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Structural insight on assembly-line catalysis in terpene biosynthesis

Jacque L. Faylo, Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. Garcia, Kenji Murakami, David W. Christianson
2021 Nature Communications  
Cryo-electron microscopy and chemical crosslinking experiments additionally show that compact conformations can be achieved in which cyclase domains are more closely associated with the prenyltransferase  ...  from National Institutes of Health grant R01-GM129325 and from the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.  ...  Molecular graphics and analyses were performed with UCSF ChimeraX, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support  ... 
doi:10.1038/s41467-021-23589-9 pmid:34108468 fatcat:tz7yigntt5c4hj6exozxiazjyu

Bayesian topic models for describing computer network behaviors

Christopher Cramer, Lawrence Carin
2011 2011 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)  
Each identified behavior topic included a variety of different, but related, protocols without using any a priori knowledge of the purpose of the protocol.  ...  In our experiments, these topics of user behavior included: (i) web traffic, (ii) email client and instant messaging, (iii) Microsoft file access, (iv) email server, and (v) other miscellaneous traffic  ...  However, it is unlikely that topics would map explicitly to malicious and normal behaviors.  ... 
doi:10.1109/icassp.2011.5946875 dblp:conf/icassp/CramerC11 fatcat:tzqxbns5yfgclaiplprrwhj3eq

Architectures of Advanced Function Printing

R. K. deBry, B. G. Platte, C. L. Berinato, J. W. Marlin
1988 IBM Systems Journal  
stream for all-points-addressable printing'* and has been defined as an SAA protocol.  ...  Recall that 1pps defines a two-way communications path between the host and the printer.  ... 
doi:10.1147/sj.272.0234 fatcat:eubo6vxydfbdvdwzcftfpnowbq

An End-Host View on Local Traffic at Home and Work [chapter]

Ahlem Reggani, Fabian Schneider, Renata Teixeira
2012 Lecture Notes in Computer Science  
This paper compares local and wide-area traffic from end-hosts connected to different home and work networks.  ...  Local connections are often shorter and smaller than Internet connections.  ...  Second, we label any connection that remains unclassified based on the application protocol as derived from the port number using the IANA mapping.  ... 
doi:10.1007/978-3-642-28537-0_3 fatcat:e4i75fwv35cvvdr7kehoiiubdu

Identification of adaptive changes in an evolving population of Escherichia coli: the role of changes with regulatory and highly pleiotropic effects

1991 Molecular biology and evolution  
Acknowledgments We thank Liz Hutton and David Appleby for help in the development of twodimensional electrophoresis technique and in computer image analysis, E. D.  ...  Rothman for statistical advice, and Jan Fronk and F. Neidhardt for helpful discussion. This work was supported in part by National Institutes of Health grant GM30959.  ...  (PDI; Huntington Station, N.Y .) protocols, with PDI sample kit PDI-100 1.  ... 
doi:10.1093/oxfordjournals.molbev.a040650 pmid:2072859 fatcat:cc7e42vsofdqlfykbbeflgyvra

A Flow Classifier with Tamper-Resistant Features and an Evaluation of Its Portability to New Domains

Guixi Zou, George Kesidis, David J. Miller
2011 IEEE Journal on Selected Areas in Communications  
We address issues in reconciling differences in class definitions between the two domains.  ...  In this thesis, we propose a TCP flow classifier that employs neither packet header information that is protocol-specific (including port numbers) nor packet-payload information.  ...  between the client and server.  ... 
doi:10.1109/jsac.2011.110810 fatcat:i56jpynxarcjffyqn42iewylai

Access Networks [chapter]

2005 Connection-Oriented Networks  
Label request message An LSR sends a label request message to an LPD peer to request a mapping to particular FEC.  ...  These primitive types are also used between a signaling protocol and SAAL (see Figure 5 .4).  ...  SONET/SDH AND GFP (CHAPTER 2) The SONET/SDH specifications can be found in References 1 and 2. References 3 and 4 describe how PPP frames can be transmitted over SONET/SDH.  ... 
doi:10.1002/0470016361.ch11 fatcat:kah6edcdxjgbrpc4ihj7ccvrku

