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Transição agroecológica e inovação socioterritorial

Marc Piraux, Luciano Silveira, Paulo Diniz, Ghislaine Duque
2013 Estudos Sociedade e Agricultura  
A transição agroecológica dos sistemas de produção é um processo complexo que envolve mudanças técnicas e sociais. Tomando como exemplo a Borborema, no Agreste da Paraíba, analisa-se a trajetória de transição agroecológica a partir das teorias da inovação social e territorial. A transição tem levado a uma mudança social para satisfazer às necessidades básicas das pessoas mais vulneráveis. Processos de aprendizagem, transformações das relações sociais, fortalecimento das redes sociais e mudança
more » ... as condições de governança do desenvolvimento foram importantes para promover a integração social e política dos camponeses. As inovações técnicas, sociais e institucionais estão enraizadas no território, entendido como um espaço de institucionalização dos processos de transição agroecológica.
doaj:bbd09796d42541dc9a3f629f12daccc2 fatcat:i4jlf724k5aubeocrg7dlrk2je

Customizing Service Platforms (Dagstuhl Seminar 13171)

Luciano Baresi, Andreas Rummler, Klaus Schmid, Marc Herbstritt
2013 Dagstuhl Reports  
My View on Customizing Service Platforms Luciano Baresi (Polytechnic University of Milano, IT) License Creative Commons BY 3.0 Unported license © Luciano Baresi A service platform is a set of related  ...  Table of Contents Executive Summary Luciano Baresi, Andreas Rummler, and Klaus Schmid . . . . . . . . . . . . . . . .  ... 
doi:10.4230/dagrep.3.4.114 dblp:journals/dagstuhl-reports/BaresiRS13 fatcat:fyscueobxbeufhyzjo4n2qenh4

"O grande desastre aéreo de ontem": onirismo, montagem poética e ressonâncias de Marc Chagall em Jorge de Lima

Luciano Dias Cavalcanti
2018 Raído  
Nesse texto, pretendemos fazer a análise do poema "O grande desastre aéreo de ontem", de modo a perceber as ressonâncias da obra pictural de Marc Chagall na poesia de Jorge de Lima.  ...  (LIMA, 1958, p. 446) MARC CHAGALL 5 "A dança" -Marc Chagall 5 "Obsessão" -Marc Chagall "O sonho de Jacob" -Marc Chagall "Cantar dos Cantares" -Marc Chagall ) . ) Chagall criou um estilo  ...  Marc Chagall Marc Chagall (1887-1953), de origem judaica, iniciou-se na pintura na pequena cidade russa de Vitebsk, dando continuidade a seus estudos em São Petersburgo e em raído, Dourados, MS, v. 11,  ... 
doi:10.30612/raido.v11i28.6547 fatcat:4js2l6ubebadjfjrdjlhijiqwu

Measuring H_0 in PTA with gravitational waves [article]

Domènec Espriu, Luciano Gabbanelli, Marc Rodoreda
2019 arXiv   pre-print
Pulsar Timing Arrays have yet to find convincing evidence of gravitational waves. Some time ago it was pointed out by one of the authors that a dramatic enhancement of the signal would take place for particular values of the angle subtended by the source and the observed pulsar. This enhancement is due to the fact that waves propagate in a Friedmann-Lemaitre-Robertson-Walker metric where, contrary to some wide-spread belief, a simple harmonic function with a red-shifted frequency is not a
more » ... on of the equation of motion. At the first non-trivial order, proper solutions have an effective wave number that differs from the frequency. This leads to some interesting effects in Pulsar Timing Arrays whose most visible manifestation is the enhancement of the signal that, all other parameters kept fixed, is related in a simple manner to the value of H_0. In this work we rederive in an alternative way the main results, extend the formalism to a more realistic setting where all components in the cosmological budget are included, investigate in detail the dependence of the signal on the various parameters involved and propose an observational set-up to hopefully detect this very relevant effect.
arXiv:1908.08472v1 fatcat:uqgo3jlf4reujeetl7wxycmvy4

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Bernd Schuettengruber, Henri-Marc Bourbon, Luciano Di Croce, Giacomo Cavalli
2017 Cell  
doi:10.1016/j.cell.2017.08.002 pmid:28938122 fatcat:bzqg3uplpna5vhyui4ezpgno4i

