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Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

Oscar J. Pellicer-Valero, José D. Martín-Guerrero, César Fernández-de-las-Peñas, Ana I. De-la-Llave-Rincón, Jorge Rodríguez-Jiménez, Esperanza Navarro-Pardo, Margarita I. Cigarán-Méndez
2021 Symmetry  
i,j = exp − xi−xj 2 2σ 2 - Build the normalized graph Laplacian matrix: L rw = I − D −1 W, where I is the identity matrix and D = (w i,j ) is a diagonal matrix with d i,i = ∑ j∈V w i,j - Obtain the k  ...  Note: u i ∈ R N -Apply k-means clustering over the transformed data points defined as y i = u i,1 , u i,2 , . . . , u i,k ∈ R k . - The cluster label C i assigned to each y i by k-means is the same label  ... 
doi:10.3390/sym13061042 fatcat:rnvjclq5vvaxve33iscvf3bmda

Mathematical Modeling for Neuropathic Pain: Bayesian Linear Regression and Self-Organizing Maps Applied to Carpal Tunnel Syndrome

Oscar J. Pellicer-Valero, José D. Martín-Guerrero, Margarita I. Cigarán-Méndez, Carmen Écija-Gallardo, César Fernández-de-las-Peñas, Esperanza Navarro-Pardo
2020 Symmetry  
probability distribution of the parameters θ and the intercept I of the BLR model, which is proportional to the prior probability of θ and I, and the likelihood P(y θ, I, x) , both of which are known.  ...  By developing Bayes theorem using the parameters from Equation (2) , and realizing that P(θ, I x) does not actually depend on x, we finally arrive at Equation (3) , where P(θ, I x, y) is the posterior  ... 
doi:10.3390/sym12101581 fatcat:i3wjrfdzmvaphkm25t7fyvj7by

Patient Profiling Based on Spectral Clustering for an Enhanced Classification of Patients with Tension-Type Headache

Oscar J. Pellicer-Valero, César Fernández-de-las-Peñas, José D. Martín-Guerrero, Esperanza Navarro-Pardo, Margarita I. Cigarán-Méndez, Lidiane L. Florencio
2020 Applied Sciences  
b) constructing a normalized graph Laplacian matrix L rw = I − D −1 W, where I is the identity matrix, and D is a diagonal matrix with values d i,i = j∈V w i,j , (c) getting the eigenvectors associated  ...  As a very short summary, SC works by (a) building a similarity matrix W = w i,j (we employed the pairwise Gaussian similarity between points with σ = 0.1, which is a typical choice for data in R n ), (  ... 
doi:10.3390/app10249109 fatcat:3hrp3iozmnagrkvbgznm4b3vum

Fatigue and Dyspnoea as Main Persistent Post-COVID-19 Symptoms in Previously Hospitalized Patients: Related Functional Limitations and Disability

César Fernández-de-las-Peñas, Domingo Palacios-Ceña, Víctor Gómez-Mayordomo, María Palacios-Ceña, Jorge Rodríguez-Jiménez, Ana I. de-la-Llave-Rincón, María Velasco-Arribas, Stella Fuensalida-Novo, Silvia Ambite-Quesada, Carlos Guijarro, María L. Cuadrado, Lidiane L. Florencio (+10 others)
2021 Respiration  
<b><i>Background:</i></b> Multicentre studies focussing on specific long-term post-COVID-19 symptoms are scarce. <b><i>Objective:</i></b> The aim of this study was to determine the levels of fatigue and dyspnoea, repercussions on daily life activities, and risk factors associated with fatigue or dyspnoea in COVID-19 survivors at long term after hospital discharge. <b><i>Methods:</i></b> Age, gender, height, weight, symptoms at hospitalization, pre-existing medical comorbidity, intensive care
more » ... t admission, and the presence of cardio-respiratory symptoms developed after severe acute respiratory syndrome coronavirus 2 infection were collected from patients who recovered from COVID-19 at 4 hospitals in Madrid (Spain) from March 1 to May 31, 2020 (first COVID-19 wave). The Functional Impairment Checklist was used for evaluating fatigue/dyspnoea levels and functional limitations. <b><i>Results:</i></b> A total of 1,142 patients (48% women, age: 61, standard deviation [SD]: 17 years) were assessed 7.0 months (SD 0.6) after hospitalization. Fatigue was present in 61% patients, dyspnoea with activity in 55%, and dyspnoea at rest in 23.5%. Only 355 (31.1%) patients did not exhibit fatigue and/or dyspnoea 7 months after hospitalization. Forty-five per cent reported functional limitations with daily living activities. Risk factors associated with fatigue and dyspnoea included female gender, number of pre-existing comorbidities, and number of symptoms at hospitalization. The number of days at hospital was a risk factor just for dyspnoea. <b><i>Conclusions:</i></b> Fatigue and/or dyspnoea were present in 70% of hospitalized COVID-19 survivors 7 months after discharge. In addition, 45% patients exhibited limitations on daily living activities. Being female, higher number of pre-existing medical comorbidities and number of symptoms at hospitalization were risk factors associated to fatigue/dyspnoea in COVID-19 survivors 7 months after hospitalization.
doi:10.1159/000518854 pmid:34569550 pmcid:PMC8678253 fatcat:sji74dsgrnfjzb2b5l5wyk6pzi

Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

César Fernández-de-las-Peñas, José D. Martín-Guerrero, Óscar J. Pellicer-Valero, Esperanza Navarro-Pardo, Víctor Gómez-Mayordomo, María L. Cuadrado, José A. Arias-Navalón, Margarita Cigarán-Méndez, Valentín Hernández-Barrera, Lars Arendt-Nielsen
2022 Journal of Clinical Medicine  
D+i en materia de respuesta a COVID 19 (LONG-COVID-EXP-CM).  ...  Foundation 0067235 (Denmark) and by a grant associated with the Fondo Europeo De Desarrollo Regional-Recursos REACT-UE del Programa Operativo de Madrid 2014-2020, en la línea de actuación de proyectos de I+  ... 
doi:10.3390/jcm11020413 pmid:35054108 pmcid:PMC8778106 fatcat:4etvpcyunfhavcw3pwy6zo6ogm

Muscle Trigger Points and Pressure Pain Sensitivity Maps of the Feet in Women with Fibromyalgia Syndrome

Maria C. Tornero-Caballero, Jaime Salom-Moreno, Margarita Cigarán-Méndez, Matilde Morales-Cabezas, Pascal Madeleine, César Fernández-de-las-Peñas
2016 Pain medicine (Malden, Mass.)  
The examiner asked each participant: "When I pressed this muscle, did you feel any pain just locally, and in another area?  ... 
doi:10.1093/pm/pnw090 pmid:27257287 fatcat:6cm2lrgsyrbixku7kbu34t22hi