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Changes in cognition

Marilyn S. Albert
2011 Neurobiology of Aging  
et al. 2001; Chen et al., 2000; Albert et al., 2007; Grober et al., 2008) .  ...  , 1988; Milberg & Albert, 1988; Hodges et al., 1990; Troster et al., 1993; Lange et al., 1995; Connor et al., 1998; Rascovsky et al., 2002; Hamilton et al., 2004) .  ... 
doi:10.1016/j.neurobiolaging.2011.09.010 pmid:22078174 pmcid:PMC3929949 fatcat:vxofo2tuobg5rf73aglygqulgu

Randomized controlled trials in mild cognitive impairment

Ronald C. Petersen, Ronald G. Thomas, Paul S. Aisen, Richard C. Mohs, Maria C. Carrillo, Marilyn S. Albert
2017 Neurology  
Albert: obtaining data, reviewing data, reviewing manuscript.  ... 
doi:10.1212/wnl.0000000000003907 pmid:28381516 pmcid:PMC5409843 fatcat:krzvhnocizhwtfuvalvzggdtjy

Role of predictability of sequence in auditory stream segregation

Marilyn French-St. George, Albert S. Bregman
1989 Perception & Psychophysics  
Role of predictability of sequence in auditory stream segregation MARILYN FRENCH-ST. GEORGE and ALBERT S.  ...  Van Noorden (1975) has investigated the perceptual segregation of an isochronous sequence of tones in which Correspondence may be addressed to Marilyn French-St.  ... 
doi:10.3758/bf03204992 pmid:2798032 fatcat:gi3jrj4v4je3vfx5sv6n5udvfi

Change in Cognitive Function in Older Persons From a Community Population

Robert S. Wilson, Laurel A. Beckett, David A. Bennett, Marilyn S. Albert, Denis A. Evans
1999 Archives of Neurology  
Medicine (Drs Beckett and Evans), and Psychology (Dr Wilson), Rush University and Rush-Presbyterian-Saint Luke's Medical Center, Chicago, Ill; and the Departments of Psychiatry and Neurology (Dr Albert  ... 
doi:10.1001/archneur.56.10.1274 pmid:10520945 fatcat:eelpuztdzbfw5gsnl34x5xyj74

Assessment of cognition in mild cognitive impairment: A comparative study

Peter J. Snyder, Colleen E. Jackson, Ronald C. Petersen, Ara S. Khachaturian, Jeffrey Kaye, Marilyn S. Albert, Sandra Weintraub
2011 Alzheimer's & Dementia  
If this question is not applicable for your test(s) or measure(s), please indicate this.  ...  to your test(s) and/or cognitive battery.  ...  How many separate languages have your test(s) been translated into for use in clinical research?  ... 
doi:10.1016/j.jalz.2011.03.009 pmid:21575877 pmcid:PMC4042858 fatcat:aoepny3n2vagnoejs5alccy3fq


Olivia I. Okereke, Norberto Pantoja-Galicia, Maura Copeland, Bradley T. Hyman, Taylor Wanggaard, Marilyn S. Albert, Rebecca A. Betensky, Deborah Blacker
2012 Alzheimer Disease and Associated Disorders  
50.7 (9.5) 34.7 (9.6) CVLT Percent Retention 84.4 (17.8) 88.5 (14.3) 53.9 (25.4) Time to Complete Trails B (seconds) 92.8 (35.2) 103.7 (57.1) 127.4 (85.6) Phonemic Fluency (total of F, A, S)  ... 
doi:10.1097/wad.0b013e318231cd30 pmid:21986342 pmcid:PMC3257375 fatcat:qogluhcupffllh7agg5y4ihxny


Ned Sacktor, Anja Soldan, Maura Grega, Leonie Farrington, Qing Cai, Mei-Cheng Wang, Rebecca F. Gottesman, Raymond S. Turner, Marilyn Albert
2017 Alzheimer Disease and Associated Disorders  
Background-Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. Objective-To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. Methods-222 participants in the BIOCARD study received a detailed history, physical
more » ... xamination, and neuropsychological testing annually. An index was calculated by including questions about memory problems, depression, age, education, history of cerebrovascular disease risk factors, and brain injury, family history of dementia, and the Mini-Mental State examination (MMSE) score. Cox regression analyses were used to determine if this index score was related to diagnosis of MCI. Results-The BIOCARD Index score mean for individuals who progressed to MCI was 20.3 (SD=2.9), whereas the score for individuals who remained normal was 24.8(SD=2.3), (p<0.001), [Hazard Ratio (HR) (Standard error (SE) for subsequent diagnosis of MCI = 0.75 (0.67-0.84), (p<0.001)]. Conclusion-Lower BIOCARD Index score predicted symptoms of MCI several years before the MCI diagnosis. The BIOCARD Index can be easily used in clinics to identify cognitively normal older individuals who are at risk for deterioration.
doi:10.1097/wad.0000000000000194 pmid:28394770 pmcid:PMC5443710 fatcat:pjcjuunyvbcorop42cylxoquuq

