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Psoriasis as a multisystem disease - cost of illness analysis

Inna Popova, Maria Kamusheva, Guenka Petrova, Lubka Miteva
2017 Global Dermatology  
Indirect costs increase the total financial burden as they constitute a significant part of the total costs paid by the society for one patient with psoriasis.  ...  Introduction Psoriasis is a chronic autoimmune disease, which consumes significant part of healthcare resources due to the significantly high pharmacotherapy costs for the main and for the concomitant  ... 
doi:10.15761/god.1000215 fatcat:uva4pxmfmzhzbchr44yj7wyfei

Standard karyotyping - a look through the European guidelines

Mari Hachmeriyan, Maria Levkova, Milena Stoyanova, Valentina Miteva, Lyudmila Angelova
2019 Varnenski medicinski forum  
Following the established European guidelines for genetic analysis and/or re-contacting patients with a possible genetic diagnosis will provide up-to-date medical service.  ...  Ключови думи: стандартно кариотипиране, цитогеномика, ръководство, повторен контакт ABSTRACT Standard karyotyping is a method for genetic testing for chromosomal aberrations, based on specific clinical  ... 
doi:10.14748/vmf.v8i1.5893 fatcat:zyahpgo7ffhtfi3bxk47mwq7ye

Vitamin D and Autoimmune Thyroid Diseases - a Review

Mariya Zh. Miteva, Boyan I. Nonchev, Maria M. Orbetzova, Snejana D. Stoencheva
2020 Folia Medica  
Vitamin D deficiency has become a major public health problem worldwide.  ...  This is the major circulating form of vitamin D with a half-life of 2-3 weeks. 1,25(OH) 2 D 3 does not reflect vitamin D status as it has a half-life of ~4h, peripheral levels 1000 times lower than 25(  ...  В отличие от многих исследований, в которых было доказано, что полиморфизм генов РВD связан с AИЗЩЖ, в очень немногих исследованиях рассмотрено влияние дефицита витамина D на частоту возникновения AИЗЩЖ  ... 
doi:10.3897/folmed.62.e47794 pmid:32666762 fatcat:3c7ifgk3fvbujop5f6m7duye6q

Micronutrients in hair loss

Susana A. Ruiz-Tagle, Marcella M. Figueira, Verónica Vial, Leonardo Espinoza-Benavides, Miteva Maria
2018 Nasza Dermatologia Online  
Alopecia is a common dermatological complaint.  ...  Both lower and increased vitamin A levels can result in telogen effluvium, but lower levels are associated also with hair breakage.  ...  Vitamin A Vitamin A is a fat-soluble vitamin. There are two main forms of vitamin A: 1) retinoids or preformed vitamin A and 2) carotenoids or provitamin A. Retinoids are the active form.  ... 
doi:10.7241/ourd.20183.25 fatcat:ipythjmh4ngbldryzjt5kixspi

Virtual Ligand Screening for Structure-based Drug Design: Approaches and Progress

Olivier Sperandio, Maria A. Miteva, Bruno O. Villoutreix
2007 Bioautomation  
Today technologies like combinatorial chemistry and high-throughput screening (HTS) authorize biological assays of a large number of small molecules against the therapeutically relevant targets.  ...  The method MCDOCK [64] is a three-stage strategy using a Monte Carlo algorithm.  ...  HierVLS (hierarchical virtual ligand screeing) [27] is a fast hierarchical docking approach that starts with a coarse grain conformational search over a large number of configurations filtered with a  ... 
doaj:ff15b8741a9e4e538ca40e68434b1c85 fatcat:ky74ryvp6razpkhwimn76hy44q

