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Anisotropic composite material phantom to improve skeletal muscle characterization using magnetic resonance elastography

Martina Guidetti, Gloria Lorgna, Margaret Hammersly, Phillip Lewis, Dieter Klatt, Pasquale Vena, Ramille Shah, Thomas J. Royston
2019 Journal of The Mechanical Behavior of Biomedical Materials  
Dynamic elastography methods for noninvasive measurement of tissue mechanical properties have been under development for nearly three decades.  ...  one seeks to improve the accuracy and resolution in mechanical property assessment, heterogeneity and anisotropy need to be accounted for in order to optimize both the dynamic elastography experimental  ...  Acknowledgments Shah Tissue Engineering and Additive Manufacturing Lab (Department of Biomedical Engineering, Northwestern University, Chicago, USA) is acknowledged.  ... 
doi:10.1016/j.jmbbm.2018.09.032 pmid:30292169 pmcid:PMC6211788 fatcat:26kux6b43jdylowfljbiwpok7a

Magnetic Resonance Elastography Reconstruction for Anisotropic Tissues

Behzad Babaei, Daniel Fovargue, Robert A. Lloyd, Renee Miller, Lauriane Jugé, Max Kaplan, Ralph Sinkus, David A. Nordsletten, Lynne E. Bilston
2021 Medical Image Analysis  
The objective of this study was to develop and validate a novel elastography reconstruction technique suitable for estimating the linear viscoelastic mechanical properties of transversely isotropic soft  ...  This new reconstruction method can be applied to quantify tissue mechanical properties of anisotropic soft tissues, such as muscle, in health and disease.  ...  This approach extends our recent isotropic finite element inversion method ( Fovargue et al., 2018a; 2018b ) to transversely isotropic tissues.  ... 
doi:10.1016/j.media.2021.102212 pmid:34587584 fatcat:a7gsxcexmbghzfnugep372vsxq

Magnetic resonance elastography of slow and fast shear waves illuminates differences in shear and tensile moduli in anisotropic tissue

J.L. Schmidt, D.J. Tweten, A.N. Benegal, C.H. Walker, T.E. Portnoi, R.J. Okamoto, J.R. Garbow, P.V. Bayly
2016 Journal of Biomechanics  
Mechanical anisotropy is an important property of fibrous tissues; for example, the anisotropic 3 mechanical properties of brain white matter may play a key role in the mechanics of traumatic brain 4 injury  ...  The simplest anisotropic material model for small deformations of soft tissue is a nearly 5 incompressible, transversely isotropic (ITI) material characterized by three parameters: minimum shear 6 modulus  ...  Three-parameter shear wave inversion in MR 325 elastography of incompressible transverse isotropic media: Application to in vivo lower leg 326 muscles. Magn. Reson. Med. In press.  ... 
doi:10.1016/j.jbiomech.2016.02.018 pmid:26920505 pmcid:PMC4851613 fatcat:dx3n4gsgf5hsphihzxvamiiojm

Tomography-based 3-D anisotropic elastography using boundary measurements

Yi Liu, L.Z. Sun, Ge Wang
2005 IEEE Transactions on Medical Imaging  
While ultrasound-and magnetic resonance-based elastography techniques have proved to be powerful biomedical imaging tools, most approaches assume isotropic material properties.  ...  For isotropic phantom, one set of the boundary measurements enables unique reconstruction results for the tissue and tumor.  ...  Therefore, most tissues can be effectively considered homogeneous in mechanical properties.  ... 
doi:10.1109/tmi.2005.857232 pmid:16229418 fatcat:4fntcscv3jfynhzuyq32my6kam

Viscoelasticity Imaging of Biological Tissues and Single Cells Using Shear Wave Propagation

Hongliang Li, Guillaume Flé, Manish Bhatt, Zhen Qu, Sajad Ghazavi, Ladan Yazdani, Guillaume Bosio, Iman Rafati, Guy Cloutier
2021 Frontiers in Physics  
Changes in biomechanical properties of biological soft tissues are often associated with physiological dysfunctions.  ...  At a macroscopic scale, techniques for inducing shear waves using an external mechanical vibration, an acoustic radiation pressure or a Lorentz force are reviewed along with imaging approaches proposed  ...  Transversely isotropic materials are organized in layers where in-plane mechanical properties are isotropic, and out-of-plane ones are anisotropic.  ... 
doi:10.3389/fphy.2021.666192 fatcat:qvn4pciaxbdbfhynp4spzszrii

