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Many drugs are still being prescribed in a "off-label mode" and especially in psychiatry. Off-label prescription situations may vary depending on several factors and such practice is not well identifiable in the literature. Methods: A new public academic drug database has been recently created and is able to contain off-label indications, especially in psychiatry in the context of the PSYHAMM French research project. For each situation, bibliographic references have been collected to make thedoi:10.1101/2021.11.25.21266864 fatcat:ak7obk3pqre2zavonu4bhdwsxe
more »... ientific information available to all. Results: this new off-label drug database contains more than 18,154 lines. It is freely available at https://www.hetop.eu/hetop/medicaments. Several off-label usages have been formally described and the system is extensible to all drugs and all specialties. Conclusion: An off-label drug database can be a valuable tool for health professionals and students.
Référence électronique Michèle Grosjean , « Anne-Marie Arborio, Un personnel invisible. ... Pour citer cet article Référence papier Michèle Grosjean , « Anne-Marie Arborio, Un personnel invisible. ...doi:10.4000/sdt.32066 fatcat:ux6f4o2um5ai3fbmthv2vremse
The recent emergence of nanofluidics has highlighted the exceptional properties of graphene and its boron-nitride counterpart as confining nanomaterials for water and ion transport. Surprisingly, ionic transport experiments have unveiled a consequent electrification of the water/carbon surfaces, with a contrasting response for its water/boron-nitride homologue. In this paper, we report free energy calculations based on ab initio molecular dynamics simulations of hydroxide OH- ions in water neardoi:10.1038/s41467-019-09708-7 pmid:30971700 pmcid:PMC6458114 fatcat:nbagrp7j7nak3ayvcfpmnt5i2m
more »... graphene and hexagonal boron nitride (h-BN) layers. Our results disclose that both surfaces get charged through hydroxide adsorption, but two strongly different mechanisms are evidenced. The hydroxide species shows weak physisorption on the graphene surface while it exhibits also strong chemisorption on the h-BN surface. Interestingly OH- is shown to keep very fast lateral dynamics and interfacial mobility within the physisorbed layer on graphene. Taking into account the large ionic surface conductivity, an analytic transport model allows to reproduce quantitatively the experimental data.
The Global Biodiversity Information Facility (GBIF) was established by governments in 2001, largely through the initiative and leadership of the natural history collections community, following the 1999 recommendation by a working group under the Megascience Forum (predecessor of the Global Science Forum) of the Organization for Economic Cooperation and Development (OECD). Over 20 years, GBIF has helped develop standards and convened a global community of data-publishing institutions,doi:10.3897/biss.3.37216 fatcat:454eo55enfcxnnoraeyhdndq5a
more »... g over one billion species occurrence records freely and openly available for use in research and policy making. Of these more than 150 million records originate from specimens preserved by the collections community. The recent adoption of the Global Registry of Scientific Collections by GBIF (https://www.gbif.org/news/5kyAslpqTVxYqZTwYn1cub) is the first step by GBIF to better enable a picture of the natural history collections of the world along with the associated science that they have and continue to enable. Recognising that other collection metadata initiatives exists, GBIF aims to discuss with the community and progress topics such as: Synchronising with existing metadata catalogues to ensure accurate, up-to-date information is available without unnecessary burden for authors Defining, testing and formalizing the Collection Descriptions standard (https://github.com/tdwg/cd) Providing clear guidelines of citation practice for collections, potentially building on the success of the Digital Object Identifier (DOI) approach used for datasets mediated through GBIF.org. Tracking citations of use through both data downloads and through references in literature, such as materials examined in a taxonomic publication Improving the linkages and discoverability of specimen records derived from the same collecting event but preserved in multiple institutions Improving the linkages between the people involved in collecting, preserving, and identifying specimen records through the use of Open Researcher and Contributor IDs (ORCID) Lowering the technical threshold to deploy tools such as "data dashboards" and specimen search/download on collection related websites Synchronising with existing metadata catalogues to ensure accurate, up-to-date information is available without unnecessary burden for authors Defining, testing and formalizing the Collection Descriptions standard (https://github.com/tdwg/cd) Providing clear guidelines of citation practice for collections, potentially building on the success of the Digital Object Identifier (DOI) approach used for datasets mediated through GBIF.org. Tracking citations of use through both data downloads and through references in literature, such as materials examined in a taxonomic publication Improving the linkages and discoverability of specimen records derived from the same collecting event but preserved in multiple institutions Improving the linkages between the people involved in collecting, preserving, and identifying specimen records through the use of Open Researcher and Contributor IDs (ORCID) Lowering the technical threshold to deploy tools such as "data dashboards" and specimen search/download on collection related websites The progress made to date will be summarised and a roadmap for the future will be introduced.