Yoga and Rehabilitation: Physical, Psychological, and Social

Shirley Telles, Elisa Kozasa, Luciano Bernardi, Marc Cohen
2013 Evidence-Based Complementary and Alternative Medicine  
Shirley Telles Elisa Kozasa Luciano Bernardi Marc Cohen  ... 
doi:10.1155/2013/624758 pmid:24348711 pmcid:PMC3853042 fatcat:5g7r3neubngubpxsi36legtwfa

Loss of CDC50A function drives Aβ/p3 production via increased β/α-secretase processing of APP [article]

Marc D Tambini, Luciano D'Adamio
2020 bioRxiv   pre-print
The Amyloid Precursor Protein (APP) undergoes extensive proteolytic processing to produce several biologically active metabolites which affect Alzheimer's disease (AD) pathogenesis. Sequential cleavage of APP by β- and γ-secretases results in Aβ, while cleavage by α- and γ-secretases produces the smaller p3 peptide. Here we report that in cells in which the P4-ATPase flippase subunit CDC50A has been knocked out, large increases in the products of β- and α-secretase cleavage of APP (sAPPβ/βCTF
more » ... d sAPPα/αCTF, respectively) and the downstream metabolites Aβ and p3 are seen. These data indicate that APP cleavage by α/β-secretase are increased and suggest that phospholipid asymmetry plays an important role in APP metabolism and Aβ production.
doi:10.1101/2020.11.12.379636 fatcat:roocgiuzxfhszhunfboje65pji

Chromatin remodelling and histones mRNA accumulation in bovine germinal vesicle oocyte

Remi Labrecque, Valentina Lodde, Cecilia Dieci, Irene Tessaro, Alberto M Luciano, Marc-Andre Sirard
2014 Reproduction Abstracts  
Introduction Forkhead box protein N1 (FoxN1) regulates development, differentiation, and function of thymus epithelial cells (TECs), both in the prenatal and postnatal thymus. In mice, knockout of the FoxN1 results in two well-known defects as hairlessness and athymia. However, knockout of FoxN1 in other species has not been discovered yet. RNA-guided endonucleases (RGENs), derived from the prokaryotic type II CRISPR-Cas system, enable targeted specific genes. We successfully targeted FoxN1 in
more » ... ig by using CRISPR-Cas system. Materials and methods RGEN design: We designed specific single-guide RNA (sgRNAs) which targets exon 2 of porcine FoxN1, and constructed Cas9 vector system. Transfection and Microinjection: Cas9-FoxN1 vectors were transfected intoporcine fibroblastusing lipofectamin 2000 reagent according to manufacturer's protocol. Also to induce parthenogenesis, Cas9-FoxN1 vectors (4, 8, and 16 ng/ml) were microinjected into the porcineoocytes and these were activated by BTX. T7 endonuclease I assay: The region of DNA containing the target site was amplified by PCR using the specific primer set. The PCR products were hybridized to form heteroduplex DNA, and digested by T7 endonuclease I for 1 h at 37 8C. The DNA was analyzed by gel electrophoresis using 2% agarose gel. Results and discussion To confirm the knockout of FoxN1, we analyzed the DNA cleavage activities by T7 endonuclease I assay both fibroblasts and oocytes. As a result, there was no significantly difference in knockout efficiency among injected DNA concentrations, 4 ng (20.7%), 8 ng (15.4%) and 16 ng (20%), respectively. However, we checked that Cas9-FoxN1 could successfully knockout the porcine FoxN1. This study suggests that knockout pig is also producible using Cas9-system by DNA microinjection into zygotes, directly. Introduction The pre-implantation embryo has two distinct cell lineages at the blastocyst stage. An outer epithelial monolayer called trophectoderm and the non-polar inner cell mass. Tight junctions (TJ) form continuous intercellular contacts between neighbouring trophectoderm cells and are crucial in establishing a blastocoele cavity. TJs are composed of several transmembrane proteins including Claudins, a large family of proteins that play a central role in the formation of the epithelial barrier. Claudins (Cl) show distinct distribution patterns among epithelial tissues and several isotypes can exist in the same TJ. Methods mRNA extracted from different stages of mouse embryos was reverse-transcribed before amplification of cDNA for particular Claudin isotypes. Embryos at 2-cell, 8-cell, morula and blastocyst stage were fixed for immunofluorescence and confocal microscopy. Zygotes were microinjected with siRNA and development to blastocyst observed. Results RT-PCR showed that Cl-4 and 7 were transcribed from compaction to blastocyst stage, while mRNA for Cl-3 and 6 were present from late morula stage. mRNA for Cl-12 was only present in blastocysts and mRNA for Cl-2 and 15 was absent throughout. Immunofluorescence showed Cl-4 and 7 proteins assembling at cellcell contacts after compaction in a dis-continuous pattern. By late blastocyst stage, Cl-3, 4, and 7 all displayed continuous staining at trophectoderm TJs, whilst Cl-12 and 15 were absent at TJs. siRNA inhibition of Cl-4 and 6 reduced percentage of blastocysts formed, whilst cavitation was not affected by Cl-7 siRNA. Our study shows that five different claudins are expressed in the early embryo and two play a crucial role in blastocyst formation. Funding by BBSRC to TPF.
doi:10.1530/repabs.1.p092 fatcat:kvx7pw24sbcdtn7375rovnebxi