Selectivity of executive function deficits in mild cognitive impairment

Jason Brandt, Eleni Aretouli, Eleanor Neijstrom, Jaclyn Samek, Kevin Manning, Marilyn S. Albert, Karen Bandeen-Roche
2009 Neuropsychology  
., and the staff and participants of the Johns Hopkins Alzheimer=s Disease Research Center. Arnold Bakker, M.S. and Egberdina J. van der Hulst assisted in data collection.  ...  et al., 2001 Albert et al., , 2007 Rapp & Reischies, 2005) .  ...  Most participants (81%) were recruited from the Johns Hopkins Alzheimer=s Disease Research Center (ADRC) and other research studies.  ... 
doi:10.1037/a0015851 pmid:19702414 pmcid:PMC2769993 fatcat:3ctt57zrencoxhhrex7spezbnm

Automatic Statistical Identification of Neuroanatomical Abnormalities between Different Populations [chapter]

Alexandre Guimond, Svetlana Egorova, Ronald J. Killiany, Marilyn S. Albert, Charles R. G. Guttmann
2002 Lecture Notes in Computer Science  
Two important statistics that can be computed from these displacements are the groups' sample mean vector u i (x) and covariance matrix S i (x), u i (x) = 1 N i N i ∑ j=1 u i j (x), (1) S i (x) = 1 N i  ...  In this case, assuming without loss of generality that N a ≤ N b , N a (N a − 3) 3(N a − 1) [u a (x) − u b (x)] S −1 [u a (x) − u b (x)] (7) where S = 1 N a − 1 N a ∑ j=1 [y j (x) − y(x)] [y j (x) − y(  ... 
doi:10.1007/3-540-45786-0_97 fatcat:axyflefdurfxzac53fvzaxrrw4

Seizures in Alzheimer Disease

Nikolaos Scarmeas, Lawrence S. Honig, Hyunmi Choi, Julio Cantero, Jason Brandt, Deborah Blacker, Marilyn Albert, Joan C. Amatniek, Karen Marder, Karen Bell, W. Allen Hauser, Yaakov Stern
2009 Archives of Neurology  
Transient symptoms in Alzheimer disease (AD) are frequent and include seizures, syncope, and episodes of inattention or confusion. The incidence of seizures in AD and predictors of which patients with AD might be more predisposed to them is based primarily on retrospective studies and is not well established. Objective: To determine the incidence and predictors of new-onset unprovoked seizures. Design: Prospective cohort study. Setting: Three academic centers. Patients: Four hundred fifty-three
more » ... patients with probable AD observed prospectively from mild disease stages since 1992. Main Outcome Measure: Informant interviews every 6 months included questions about whether the patient had a seizure (convulsion, fainting, or "funny" spell) and whether diagnosis or treatment for epilepsy or seizure was made. Two epileptologists independently retrospectively reviewed all available medical records for 52 patients with positive responses to either of these questions, and using a specific checklist form, events were diagnosed as to whether they were unprovoked seizures (intrarater concordance, =0.67). Diagnosis of unprovoked seizures constituted the event in survival analyses. Potential predictors included sex, age, race/ ethnicity, educational achievement, duration of illness, baseline cognition and function, depression, medical comorbidities, and time-dependent use of cholinesterase inhibitors and neuroleptic agents, apolipoprotein E genotype, and previous electroencephalographic findings. Results: Over the course of 3518 visit-assessments (per patient: mean, 7.8; maximum, 27), 7 patients (1.5%) developed seizures. Younger age was associated with higher risk (hazard ratio, 1.23; 95% confidence interval, 1.08-1.41; P =.003 for each additional year of age) of seizure incidence. No other predictor was significant. The overall incidence of seizures was low (418 per 100 000 personyears of observation) although significantly higher than expected for idiopathic unprovoked seizures in similar age ranges of the general population (hazard ratio, 8.06; 95% confidence interval, 3.23-16.61). Conclusions: Unprovoked seizures are uncommon in AD, but they do occur more frequently than in the general population. Younger age is a risk factor for seizures in AD. Neurol. 2009;66(8):992-997 Arch
doi:10.1001/archneurol.2009.130 pmid:19667221 pmcid:PMC2768279 fatcat:fxbim25cgbds3negdo3xg4pxji

Alzheimer's disease severity, objectively determined and measured

Alden L. Gross, Dan M. Mungas, Jeannie-Marie S. Leoutsakos, Marilyn S. Albert, Richard N. Jones
2016 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
S. L. ' (7) the Neuropathology Core (Juan Troncoso, Barbara Crain, Olga Pletnikova, Gay Rudow, Karen Fisher).  ...  A second feature of the dynamic biomarkers model is the hypothesized sigmoidal (s-shaped) relationship between each disease severity marker and disease stage.  ... 
doi:10.1016/j.dadm.2016.08.005 pmid:27830173 pmcid:PMC5078784 fatcat:cmlizsdfmre2pavsdldlmoi2xa