A Role of Cytokine Gene Polymorphisms in Cognitive Functioning

Anastasiya G. Trenova, Georgi S. Slavov, Maria G. Manova, Lyuba D. Miteva, Spaska A. Stanilova
2018 Folia Medica  
The changes in cognitive functions that occur with aging and in various pathological conditions are a subject of growing interest.  ...  The balance between pro-inflammatory and anti-inflammatory cytokines has been established as a necessary factor for normal cognitive functioning.  ...  al., 2009 IL-10 -1082 G/A rs1800896 -592 C/A rs1800872 4259 A/G rs3024498 -2849 G/A rs6703630 5804 Caucasians; mean age 75.3±3.3 yrs Global cognition No No Yes Yes Trompet et al.,  ... 
doi:10.1515/folmed-2017-0094 pmid:30355827 fatcat:c6ra2l2ozraodd4u5dnsi4nu5y

Cognitive Impairment in Multiple Sclerosis

Anastasiya G. Trenova, Georgi S. Slavov, Maria G. Manova, Jana B. Aksentieva, Lyuba D. Miteva, Spaska A. Stanilova
2016 Folia Medica  
The relationship between pathological brain findings and cognitive impairment is a subject of intensive research.  ...  Multiple sclerosis (MS) is a socially significant immune-mediated disease, characterized by demyelination, axonal transection and oligodendropathy in the central nervous system.  ...  The neuropsychological examination can vary from a short screening test to a detailed evaluation of overall cognitive functioning of a patient.  ... 
doi:10.1515/folmed-2016-0029 pmid:27760012 fatcat:2anbyeesaragbiqt577mxszkda

Analyzing Effects of Naturally Occurring Missense Mutations

Zhe Zhang, Maria A. Miteva, Lin Wang, Emil Alexov
2012 Computational and Mathematical Methods in Medicine  
Single-point mutation in genome, for example, single-nucleotide polymorphism (SNP) or rare genetic mutation, is the change of a single nucleotide for another in the genome sequence.  ...  This paper focuses on genetic mutations resulting in a change in the amino acid sequence of the corresponding protein and how to assess their effects on protein wild-type characteristics.  ...  , in a family.  ... 
doi:10.1155/2012/805827 pmid:22577471 pmcid:PMC3346971 fatcat:bmhlyyuhifhuhcoie27nuhj4my

AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening

Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno O Villoutreix, Maria A Miteva
2008 BMC Bioinformatics  
Our enrichment study suggests that AMMOS, designed to minimize a large number of ligands pre-docked in a protein target, can successfully be applied in a final postprocessing step and that it can take  ...  Next, AMMOS was used for full flexible minimization of protein-ligands complexes obtained from a mutli-step virtual screening.  ...  Acknowledgements TP appreciates a grant from the City Hall of Paris. IP thanks Prof. M.  ... 
doi:10.1186/1471-2105-9-438 pmid:18925937 pmcid:PMC2588602 fatcat:biajbyr2kvfqjpoxebi5whfowu

FAF-Drugs3: a web server for compound property calculation and chemical library design

David Lagorce, Olivier Sperandio, Jonathan B. Baell, Maria A. Miteva, Bruno O. Villoutreix
2015 Nucleic Acids Research  
Drug attrition late in preclinical or clinical development is a serious economic problem in the field of drug discovery.  ...  Here, we present FAF-Drugs3, a web server that can be used for drug discovery and chemical biology projects to help in preparing compound libraries and to assist decision-making during the hit selection  ...  Tufféry, A. Saladin and J. Rey for helpful discussions on the Mobyle Portal.  ... 
doi:10.1093/nar/gkv353 pmid:25883137 pmcid:PMC4489254 fatcat:ehwxbuu36vh6bewmfkikoovbeu

Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors

David Lagorce, Dominique Douguet, Maria A. Miteva, Bruno O. Villoutreix
2017 Scientific Reports  
All datasets were prepared and curated using the same protocol including a filtering step that selects subsets of diverse and representative molecules (see the Methods section).  ...  lipophilicity (analyzed via log P calculations) and a high molecular weight (MW), properties that are usually not favorable to the development of oral drugs (although there are numerous exceptions to  ...  In general, a compound is considered to have a high Caco-2 permeability if it has a Papp A → B > 8 · 10 −6 cm/sec.  ... 
doi:10.1038/srep46277 pmid:28397808 pmcid:PMC5387685 fatcat:iokufqkbtfd5rmwom5udc37dsm

