A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Filters
Olfactory Ensheathing Cells: Characteristics, Genetic Engineering, and Therapeutic Potential
2006
Journal of Neurotrauma
Preserved Fulltext
J. Neurosci. 24, 9799-9810. FIELD, P., LI, Y., and RAISMAN, G. (2003). Ensheathment of the olfactory nerves in the adult rat. J. Neurocytol. 32, 317-324. ...
BLITS, B., DIJKHUIZEN, P.A., BOER, G.J., and VERHAA-GEN, J. (2000). ...
doi:10.1089/neu.2006.23.468
pmid:16629630
fatcat:tuwx5wcwhjbqxijbc7lxdn3tci
Traumatic Spinal Cord Injury and the Gut Microbiota: Current Insights and Future Challenges
2020
Frontiers in Immunology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Copyright © 2020 Jogia and Ruitenberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...
doi:10.3389/fimmu.2020.00704
pmid:32528463
pmcid:PMC7247863
fatcat:ox2uy5xsgfdndac32qpz7ipjwm
Promoting central nervous system regeneration: lessons from cranial nerve I
2008
Restorative Neurology and Neuroscience
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Acknowledgements Marc Ruitenberg is a postdoctoral fellow supported by the Australian Research Council (Grant No. DP0774113). The authors would like to thank their colleague Prof. Alan R. ...
J., & Cowan, W. ...
., 2003; Ruitenberg et al., 2004) . ...
pmid:18820410
fatcat:32svq3fvkjg6hkybvynwwvptbu
Complement activation in the injured central nervous system: another dual-edged sword?
2012
Journal of Neuroinflammation
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators support various aspects of both normal central nervous system (CNS) function and pathology has led to a renaissance of complement research in neuroscience. Various studies have revealed particularly novel findings on the wideranging involvement of complement in neural development, synapse elimination
doi:10.1186/1742-2094-9-137
pmid:22721265
pmcid:PMC3464784
fatcat:7a4iut25gffa7olsj2cpn7es64
more »
... nd maturation of neural networks, as well as the progression of pathology in a range of chronic neurodegenerative disorders, and more recently, neurotraumatic events, where rapid disruption of neuronal homeostasis potently triggers complement activation. The purpose of this review is to summarise recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions.
Systemic Immune Response to Traumatic CNS Injuries—Are Extracellular Vesicles the Missing Link?
2019
Frontiers in Immunology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Copyright © 2019 Yates, Anthony, Ruitenberg and Couch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...
doi:10.3389/fimmu.2019.02723
pmid:31824504
pmcid:PMC6879545
fatcat:7rr5i3u5yzgmjode37dd4mqxe4
Vertebral landmarks for the identification of spinal cord segments in the mouse
2013
NeuroImage
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Accurate identification of spinal cord segments in relation to vertebral landmarks is essential to surgery aimed at experimental spinal cord injury. We have analyzed a complete series of high-resolution magnetic resonance (MR) images from the mouse spine in order to delineate the boundaries of spinal cord segments in relation to vertebral landmarks. The resulting atlas can be used to plan experimental approaches that require the accurate identification of a target spinal cord segment.
doi:10.1016/j.neuroimage.2012.11.048
pmid:23246856
fatcat:tpm65m45knhgtpo5uxe2ykug64
Prognostic value of early leukocyte fluctuations for recovery from traumatic spinal cord injury
[article]
2020
biorxiv/medrxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Marc J. ...
Patients with cervical injury (B and J) and those that were intubated/mechanically ventilated (C and K) were more likely to acquire an airway infection (Fisher's and χ 2 test for B-C and J-K, respectively ...
