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Heritability of non-speech auditory processing skills

Carmen C Brewer, Christopher K Zalewski, Kelly A King, Oliver Zobay, Alison Riley, Melanie A Ferguson, Jonathan E Bird, Margaret M McCabe, Linda J Hood, Dennis Drayna, Andrew J Griffith, Robert J Morell (+2 others)
2016 European Journal of Human Genetics  
General foreword This Position Statement represents a brief synthesis of the current evidencebase and consensus on APD, as prepared and reviewed by national and international experts, and approved by the British Society of Audiology (BSA). Although care has been taken in preparing this information, the BSA does not and cannot guarantee the interpretation and application of it. The BSA cannot be held responsible for any errors or omissions, and the BSA accepts no liability whatsoever for any
more » ... or damage howsoever arising. This document supersedes any previous statement on APD by the BSA and stands until superseded or withdrawn by the BSA.
doi:10.1038/ejhg.2015.277 pmid:26883091 pmcid:PMC4872837 fatcat:4ypip2nkbzcfjgxt26kvileb7m

Zinc and Zinc Transporters in Macrophages and Their Roles in Efferocytosis in COPD

Rhys Hamon, Claire C. Homan, Hai B. Tran, Violet R. Mukaro, Susan E. Lester, Eugene Roscioli, Mariea D. Bosco, Chiara M. Murgia, Margaret Leigh Ackland, Hubertus P. Jersmann, Carol Lang, Peter D. Zalewski (+2 others)
2014 PLoS ONE  
Our previous studies have shown that nutritional zinc restriction exacerbates airway inflammation accompanied by an increase in caspase-3 activation and an accumulation of apoptotic epithelial cells in the bronchioles of the mice. Normally, apoptotic cells are rapidly cleared by macrophage efferocytosis, limiting any secondary necrosis and inflammation. We therefore hypothesized that zinc deficiency is not only pro-apoptotic but also impairs macrophage efferocytosis. Impaired efferocytic
more » ... ce of apoptotic epithelial cells by alveolar macrophages occurs in chronic obstructive pulmonary disease (COPD), cigarette-smoking and other lung inflammatory diseases. We now show that zinc is a factor in impaired macrophage efferocytosis in COPD. Concentrations of zinc were significantly reduced in the supernatant of bronchoalveolar lavage fluid of patients with COPD who were current smokers, compared to healthy controls, smokers or COPD patients not actively smoking. Lavage zinc was positively correlated with AM efferocytosis and there was decreased efferocytosis in macrophages depleted of Zn in vitro by treatment with the membrane-permeable zinc chelator TPEN. Organ and cell Zn homeostasis are mediated by two families of membrane ZIP and ZnT proteins. Macrophages of mice null for ZIP1 had significantly lower intracellular zinc and efferocytosis capability, suggesting ZIP1 may play an important role. We investigated further using the human THP-1 derived macrophage cell line, with and without zinc chelation by TPEN to mimic zinc deficiency. There was no change in ZIP1 mRNA levels by TPEN but a significant 3-fold increase in expression of another influx transporter ZIP2, consistent with a role for ZIP2 in maintaining macrophage Zn levels. Both ZIP1 and ZIP2 proteins were localized to the plasma membrane and cytoplasm in normal human lung alveolar macrophages. We propose that zinc homeostasis in macrophages involves the coordinated action of ZIP1 and ZIP2 transporters responding differently to zinc deficiency signals and that these play important roles in macrophage efferocytosis.
doi:10.1371/journal.pone.0110056 pmid:25350745 pmcid:PMC4211649 fatcat:su2yz62nmba7bjopyrmsbek2lm

Atypical patterns of segregation of familial enlargement of the vestibular aqueduct

