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Psoriasis as a multisystem disease - cost of illness analysis
2017
Global Dermatology
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Indirect costs increase the total financial burden as they constitute a significant part of the total costs paid by the society for one patient with psoriasis. ...
Introduction Psoriasis is a chronic autoimmune disease, which consumes significant part of healthcare resources due to the significantly high pharmacotherapy costs for the main and for the concomitant ...
doi:10.15761/god.1000215
fatcat:uva4pxmfmzhzbchr44yj7wyfei
Standard karyotyping - a look through the European guidelines
2019
Varnenski medicinski forum
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Following the established European guidelines for genetic analysis and/or re-contacting patients with a possible genetic diagnosis will provide up-to-date medical service. ...
Ключови думи: стандартно кариотипиране, цитогеномика, ръководство, повторен контакт ABSTRACT Standard karyotyping is a method for genetic testing for chromosomal aberrations, based on specific clinical ...
doi:10.14748/vmf.v8i1.5893
fatcat:zyahpgo7ffhtfi3bxk47mwq7ye
Vitamin D and Autoimmune Thyroid Diseases - a Review
2020
Folia Medica
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Vitamin D deficiency has become a major public health problem worldwide. ...
This is the major circulating form of vitamin D with a half-life of 2-3 weeks. 1,25(OH) 2 D 3 does not reflect vitamin D status as it has a half-life of ~4h, peripheral levels 1000 times lower than 25( ...
В отличие от многих исследований, в которых было доказано, что полиморфизм генов РВD связан с AИЗЩЖ, в очень немногих исследованиях рассмотрено влияние дефицита витамина D на частоту возникновения AИЗЩЖ ...
doi:10.3897/folmed.62.e47794
pmid:32666762
fatcat:3c7ifgk3fvbujop5f6m7duye6q
Micronutrients in hair loss
2018
Nasza Dermatologia Online
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Alopecia is a common dermatological complaint. ...
Both lower and increased vitamin A levels can result in telogen effluvium, but lower levels are associated also with hair breakage. ...
Vitamin A Vitamin A is a fat-soluble vitamin. There are two main forms of vitamin A: 1) retinoids or preformed vitamin A and 2) carotenoids or provitamin A. Retinoids are the active form. ...
doi:10.7241/ourd.20183.25
fatcat:ipythjmh4ngbldryzjt5kixspi
Virtual Ligand Screening for Structure-based Drug Design: Approaches and Progress
2007
Bioautomation
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Today technologies like combinatorial chemistry and high-throughput screening (HTS) authorize biological assays of a large number of small molecules against the therapeutically relevant targets. ...
The method MCDOCK [64] is a three-stage strategy using a Monte Carlo algorithm. ...
HierVLS (hierarchical virtual ligand screeing) [27] is a fast hierarchical docking approach that starts with a coarse grain conformational search over a large number of configurations filtered with a ...
doaj:ff15b8741a9e4e538ca40e68434b1c85
fatcat:ky74ryvp6razpkhwimn76hy44q
A Role of Cytokine Gene Polymorphisms in Cognitive Functioning
2018
Folia Medica
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The changes in cognitive functions that occur with aging and in various pathological conditions are a subject of growing interest. ...
The balance between pro-inflammatory and anti-inflammatory cytokines has been established as a necessary factor for normal cognitive functioning. ...
al.,
2009
IL-10
-1082 G/A
rs1800896
-592 C/A
rs1800872
4259 A/G rs3024498
-2849 G/A rs6703630
5804 Caucasians; mean age
75.3±3.3 yrs
Global cognition
No
No
Yes
Yes
Trompet et al., ...
doi:10.1515/folmed-2017-0094
pmid:30355827
fatcat:c6ra2l2ozraodd4u5dnsi4nu5y
Cognitive Impairment in Multiple Sclerosis
2016
Folia Medica
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The relationship between pathological brain findings and cognitive impairment is a subject of intensive research. ...
Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system. ...
The neuropsychological examination can vary from a short screening test to a detailed evaluation of overall cognitive functioning of a patient. ...
doi:10.1515/folmed-2016-0029
pmid:27760012
fatcat:2anbyeesaragbiqt577mxszkda
Analyzing Effects of Naturally Occurring Missense Mutations
2012
Computational and Mathematical Methods in Medicine
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Single-point mutation in genome, for example, single-nucleotide polymorphism (SNP) or rare genetic mutation, is the change of a single nucleotide for another in the genome sequence. ...
This paper focuses on genetic mutations resulting in a change in the amino acid sequence of the corresponding protein and how to assess their effects on protein wild-type characteristics. ...
, in a family. ...
doi:10.1155/2012/805827
pmid:22577471
pmcid:PMC3346971
fatcat:bmhlyyuhifhuhcoie27nuhj4my
AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening
2008
BMC Bioinformatics
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Our enrichment study suggests that AMMOS, designed to minimize a large number of ligands pre-docked in a protein target, can successfully be applied in a final postprocessing step and that it can take ...
