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Interactions between Neuronal Fusion Proteins Explored by Molecular Dynamics

Marie-Pierre Durrieu, Richard Lavery, Marc Baaden
2008 Biophysical Journal  
Joséphine Abi Ghanem, Franc xois Darchen, Brigitte Hartmann, Jean-Pierre Henry, and Brahim Heddi are thanked for stimulating discussions. M.  ... 
doi:10.1529/biophysj.107.123117 pmid:18212009 pmcid:PMC2292394 fatcat:6srkm2xnpnax3cbh4qsuwbnkjq

Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells

Simon Latour, Marion Zanese, Valérie Le Morvan, Anne-Marie Vacher, Nelly Menard, Fontanet Bijou, Francoise Durrieu, Pierre Soubeyran, Ariel Savina, Pierre Vacher, Laurence Bresson-Bepoldin
2019 Cancers  
GA101/obinutuzumab is a novel type II anti-CD20 monoclonal antibody (mAb), which is more effective than rituximab (RTX) in preclinical and clinical studies when used in combination with chemotherapy. Ca2+ signaling was shown to play a role in RTX-induced cell death. This report concerns the effect of GA101 on Ca2+ signaling and its involvement in the direct cell death induced by GA101. We reveal that GA101 triggered an intracellular Ca2+ increase by mobilizing intracellular Ca2+ stores and
more » ... ating Orai1-dependent Ca2+ influx in non-Hodgkin lymphoma cell lines and primary B-Cell Chronic Lymphocytic Leukemia (B-CLL) cells. According to the cell type, Ca2+ was mobilized from two distinct intracellular compartments. In Raji, BL2, and B-CLL cells, GA101 induced a Ca2+ release from lysosomes, leading to the subsequent lysosomal membrane permeabilization and cell death. Inhibition of this calcium signaling reduced GA101-induced cell death in these cells. In SU-DHL-4 cells, GA101 mobilized Ca2+ from the endoplasmic reticulum (ER). Inhibition of ER replenishment, by blocking Orai1-dependent Ca2+ influx, led to an ER stress and unfolded protein response (UPR) which sensitized these cells to GA101-induced cell death. These results revealed the central role of Ca2+ signaling in GA101's action mechanism, which may contribute to designing new rational drug combinations improving its clinical efficacy.
doi:10.3390/cancers11030291 pmid:30832225 pmcid:PMC6468563 fatcat:64be6ozdo5cadks4dqzmdmpofa

Adverse drug reactions in patients with Alzheimer's disease and related dementia in France: a national multicentre cross-sectional study

Marie-Laure Laroche, Marie-Christine Perault-Pochat, Isabelle Ingrand, Louis Merle, Carmen Kreft-Jais, Anne Castot-Villepelet, Geneviève Durrieu, Valérie Gras, Claire Guy, Marie-Josèphe Jean-Pastor, Annie-Pierre Jonville-Béra, Isabelle Merlet-Chicoine (+3 others)
2013 Pharmacoepidemiology and Drug Safety  
Purpose To assess the prevalence of adverse drug reactions (ADRs) occurring in patients with Alzheimer's disease (AD) or other dementia in France. Methods A cross-sectional multicentre study was conducted by the French network of the 31 regional pharmacovigilance centres on a given day. The subjects were selected by random draw to be a representative sample of French patients with dementia: consultations of dementia clinics, nursing-homes, acute and long care geriatric units, rehabilitation
more » ... geriatric units. The staff of each medical structure together with that of the pharmacovigilance centre defined a day for including the patients. Socio-demographic data, history, ADR and drugs given were registered. Results There were 1332 subjects included, 51.1% living at home, 48.8% in institutions, aged 82.0 AE 8.0 years (46-108); 61.3% suffered from AD. Mean number of drugs was 6.3 AE 3.1. Anti-dementia drugs were given to 66.4% subjects. ADR prevalence was 5.0% (95% CI: 3.9-6.2) without a significant difference between at home and institutionalized patients. ADR consisted of gastro-intestinal (23.2%), central nervous system (17.4%) and psychiatric disorders (8.7%). Of the ADR, 31.9% were serious, and 47.8% preventable. The drugs most often involved were anti-dementia (28.9%), cardio-vascular (28.9%) and psychotropic drugs (26.4%, anxiolytics, hypnotics, antidepressants, neuroleptics). Conclusion This national scale study showed that iatrogenesis in patients with AD and related dementia can at times be serious and preventable. Therefore, special attention is required when prescribing psychotropic and anti-dementia drugs, as they are frequently used and induce half of the ADR in this population.
doi:10.1002/pds.3471 pmid:23794320 fatcat:ciqme2gdpjbmjpqrzbthlc6nhm