Measurement of anisotropic mechanical properties in porcine brain white matter ex vivo using magnetic resonance elastography

J.L. Schmidt, D.J. Tweten, A.A. Badachhape, A.J. Reiter, R.J. Okamoto, J.R. Garbow, P.V. Bayly
2018 Journal of The Mechanical Behavior of Biomedical Materials  
to analyze MRE measurements of ex vivo porcine Abstract Keywords MR elastography; shear waves; anisotropy; transversely isotropic material; white matter brain tissue Schmidt et al.  ...  Magnetic resonance elastography (MRE) is a powerful tool for non-invasive estimation of the mechanical properties of soft tissues.  ...  Discussion In this study, slow shear waves were imaged using MR elastography techniques in WM ex vivo brain tissue.  ... 
doi:10.1016/j.jmbbm.2017.11.045 pmid:29253729 pmcid:PMC5807163 fatcat:cqr66nfcozcr5kxqbezp2eboau

Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo

Lynne E. Bilston, Bart Bolsterlee, Antoine Nordez, Shantanu Sinha
2019 Journal of applied physiology  
Elastography measurements can provide in vivo maps of passive muscle mechanical parameters, and both MRI and ultrasound methods are available (magnetic resonance elastography and ultrasound shear wave  ...  Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo.  ...  More recently, anisotropic MRE methods have been developed (e.g., 74) that consider muscle to be a transversely isotropic material.  ... 
doi:10.1152/japplphysiol.00672.2018 pmid:30236053 fatcat:ivevskrxqndjhn6t6r5cjuwqzy

Magnetic resonance elastography of skeletal muscle deep tissue injury

Jules L. Nelissen, Ralph Sinkus, Klaas Nicolay, Aart J. Nederveen, Cees W.J. Oomens, Gustav J. Strijkers
2019 NMR in Biomedicine  
In this paper we quantified the spatial-temporal changes in mechanical properties upon damage development and recovery in a rat model of deep tissue injury.  ...  Magnetic resonance elastography (MRE), T2 -weighted, and T2 -mapping measurements were performed before, directly after indentation, and at several timepoints during a 14-day follow-up.  ...  ACKNOWLEDGEMENTS The authors thank Tom Bruijnen, Martijn Blatter, Tom Schreurs and Larry de Graaf for help with the MRE sequence design and experimental setup, and Leonie Niesen, Jo Habets, Marije Janssen  ... 
doi:10.1002/nbm.4087 pmid:30897280 pmcid:PMC6593838 fatcat:tv55ew6q4na6tpiz2tcl5myzti

Towards noninvasive estimation of tumour pressure by utilising MR elastography and nonlinear biomechanical models: a simulation and phantom study

Daniel Fovargue, Marco Fiorito, Adela Capilnasiu, David Nordsletten, Jack Lee, Ralph Sinkus
2020 Scientific Reports  
We present a proof-of-concept method to infer the total tumour pressure, that is the sum of the fluid and solid parts, by examining stiffness in the peritumoural tissue with MR elastography and utilising  ...  nonlinear biomechanical models.  ...  Combining MR elastography and diffusion tensor imaging for the assessment of anisotropic mechanical properties: A phantom study.  ... 
doi:10.1038/s41598-020-62367-3 pmid:32221324 pmcid:PMC7101441 fatcat:yfkk5ueuq5b6hedg5lpgij2r2e

Finite deformation elastography of articular cartilage and biomaterials based on imaging and topology optimization

