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The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with longstanding RA in remission or with stable low disease activity, randomized to stopping TNFi treatment in the multicenter POET trial. Prolonged acceptable disease control was defined as not restarting TNFi treatment within 12doi:10.1186/s41927-019-0071-x pmid:31225430 pmcid:PMC6567570 fatcat:vffp26ivkzddzabikgervqz3ve
more »... months after stopping. Baseline demographic and disease-related variables were included in univariate and multivariate logistic regression analysis for identifying predictors of relapse. One year after baseline, 220 patients (50.1%) had not restarted TNFi treatment. Use of an anti-TNF monoclonal antibody (versus a receptor antagonist, OR = 2.41; 95% CI: 1.58-3.67), ≤10 yrs. disease duration (OR = 2.15; 95% CI: 1.42-3.26) and low or moderate multi-biomarker disease activity (MBDA) scores (OR = 2.00; 95% CI: 1.10-3.64) at baseline were independently predictive of successful TNFi discontinuation (area under the receiver operating characteristic curve = 0.66; 95% CI: 0.61-0.71). Results were similar when using no physician-reported flare as the criterion. TNFi-free survival was significantly different for patient groups based on the number of predictors present, ranging from 21.4% of patients with no predictor present to 66.7% of patients with all three predictors present. Patients using an anti-TNF monoclonal antibody, with shorter disease duration and low or moderate baseline MBDA score are most likely to achieve prolonged disease control after TNFi discontinuation. Netherlands Trial Register NTR3112, 21 October 2011.
Library Resources & Technical Services
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(e) Complex:21 and 31 containing several ubiquitin conjugating or modifying enzymes in interaction with the GID and exocyst complexes. ... In addition, we selected part of our candidate list of ciliary proteins which is a compilation of a subset from the ciliary proteome database 8 (type: non-reciprocal; e-value cut-off: 1E À 10; study selection ...doi:10.1038/ncomms11491 pmid:27173435 pmcid:PMC4869170 fatcat:3vjhl4ie7jf7phjug4rsg3qhtm
The Wiley-Blackwell Companion to Economic Geography
Coe and Martin Hess 10 The Global Economy 170 Jim Glassman 11 Evolutionary Economic Geographies 183 Jurgen Essletzbichler 12 Geographies of Marketization 199 Christian Berndt and Marc Boeckler ... The Geographies of Alter-globalization 330 Joel Wainwright 21 Reinventing the State: Neoliberalism, State Transformation, and Economic Governance 344 Danny MacKinnon 22 New Subjects 358 Wendy Lamer ...doi:10.1002/9781118384497.ch17 fatcat:6mp4fimdxjamhfcyfyjqljli6a
Astronomy and Astrophysics
.: 1979, Astrophys.J. 230, L77 Schreier,E., Giacconi,R., Gursky,H., Kellog,E., Tanan- baum,H.: 1972, Astrophys.J. 178, L71 Snijders,M.A.J.: 1980, SRC-IUE Newsletter No.5 Tarenghi,M., Tanzi,E.G., Treves ... Rad Marc Labor: Recei\ ABSTR. drive cribi and si itera non 1. main | wheth it is or we tion the a it is accur would would spher veloc of th termi are t fence radia radia trans expan the p model L= from ...
Marc, 39277 G., 36766 on s FF ! ... M., 36929 Lamers, William M. Jr., 38465 Lamminpaa, Anne, 36303 Lamont, Michéle, 36499 Lamorey, r—* 38985 Lancaster, Cheryl, 36757 Lancioni Giulio. ...
International Review of Criminal Policy
: 113 Lackner, Karl: 923 Lafon, R.: 804 Laidet: 924 Lalive, Pierre-A.: 272 Lambert, L.: 195, 990 Lamers, E. ... E.: 117 McKenna, J. ...
Reseña escrita por María Asunción Sánchez Manzano de Karl Enenkel Marc Laureys Christoph Pieper Discourses of Power ... E. Enenkel. ... El sangriento y extenuante (para las arcas de la corona española) territorio trabajó Maarten van Rossum en su De bello Sicambrico, comentada por Marc Laureys. ...doi:10.18002/ehf.v0i36.1411 fatcat:rnx67wmzx5gcxiujbqjzvowbla
E., 15093 Lancioni, Giulio, 12833 Lanctét, Krista L., 14902 Land, Cantey, 13467 Landa, R., 14674 Lande, Marc B., 14775 Landolt, Hans-Peter, 13562 Landreth, Gary E., 13499 Landry, Donald W., 13627 Landsbergis ... W., 15801 le Cog, E. ...
The Journal of Investigative Dermatology
Brinson GM, Siltharm S, deSerres S, ¢ Allogeneic sensitize the 879. 19% fibroblasts used to persist in graft recipient for accelerated second-set 1 60, 1996 onker A, Geerts WJC, Chieco P, Moorman AFM, Lamers ... 5:87 1 502, 1995 1m Partial dermal r Expression of ] Derm Postlethwaite 875, 1978 Keski-Oja J, Balian G by fibronectin: lo of th Postlethwaite Af gelatin-binding fragment Xamos JA, Ramis AJ, Marc« immunohistochemical ...
Catholic School Journal
THE THUNDERMAKER By William Lamers The adventures of Thomas Meagher, Catholic Civil War general. $2.00 7. BROTHER DUTTON OF MOLOKAI By Howard E. Crouch The life story of Father Damien’s assistant. 8. ... Marc, a young Roman, must choose be- tween paganism and his faith. $2.00 11. A CANDLE FOR OUR LADY By Regina Victoria Hunt The story of Walsingham Shrine during the reign of Henry VIII. $2.00 12. ...
doi:10.1186/s13613-022-00979-w pmid:35015163 pmcid:PMC8748185 fatcat:cqj22fimhjax5fhxgm7sz5zgba
The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed withdoi:10.3389/fimmu.2019.01272 pmid:31379802 pmcid:PMC6659583 fatcat:t2a52zqkdvfu5cwbzgfhkxztee
more »... software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1-25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0-88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%-subcutaneous; 29%-intravenous; 1%-unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
Source : Paris (France), Fonds Maslow. siaf/Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, 251 ifa 17. Figure 3 : Porte Bab Lamer (Fès, Maroc). ... Source : Paris (France), Fonds Maslow. siaf /Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, EC-06-10-14-01. Figure 4 : Porte Bab Lamer (Fès, Maroc). ...doi:10.4000/abe.3464 fatcat:jpwhpv7mtjfihkkkakd43lkkuq
Journal of Urology
LAMB C LAMERS DONALD L. LAMM EZEKIEL HAROLD LANDAU J. RICHARD LANDIS JAIME LANDMAN BRIAN R. LANE RICHARD JOHN LANG ERICH K. LANG PAUL H. ... GOLDRAICH MARC GOLDSTEIN IRWIN GOLDSTEIN ANDREW T. GOLDSTEIN DRAGAN GOLIJANIN ERIK T. GOLUBOFF LEONARD G. GOMELLA MOHAMED A. GOMHA MICHAEL GONG ZHIHONG GONG CHRIS M. GONZALEZ RICARDO R. ...doi:10.1016/j.juro.2009.03.035 fatcat:577a3he4mnhh7hzmq7rp4bm72m
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