Vascular Imaging Abnormalities and Cognition

David S. Knopman, Michael E. Griswold, Seth T. Lirette, Rebecca F. Gottesman, Kejal Kantarci, A. Richey Sharrett, Clifford R. Jack, Jonathan Graff-Radford, Andrea L.C. Schneider, B. Gwen Windham, Laura H. Coker, Marilyn S. Albert (+1 others)
2015 Stroke  
and Purpose-The relationships between cerebrovascular lesions visible on imaging and cognition are complex. We explored the possibility that the cerebral cortical volume mediated these relationships. Methods-Total of 1906 nondemented participants (59% women; 25% African-American; mean age, 76.6 years) in the Atherosclerosis Risk in Communities (ARIC) study underwent cognitive assessments, risk factor assessments, and quantitative MRI for white matter hyperintensities (WMH) and infarcts. The
more » ... surfer imaging analysis pipeline was used to determine regional cerebral volumes. We examined the associations of cognitive domain outcomes with cerebral volumes (hippocampus and separate groups of posterior and frontal cortical regions of interest) and cerebrovascular imaging features (presence of large or small cortical/subcortical infarcts and WMH volume). We performed mediation pathway analyses to assess the hypothesis that hippocampal and cortical volumes mediated the associations between cerebrovascular imaging features and cognition. Results-In unmediated analyses, WMH and infarcts were both associated with worse psychomotor speed/executive function. In mediation analyses, WMH and infarct associations on psychomotor speed/executive function were significantly attenuated, but not abolished, by the inclusion of the posterior cortical regions of interest volume in the models, and the infarcts on psychomotor speed/executive function association were attenuated, but not abolished, by inclusion of the frontal cortical regions of interest volume. Conclusions-Both WMH and infarcts were associated with cortical volume, and both lesions were also associated with cognitive performance, implying shared pathophysiological mechanisms. Although cross-sectional, our findings suggest that WMH and infarcts could be proxies for clinically covert processes that directly damage cortical regions. Microinfarcts are 1 candidate for such a clinically covert process. The online-only Data Supplement is available with this article at
doi:10.1161/strokeaha.114.007847 pmid:25563642 pmcid:PMC4308430 fatcat:rkiucno6gnbvjafuuyowg5qtly

The Structured Interview & Scoring Tool–Massachusetts Alzheimer's Disease Research Center (SIST-M)

Olivia I. Okereke, Maura Copeland, Bradley T. Hyman, Taylor Wanggaard, Marilyn S. Albert, Deborah Blacker
2011 Archives of Neurology  
Obtained funding: Okereke, Hyman, Albert, and Blacker. Administrative, technical, and material support: Okereke, Hyman, Wanggaard, Albert, and Blacker.  ...  Acquisition of data: Okereke, Copeland, Hyman, Wanggaard, Albert, and Blacker.  ... 
doi:10.1001/archneurol.2010.375 pmid:21403019 pmcid:PMC3058542 fatcat:eot7yancbfbm3lbfap4xq6fdta

Increase in Urinary Cortisol Excretion and Memory Declines: MacArthur Studies of Successful Aging1

Teresa E. Seeman, Bruce S. McEwen, Burton H. Singer, Marilyn S. Albert, John W. Rowe
1997 Journal of Clinical Endocrinology and Metabolism  
4) ability to stand from a seated position five times within 20 s, 5) scores of 6 or more correct on the nine-item Short Portable Mental Status Questionnaire (37), and 6) ability to remember three or  ...  Daily Living scale (34) , 2) no more than one reported mild disability for eight items testing gross mobility and range of motion (35, 36) , 3) ability to hold a semitandem balance for at least 10 s,  ... 
doi:10.1210/jcem.82.8.4173 pmid:9253318 fatcat:redu2jochrd5lfcgsxqugdfr4m

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

Arnold Bakker, Gregory L. Krauss, Marilyn S. Albert, Caroline L. Speck, Lauren R. Jones, Craig E. Stark, Michael A. Yassa, Susan S. Bassett, Amy L. Shelton, Michela Gallagher
2012 Neuron  
s role in the current study was in compliance with the conflict of interest policies of the Johns Hopkins School of Medicine. G.L.K. is an investigator and received research support from UCB Pharma.  ...  weighted echo planar single shot pulse sequence with an acquisition matrix of 64 3 64, an echo time of 30 ms, flip angle of 70 , a SENSE factor of 2, an in plane resolution of 1.5 3 1.5 mm, and a TR of 1.5 s  ... 
doi:10.1016/j.neuron.2012.03.023 pmid:22578498 pmcid:PMC3351697 fatcat:qm4n6sg5ungk5d5yaqjxz4deta
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