Julie A. Muskett, Parna Chattaraj, John F. Heneghan, Fabian R. Reimold, Boris E. Shmukler, Carmen C. Brewer, Kelly A. King, Christopher K. Zalewski, Thomas H. Shawker, John A. Butman, Margaret A. Kenna, Wade W. Chien (+2 others)
2015 The Laryngoscope  
Objective-Hearing loss and enlargement of the vestibular aqueduct (EVA) can be inherited as an autosomal recessive trait caused by mutant alleles of the SLC26A4 gene. In some other families, EVA does not segregate in a typical autosomal recessive pattern. The goal of this study was to characterize the SLC26A4 genotypes and phenotypes of extended families with atypical segregation of EVA. Study Design-Prospective study of cohort of families ascertained between 1998 and 2014 at the National
more » ... utes of Health Clinical Center. Methods-Study subjects were members of eight families segregating EVA in at least two members who were not related as siblings. Evaluations included pure-tone audiometry, temporal bone imaging, SLC26A4 nucleotide sequence analysis, SLC26A4-linked marker genotype and haplotype analysis, and pedigree analysis. Results-One family had members with EVA caused by different etiologies, and two families had pseudo-dominant inheritance of recessive mutations of SLC26A4. In five families, the etiology remained unknown and could include inheritance of mutant alleles at another genetic locus, non-genetic influences, or a combination of these factors. Conclusions-Familial EVA can demonstrate a variety of atypical segregation patterns. Pseudo-dominant inheritance of SLC26A4 mutations or recessive alleles of other hearing loss genes may be more likely to occur in families in which deaf individuals have intermarried. The etiologic basis of atypical segregation of EVA without detectable SLC26A4 mutations remains unknown. Future studies of these families may reveal novel genes for EVA.
doi:10.1002/lary.25737 pmid:26485571 pmcid:PMC4838554 fatcat:grayir24djhkpigo6tqunw74t4

Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation

Chiara Murgia, Dion Grosser, Ai Q. Truong-Tran, Eugene Roscioli, Agnes Michalczyk, Margaret Leigh Ackland, Meredin Stoltenberg, Gorm Danscher, Carol Lang, Darryl Knight, Giuditta Perozzi, Richard E. Ruffin (+1 others)
2011 Nutrients  
We acknowledge the helpful advice given by Anthony Kicic (Princess Margaret Hospital, Western Australia) and Paul Foster (University of Newcastle) and Rakesh Kumar (University of NSW).  ... 
doi:10.3390/nu3110910 pmid:22254085 pmcid:PMC3257720 fatcat:exudrfitejadtiqs3d2fetqh6q

The feasibility of a strategy for the remote recruitment, consenting and assessment of recent referrals: a protocol for phase 1 of the On-Line Parent Training for the Initial Management of ADHD referrals (OPTIMA)

Katarzyna Kostyrka-Allchorne, Claire Ballard, Sarah Byford, Samuele Cortese, David Daley, Johnny Downs, Blandine French, Cristine Glazebrook, Kimberley Goldsmith, Madeleine J. Groom, Charlotte L. Hall, Ellen Hedstrom (+13 others)
2022 Pilot and Feasibility Studies  
Background In the UK, children with high levels of hyperactivity, impulsivity and inattention referred to clinical services with possible attention-deficit/hyperactivity disorder (ADHD) often wait a long time for specialist diagnostic assessment. Parent training (PT) has the potential to support parents during this difficult period, especially regarding the management of challenging and disruptive behaviours that often accompany ADHD. However, traditional face-to-face PT is costly and difficult
more » ... to organise in a timely way. We have created a low-cost, easily accessible PT programme delivered via a phone app, Structured E-Parenting Support (STEPS), to address this problem. The overall OPTIMA programme will evaluate the efficacy and cost-effectiveness of STEPS as a way of helping parents manage their children behaviour while on the waitlist. To ensure the timely and efficient evaluation of STEPS in OPTIMA, we have worked with children's health services to implement a remote strategy for recruitment, screening and assessment of recently referred families. Part of this strategy is incorporated into routine clinical practice and part is OPTIMA specific. Here, we present the protocol for Phase 1 of OPTIMA—a study of the feasibility of this remote strategy, as a basis for a large-scale STEPS randomised controlled trial (RCT). Methods This is a single arm observational feasibility study. Participants will be parents of up to 100 children aged 5-11 years with high levels of hyperactivity/impulsivity, inattention and challenging behaviour who are waiting for assessment in one of five UK child and adolescent mental health or behavioural services. Recruitment, consenting and data collection will occur remotely. The primary outcome will be the rate at which the families, who meet inclusion criteria, agree in principle to take part in a full STEPS RCT. Secondary outcomes include acceptability of remote consenting and online data collection procedures; the feasibility of collecting teacher data remotely within the required timeframe, and technical difficulties with completing online questionnaires. All parents in the study will receive access to STEPS. Discussion Establishing the feasibility of our remote recruitment, consenting and assessment strategy is a pre-requisite for the full trial of OPTIMA. It can also provide a model for future trials conducted remotely.
doi:10.1186/s40814-021-00959-0 pmid:34980279 pmcid:PMC8720938 fatcat:6pmdzmekjbhwnndsq57sq3dzcq

