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Robin Haring, Henri Wallaschofski, Matthias Nauck, Marcus Dörr, Sebastian E. Baumeister, Henry Völzke
2009 Hepatology  
We read with great interest the article by Haring et al. 1 In this population-based study, they found that elevated gamma-glutamyl transpeptidase (GGT) level was associated with an increased risk of all-cause and cardiovascular disease (CVD) mortality in men, and these associations were even stronger in men with hepatic steatosis. Their results indeed provide important data to improve our understanding about the interactions among GGT, CVD risk, and mortality; however, several issues deserve
more » ... ther discussion. First, GGT level is found to be strongly associated with all-cause mortality, largely due to CVD in the top quintile of the GGT distribution. This is the first study to document a direct association of elevated GGT level and hepatic steatosis with all-cause and CVD mortality in men, suggesting ultrasonographic hepatic steatosis may increase the prediction value of elevated GGT level in mortality risk. Of interest is that serum alanine aminotransferase (ALT), a marker of liver inflammation or injury, can also predict CVD events in a 10-year follow-up study. 2 Additionally, increased overall mortality and risk of CVD were reported in patients with nonalcoholic fatty liver disease (NAFLD). 3 Taking these lines of evidence together, serum liver enzymes including GGT and ALT as well as hepatic steatosis seem to have similar and even synergistic association with the risks of CVD and all-cause mortality. Our previous study also demonstrated that serum ALT level was positively associated with carotid atherosclerosis in patients with NAFLD, suggesting serum ALT level may predict CVD risk in patients with NAFLD. 4 Therefore, it will help us understand more about the relationship among these parameters with CVD risk and mortality if the authors could perform further analyses stratified by different serum ALT levels. Second, the present study didn't exclude participants with the habit of alcohol consumption, and the mean alcohol consumption in men was near the level of risk (20 g/day). In our clinical practice, elevated GGT level is usually observed in patients with biliary or alcoholic liver diseases that could be the major component of the top quintile GGT group. In addition, heavy alcohol consumption has been reported to increase mortality risk. 5 To solve this issue, the authors should provide data about the percentage of alcohol consumption in the top quintile group and the association of GGT with all-cause mortality in men without alcohol consumption to prevent the confounding effect of alcohol on serum GGT level and all-cause mortality. Finally, finding an ideal marker to predict mortality or life expectancy is a dream of practicing physicians. All of the reported candidate markers seem to be associated with the existence of NAFLD. It is generally believed that NAFLD is a hepatic manifestation of metabolic syndrome, which contributes to the risk of CVD. According to the chronological sequence of development, NAFLD may be an earlier manifestation of metabolic syndrome compared to CVD. Therefore, NAFLD-related markers including serum GGT, ALT, and hepatic steatosis may predict CVD risk or even mortality. However, whether liver itself could serve as an alarm bell for mortality or life expectancy deserves further investigations.
doi:10.1002/hep.23494 fatcat:m6krccwiefacjcroniqkpl72oy

Wirusowa choroba serca - leczenie

Agnieszka Pawlak, Katarzyna E. Gil, Marcus Dörr
2017 Kardiologia polska  
Professor Marcus Dörr graduated from Humboldt University (Charité) in Berlin, Germany and is a board-certified specialist in Internal Medicine and Cardiology.  ...  Professor Dörr has contributed to more than 250 publications in peer-reviewed international journals.  ... 
doi:10.5603/kp.a2017.0141 pmid:28715067 fatcat:hmsne3bmdragtgylhzj4xv6ose