doi:10.1101/2020.10.26.20220236
fatcat:6sipf2jibncazoo67qtd6k2yaa
Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy
2017
Scientific Reports
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Novel therapies that prevent or modify the development of epilepsy following an initiating brain insult could significantly reduce the burden of this disease. In light of evidence that immune mechanisms play an important role in generating and maintaining the epileptic condition, we evaluated the effect of a well-established immunomodulatory treatment, intravenous immunoglobulin (IVIg), on the development of epilepsy in an experimental model of epileptogenesis. In separate experiments, IVIg was
doi:10.1038/srep40528
pmid:28074934
pmcid:PMC5225452
fatcat:ahqdouboxvby5m74h5cvruvciu
more »
... administered either before (pre-treatment) or after (post-treatment) the onset of pilocarpine status epilepticus (SE). Our results show that both pre-and post-treatment with IVIg attenuated acute inflammation in the SE model. Specifically, IVIg reduced local activation of glial cells, complement system activation, and blood-brain barrier damage (BBB), which are all thought to play important roles in the development of epilepsy. Importantly, post-treatment with IVIg was also found to reduce the frequency and duration of subsequent spontaneous recurrent seizures as detected by chronic videoelectroencephalographic (video-EEG) recordings. This finding supports a novel application for IVIg, specifically its repurposing as a disease-modifying therapy in epilepsy.
Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury
2021
Journal of Neuroinflammation
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Background The acute phase response (APR) to CNS insults contributes to the overall magnitude and nature of the systemic inflammatory response. Aspects of this response are thought to drive secondary inflammatory pathology at the lesion site, and suppression of the APR can therefore afford some neuroprotection. In this study, we examined the APR in a mouse model of traumatic spinal cord injury (SCI), along with its relationship to neutrophil recruitment during the immediate aftermath of the
doi:10.1186/s12974-020-02050-6
pmid:33407641
fatcat:x7xt6ugh6vb6jhnb5kmcyrck6q
more »
... lt. We specifically investigated the effect of IL-1 receptor antagonist (IL-1RA) administration on the APR and leukocyte recruitment to the injured spinal cord. Methods Adult female C57BL/6 mice underwent either a 70kD contusive SCI, or sham surgery, and tissue was collected at 2, 6, 12, and 24 hours post-operation. For IL-1RA experiments, SCI mice received two intraperitoneal injections of human IL-1RA (100mg/kg), or saline as control, immediately following, and 5 hours after impact, and animals were sacrificed 6 hours later. Blood, spleen, liver and spinal cord were collected to study markers of central and peripheral inflammation by flow cytometry, immunohistochemistry and qPCR. Results were analysed by two-way ANOVA or student's t-test, as appropriate. Results SCI induced a robust APR, hallmarked by elevated hepatic expression of pro-inflammatory marker genes and a significantly increased neutrophil presence in the blood, liver and spleen of these animals, as early as 2 hours after injury. This peripheral response preceded significant neutrophil infiltration of the spinal cord, which peaked 24 hours post-SCI. Although expression of IL-1RA was also induced in the liver following SCI, its response was delayed compared to IL-1β. Exogenous administration of IL-1RA during this putative therapeutic window was able to suppress the hepatic APR, as evidenced by a reduction in CXCL1 and SAA-2 expression as well as a significant decrease in neutrophil infiltration in both the liver and the injured spinal cord itself. Conclusions Our data indicate that peripheral administration of IL-1RA can attenuate the APR which in turn reduces immune cell infiltration at the spinal cord lesion site. We propose IL-1RA treatment as a viable therapeutic strategy to minimise the harmful effects of SCI-induced inflammation.
Immune cell trafficking from the brain maintains CNS immune tolerance
2014
Journal of Clinical Investigation
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2015; you can also visit the original URL.
The file type is application/pdf.
In the CNS, no pathway dedicated to immune surveillance has been characterized for preventing the anti-CNS immune responses that develop in autoimmune neuroinflammatory disease. Here, we identified a pathway for immune cells to traffic from the brain that is associated with the rostral migratory stream (RMS), which is a forebrain source of newly generated neurons. Evaluation of fluorescently labeled leukocyte migration in mice revealed that DCs travel via the RMS from the CNS to the cervical
doi:10.1172/jci71544
pmid:24569378
pmcid:PMC3934177
fatcat:jle7oq7a2bewlngn27m5siybta
more »
... (CxLNs), where they present antigen to T cells. Pharmacologic interruption of immune cell traffic with the mononuclear cell-sequestering drug fingolimod influenced anti-CNS T cell responses in the CxLNs and modulated experimental autoimmune encephalomyelitis (EAE) severity in a mouse model of multiple sclerosis (MS). Fingolimod treatment also induced EAE in a disease-resistant transgenic mouse strain by altering DC-mediated Treg functions in CxLNs and disrupting CNS immune tolerance. These data describe an immune cell pathway that originates in the CNS and is capable of dampening anti-CNS immune responses in the periphery. Furthermore, these data provide insight into how fingolimod treatment might exacerbate CNS neuroinflammation in some cases and suggest that focal therapeutic interventions, outside the CNS have the potential to selectively modify anti-CNS immunity. Results CD11c + cells are associated with the rostral migratory stream (RMS). APCs are present in the choroid plexus and the meninges (22); however, their localization to the brain parenchyma in health is disputed
The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury
2017
Journal of Neurotrauma
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
more than 10 generations onto a C57BL6/J genetic background. ...