Page 751 of Linguistics and Language Behavior Abstracts: LLBA Vol. 28, Issue 2 [page]

1994 Linguistics and Language Behavior Abstracts: LLBA  
F., 9403231 Ziegesar, Detlef, 94r01521 Ziegesar, Margaret, 94r01521 Zierhofer, C., 9403859 come. J.  ...  , Jan P., 9402404 Zalewski, Jan Pawel, 9402405 Zamir, Jan R., 94r01517 Zanaret, M., 9403718, 9403772 Zane, Jonna Davis, 9403455 Zanola, Annalisa, 94101337 Zawadzka, Elzbieta, 9402406, 94r01518 ler, Jurgen  ... 

Spis treści

. .
2007 Przestrzenie Teorii  
O znaczeniu podróży do Francji w roku 1890 dla poglądów i postawy artystycznej Stanisława Wyspiańskiego 89 Cezary Zalewski Antropologia fotografii.  ...  (krótki komentarz do rozpraw Jana Kordysa) Przesłania motywów elewacji w poezji Bertranda Degotta 195 Anna Igielska "Sny" Jarosława Iwaszkiewicza -subiectum w obiektywie 205 Przekłady Margaret  ... 
doaj:85d053bac17048318a08edf81efc4951 fatcat:zpjfzuudojhp3g7nni35b33xcu

Page 171 of The Journal of Speech and Hearing Disorders Vol. 20, Issue SUPPLEMENT [page]

1955 The Journal of Speech and Hearing Disorders  
Warren, MArGARET Dept. of Sp., L. S. U., Baton Rouge, La. Waszkiewicz, Maureen 9435 Mitchell, Detroit 12, Mich.  ...  ZALEWSKI, ExvizApetH 20466 Hanna, Detroit, Mich. ZANOLLI, THORNTON 28 W. Adams, Suite 702, Detroit 26, Mich ZarRA, CATHERINE DeStrerano (Mrs.) 231 Lake St., Newark, N. J.  ... 

Index [chapter]

Colin Coulter, Michael Murray
2016 Northern Ireland after the troubles  
., 161−2 Zalewski, M., 157, 170 Zukin, S., 218 99, 216 violence, politically-or racially- motivated, 14−15, 18, 76−80, 83−5, 144−7, 151, 198−9 voting systems in Northern Ireland, 59, 166−7 war crimes  ...  , 31 Ward, Margaret, 168 Warner, M., 160 Wayne, N., 181 Welsh Assembly, 163 Wheeler, Tim, 245 whiteness as a racial identity, 195−6, 204−5, 208−9 Colin Coulter and Michael Murray -9780719095160  ... 
doi:10.7765/9780719095160.00024 fatcat:z3pbug6zsrfsdehhfevbvfqjk4

Page 621 of The Journal of Speech and Hearing Disorders Vol. 22, Issue 4 [page]

1957 The Journal of Speech and Hearing Disorders  
Flint: Cole, Ernest; Conklin, John; Donelson, Ruth A.; Eggleston, Jean M.,; Haak, Ethel S.; Hagle, Nancy; Hill, Margaret L.; Owen, Delma; Poulos, Thomas H.  ...  (BS); Weitzel, Agnes; Zalewski, Elizabeth E. Detroit: Hamnett, David E. Lansing: Auston, John T.; Edwards, Elsie “{. (AS); Herbst, Wilbur C.; King, Paul (BS); Koons, Roberta G.; Leutenegger, Ralph R.  ... 