Characterizing, modelling and understanding the climate variability of the deep water formation in the North-Western Mediterranean Sea

Samuel Somot, Loic Houpert, Florence Sevault, Pierre Testor, Anthony Bosse, Isabelle Taupier-Letage, Marie-Noelle Bouin, Robin Waldman, Christophe Cassou, Emilia Sanchez-Gomez, Xavier Durrieu de Madron, Fanny Adloff (+2 others)
2016 Climate Dynamics  
This convection indicator was already used for example in Herrmann et al. (2010) and Durrieu de Madron et al. (2013) .  ...  This situation probably occurred during winter 2006 and 2012 (Schroeder et al. 2008; Durrieu de Madron et al. 2013).  ... 
doi:10.1007/s00382-016-3295-0 fatcat:yp7fph72vbh5rhqi3gvfpip2dy

High resolution modeling of dense water formation in the north-western Mediterranean during winter 2012-2013: Processes and budget

Claude Estournel, Pierre Testor, Pierre Damien, Fabrizio D'Ortenzio, Patrick Marsaleix, Pascal Conan, Faycal Kessouri, Xavier Durrieu de Madron, Laurent Coppola, Jean-Michel Lellouche, Sophie Belamari, Laurent Mortier (+3 others)
2016 Journal of Geophysical Research - Oceans  
It has achieved an average of 70 CTD surface to bottom profiles to highlight the characteristics of deep water possibly formed in the previous winter [Durrieu de Madron et al., 2013] .  ...  For example, Durrieu de Madron et al. [2013] proposed an estimation of the volume of dense water formed during winter 2011-2012 based on a completely mixed vertical density profile and a satellite image  ... 
doi:10.1002/2016jc011935 fatcat:coobbqnqwfb53lr2mgklbafnqy

Incidence and outcome of BCR‐ABL mutated chronic myeloid leukemia patients who failed to tyrosine kinase inhibitors

Gabriel Etienne, Stéphanie Dulucq, Françoise Huguet, Anna Schmitt, Axelle Lascaux, Sandrine Hayette, Marie‐Pierre Fort, Pierre Sujobert, Fontanet Bijou, Stéphane Morisset, Suzanne Tavitian, Audrey Bidet (+7 others)
2019 Cancer Medicine  
ACKNOWLEDGMENTS We thank Fanny Robbesyn, Marie-Pierre Fort and Madeleine Etienne for monitoring the clinical data. CONFLICTS OF INTEREST None declared.  ... 
doi:10.1002/cam4.2410 pmid:31350815 pmcid:PMC6718576 fatcat:3oz2njroobdvje3pzxd2iq4lia

HyMeX-SOP2: The Field Campaign Dedicated to Dense Water Formation in the Northwestern Mediterranean

Claude Estournel, Pierre Testor, Isabelle Taupier-Letage, Marie-Noelle Bouin, Laurent Coppola, Pierre Durand, Pascal Conan, Anthony Bosse, Pierre-Etienne Brilouet, Laurent Beguery, Sophie Belamari, Karine Béranger (+18 others)
2016 Oceanography  
Credit: Xavier Durrieu de Madron (5) Servicing the Lion meteorological buoy.  ...  Credit: Pierre Testor From left to right: (1) CTD rosette. Credit: Laurent Coppola (2) Autonomous gliders. Credit: Pierre Testor (3) Waverider deployment from R/V Tethys II.  ... 
doi:10.5670/oceanog.2016.94 fatcat:afkk22ncsnesjcgn7mhsxxwhc4

Abrupt warming and salinification of intermediate waters interplays with decline of deep convection in the Northwestern Mediterranean Sea

