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Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment

Marjan Ghiti Moghadam, Femke B. G. Lamers-Karnebeek, Harald E. Vonkeman, Peter M. ten Klooster, Janneke Tekstra, Barbara van Schaeybroeck, Ruth Klaasen, Marieke van Onna, Hein J. Bernelot Moens, Henk Visser, Annemarie M. Schilder, Marc R. Kok (+4 others)
2019 BMC Rheumatology  
The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with longstanding RA in remission or with stable low disease activity, randomized to stopping TNFi treatment in the multicenter POET trial. Prolonged acceptable disease control was defined as not restarting TNFi treatment within 12
more » ... months after stopping. Baseline demographic and disease-related variables were included in univariate and multivariate logistic regression analysis for identifying predictors of relapse. One year after baseline, 220 patients (50.1%) had not restarted TNFi treatment. Use of an anti-TNF monoclonal antibody (versus a receptor antagonist, OR = 2.41; 95% CI: 1.58-3.67), ≤10 yrs. disease duration (OR = 2.15; 95% CI: 1.42-3.26) and low or moderate multi-biomarker disease activity (MBDA) scores (OR = 2.00; 95% CI: 1.10-3.64) at baseline were independently predictive of successful TNFi discontinuation (area under the receiver operating characteristic curve = 0.66; 95% CI: 0.61-0.71). Results were similar when using no physician-reported flare as the criterion. TNFi-free survival was significantly different for patient groups based on the number of predictors present, ranging from 21.4% of patients with no predictor present to 66.7% of patients with all three predictors present. Patients using an anti-TNF monoclonal antibody, with shorter disease duration and low or moderate baseline MBDA score are most likely to achieve prolonged disease control after TNFi discontinuation. Netherlands Trial Register NTR3112, 21 October 2011.
doi:10.1186/s41927-019-0071-x pmid:31225430 pmcid:PMC6567570 fatcat:vffp26ivkzddzabikgervqz3ve

Page 14 of Library Resources & Technical Services Vol. 57, Issue 1 [page]

2013 Library Resources & Technical Services  
Saleh Larne 429 fo lf l[wsame am Mustate — 49) fo | [we Swen Larne: Mostata 432 I if [\o Musteta Salem Lamer = script in the linking 49) fo lf] [we Sater Larne: Mustata ~ > se jet MARC 21 field 500 $33  ...  El-Sherbini LRTS 57(1) oI — [cos [06 1028rq acannaabn ouwars 82152020 | JL ][\s @carcyecesaaeass2 aoe cS aa vt's001 06.4502 a rr C eng « DLC W EG-AIBA } 103 ue \e Maustata Sam lent a iit i | |[\a Mostata  ... 

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers (+84 others)
2016 Nature Communications  
(e) Complex:21 and 31 containing several ubiquitin conjugating or modifying enzymes in interaction with the GID and exocyst complexes.  ...  In addition, we selected part of our candidate list of ciliary proteins which is a compilation of a subset from the ciliary proteome database 8 (type: non-reciprocal; e-value cut-off: 1E À 10; study selection  ... 
doi:10.1038/ncomms11491 pmid:27173435 pmcid:PMC4869170 fatcat:3vjhl4ie7jf7phjug4rsg3qhtm

Waste/Value1 [chapter]

Vinay Gidwani
2012 The Wiley-Blackwell Companion to Economic Geography  
Coe and Martin Hess 10 The Global Economy 170 Jim Glassman 11 Evolutionary Economic Geographies 183 Jurgen Essletzbichler 12 Geographies of Marketization 199 Christian Berndt and Marc Boeckler  ...  The Geographies of Alter-globalization 330 Joel Wainwright 21 Reinventing the State: Neoliberalism, State Transformation, and Economic Governance 344 Danny MacKinnon 22 New Subjects 358 Wendy Lamer  ... 
doi:10.1002/9781118384497.ch17 fatcat:6mp4fimdxjamhfcyfyjqljli6a

Page 344 of Astronomy and Astrophysics Vol. 106, Issue 2 [page]

1982 Astronomy and Astrophysics  
.: 1979, Astrophys.J. 230, L77 Schreier,E., Giacconi,R., Gursky,H., Kellog,E., Tanan- baum,H.: 1972, Astrophys.J. 178, L71 Snijders,M.A.J.: 1980, SRC-IUE Newsletter No.5 Tarenghi,M., Tanzi,E.G., Treves  ...  Rad Marc Labor: Recei\ ABSTR. drive cribi and si itera non 1. main | wheth it is or we tion the a it is accur would would spher veloc of th termi are t fence radia radia trans expan the p model L= from  ... 

Page 4958 of Psychological Abstracts Vol. 82, Issue 10 [page]

1995 Psychological Abstracts  
Marc, 39277 G., 36766 on s FF !  ...  M., 36929 Lamers, William M. Jr., 38465 Lamminpaa, Anne, 36303 Lamont, Michéle, 36499 Lamorey, r—* 38985 Lancaster, Cheryl, 36757 Lancioni Giulio.  ... 

Page 154 of International Review of Criminal Policy Vol. , Issue 6 [page]

1954 International Review of Criminal Policy  
: 113 Lackner, Karl: 923 Lafon, R.: 804 Laidet: 924 Lalive, Pierre-A.: 272 Lambert, L.: 195, 990 Lamers, E.  ...  E.: 117 McKenna, J.  ... 