Page 527 of The Journal of Speech and Hearing Disorders Vol. 23, Issue 4 [page]

1958 The Journal of Speech and Hearing Disorders  
Flint: Bourgeault, Stanley E.; Cole, Ernest; Donelson, Ruth A.; Eggleston, Jean M.; Haak, Ethel S.; Hill, Margaret L.; Poulos, Thomas H.  ...  .; Zalewski, Elizabeth East Detroit: Hamnett, David (BS); Holste, Herman; Rinehart, Robert B. East Lansing: Dietrich, Rosanne; Edwards, Elsie M.  ... 

Creating Cultural and Commercial Value in Late Nineteenth-Century New York Art Catalogues [chapter]

Leanne Zalewski
2019 Art Crossing Borders  
Vanderbilt's House and Collection (Boston, 1883-84), s.p., labelled by Leanne Zalewski © Leanne Zalewski Leanne Zalewski -9789004291997 Downloaded from Brill.com04/27/2019 03:38:03AM via free access i  ...  Laster, "Catharine Lorillard Wolfe: Collecting and Patronage in the Gilded Age," (PhD diss., Graduate Center, City University of New York, 2013); Margaret Laster, "The Collecting and Patronage of Catharine  ... 
doi:10.1163/9789004291997_005 fatcat:ak57xsefyfhdrhjur4wao2jcau

Index [chapter]

Jenny Edkins
2019 Change and the politics of certainty  
Watts, Michael 171 Watts, Susan 36, 37 Weber, Max 29-30 Weizman, Eyal 137 White, Rob 160 Whyte, David 172 Wigley, Mark 173 Wilcox, Fiona 181 women see gender World War I 13 World War II 8, 52, 67, 97 Zalewski  ...  81 Suetsugu, Marie 26 symbolic order 59-63, 104, 204 Syrian refugees 178 Szymborska, Wisl / awa 111, 123n6 teleology 3, 217, 218 terrorism 24-5, 42-3, 60, 144 see also United States Thatcher, Margaret  ... 
doi:10.7765/9781526147264.00017 fatcat:qnkypahmibha7b2436flw4x3nu

Page 2300 of Mathematical Reviews Vol. , Issue 82e [page]

1982 Mathematical Reviews  
See Zalewski, Z. Zalewski, Z. ......... 65101 Zamfirescu, Tudor 53096-53097 Zamolodchikov, A. B. . . See Zamolodtikov, Aleksander B. Zamolodtikov, Aleksander B. Zarati, Said Zas‘ko, Ju. N. ...  ...  Wright, Margaret H. .. ee ee 03023 Wschebor, M Wu, Cang Pu Wu, H. ... See Wu, Hung Hai Wu, Hung Hai Wu, Jang Mei G. 30015, 30048 Wu, Min Yen Wu, 8. Y. .. Wu, Shi Yu Wuidar, J Wulbert, D. E.  ... 

Page 1800 of Psychological Abstracts Vol. 44, Issue 10 [page]

1970 Psychological Abstracts  
., 17519 Yeakel, Margaret, 16401 Yee, Albert H., 17539 Yeganeh, Mehdi L., 16869 Yetman, Norman R., 16657 Yeudall, L.  ...  M., 16570, 17431, 17551 Zaimov, K., 17056 Zalesskii, A. 1. 16459 Zalewski, Andrew A., 16153 Zalkind, Sheldon S., 17599 Zamskii, Kh. S., 17390 Zand, Dale E., 17599 Zangwill, O.  ... 
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