The common language of speech perception and action: a neurocognitive perspective

Jean-Luc Schwartz, Marc Sato, Luciano Fadiga
2008 Revue Française de Linguistique Appliquée  
Luciano Fadiga was supported by CE grants Robotcub, Poeticon and Contact. Marc Sato and Jean-Luc Schwartz benefited from a support from the ISCC CNRS program (Cog-Speech project).  ...  }@gipsa-lab.inpg.fr> Luciano Fadiga : University of Ferrara, Section of Human Physiology, and The Italian Institute of Technology, Genova, Italy <fdl@unife.it> (Pulvermuller & al., 2006; Skipper &  ...  Jean-Luc Schwartz, Marc Sato : Univ. de Grenoble, Département Parole et Cognition, GIPSA-Lab, UMR 5216 CNRS Domaine universitaire, BP 46 F-38402 Saint Martin d'Hères Cedex <{Jean-Luc.Schwartz, Marc.Sato  ... 
doi:10.3917/rfla.132.0009 fatcat:indpthtsyvht3oeztljdk5amsy

Undecidable Properties of Limit Set Dynamics of Cellular Automata

Pietro Di Lena, Luciano Margara, Marc Herbstritt
2009 Symposium on Theoretical Aspects of Computer Science  
Cellular Automata (CA) are discrete dynamical systems and an abstract model of parallel computation. The limit set of a cellular automaton is its maximal topological attractor. A well know result, due to Kari, says that all nontrivial properties of limit sets are undecidable. In this paper we consider properties of limit set dynamics, i.e. properties of the dynamics of Cellular Automata restricted to their limit sets. There can be no equivalent of Kari's Theorem for limit set dynamics. Anyway
more » ... show that there is a large class of undecidable properties of limit set dynamics, namely all properties of limit set dynamics which imply stability or the existence of a unique subshift attractor. As a consequence we have that it is undecidable whether the cellular automaton map restricted to the limit set is the identity, closing, injective, expansive, positively expansive, transitive. 1998 ACM Subject Classification: Theory of Computation, Computation by Abstract Devices.
doi:10.4230/lipics.stacs.2009.1819 dblp:conf/stacs/LenaM09 fatcat:6i6ei4ifwbdf5o3kvri7rr6aai

Insight into glucocorticoid receptor signalling through interactome model analysis

Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos, Andrey Rzhetsky
2017 PLoS Computational Biology  
Supervision: Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos. Validation: Emyr Bakker, Kun Tian, Jean-Marc Schwartz, Marija Krstic-Demonacos.  ...  Funding acquisition : acquisition Luciano Mutti, Marija Krstic-Demonacos. Investigation: Emyr Bakker, Kun Tian, Jean-Marc Schwartz, Marija Krstic-Demonacos.  ... 
doi:10.1371/journal.pcbi.1005825 pmid:29107989 pmcid:PMC5690696 fatcat:bqj2xzilfbg7vjozemsuu3abmu