Karl Enenkel- Marc Laureys- Christoph Pieper (eds.) Discourses of Power Ideology and Politics in Neo-Latin Literature (María Asunción Sánchez Manzano)

María Asunción Sánchez Manzano
2014 Estudios Humanisticos: Filologia  
Reseña escrita por María Asunción Sánchez Manzano de Karl Enenkel Marc Laureys Christoph Pieper Discourses of Power  ...  E. Enenkel.  ...  El sangriento y extenuante (para las arcas de la corona española) territorio trabajó Maarten van Rossum en su De bello Sicambrico, comentada por Marc Laureys.  ... 
doi:10.18002/ehf.v0i36.1411 fatcat:rnx67wmzx5gcxiujbqjzvowbla

Page 2105 of Psychological Abstracts Vol. 88, Issue 5 [page]

2001 Psychological Abstracts  
E., 15093 Lancioni, Giulio, 12833 Lanctét, Krista L., 14902 Land, Cantey, 13467 Landa, R., 14674 Lande, Marc B., 14775 Landolt, Hans-Peter, 13562 Landreth, Gary E., 13499 Landry, Donald W., 13627 Landsbergis  ...  W., 15801 le Cog, E.  ... 

Page 995 of The Journal of Investigative Dermatology Vol. 111, Issue 6 [page]

1998 The Journal of Investigative Dermatology  
Brinson GM, Siltharm S, deSerres S, ¢ Allogeneic sensitize the 879. 19% fibroblasts used to persist in graft recipient for accelerated second-set 1 60, 1996 onker A, Geerts WJC, Chieco P, Moorman AFM, Lamers  ...  5:87 1 502, 1995 1m Partial dermal r Expression of ] Derm Postlethwaite 875, 1978 Keski-Oja J, Balian G by fibronectin: lo of th Postlethwaite Af gelatin-binding fragment Xamos JA, Ramis AJ, Marc« immunohistochemical  ... 

Page 17 of Catholic School Journal Vol. 60, Issue 7 [page]

1960 Catholic School Journal  
THE THUNDERMAKER By William Lamers The adventures of Thomas Meagher, Catholic Civil War general. $2.00 7. BROTHER DUTTON OF MOLOKAI By Howard E. Crouch The life story of Father Damien’s assistant. 8.  ...  Marc, a young Roman, must choose be- tween paganism and his faith. $2.00 11. A CANDLE FOR OUR LADY By Regina Victoria Hunt The story of Walsingham Shrine during the reign of Henry VIII. $2.00 12.  ... 

Correction to: Characteristics and prognosis of bloodstream infection in patients with COVID‑19 admitted in the ICU: an ancillary study of the COVID‑ICU study

Nicolas Massart, Virginie Maxime, Pierre Fillatre, Keyvan Razazi, Alexis Ferré, Pierre Moine, Francois Legay, Guillaume Voiriot, Marlene Amara, Francesca Santi, Saad Nseir, Stephanie Marque-Juillet (+552 others)
2022 Annals of Intensive Care  
doi:10.1186/s13613-022-00979-w pmid:35015163 pmcid:PMC8748185 fatcat:cqj22fimhjax5fhxgm7sz5zgba

The German National Registry of Primary Immunodeficiencies (2012–2017)

Sabine M. El-Helou, Anika-Kerstin Biegner, Sebastian Bode, Stephan R. Ehl, Maximilian Heeg, Maria E. Maccari, Henrike Ritterbusch, Carsten Speckmann, Stephan Rusch, Raphael Scheible, Klaus Warnatz, Faranaz Atschekzei (+138 others)
2019 Frontiers in Immunology  
The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with
more » ... software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1-25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0-88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%-subcutaneous; 29%-intravenous; 1%-unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
doi:10.3389/fimmu.2019.01272 pmid:31379802 pmcid:PMC6659583 fatcat:t2a52zqkdvfu5cwbzgfhkxztee

Penser la restauration des monuments historiques au Maroc dans les années 1920-1940

Claire Déléry, Vlada Boussyguina
2017 ABE Journal  
Source : Paris (France), Fonds Maslow. siaf/Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, 251 ifa 17. Figure 3 : Porte Bab Lamer (Fès, Maroc).  ...  Source : Paris (France), Fonds Maslow. siaf /Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, EC-06-10-14-01. Figure 4 : Porte Bab Lamer (Fès, Maroc).  ... 
doi:10.4000/abe.3464 fatcat:jpwhpv7mtjfihkkkakd43lkkuq

2008 Journal of Urology Consultants

William D. Steers
2009 Journal of Urology  
LAMB C LAMERS DONALD L. LAMM EZEKIEL HAROLD LANDAU J. RICHARD LANDIS JAIME LANDMAN BRIAN R. LANE RICHARD JOHN LANG ERICH K. LANG PAUL H.  ...  GOLDRAICH MARC GOLDSTEIN IRWIN GOLDSTEIN ANDREW T. GOLDSTEIN DRAGAN GOLIJANIN ERIK T. GOLUBOFF LEONARD G. GOMELLA MOHAMED A. GOMHA MICHAEL GONG ZHIHONG GONG CHRIS M. GONZALEZ RICARDO R.  ... 
doi:10.1016/j.juro.2009.03.035 fatcat:577a3he4mnhh7hzmq7rp4bm72m
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