The equilibrium position of a spherical air bubble in a solid body rotating flow around a horizontal axis is investigated experimentally. The flow without bubbles is checked to be solid body rotating. The area of influence of the bubble is characterized to determine for each bubble whether the incoming flow is perturbed or not. The demineralized water used is shown to Tbe contaminated, and spinning of the bubble's interface is observed and measured. From the measurement of the bubble'sdoi:10.1017/s0022112008005399 fatcat:32xgmu3dsngpbije4527hii7qu
more »... um position, drag and lift coefficients are determined. They appear to be dependent on two dimensionless numbers. Eo the Eötvös number and R ω the rotational Reynolds number (or Taylor number Ta) can be varied independently by changing the control parameters, and for that reason are the convenient choice for experiments. (Re, Ro) with Ro the Rossby number is an equivalent choice generally adopted in the literature for numerical simulations, and Re denotes the Reynolds number. When using this second representation, the Ro number appears to be an indicator of the influence on the force coefficients of the shear, of the curvature of the streamlines of the flow and of the bubble's spinning. The bubble's spinning effect on the lift force is far from trivial. Its contribution explains the important gap between lift values for a bubble (not spinning) in a clean fluid and for a bubble (spinning) in a contaminated fluid as present.
*Sebastian C K Shaw, Sue McCowan, Mary Doherty, Bernadette Grosjean, Malcolm Kinnear ...doi:10.1016/s2215-0366(21)00247-9 fatcat:5kdoiyqoc5fetph2w5jto4qchm
These authors contributed equally to this work. The increase in atmospheric CO 2 due to anthropic activities results in an acidification of the surface waters of the oceans. The impact of these chemical changes differs according to the considered organisms. The intertidal rocky shores may harbor organisms pre-adapted to the upcoming changes as they already face tidal pH and temperature fluctuations. In order to cope with the changes in seawater pH, these organisms possess different mechanismsdoi:10.1016/j.cbpa.2013.06.002 pmid:23752123 fatcat:yiwtvqtlgvfdxg635wscxkdjji
more »... volved in acid-base regulation. Some organisms present a higher buffer capacity than seawater, among which echinoderms. The properties of this buffer capacity and the factors influencing it were investigated in the sea urchin Paracentrotus lividus and in the starfish Asterias rubens, both species occurring in the intertidal zone of the North Atlantic and the North Sea, respectively. Buffer capacity is partly due to the coelomocytes present in the coelomic fluid and, in P. lividus, it is also due to a compound which contributes to a higher buffer capacity of the coelomic fluid of this species compared to that of the starfish. The effect of a decreased seawater pH (in the scope of predicted future ocean acidification) on this buffer capacity in P. lividus was investigated. A gradual increase of the buffer capacity was recorded when the seawater pH was decreased. Moreover, the comparison of different echinoderm species showed that Euechinoidea present a very high buffer capacity while Cidadroidea (other sea urchins), starfish and holothurians have a lower one. This can be explained either by the presence of the compound only in Euechinoidea, linked to differences in the respiratory machinery, or by metabolic differences between the various classes of echinoderms.
Copyright © 2018 Grosjean, Gross, Le Jean and Blaudez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fmicb.2018.02005 pmid:30233513 pmcid:PMC6131306 fatcat:qkbg66kl6nd7lgekk3ge25ddce
© Grosjean M et al. ... Presenting author Marie Grosjean Presented at TDWG 2021 ...doi:10.3897/biss.5.74354 fatcat:4dh7e2ltovftxg64m66wzm2hba
Kinetochores begin to align at the spindle center in phase 1 (Mary et al., 2015) . ... In phase 2 (prometaphase/metaphase/anaphase A), the spindle maintains roughly the same length, and the kinetochores oscillate between the two spindle pole bodies (SPBs; Mary et al., 2015) . ...doi:10.1091/mbc.e16-10-0723 pmid:28450455 pmcid:PMC5469604 fatcat:chnswlqch5hhxlesxhbgamtyhi
AimsWe aim to raise awareness of the existence and value of autistic doctors in psychiatry and to also signpost psychiatrists who are or suspect they might be autistic towards peer support.MethodAutism refers to a lifelong difference in how people communicate and interact with the world. These differences lead to strengths and challenges with individual profiles which include special interests, hyper-focus, and often sensory differences and anxiety. Autism has an estimated prevalence of 1-2%,doi:10.1192/bjo.2021.157 fatcat:dv7taq4f5rd75kb4olbkw4gqvq
more »... ich is likely an underestimate. It was noted that there was little in the way of advocacy for autistic doctors around the world. Anecdotal evidence also suggested possible issues of misunderstanding and stigmatisation of autistic doctors. As such, there was a need to tackle this to promote positive change. MD founded the group Autistic Doctors International (ADI) in 2019 to foster camaraderie, advocacy and support. ADI has flourished with 250+ members currently. In a recent member poll, 24 of 180 respondents identified themselves as psychiatrists – second only to general practice (n = 54). Several other consultant psychiatrists are known to self-identify as autistic but have not formally joined due to the fear of disclosure. The group has additionally supported multiple doctors to tackle prejudice and discrimination in the workplace / training environment. It has also brought together autistic doctors with academic interests and has generated multiple academic outputs in the form of publications, research grants and conference posters/papers regarding autism.ResultPsychiatrists, and doctors in general, are a self-selecting group for many autistic strengths such as hyper-focus, curiosity, self-motivation, a desire to study social communication, attention to detail, pattern recognition, problem solving and empathy, which, contrary to prevailing stereotypes, can be marked in autism. The increasing numbers of doctors joining ADI supports the assumption that autistic individuals are safe and effective clinicians. It is worth noting that many members are not 'doctors in difficulty'. Those who have been able to achieve suitable accommodations, often without realising why they were needed, have flourished. Such accommodations and outcomes are in line with the neurodiversity movement, which promotes a view of autism as difference, rather than pure disability or disorder. This aims to challenge stereotypes and the tragedy narrative surrounding autism.ConclusionAutism awareness is increasing amongst doctors but more open discussion is still needed in order to facilitate appropriate peer and workplace support. This is likely to improve mental wellbeing and resilience for autistic psychiatrists.