MTiOpenScreen: a web server for structure-based virtual screening

Céline M. Labbé, Julien Rey, David Lagorce, Marek Vavruša, Jérome Becot, Olivier Sperandio, Bruno O. Villoutreix, Pierre Tufféry, Maria A. Miteva
2015 Nucleic Acids Research  
Open screening endeavors play and will play a key role to facilitate the identification of new bioactive compounds in order to foster innovation and to improve the effectiveness of chemical biology and  ...  It includes two services, MTiAutoDock and MTiOpenScreen, allowing performing docking into a user-defined binding site or blind docking using AutoDock 4.2 and automated virtual screening with AutoDock Vina  ...  MTi-AutoDock takes in average 25 min for a protein receptor requiring a grid of 170×170×170 points and a grid spacing of 0.6Å and up to 1 h for a protein receptor requiring 180×180×180 points and a grid  ... 
doi:10.1093/nar/gkv306 pmid:25855812 pmcid:PMC4489289 fatcat:rt6ebhk2gbfbbhnvmmalg4iybm

New machine learning and physics-based scoring functions for drug discovery

Isabella A. Guedes, André M. S. Barreto, Diogo Marinho, Eduardo Krempser, Mélaine A. Kuenemann, Olivier Sperandio, Laurent E. Dardenne, Maria A. Miteva
2021 Scientific Reports  
We developed a set of new empirical scoring functions, named DockTScore, by explicitly accounting for physics-based terms combined with machine learning.  ...  However, the accurate prediction of binding affinity by scoring functions remains a challenging task. The performance of scoring functions is very heterogeneous across different target classes.  ...  A charged atom was defined as a non-hydrogen and a non-carbon atom with a partial charge q > 0.8.  ... 
doi:10.1038/s41598-021-82410-1 pmid:33542326 pmcid:PMC7862620 fatcat:jstufcgu7ze4pndbtxdcenqvbq

Toward in silico structure-based ADMET prediction in drug discovery

Gautier Moroy, Virginie Y. Martiny, Philippe Vayer, Bruno O. Villoutreix, Maria A. Miteva
2012 Drug Discovery Today  
Miteva, M.A. (maria.miteva@univ-paris-diderot.fr) 44 www.drugdiscoverytoday.com  ...  Applying docking-scoring methods to ADMET proteins is a challenging process because they usually have a large and flexible binding cavity; however, promising results relating to metabolizing enzymes have  ...  (fluoxetine a ) 2C9 Compounds containing dipole or negative charge, lipophilic groups: piroxicam a , ibuprofen a , chlorpropamide a , nateglinide a , phenytoin a , warfarin a , diclofenac a 2B6 Anticancer  ... 
doi:10.1016/j.drudis.2011.10.023 pmid:22056716 fatcat:jiela55gcra6zpwhsbttc7d64i

Production, purification, and characterization of a novel cold-active superoxide dismutase from the Antarctic strain Aspergillus glaucus 363

Radoslav Abrashev, Georges Feller, Nedelina Kostadinova, Ekaterina Krumova, Zlatka Alexieva, Maria Gerginova, Boryana Spasova, Jeni Miteva-Staleva, Spassen Vassilev, Maria Angelova
2016 Fungal Biology  
Biosynthesis Cold-active SOD Cu/Zn-SOD gene sequence Enzyme characterization a b s t r a c t The Antarctic fungal strain Aspergillus glaucus 363 produces cold-active (CA) Cu/Znsuperoxide dismutase (SOD  ...  To our knowledge, this is the first nucleotide sequence of a CA Cu/Zn-SOD gene in fungi.  ...  SOD samples were applied to a column of Sephadex (A), Phenyl-Sepharose (B), and Q-Sepharose (C). Fig 5 e 5 PAGE analyses of A. glaucus SOD isoenzymes after different step of purification.  ... 
doi:10.1016/j.funbio.2016.03.002 pmid:27109365 fatcat:5oa5fqilaja4ndqzjsj4p52rom
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