Methodology for Energy Efficiency on Process Level

Marcus Dörr, Sylvia Wahren, Thomas Bauernhansl
2013 Procedia CIRP  
Today, energy efficiency issues are becoming more and more important within organizations. Many problems arise when these organizations take the challenge of producing with fewer resources, like materials and energy. There is no general procedure to integrate these aspects in everyday organizational practices. The international standard ISO 50001 defines general requirements for the operational and organizational structure for companies but the standard gives no information about how to realize
more » ... energyefficient processes on productive or non-productive level. The energy consumption of processes is rarely known because of an insufficient existing infrastructure and missing measuring devices. Furthermore, often there is a lack of manpower and knowledge about new and innovative technologies. If any expertise exists, it is linked to individual positions and not systematically integrated in projects or structures for the improvement of production processes. The integration of know-how in energy performance such as energy efficiency, energy use and consumption in organizations needs a knowledge management system and a procedure for the consideration of energy aspects. The new approach is to link a systematic methodology for the identification of energy saving potential to the proposal of measures for their improvement. This approach requires a detailed analysis of the technical and structural facts in production processes. The outcomes of this analysis combined with a database of common measures are generating company-specific measures. The measures are going to be evaluated by defined criteria. The results will be provided for the different roles in an organization. Examples are user-specific checklists or processes for individual tasks. With this approach it is possible for organizations to recognize and to document their knowledge about energy efficiency and to build up a base for a continuous improvement process.
doi:10.1016/j.procir.2013.06.048 fatcat:e6vuq4t52na27gfmdjoqpextri

Focusing Extreme Programming on Usability

Ralf Carbon, Jörg Dörr, Marcus Trapp
2004 Jahrestagung der Gesellschaft für Informatik  
Agile methods such as extreme programming are becoming increasingly important for the rapid development of software applications. They proofed to be applicable and beneficial for a variety of domains. Nevertheless, due to the iterative nature of these approaches, software developers focus on functional aspects and tend to neglect nonfunctional characteristics, like usability. This paper addresses this issue by providing an extension suggestion for extreme programming that helps the on-site
more » ... mer and development team to take into account usability. Usability criteria are attached to user stories, and a new type of user stories, called usability stories are introduced. This also influences the way on-site customers perform the acceptance test. We present first results of a case study where small changes to extreme programming have been introduced. The benefits were an increased perception of usability due to the integration into the user stories and an early evaluation of usability criteria in the acceptance test. Eventually, these measures lead to a high usability of the software system.
dblp:conf/gi/CarbonDT04 fatcat:mcopqbg4i5b7rg6tvlen6p3pmu

The Authors Reply:

Thorsten Reffelmann, Marcus Dörr, Henry Völzke, Nele Friedrich, Alexander Krebs, Till Ittermann, Stephan B. Felix
2010 Kidney International  
reflect that vascular dysfunction may promote early stages of renal disease or mildly reduced kidney function results in altered vascular functioning or both, remains to be determined. 1 . 1 Reffelmann T, Dorr  ... 
doi:10.1038/ki.2010.308 fatcat:tcy2shi5hnhg5ch4scrxeoll6a

Giant Mesenteric Lymphangioma

Eva Schest, Herwig Cerwenka, Bernd Höfler, Marcus Rigler, Thomas Auer, Katrin Dorr, Hans-Jörg Mischinger
2009 Digestive Surgery  
A 34-year-old man presented at the urology department with prostatitis and was put on antibiotics. He had no history of abdominal pain or weight gain. Seven days later, he underwent ultrasonography of both kidneys. As the left kidney could not be displayed, a magnetic resonance image (MRI) was ordered. This showed a multicystic tumor extending from the diaphragm to the lower abdomen and involving the spleen.
doi:10.1159/000227770 pmid:19590211 fatcat:hyrfwbynybgjhnaeeijirnz73q

Expression of a transcript encoding for cytosolic renin in the diseased human heart [article]

Jaroslaw Sczodrok, Philipp Lutze, Doreen Staar, Marcus Dörr, Joerg Peters
2020 bioRxiv   pre-print
Secretory renin promotes hypertrophy, apoptosis, necrosis and fibrosis through angiotensin generation. It has been claimed that local expression of renin contributes to the deleterious effects of the renin-angiotensin system in the heart. Besides the classic renin transcript (renin-a), encoding for secretory renin, a putative brain-specific (renin-b) and a putative lung-specific (renin-c) transcript may exist in human. In contrast to secretory renin, renin-b cannot be secreted, remains within
more » ... e cytosol and is imported into mitochondria. In contradiction to renin-a, renin-b exerts cardioprotective effects in hearts and in cardiac cells of the rat under ischemia related conditions. To date, available data on cardiac renin expression remain inconsistent. Nobody has yet investigated which renin transcripts are expressed in the human heart. We systematically analyzed the levels of renin transcripts using specific and sensitive nested reverse-transcriptase polymerase chain reactions (RT-PCR) in human ventricular biopsies obtained from patients with heart diseases. In the 33 biopsies available, neither the expression of classic renin-a, nor of the alternative renin-c was detected. In contrast, the renin-b transcript, which was previously classified as brain-specific, was found in 11/33 ventricular biopsies. Our data exclude the expression of secretory renin and indicate that local expression of cytosolic renin but not of secretory renin can play a functional role in the human heart.
doi:10.1101/2020.04.02.021592 fatcat:lxo6c2wo4rg4thdr4pcadyinka

