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Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI

M.L.J. Schouw, A.M. Kaag, M.W.A. Caan, D.F.R. Heijtel, C.B.L.M. Majoie, A.J. Nederveen, J. Booij, L. Reneman
2013 NeuroImage  
Here we investigated the hemodynamic response to a dopaminergic (DAergic) challenge with dextroamphetamine (dAMPH) in humans using arterial spin labeling (ASL) based phMRI.  ...  a r t i c l e i n f o Pharmacological magnetic resonance imaging (phMRI) maps the neurovascular response to a pharmacological challenge and is increasingly used to assess neurotransmitter systems.  ...  Acknowledgments The authors would like to thank all subjects who participated in this study. We would also like to thank Dr. H.  ... 
doi:10.1016/j.neuroimage.2012.12.056 pmid:23296186 fatcat:wfpbk7smcrabnonik5rs2xh4c4

Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: A human pharmacological magnetic resonance imaging study at 1.5 and 4 T

Stephen E. Rose, Andrew L. Janke, Mark W. Strudwick, Katie L. McMahon, Jonathan B. Chalk, Peter Snyder, Greig I. De zubicaray
2005 Magnetic Resonance in Medicine  
response to d-amphetamine challenge in human subjects at both 1.5 and 4 T.  ...  Pharmacological MRI (phMRI) techniques can be used to monitor the neurophysiological effects of central nervous system (CNS) active drugs.  ...  ACKNOWLEDGMENTS We thank Michael Walsh and Jenny Stephenson for organizing and managing the study participants.  ... 
doi:10.1002/mrm.20749 pmid:16342159 fatcat:3qy7tbmuzzga7kmd4nvie2e4ri

The effects of acute alcohol administration on the human brain: Insights from neuroimaging

James M. Bjork, Jodi M. Gilman
2014 Neuropharmacology  
In this review, we will summarize recent findings about acute human brain responses to alcohol using neuroimaging techniques, and how they might explain behavioral effects of alcohol intoxication.  ...  Over the last quarter century, researchers have peered into the living human brain to develop and refine mechanistic accounts of alcohol-induced behavior, as well as neurobiological mechanisms for development  ...  Acknowledgments We are indebted to the training, fellowship, and inspiration of our former mentor, Dr. Daniel W. Hommer.  ... 
doi:10.1016/j.neuropharm.2013.07.039 pmid:23978384 pmcid:PMC3971012 fatcat:ibcxzzx6ijgzfbs4dmgoflpmeq

The effects of naltrexone on neural responses to methamphetamine cues

Kelly Elizabeth Courtney, Dara Ghahremani, Lara Ray
2017 Drug and Alcohol Dependence  
Despite multiple legislative attempts to restrict access, methamphetamine remains a widely used drug in the United States, and a significant number of individuals develop methamphetamine problems following  ...  The knowledge of these neurobiological pathways may prove to be useful in the prediction of clinical outcomes and aid in the development and application of medications such as naltrexone for the treatment  ...  Cues + Control Cues, convolved with a hemodynamic response function), a 'physiological' regressor to model the seed time course, and the 'psychophysiological interaction' regressor which is the product  ... 
doi:10.1016/j.drugalcdep.2016.08.141 fatcat:biien6pwqfbpjnm2lj4g5wdswi

Poster Session II

2010 Neuropsychopharmacology  
A canonical SPM hemodynamic response function was used to estimate the hemodynamic responses for the conditions of interest.  ...  The current study aimed to resolve the conflicting findings by investigating DA release in treatment-naïve adults with ADHD in response to a challenge with d-AMP.  ...  Baseline plasma samples were profiled using the Liquid Chromatography Electrochemical Array; the output was digitized to create a ''digital map'' of the entire measurable response for a particular sample  ... 
doi:10.1038/npp.2010.217 fatcat:gbcgyi35jbdndlwhlgwio7ts7y

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  Prior to injection, we obtained a T1-weighted MRI to obtain anatomical information to guide the placement of the cannula.  ...  The hemodynamic response was modeled with a double gamma function, without temporal derivatives, using the general linear model. A 128 s high pass filter was applied.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

Poster Session I

2004 Neuropsychopharmacology  
Our previous studies have revealed that the regional cerebral blood flow (rCBF) response to procaine, a limbic-stimulant with relatively high affinity to the 5HT3 receptors, was different in cocaine-addicted  ...  Single photon emission computed tomography (SPECT) was used to compare the rCBF response to procaine and saline. SPM99 analytic techniques were used to assess differences within groups.  ...  In the human LFMS study, BP subjects received a spectroscopic MRI exam with an unusual scan orientation on a 1.5T scanner over multiple visits.  ... 
doi:10.1038/sj.npp.1300646 fatcat:ee4zdyczlzc2pgxomn5ucq6cm4

Abstracts Presented at the Thirty–Fourth Annual International Neuropsychological Society Conference, February 1–4, 2006, Boston, Massachussetts, USA

2006 Journal of the International Neuropsychological Society  
Previous investigations using functional magnetic resonance imaging (fMRI) during RI have reported different activation patterns in patients with TBI, relative to control subjects.  ...  The current study used fMRI to study RI following TBI and to examine regressions with RI accuracy and reaction time.  ...  One series of MTBI patients and healthy controls was studied with fMRI after a challenge with bromocriptine, a dopaminergic (DA) agonist compared to placebo.  ... 
doi:10.1017/s1355617706069918 fatcat:cy3cbwlgrvccfnn6w7inplceni