Reactive clocks with variability-tracking jitter

Jordi Cortadella, Luciano Lavagno, Pedro Lopez, Marc Lupon, Alberto Moreno, Antoni Roca, Sachin S. Sapatnekar
2015 2015 33rd IEEE International Conference on Computer Design (ICCD)  
The growing variability in nanoelectronic devices, due to uncertainties from the manufacturing process and environmental conditions (power supply, temperature, aging), requires increasing design guardbands, forcing circuits to work with conservative clock frequencies. Various schemes for clock generation based on ring oscillators and adaptive clocks have been proposed with the goal to mitigate the power and performance losses attributable to variability. However, there has been no systematic
more » ... lysis to quantify the benefits of such schemes and no signoff method has been proposed for timing correctness. This paper presents and analyzes a Reactive Clocking scheme with Variability-Tracking Jitter (RClk) that uses variability as an opportunity to reduce power by continuously adjusting the clock frequency to the varying environmental conditions, and thus, reduces guardband margins significantly. Power can be reduced between 20% and 40% at iso-performance and performance can be boosted by similar amounts at iso-power. Additionally, energy savings can be translated to substantial advantages in terms of reliability and thermal management. More importantly, the technology can be adopted with minimal modifications to conventional EDA flows.
doi:10.1109/iccd.2015.7357159 dblp:conf/iccd/CortadellaLLLMR15 fatcat:tvt5wpbds5a2tdljidne7mfa2u

The genus Indigofera (Leguminosae) in New Caledonia: two new species and a key for the species

Marc Pignal, Luciano Paganucci de Queiroz
2019 PhytoKeys  
The authors heartily thank Jacques Florence (IRD) for transforming our botanical Latin into more ciceronian and elegant results, Marc Jeanson (P) for his help with the English correction of the manuscript  ... 
doi:10.3897/phytokeys.119.32221 pmid:30936775 pmcid:PMC6437132 fatcat:o7ildsyhpzhrbhufvlqwgzjdnq

The Expanded p53 Interactome as a Predictive Model for Cancer Therapy

Michelle Hussain, Kun Tian, Luciano Mutti, Marija Krstic-Demonacos, Jean-Marc Schwartz
2015 Genomics and Computational Biology  
The tumor suppressor gene TP53 is implicated in the majority of all human cancers, thus pivotal to genomic integrity. There are more than 72,000 scientific publications describing p53's function, yet, due to the complexity of its interactions we are still far from fully elucidating p53's role in tumorigenesis. Computational methodologies are novel tools to depict and dissect complex disease networks. The Boolean PKT206 p53 – DNA damage model has previously demonstrated good predictive
more » ... for p53 wild-type and null tumors in various in silico knockouts. Here, we have expanded PKT206 to generate a more clinically robust representation of p53 dynamics. The new PMH260 model incorporates 260 nodes representing genes, with 980 interactions between them representing inhibitions and activations. Additional biological outputs, including angiogenesis, cell cycle arrest and DNA repair were also amalgamated into the model. Three in silico knockouts of highly connected nodes (p53, MDM2 and FGF2) were generated and logical steady state analysis and dependency relationships applied. 71 % of predictions were considered true from superimposition of human osteosarcoma and HCT116 microarray profiles. In silico knockout analysis revealed 98 potential novel predictions, of which 13 were validated by literature; 83 % of them were overlapping with PKT206. Thus the expanded Boolean PMH260 model offers a promising platform for clinical potential in targeted cancer therapeutics.
doi:10.18547/gcb.2015.vol1.iss1.e20 fatcat:6rtqk3n7j5dz7epzllwcxsvswu

On the Complexity of Two Dots for Narrow Boards and Few Colors

Davide Bilò, Luciano Gualà, Stefano Leucci, Neeldhara Misra, Marc Herbstritt
2018 Fun with Algorithms  
Two Dots ® is a popular single-player puzzle video game for iOS and Android. A level of this game consists of a grid of colored dots. The player connects two or more adjacent dots, removing them from the grid and causing the remaining dots to fall, as if influenced by gravity. One special move, which is frequently a game-changer, consists of connecting a cycle of dots: this removes all the dots of the given color from the grid. The goal is to remove a certain number of dots of each color using
more » ... limited number of moves. The computational complexity of Two Dots has already been addressed in [Misra, FUN 2016], where it has been shown that the general version of the problem is NP-complete. Unfortunately, the known reductions produce Two Dots levels having both a large number of colors and many columns. This does not completely match the spirit of the game, where, on the one hand, only few colors are allowed, and on the other hand, the grid of the game has only a constant number of columns. In this paper, we partially fill this gap by assessing the computational complexity of Two Dots instances having a small number of colors or columns. More precisely, we show that Two Dots is hard even for instances involving only 3 colors or 2 columns. As a contrast, we also prove that the problem can be solved in polynomial-time on single-column instances with a constant number of goals.
doi:10.4230/lipics.fun.2018.7 dblp:conf/fun/BiloG0M18 fatcat:gkiclr4hsfdethxiiwhmt46pty
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