Luyao Cai, Eric A. Nauman, Claus B. W. Pedersen, Corey P. Neu
2020 Scientific Reports  
Conventional elastography quantifies stiffness in soft (e.g. brain, liver) tissue, but robust quantification in stiff (e.g. musculoskeletal) tissues is challenging due to dissipation of high frequency  ...  or tissue degeneration.  ...  Elastography provides a spatial map of mechanical quantities, including strain fields and elastic properties, using noninvasive (e.g. often imaging-based) tools to assess intra-tissue mechanics.  ... 
doi:10.1038/s41598-020-64723-9 pmid:32409711 fatcat:xnnjlc7fyje4ldieyn7faj76c4

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Guillermo Rus, Inas H. Faris, Jorge Torres, Antonio Callejas, Juan Melchor
2020 Sensors  
The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues' mechanical properties.  ...  Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry.  ...  [258] measured the compressive viscoelastic mechanical properties of Ex vivo human cervical tissue using indentation and an inverse finite element analysis, to conclude that the human cervix is nonlinear  ... 
doi:10.3390/s20082379 pmid:32331295 pmcid:PMC7219338 fatcat:xpqhc4vujvcxtd76xasuchg5je

Magnetic resonance elastography: Inversions in bounded media

Arunark Kolipaka, Kiaran P. McGee, Armando Manduca, Anthony J. Romano, Kevin J. Glaser, Philip A. Araoz, Richard L. Ehman
2009 Magnetic Resonance in Medicine  
Magnetic resonance elastography (MRE) is a noninvasive imaging technique capable of quantifying and spatially resolving the shear stiffness of soft tissues by visualization of synchronized mechanical wave  ...  However, MRE inversions generally assume that the measured tissue motion consists primarily of shear waves propagating in a uniform, infinite medium.  ...  Mccullough for conducting mechanical testing. Grant Support: National Institutes of Health Grants EB001981  ... 
doi:10.1002/mrm.22144 pmid:19780146 pmcid:PMC2849111 fatcat:6umkdiiqmreyrg6ybuuxlbzczi

Quantitative Imaging Methods for the Development and Validation of Brain Biomechanics Models

Philip V. Bayly, Erik H. Clayton, Guy M. Genin
2012 Annual Review of Biomedical Engineering  
First, they must capture the biomechanics of the brain as both a material and a structure, including the mechanics of brain tissue and its interactions with the skull.  ...  Rapid deformation of brain tissue in response to head impact or acceleration can lead to numerous pathological changes, both immediate and delayed.  ...  , heterogeneous, anisotropic, and nonlinear.  ... 
doi:10.1146/annurev-bioeng-071811-150032 pmid:22655600 pmcid:PMC3711121 fatcat:47s3wfpuuvdbdkjvarssnxsidq

Automatic Segmentation of Mechanically Inhomogeneous Tissues Based on Deformation Gradient Jump

Colleen M. Witzenburg, Rohit Y. Dhume, Spencer P. Lake, Victor H. Barocas
2016 IEEE Transactions on Medical Imaging  
Variations in properties, active behavior, injury, scarring, and/or disease can all cause a tissue's mechanical behavior to be heterogeneous.  ...  However, the determination of the mechanical behavior of heterogeneous soft tissue requires a spatially varying constitutive equation (i.e. one in which the material parameters vary with position).  ...  A few elastographic inverse techniques have been employed which account for the anisotropic, nonlinear behavior exhibited by soft tissues.  ... 
doi:10.1109/tmi.2015.2453316 pmid:26168433 pmcid:PMC4739827 fatcat:nbshgrwr45hetlpjzua2prse4y

Magnetic resonance elastography (MRE) in cancer: Technique, analysis, and applications

Kay M. Pepin, Richard L. Ehman, Kiaran P. McGee
2015 Progress in nuclear magnetic resonance spectroscopy  
Tissue mechanical properties are significantly altered with the development of cancer.  ...  Magnetic resonance elastography (MRE) is a noninvasive technique capable of quantifying tissue mechanical properties in vivo.  ...  techniques for the calculation of viscoelastic properties in nonlinear, anisotropic brain tissue with complex boundary conditions.  ... 
doi:10.1016/j.pnmrs.2015.06.001 pmid:26592944 pmcid:PMC4660259 fatcat:q7e5tzbfkjdlvcf62s5f2ptpke
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