Hypertension in Germany

Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B. Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
2016 Deutsches Ärzteblatt International  
►Zitierweise Neuhauser H, Diederichs C, Boeing H, Felix SB, Jünger C, Lorbeer R, Meisinger C, Peters A, Völzke H, Weikert C, Wild P, Dörr M: Hypertension in Germany-data from seven population-based epidemiological  ... 
doi:10.3238/arztebl.2016.0809 pmid:28073425 pmcid:PMC5241792 fatcat:yeil37rwozfkjkaeklllmbixry

Interobserver variability of ventilatory anaerobic threshold in asymptomatic volunteers

Sabine Kaczmarek, Dirk Habedank, Anne Obst, Marcus Dörr, Henry Völzke, Sven Gläser, Ralf Ewert
2019 Multidisciplinary Respiratory Medicine  
The ventilatory anaerobic threshold (VO2@AT) has been used in preoperative risk assessment and rehabilitation for many years. Our aim was to determine the interobserver variability of AT using cardiopulmonary exercise (CPET) data from a large epidemiological study (SHIP, Study of Health in Pomerania). Methods: VO2@AT was determined from CPET of 1,079 cross-sectional volunteers, according to American Heart Association guidelines. VO2@AT determinations were compared between two experienced
more » ... ans, between physicians and qualified medical assistants, and between physicians or medical assistants and software-based algorithms. For the first 522 data sets, the two physicians discussed discrepant readings to reach consensus; the remaining data sets were analyzed without consensus discussion. Results: VO2@AT was detectable in 1,056 data sets. The physicians recorded identical VO2@AT values in 319 out of 522 cases before consensus discussion (61.1%; intraclass correlation coefficient [ICC]: 0.90; 95% confidence interval [CI]: 0.88–0.92) and in 700 out of 1,056 cases overall (66.3%; ICC: 0.95; 95% CI: 0.95–0.96), with an interobserver difference of 0 ± 8% (95% limits of agreement [LOA]: ±161 mL/min). The interobserver difference was − 2 ± 18% (95% LOA: ±418 mL/min) between a physician and medical assistants, and − 19 ± 24% to − 22 ± 26% (95% LOAs: ±719–806 mL/min) between physicians or medical assistants and software-based algorithms. Conclusions: Experienced physicians show high agreement when determining AT in asymptomatic volunteers. However, agreement between physicians and qualified medical assistants is lower, and there is substantial deviation in AT determination between physicians or medical assistants and software-based algorithms. This must be considered when using AT as a decision tool.
doi:10.4081/mrm.2019.21 fatcat:6g2r22p2hfbkdiwragkvctb6bq

Variants of Toll-like Receptor 4 Predict Cardiac Recovery in Patients with Dilated Cardiomyopathy

Alexander Riad, Henriette Meyer zu Schwabedissen, Kerstin Weitmann, Lars R. Herda, Marcus Dörr, Klaus Empen, Arne Kieback, Astrid Hummel, Marcus Reinthaler, Marcus Grube, Karin Klingel, Matthias Nauck (+4 others)
2012 Journal of Biological Chemistry  
The impact of polymorphisms of TLR4 on left ventricular performance in DCM patients is unknown. Results: Patients carrying TLR4 variants had reduced improvement of left ventricular function and dilation and no increase in NT-pro-BNP level at follow up when compared with wild type genes. Conclusion: TLR4 variants predict cardiac recovery in DCM. . 2 The abbreviations used are: DCM, dilated cardiomyopathy; LV, left ventricular; BNP, brain natriuretic peptide; CRP, C-reactive protein; LVEDD, left
more » ... entricular end-diastolic diameter; LVEF, left ventricular end fraction.
doi:10.1074/jbc.m112.369728 pmid:22645142 pmcid:PMC3411065 fatcat:n2vv2w4qvrbtneeancumdgwnuy