All experimental mice were obtained from breeding colonies at The University of Queensland Biological Resources facility (Brisbane, Australia) (C5ar2 -/and C57BL6/J). ...
Blood plasma analysis showed that C5ar2 -/mice also had significantly lower circulating IL12p70 levels (H), but not TNF (I), IL-6 (J), IFN-c (K), MCP-1 (L), and IL-10 (M). ...
doi:10.1089/neu.2016.4701
pmid:28173736
fatcat:uv4o23tibzggjaoaxlja4sbhuu
Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration
2020
Journal of Immunology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Intestinal villus neutrophil counts with esterase stain (J) confirmed elevated neutrophil numbers in C5aR2 2/2 mice compared with WT mice after IR injury. ...
injury (7) and the dampening effect of C5aR2 on C5a-induced neutrophil chemotaxis (18) , a greater presence of these cells was observed in C5aR2 2/2 mice with IR compared with WT controls (Fig. 2F-J ...
doi:10.4049/jimmunol.2000778
pmid:33028618
fatcat:56nnupivg5frhd47ilewh5l4iq
IVIg attenuates complement and improves spinal cord injury outcomes in mice
2016
Annals of Clinical and Translational Neurology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
A total of 99 wild-type (WT) C57BL6/J and 9 Emx1-creERT2:Rosa26-tdTomato mice on a C57BL6/J background were used in this study. ...
which was again confirmed by "area under the curve" analysis (J). ...
doi:10.1002/acn3.318
pmid:27386499
pmcid:PMC4931715
fatcat:kszmifmjozeqzlx5pvks4sldxq
The Chemokine Receptor CX3CR1 Mediates Homing of MHC class II-Positive Cells to the Normal Mouse Corneal Epithelium
2007
Investigative Ophthalmology and Visual Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
FIGURE 3 . 3 Confocal microscopic analysis of corneal wholemounts from naïve WT (A), CX 3 CR1 ϩ/GFP (B, I), and CX 3 CR1 GFP/GFP (C, D-H, J-O) mice. ...
Similar observations in our laboratory suggest that the same phenomena may also be true of monocyte-derived cells in the connective tissues of the respiratory mucosa (Ruitenberg M, unpublished data, 2006 ...
doi:10.1167/iovs.06-0746
pmid:17389486
pmcid:PMC3392181
fatcat:uhz2tpbwbrallfhmxy3co5s53u
Influence of adult Schwann cells and olfactory ensheathing glia on axontarget cell interactions in the CNS a comparative analysis using a retinotectal cograft model
2007
Neuron Glia Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
j. ruitenberg and alan r. harvey We used an in vivo transplant approach to examine how adult Schwann cells and olfactory ensheathing glia (OEG) influence the specificity of axon-target cell interactions ...
Influence of adult Schwann cells and olfactory ensheathing glia on axon-target cell interactions in the CNS: a comparative analysis using a retinotectal co-graft model jana vukovic giles w. plant marc ...
Scale bars: A-D,G,H,J,K, 100 mm; E,F,I, 50 mm; L,M, 40 mm.
Fig. 3 . 3 Quantitative analysis of cell survival and graft volume. ...
doi:10.1017/s1740925x07000671
pmid:18634570
fatcat:jbjq5xno4ja7lg4hsrsy237mju
« Previous
Showing results 1 — 15 out of 51 results