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Predictors of biologic-free disease control in patients with rheumatoid arthritis after stopping tumor necrosis factor inhibitor treatment
2019
BMC Rheumatology
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The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA). Post-hoc analysis of 439 RA patients (67.3% rheumatoid factor positive) with longstanding RA in remission or with stable low disease activity, randomized to stopping TNFi treatment in the multicenter POET trial. Prolonged acceptable disease control was defined as not restarting TNFi treatment within 12
doi:10.1186/s41927-019-0071-x
pmid:31225430
pmcid:PMC6567570
fatcat:vffp26ivkzddzabikgervqz3ve
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... months after stopping. Baseline demographic and disease-related variables were included in univariate and multivariate logistic regression analysis for identifying predictors of relapse. One year after baseline, 220 patients (50.1%) had not restarted TNFi treatment. Use of an anti-TNF monoclonal antibody (versus a receptor antagonist, OR = 2.41; 95% CI: 1.58-3.67), ≤10 yrs. disease duration (OR = 2.15; 95% CI: 1.42-3.26) and low or moderate multi-biomarker disease activity (MBDA) scores (OR = 2.00; 95% CI: 1.10-3.64) at baseline were independently predictive of successful TNFi discontinuation (area under the receiver operating characteristic curve = 0.66; 95% CI: 0.61-0.71). Results were similar when using no physician-reported flare as the criterion. TNFi-free survival was significantly different for patient groups based on the number of predictors present, ranging from 21.4% of patients with no predictor present to 66.7% of patients with all three predictors present. Patients using an anti-TNF monoclonal antibody, with shorter disease duration and low or moderate baseline MBDA score are most likely to achieve prolonged disease control after TNFi discontinuation. Netherlands Trial Register NTR3112, 21 October 2011.
Page 14 of Library Resources & Technical Services Vol. 57, Issue 1
[page]
2013
Library Resources & Technical Services
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Saleh Larne
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49) fo | [we Swen Larne: Mostata 432 I if [\o Musteta Salem Lamer = script in the linking 49) fo lf] [we Sater Larne: Mustata ~ > se jet MARC 21 field 500 $33 ...
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LRTS 57(1)
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An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
2016
Nature Communications
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(e) Complex:21 and 31 containing several ubiquitin conjugating or modifying enzymes in interaction with the GID and exocyst complexes. ...
In addition, we selected part of our candidate list of ciliary proteins which is a compilation of a subset from the ciliary proteome database 8 (type: non-reciprocal; e-value cut-off: 1E À 10; study selection ...
doi:10.1038/ncomms11491
pmid:27173435
pmcid:PMC4869170
fatcat:3vjhl4ie7jf7phjug4rsg3qhtm
Waste/Value1
[chapter]
2012
The Wiley-Blackwell Companion to Economic Geography
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Coe and Martin Hess
10 The Global Economy
170
Jim Glassman
11 Evolutionary Economic Geographies
183
Jurgen Essletzbichler
12 Geographies of Marketization
199
Christian Berndt and Marc Boeckler ...
The Geographies of Alter-globalization
330
Joel Wainwright
21 Reinventing the State: Neoliberalism, State Transformation, and
Economic Governance
344
Danny MacKinnon
22 New Subjects
358
Wendy Lamer ...
doi:10.1002/9781118384497.ch17
fatcat:6mp4fimdxjamhfcyfyjqljli6a
Page 344 of Astronomy and Astrophysics Vol. 106, Issue 2
[page]
1982
Astronomy and Astrophysics
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.: 1979, Astrophys.J. 230, L77
Schreier,E., Giacconi,R., Gursky,H., Kellog,E., Tanan- baum,H.: 1972, Astrophys.J. 178, L71
Snijders,M.A.J.: 1980, SRC-IUE Newsletter No.5
Tarenghi,M., Tanzi,E.G., Treves ...
Rad
Marc
Labor:
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the a it is accur would would spher veloc of th termi are t fence radia radia trans expan the p
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from ...
Page 4958 of Psychological Abstracts Vol. 82, Issue 10
[page]
1995
Psychological Abstracts
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Marc, 39277 G., 36766
on
s
FF ! ...
M., 36929 Lamers, William M. Jr., 38465 Lamminpaa, Anne, 36303 Lamont, Michéle, 36499 Lamorey, r—* 38985 Lancaster, Cheryl, 36757 Lancioni Giulio. ...
Page 154 of International Review of Criminal Policy Vol. , Issue 6
[page]
1954
International Review of Criminal Policy
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: 113 Lackner, Karl: 923
Lafon, R.: 804
Laidet: 924
Lalive, Pierre-A.: 272 Lambert, L.: 195, 990 Lamers, E. ...
