.22434
pmid:24173824
pmcid:PMC3992913
fatcat:fsy4z23qcfgnvjj2jpn3stgwta
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... fied and analyzed. Peptide-like inhibi-tors or antibiotics were identified in over 1000 PDB entries, systematically reviewed and represented either as peptides with polymer sequence or as single components. For the majority of the single-component molecules, their peptide-like composition was captured in a new representation, called the subcomponent sequence. A novel concept called "group" was developed for representing complex peptide-like antibiotics and inhibitors that are composed of multiple polymer and nonpolymer components. In addition, a reference dictionary was developed with detailed information about these peptide-like molecules to aid in their annotation, identification and analysis. Based on the experience gained in this remediation, guidelines, procedures, and tools were developed to annotate new depositions containing peptide-like inhibitors and antibiotics accurately and consistently.
Models and Technologies to Manage the Institutionalization of Sustainable Innovative Development of Meso-Systems
2015
Mediterranean Journal of Social Sciences
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The relevance of the study is reasoned by the lack of manifestation in the Russian context of innovative factors of sustainable economic development and by the need for institutionalization and the development of management technologies for formation of prospective trajectories of development, creating incentives for innovation at enterprises, industries and in the national economy as a whole. The aim of the study is the search for and development of models and management technologies of
doi:10.5901/mjss.2015.v6n6s2p504
fatcat:6zkygmk635foxaw7sxwqsdibca
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... tionalization of meso-systems' innovative development. The leading method is the process modeling method of sustainable innovative development's management of economic systems on the basis of systematization of factors and trends in terms of types of economic activity. The article summarizes the ideas about model dependencies within the innovative development of economic systems, a typology of institutions for innovation development is proposed, a number of model solutions to the problems of institutional gaps is offered in order to supply the chain of innovative products and approaches to the effectiveness' evaluation of the institutionalization of sustainable innovative development are discussed. The materials of the articles -managerial and methodological solutions are of practical value for the following fields and sectors of innovation development: regulation and monitoring of innovation activities of enterprises, objects of regional innovation infrastructure and technology transfer for innovation-active enterprises in the field of manufacturing and other Materials articles -managerial and methodological solutions are of practical value for the following fields and sectors of innovation development: regulation and monitoring authorities of enterprises' innovation activities, agencies of regional innovation infrastructure and transfer technologies, for innovation-active enterprises in the field of refining manufacturing, etc. 509 to destruction of the existing institutional framework of industrial and cross-industrial interactions of market participants. Therefore, for the model of the innovation chain of added value it is necessary to explain the reasons and to allocate the institutional mechanisms to ensure the innovations' growing impulse, taking into account that a similar situation will arise throughout the chain of macro technology. The nodes of the circuit, in case of their alternativeness and belonging to different meso-systems (figure 3) mean the analogue of the bifurcation point, effecting a change (rise or fall) of the current production efficiency at the meso-, macro-, mega-levels of economic systems.
Erratum to: Expression of SOD and production of reactive oxygen species in Acinetobacter calcoaceticus caused by hydrocarbon oxidation
2016
Annals of Microbiology
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Antimicrobial Dispensing Practice in Community Pharmacies in Russia during the COVID-19 Pandemic
2022
Antibiotics
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COVID-19 has had a significant impact on health care systems, including drug use. The present study aimed to evaluate the patterns of community supply of antimicrobials from community pharmacies during the COVID-19 pandemic in five cities of Russia. In a cross-sectional study, a random sample of pharmacies reported all episodes of antimicrobials supply during a one-week period. Patterns of supply (age and gender of customer, drug name and formulation, prescription availability, indication,
doi:10.3390/antibiotics11050586
fatcat:lxu4gezwkfewnaeyito5yy4pru
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... were analyzed. Altogether, 71 pharmacies took part in the study and 5270 encounters were recorded. In total, 4.2% of visits resulted in supply of more than one antimicrobial agent and 5.2% were for parenteral formulations. The rate of prescription-based purchase in participated cities varied from 40.5 to 99.1%. Systemic antibiotics and antivirals accounted for the majority of supplies (60.5 and 26.3%, respectively). Upper respiratory tract infections were reported as the indication for antimicrobials usage in 36.9% of cases, followed by skin and soft tissue infections (12.1%) and urinary tract infections (8.7%); COVID-19 accounted for 8.4% of all supplies. Amoxicillin with clavulanic acid, azithromycin and amoxicillin were indicated as the top three antimicrobials purchased for upper respiratory tract infections, and azithromycin, umifenovir and levofloxacin were the top three for COVID-19. In general, a high rate of drugs dispensing without prescription was revealed. Antibiotics for systemic use remained the most common antimicrobials, whereas presumably viral upper respiratory tract infections were the main reason for their purchase. COVID-19 infection itself was responsible for a small proportion of the supply of antimicrobial agents, but systemic antibiotics accounted for more than a half of supplies.
Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells
2017
OncoTarget
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