Likewise, non-accumulating ferns also had a higher content of LREEs than HREEs (Grosjean N., personal communication). ... Seeds were obtained from Chiltern seeds (Wallingford, UK), the VanDusen Botanical Garden (Vancouver, Canada) and the Jean-Marie Pelt Botanical Garden (Villers-lès-Nancy, France). ...doi:10.1038/s41598-019-54238-3 pmid:31804509 pmcid:PMC6895054 fatcat:w7kupv6gx5dtjiguaj7fsycbyq
To translate the 11th edition of the International Classification of Diseases (ICD-11) into French, we proposed a lexical approach using Natural Language Processing techniques. This method relies on the 56 biomedical terminologies and ontologies included in the Cross-lingual Health Multiple Terminologies and Ontologies Portal. From a sample of 336 ICD-11 terms, the algorithm translated 164 (49%) terms into at least one French term each.pmid:26262335 fatcat:e5uaxkfznjfjxa75xkk5k63yse
In the thymus, T cell progenitors differentiate in order to generate naive T lymphocytes which migrate in the periphery where they will fulfill their function in the adaptive immune response. During thymopoiesis, genomic alterations in thymocytes can promote leukemia development. Among recurrent alteration is PTEN inactivation, which is associated to MYC overexpression. Herein, we used conditional Pten and Myc knockout mouse models and single-cell RNAsequencing approach, to investigate thedoi:10.1016/j.isci.2021.102761 fatcat:hmgqintwzfgexcgfkg62rpdkqa
more »... t of MYC loss on physio-pathological development of PTEN-proficient or PTEN-deficient T lymphocytes. First, our results confirm that MYC is mandatory for PTEN loss-mediated leukemogenesis, while it is not required for terminal steps of thymopoiesis. In contrast, we uncovered that Myc ablation in CD4 + CD8 + thymocytes disrupts T lymphocytes homeostasis in the spleen, notably by drastically reducing the number of MYC-deficient effector/memory T cells. Collectively, our data show that besides naive T cells proliferation, MYC is essential for effector/memory differentiation.
CNS drug reviews
The development of treatments for acute neurodegenerative diseases (stroke and brain trauma) has focused on (i) re-establishing blood flow to ischemic areas as quickly as possible (i.e. mainly antithrombotics or thrombolytics for stroke therapy) and (ii) on protecting neurons from cytotoxic events (i.e. neuroprotective therapies such as anti-excitotoxic or anti-inflammatory agents for stroke and neurotrauma therapies). This paper reviews the preclinical data for enoxaparin in in vivo models ofdoi:10.1111/j.1527-3458.2002.tb00213.x fatcat:id7bhvxzwbfarhnoabvpnkjspa
more »... schemia and brain trauma in rats. Following a photothrombotic lesion in the rat, enoxaparin significantly reduced edema at 24 h after lesion when the treatment was started up to 18 h after insult. Enoxaparin was also tested after an ischemic insult using the transient middle cerebral artery occlusion (tMCAO) model in the rat. Enoxaparin, 2´1.5 mg/kg i.v., significantly reduced the lesion size and improved the neuroscore when the treatment was started up to 5 h after ischemia. Enoxaparin, administered at 5h after insult, reduced cortical lesion size in a dose-dependent manner. In permanent MCAO, enoxaparin (5 and 24 h after insult) significantly reduced lesion size and improved neuroscore. A slight and reversible elevation of activated partial thromboplastin time (APTT) suggests that enoxaparin is neuroprotective at a non-hemorrhagic dose. Traumatic brain injury (TBI) is often accompanied by secondary ischemia due in part to edema-induced compression of blood vessels. When
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