Interobserver variability of ventilatory anaerobic threshold in asymptomatic volunteers

Sabine Kaczmarek, Dirk Habedank, Anne Obst, Marcus Dörr, Henry Völzke, Sven Gläser, Ralf Ewert
2019 Multidisciplinary Respiratory Medicine  
The ventilatory anaerobic threshold (VO2@AT) has been used in preoperative risk assessment and rehabilitation for many years. Our aim was to determine the interobserver variability of AT using cardiopulmonary exercise (CPET) data from a large epidemiological study (SHIP, Study of Health in Pomerania). VO2@AT was determined from CPET of 1,079 cross-sectional volunteers, according to American Heart Association guidelines. VO2@AT determinations were compared between two experienced physicians,
more » ... een physicians and qualified medical assistants, and between physicians or medical assistants and software-based algorithms. For the first 522 data sets, the two physicians discussed discrepant readings to reach consensus; the remaining data sets were analyzed without consensus discussion. VO2@AT was detectable in 1,056 data sets. The physicians recorded identical VO2@AT values in 319 out of 522 cases before consensus discussion (61.1%; intraclass correlation coefficient [ICC]: 0.90; 95% confidence interval [CI]: 0.88-0.92) and in 700 out of 1,056 cases overall (66.3%; ICC: 0.95; 95% CI: 0.95-0.96), with an interobserver difference of 0 ± 8% (95% limits of agreement [LOA]: ±161 mL/min). The interobserver difference was - 2 ± 18% (95% LOA: ±418 mL/min) between a physician and medical assistants, and - 19 ± 24% to - 22 ± 26% (95% LOAs: ±719-806 mL/min) between physicians or medical assistants and software-based algorithms. Experienced physicians show high agreement when determining AT in asymptomatic volunteers. However, agreement between physicians and qualified medical assistants is lower, and there is substantial deviation in AT determination between physicians or medical assistants and software-based algorithms. This must be considered when using AT as a decision tool.
doi:10.1186/s40248-019-0183-6 pmid:31198557 pmcid:PMC6556958 fatcat:hjgwnatianculkvwfgjxytxdfi

Positionspapier Nuklearkardiologie – Update 2018

Johann Bauersachs, Frank Bengel, Wolfgang Burchert, Jürgen vom Dahl, Rolf Dörr, Marcus Hacker, Malte Kelm, Tienush Rassaf, Christoph Rischpler, Wolfgang Schäfer, Michael Schäfers, Sigmund Silber (+2 others)
2018 NuclearMedicine  
ZusammenfasungDas gemeinsame Positionspapier der Arbeitsgemeinschaft "Kardiovaskuläre Nuklearmedizin" der Deutschen Gesellschaft für Nuklearmedizin (DGN) und der Arbeitsgruppe "Nuklearkardiologische Diagnostik" der Deutschen Gesellschaft für Kardiologie (DGK) aktualisiert das Positionspapier aus dem Jahr 2009. Es gibt einen Überblick über die Einsatzbereiche, den State of the Art und den aktuellen Stellenwert der nuklearkardiologischen Bildgebung. Behandelt werden die Themenfelder der
more » ... n KHK einschließlich der Vitalitätsdiagnostik, ferner der Kardiomyopathien, der entzündlichen Endokarditiden, der kardialen Sarkoidose und Amyloidose.
doi:10.3413/2018-06-0001 pmid:30041259 fatcat:ioqgocenezaxdig6cfp6andc5q

Dynamic adaptation of myocardial proteome during heart failure development

Julia Rüdebusch, Alexander Benkner, Axel Poesch, Marcus Dörr, Uwe Völker, Karina Grube, Elke Hammer, Stephan B. Felix, Vincenzo Lionetti
2017 PLoS ONE  
Intensity [SHAM 14d] Intensity [SHAM 21d] Intensity [SHAM 28d] Intensity [SHAM 42d] Intensity [SHAM 56d] Intensity [TAC 4d] Intensity [TAC 14d] Intensity [TAC 21d] Intensity [TAC 28d] Intensity [TAC 42d] Intensity [TAC 56d] P-Value [base] P-Value [SHAM 4d] P-Value [SHAM 14d] P-Value [SHAM 21d] P-Value [SHAM 28d] P-Value [SHAM 42d] P-Value [SHAM 56d] P-Value [TAC 4d] P-Value [TAC 14d] P-Value [TAC 21d] P-Value [TAC 28d] P-Value [TAC 42d]
doi:10.1371/journal.pone.0185915 pmid:28973020 pmcid:PMC5626523 fatcat:ikgm7b2bcrdohf4hzpkqsa3bre

Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

Stephanie Zylla, Marcus Dörr, Henry Völzke, Ulf Schminke, Stephan B. Felix, Matthias Nauck, Nele Friedrich
2018 Arteriosclerosis, Thrombosis and Vascular Biology  
Objective-Chemerin has been shown to be associated with inflammation and metabolic syndrome, which are in turn leading risk factors for atherosclerosis. A few clinical studies have concentrated on the role of chemerin in atherosclerosis but revealed divergent findings. Therefore, we aimed to investigate the association of plasma chemerin levels with different subclinical measurements of atherosclerosis in a population-based sample. Approach and Results-Linear and logistic regression models with
more » ... different atherosclerotic parameters as subclinical outcomes were applied to analyze data from 4003 subjects of the SHIP (Study of Health in Pomerania). After adjustment for metabolic and inflammatory parameters, these models revealed no association of chemerin with carotid intima-media thickness, carotid plaque, or carotid stenosis but a significant inverse association between chemerin and ankle-brachial index. In detail, logistic regression analysis showed that a 25-ng/mL increase in chemerin was associated with a 30% higher odd (95% confidence interval, 1.20-1.41) of having an ankle-brachial index value below the 25th age-and sex-specific quartile. Conclusions-Our analyses revealed a modest inverse association between chemerin and ankle-brachial index that remained consistent after adjustment for metabolic and inflammatory parameters. The association of chemerin with carotid intimamedia thickness, carotid plaque, or carotid stenosis was not significant after adjustment for the same confounder set. The investigated subclinical atherosclerotic parameters are representative for the atherosclerotic burden of different arterial regions and different disease stages. Thus, our results might suggest that the value of chemerin as a marker of higher atherosclerotic risk differs depending on the affected arterial region and disease stage. Visual Overview-An online visual overview is available for this article.
doi:10.1161/atvbaha.118.311219 pmid:29853566 pmcid:PMC6039419 fatcat:u2mtvt2xfjcnzf6oodq7si2cj4

Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes?

Lisa Balbach, Henri Wallaschofski, Henry Völzke, Matthias Nauck, Marcus Dörr, Robin Haring
2013 BMC Endocrine Disorders  
To investigate potential associations of serum prolactin concentration (PRL) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), previously observed in small and selected study samples, in a large population-based cohort. Methods: Data from 3,993 individuals (2,027 women) aged 20-79 years from the population-based Study of Health of Pomerania (SHIP) were used to analyse cross-sectional and longitudinal associations of PRL with MetS and T2DM risk in age-and multivariable-adjusted
more » ... Poisson regression models. PRL were log-transformed and modelled as continuous (per standard deviation (SD) increase) and categorical predictor (sex-specific quartiles) variable, separately for men and woman. Results: Cross-sectional analyses showed an inverse association between low PRL concentrations and prevalent T2DM risk in men and women after multivariable-adjustment (men: Q1 vs. Q4: relative risk (RR), 1.55; 95% confidence interval (CI), 1.13 -2.14; women: Q1 vs. Q4: RR, 1.70; 95% CI, 1.10 -2.62). Likewise, higher PRL concentrations were associated with significantly lower T2DM risk (RR per SD increase in log-PRL: 0.83; 95% CI, 0.72 -0.95 in men, and 0.84; 95% CI, 0.71 -0.98 in women, respectively). An inverse association between PRL and MetS risk was not retained after multivariable adjustment. Longitudinal analyses yielded no association of PRL with incident MetS or T2DM. Conclusion: The present study is the first large population-based study reporting a cross-sectional inverse association between PRL and prevalent T2DM in both genders. But the absent longitudinal associations do not support a causal role of PRL as a risk factor of incident MetS or T2DM.
doi:10.1186/1472-6823-13-12 pmid:23517652 pmcid:PMC3614874 fatcat:puy3k55ftbgerjqlsjdcqklg6m
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