Next, AMMOS was used for full flexible minimization of protein-ligands complexes obtained from a mutli-step virtual screening. ...
Acknowledgements TP appreciates a grant from the City Hall of Paris. IP thanks Prof. M. ...
doi:10.1186/1471-2105-9-438
pmid:18925937
pmcid:PMC2588602
fatcat:biajbyr2kvfqjpoxebi5whfowu
FAF-Drugs3: a web server for compound property calculation and chemical library design
2015
Nucleic Acids Research
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Drug attrition late in preclinical or clinical development is a serious economic problem in the field of drug discovery. ...
Here, we present FAF-Drugs3, a web server that can be used for drug discovery and chemical biology projects to help in preparing compound libraries and to assist decision-making during the hit selection ...
Tufféry, A. Saladin and J. Rey for helpful discussions on the Mobyle Portal. ...
doi:10.1093/nar/gkv353
pmid:25883137
pmcid:PMC4489254
fatcat:ehwxbuu36vh6bewmfkikoovbeu
Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
2017
Scientific Reports
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All datasets were prepared and curated using the same protocol including a filtering step that selects subsets of diverse and representative molecules (see the Methods section). ...
lipophilicity (analyzed via log P calculations) and a high molecular weight (MW), properties that are usually not favorable to the development of oral drugs (although there are numerous exceptions to ...
In general, a compound is considered to have a high Caco-2 permeability if it has a Papp A → B > 8 · 10 −6 cm/sec. ...
doi:10.1038/srep46277
pmid:28397808
pmcid:PMC5387685
fatcat:iokufqkbtfd5rmwom5udc37dsm
MTiOpenScreen: a web server for structure-based virtual screening
2015
Nucleic Acids Research
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Open screening endeavors play and will play a key role to facilitate the identification of new bioactive compounds in order to foster innovation and to improve the effectiveness of chemical biology and ...
It includes two services, MTiAutoDock and MTiOpenScreen, allowing performing docking into a user-defined binding site or blind docking using AutoDock 4.2 and automated virtual screening with AutoDock Vina ...
MTi-AutoDock takes in average 25 min for a protein receptor requiring a grid of 170×170×170 points and a grid spacing of 0.6Å and up to 1 h for a protein receptor requiring 180×180×180 points and a grid ...
doi:10.1093/nar/gkv306
pmid:25855812
pmcid:PMC4489289
fatcat:rt6ebhk2gbfbbhnvmmalg4iybm
New machine learning and physics-based scoring functions for drug discovery
2021
Scientific Reports
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We developed a set of new empirical scoring functions, named DockTScore, by explicitly accounting for physics-based terms combined with machine learning. ...
However, the accurate prediction of binding affinity by scoring functions remains a challenging task. The performance of scoring functions is very heterogeneous across different target classes. ...
A charged atom was defined as a non-hydrogen and a non-carbon atom with a partial charge q > 0.8. ...
doi:10.1038/s41598-021-82410-1
pmid:33542326
pmcid:PMC7862620
fatcat:jstufcgu7ze4pndbtxdcenqvbq
Toward in silico structure-based ADMET prediction in drug discovery
2012
Drug Discovery Today
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Miteva, M.A. (maria.miteva@univ-paris-diderot.fr) 44 www.drugdiscoverytoday.com ...
Applying docking-scoring methods to ADMET proteins is a challenging process because they usually have a large and flexible binding cavity; however, promising results relating to metabolizing enzymes have ...
(fluoxetine a ) 2C9 Compounds containing dipole or negative charge, lipophilic groups: piroxicam a , ibuprofen a , chlorpropamide a , nateglinide a , phenytoin a , warfarin a , diclofenac a 2B6 Anticancer ...
doi:10.1016/j.drudis.2011.10.023
pmid:22056716
fatcat:jiela55gcra6zpwhsbttc7d64i
Production, purification, and characterization of a novel cold-active superoxide dismutase from the Antarctic strain Aspergillus glaucus 363
2016
Fungal Biology
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Biosynthesis Cold-active SOD Cu/Zn-SOD gene sequence Enzyme characterization a b s t r a c t The Antarctic fungal strain Aspergillus glaucus 363 produces cold-active (CA) Cu/Znsuperoxide dismutase (SOD ...
To our knowledge, this is the first nucleotide sequence of a CA Cu/Zn-SOD gene in fungi. ...
SOD samples were applied to a column of Sephadex (A), Phenyl-Sepharose (B), and Q-Sepharose (C).
Fig 5 e 5 PAGE analyses of A. glaucus SOD isoenzymes after different step of purification. ...
doi:10.1016/j.funbio.2016.03.002
pmid:27109365
fatcat:5oa5fqilaja4ndqzjsj4p52rom
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