E.: 117 McKenna, J. ...
Karl Enenkel- Marc Laureys- Christoph Pieper (eds.) Discourses of Power Ideology and Politics in Neo-Latin Literature (María Asunción Sánchez Manzano)
2014
Estudios Humanisticos: Filologia
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Reseña escrita por María Asunción Sánchez Manzano de Karl Enenkel Marc Laureys Christoph Pieper Discourses of Power ...
E. Enenkel. ...
El sangriento y extenuante (para las arcas de la corona española) territorio trabajó Maarten van Rossum en su De bello Sicambrico, comentada por Marc Laureys. ...
doi:10.18002/ehf.v0i36.1411
fatcat:rnx67wmzx5gcxiujbqjzvowbla
Page 2105 of Psychological Abstracts Vol. 88, Issue 5
[page]
2001
Psychological Abstracts
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E., 15093 Lancioni, Giulio, 12833 Lanctét, Krista L., 14902 Land, Cantey, 13467
Landa, R., 14674
Lande, Marc B., 14775 Landolt, Hans-Peter, 13562 Landreth, Gary E., 13499 Landry, Donald W., 13627 Landsbergis ...
W., 15801
le Cog, E. ...
Page 995 of The Journal of Investigative Dermatology Vol. 111, Issue 6
[page]
1998
The Journal of Investigative Dermatology
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Brinson GM, Siltharm S, deSerres S, ¢ Allogeneic
sensitize the
879. 19% fibroblasts used to persist in
graft recipient for accelerated second-set 1
60, 1996 onker A, Geerts WJC, Chieco P, Moorman AFM, Lamers ...
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502, 1995
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Partial dermal r
Expression of
] Derm Postlethwaite 875, 1978
Keski-Oja J, Balian G
by fibronectin: lo of th
Postlethwaite Af
gelatin-binding fragment Xamos JA, Ramis AJ, Marc« immunohistochemical ...
Page 17 of Catholic School Journal Vol. 60, Issue 7
[page]
1960
Catholic School Journal
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THE THUNDERMAKER
By William Lamers The adventures of Thomas Meagher, Catholic Civil War general. $2.00 7. BROTHER DUTTON OF MOLOKAI
By Howard E. Crouch The life story of Father Damien’s assistant. 8. ...
Marc, a young Roman, must choose be- tween paganism and his faith. $2.00 11. A CANDLE FOR OUR LADY
By Regina Victoria Hunt The story of Walsingham Shrine during the reign of Henry VIII. $2.00 12. ...
Correction to: Characteristics and prognosis of bloodstream infection in patients with COVID‑19 admitted in the ICU: an ancillary study of the COVID‑ICU study
2022
Annals of Intensive Care
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The German National Registry of Primary Immunodeficiencies (2012–2017)
2019
Frontiers in Immunology
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The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with
doi:10.3389/fimmu.2019.01272
pmid:31379802
pmcid:PMC6659583
fatcat:t2a52zqkdvfu5cwbzgfhkxztee
more »
... software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1-25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0-88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%-subcutaneous; 29%-intravenous; 1%-unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
Penser la restauration des monuments historiques au Maroc dans les années 1920-1940
2017
ABE Journal
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Source : Paris (France), Fonds Maslow. siaf/Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, 251 ifa 17. Figure 3 : Porte Bab Lamer (Fès, Maroc). ...
Source : Paris (France), Fonds Maslow. siaf /Cité de l’architecture et du patrimoine/Archives d’architecture du xx e siècle, EC-06-10-14-01. Figure 4 : Porte Bab Lamer (Fès, Maroc). ...
doi:10.4000/abe.3464
fatcat:jpwhpv7mtjfihkkkakd43lkkuq
2008 Journal of Urology Consultants
2009
Journal of Urology
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LAMB
C LAMERS
DONALD L. LAMM
EZEKIEL HAROLD LANDAU
J. RICHARD LANDIS
JAIME LANDMAN
BRIAN R. LANE
RICHARD JOHN LANG
ERICH K. LANG
PAUL H. ...
GOLDRAICH MARC GOLDSTEIN IRWIN GOLDSTEIN ANDREW T. GOLDSTEIN DRAGAN GOLIJANIN ERIK T. GOLUBOFF LEONARD G. GOMELLA MOHAMED A. GOMHA MICHAEL GONG ZHIHONG GONG CHRIS M. GONZALEZ RICARDO R. ...
doi:10.1016/j.juro.2009.03.035
fatcat:577a3he4mnhh7hzmq7rp4bm72m
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