Félix Margirier, Pierre Testor, Emma Heslop, Katia Mallil, Anthony Bosse, Loïc Houpert, Laurent Mortier, Marie-Noëlle Bouin, Laurent Coppola, Fabrizio D'Ortenzio, Xavier Durrieu de Madron, Baptiste Mourre (+3 others)
2020 Scientific Reports  
AbstractThe Mediterranean Sea is a hotspot for climate change, and recent studies have reported its intense warming and salinification. In this study, we use an outstanding dataset relying mostly on glider endurance lines but also on other platforms to track these trends in the northwestern Mediterranean where deep convection occurs. Thanks to a high spatial coverage and a high temporal resolution over the period 2007–2017, we observed the warming (+0.06 $$^\circ$$ ∘ C year$$^{-1}$$ - 1 ) and
more » ... linification (+0.012 year$$^{-1}$$ - 1 ) of Levantine Intermediate Water (LIW) in the Ligurian Sea. These rates are similar to those reported closer to its formation area in the Eastern Mediterranean Sea. Further downstream, in the Gulf of Lion, the intermediate heat and salt content were exported to the deep layers from 2009 to 2013 thanks to deep convection processes. In 2014, a LIW step of +0.3 $$^\circ$$ ∘ C and +0.08 in salinity could be observed concomitant with a weak winter convection. Warmer and more saline LIW subsequently accumulated in the northwestern basin in the absence of intense deep convective winters until 2018. Deep stratification below the LIW thus increased, which, together with the air–sea heat fluxes intensity, constrained the depth of convection. A key prognostic indicator of the intensity of deep convective events appears to be the convection depth of the previous year.
doi:10.1038/s41598-020-77859-5 pmid:33262416 fatcat:otkvfadti5hfncqzllsfgtu6aa

Management of prosthetic heart valve obstruction: Fibrinolysis versus surgery. Early results and long-term follow-up in a single-centre study of 263 cases

Raymond Roudaut, Stephane Lafitte, Marie-Françoise Roudaut, Patricia Reant, Xavier Pillois, Catherine Durrieu-Jaïs, Pierre Coste, Claude Deville, Xavier Roques
2009 Archives of Cardiovascular Diseases  
Prise en charge d'une obstruction de prothèse valvulaire mécanique : fibrinolyse versus chirurgie. Résultats précoces et à long terme dans une série monocentrique de 263 cas Summary Optimal management of prosthetic heart valve obstruction (PHVO) remains controversial even though surgery is usually recommended. To better define the efficacy and safety of fibrinolysis versus surgery in the pre-and post-transoesophageal echocardiography (TEE) eras. We analysed initial results and follow-up data
more » ... m a large, retrospective, single-centre series, comparing fibrinolysis and surgery in patients with PHVO treated over 20 years. Two hundred and sixty-three consecutive episodes of PHVO in 210 patients, mainly left sided, were managed in our institution by either fibrinolysis (n = 127) or surgery (n = 136). Early clinical evolution was
doi:10.1016/j.acvd.2009.01.007 pmid:19427604 fatcat:xsr6nmlc35f43kbgqnsqwv7qxm

Incidences of Deep Molecular Responses and Treatment-Free Remission in de Novo CP-CML Patients

Gabriel Etienne, Stéphanie Dulucq, Fréderic Bauduer, Didier Adiko, François Lifermann, Corinne Dagada, Caroline Lenoir, Anna Schmitt, Emilie Klein, Samia Madene, Marie-Pierre Fort, Fontanet Bijou (+9 others)
2020 Cancers  
Acknowledgments: We thank Fanny Robbesyn, Marie-Pierre Fort, and Carole Faberes for monitoring the clinical data. Conflicts of Interest  ... 
doi:10.3390/cancers12092521 pmid:32899879 pmcid:PMC7565328 fatcat:ovsj23kxifaddjxyp2oblhj4la

Relevance of treatment-free remission recommendations in chronic phase chronic leukemia patients treated with frontline tyrosine kinase inhibitors

Gabriel Etienne, Carole Faberes, Fréderic Bauduer, Didier Adiko, François Lifermann, Corinne Dagada, Caroline Lenoir, Anna Schmitt, Emilie Klein, Marie-Pierre Fort, Fontanet Bijou, Beatrice Turcq (+10 others)
2021 Cancer Medicine  
Tyrosine kinase inhibitors (TKI) can be safely discontinued in chronic phase chronic myeloid leukemia (CP-CML) patients who had achieved a sustained deep molecular response. Based on the results of discontinuation trials, recommendations regarding patient selection for a treatment-free remission (TFR) attempt had been proposed. The aims of this study were to evaluate the rate of patients eligible for TKI discontinuation and molecular recurrence-free survival (MRFS) after stop according to
more » ... endations. Over a 10-year period, newly diagnosed CP-CML patients and treated with first-line TKI in the nine French participating centers were included. Eligibility to treatment discontinuation and MRFS were analyzed and compared according to selection criteria defined by recommendations and first-line treatments. From January 2006 to December 2015, 398 patients were considered. Among them, 73% and 27% of patients received imatinib or either second or third generation tyrosine kinase inhibitors as frontline treatment, respectively. Considering the selection criteria defined by recommendations, up to 55% of the patients were selected as optimal candidates for treatment discontinuation. Overall 95/398 (24%) discontinued treatment. MRFS was 51.8% [95% CI 41.41-62.19] at 2 years and 43.8% [31.45-56.15] at 5 years. Patients receiving frontline second-generation TKI and fulfilling the eligibility criteria suggested by recommendations had the lowest probability of molecular relapse after TKI stop when compare to others. One third of CP-CML patients treated with TKI frontline fulfilled the selection criteria suggested by European LeukemiaNet TFR recommendations. Meeting selection criteria and second-generation TKI frontline were associated with the highest MRFS.
doi:10.1002/cam4.3921 pmid:33988316 fatcat:unm7lgg4ovhdjgpi4eqwtt5v5i

Multiscale Observations of Deep Convection in the Northwestern Mediterranean Sea During Winter 2012-2013 Using Multiple Platforms

Pierre Testor, Anthony Bosse, Loïc Houpert, Félix Margirier, Laurent Mortier, Hervé Legoff, Denis Dausse, Matthieu Labaste, Johannes Karstensen, Daniel Hayes, Antonio Olita, Alberto Ribotti (+27 others)
2018 Journal of Geophysical Research - Oceans  
According to (Durrieu de Madron et al., 2011) , bloom and deep convection events result from an ''history'' of at least 6-8 months beforehand that needs to be characterized.  ...  Note that this year, cascading was relatively weak compared to intense cascading events that can be observed every 6 years or so, as shown by Durrieu de or Houpert et al. (2016) .  ... 
doi:10.1002/2016jc012671 fatcat:x5rlpqt55vhgxllazhpulwfr6a

Page 73 of National Union Catalog Vol. 7, Issue [page]

1953 National Union Catalog  
Corneille, Pierre, 1606-1684. Cour d’appel ( Rouen) . 1, France. 57-23962 t 1. Guerre, Durrieu, Paul, comte, 1855-1925. Les trés riches Heures de Jean de France, duc de Berry.  ...  Colaba, Jean, Full name: Comte Jean Marie ‘paul Simon Durrieu. ND3363.B5 1904 5-12457 rev 2° Durriyah Fahmi see Fahmy, Dorrya. Durry, Marie Jeanne, 1901- Effacé. Paris, P. Seghers ,1954, €62p. 19cm.  ... 

Page 124 of Isis Vol. 3, Issue 1 [page]

1920 Isis  
London, British Museum, 1916. 1818 Durrieu, Paul. Les origines de la gravure. Journal des Savants, xv, p. 205-212, 251-264. Paris, 1917. 1818 A propos du livre de Pierre Gusman.  ...  Gothein, Marie Luise. Geschichte der Gartenkunst. Hrg. mit. Un- terstiitzung der K. Akad. des Bauwesens in Berlin, 2 Bde gr. in-8°, vi + 446 + 506 S., 637 Abb. Jena, Dizpericus. 1914.  ... 

Pour une étude génétique du Livre des tables : les révélations du manuscrit Durrieu

Jean-Claude Fizaine
2017 Genesis  
En permettant l'étude comparative de deux versions de plusieurs séances, le manuscrit Durrieu procure une sorte de pierre de Rosette qui rend visibles les procédures employées pour établir le document  ...  Anne-Marie Amiot, Nice, Éditions Serre, 1985 , p. 99. 31. Voir CFL, t. IX, p. 1347 . 32. Ibid., p. 1214 . 33. Ibid., p. 1218 . 34.  ... 
doi:10.4000/genesis.2936 fatcat:morwcrzs7bhxdfav7ekz5shpue
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