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

Norbert Volkmar, Maria-Laetitia Thezenas, Sharon M. Louie, Szymon Juszkiewicz, Daniel K. Nomura, Ramanujan S. Hegde, Benedikt M. Kessler, John C. Christianson
2018 Journal of Cell Science  
Lipidomic and proteomic analyses revealed defective biogenesis and concomitant loss of the TMD-containing ER-resident enzymes sterol-O-acyltransferase 1 (SOAT1) and squalene synthase (SQS, also known as  ...  The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell physiology.  ...  For technical assistance, Skirmantas Kriaucionis (RNA-Seq analysis), Marketa Tomkova, Pijus Brazauskas (genomic sequencing) and Mark Shipman (microscopy), and for careful reading and commenting on the  ... 
doi:10.1242/jcs.223453 pmid:30578317 pmcid:PMC6362398 fatcat:seiyyllpdjb63ncgoyuleqyj6i

Network scan detection with LQS

Mansour Alsaleh, P. C. van Oorschot
2011 Proceedings of the 6th ACM Symposium on Information, Computer and Communications Security - ASIACCS '11  
the ability to detect stealthy scanners; 4) efficient use of monitoring system resources; and 5) immunity to evasion.  ...  Using network traces from two sites, we evaluate LQS and compare its scan detection results with those obtained by the state-of-the-art TRW algorithm.  ...  ., SMB protocol); (c) 12 ports running Line Printer Daemon protocol (LPD; port 515); (d) 10 ports running Telnet protocol; (e) 7 ports running SSH protocol; and (f) 72 various other services mostly on  ... 
doi:10.1145/1966913.1966928 dblp:conf/ccs/AlsalehO11 fatcat:mhvrh6azxnf43ndjxswy7ldw2i

Who Should Read This Book [chapter]

2016 Securing the Outdoor Construction Site  
In GUIs and graphics, for example, there is generally a rather natural mapping between manipulable visual objects and classes.  ...  About the only serious drawback of layering IPP over HTTP is that the protocol is completely driven by client requests.  ...  TCP/IP Tranmission Control Protocol/Internet Protocol. The basic protocol of the Internet since the conversion from NCP in 1983. Provides reliable transport of data streams.  ... 
doi:10.1016/b978-0-12-802383-9.00019-8 fatcat:5cxlhe2k4fbjzfwouwq6qa7iqe

Entanglement measures and their properties in quantum field theory [article]

Stefan Hollands, Ko Sanders
2018 arXiv   pre-print
In particular, we study the relative entanglement entropy, defined as the minimum relative entropy between the given state and an arbitrary separable state.  ...  We establish rigorous upper and lower bounds in various quantum field theoretic (QFT) models, as well as also model-independent ones.  ...  Proof: Let tF N,1 u be a distillation protocol for ω 1 , i.e. a sequence of cp maps such that }FN ,1 ω bN 1´ωǹ N,1 } Ñ 0. The rate of this protocol is limpln n N,1 q{N " r 1 , and similarly for ω 2 .  ... 
arXiv:1702.04924v3 fatcat:d3a6l66j4bcp7inpqlkmarspny

Negative Pressure Ventilation - A New Frontier for Ex Vivo Lung Perfusion

Nader Saber Aboelnazar
Lung transplantation is a life-saving therapy for patients suffering from end-stage lung disease; however, there exists a discrepancy between suitable donor grafts and utilization rates.  ...  To-date, all clinically accepted EVLP platforms differ with regards to their protocol strategies (perfusion and ventilation strategies); however, they unanimously utilize the same ventilation modality,  ...  LPD and Celsior (LPD: 66.5% vs.  ... 
doi:10.7939/r3-z1t4-3m92 fatcat:ctqbbfmwjvgqnfwiomi5ivac2e

Western Medical Research Conference 2017 ( Formerly Western Regional Meeting ) Camel, California, January 26–28, 2017

2016 Journal of Investigative Medicine  
Downloaded from regressions to determine the association between use of SC MTX and risk of therapeutic change/addition of biologics and created Kaplan-Meier curves to compare therapeutic Abstract 33 Figure  ...  KS results in testicular failure, androgen deficiency, and cardiometabolic morbidity and mortality.  ...  Subject maps were warped to a template with labelled ROIs using ANTs.  ... 
doi:10.1136/jim-2016-000365.1 fatcat:4g7yajiqd5evxalwbsmimjlzk4

The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session

2019 Bone Marrow Transplantation  
We verified a strong relationship between busulfan CL obtained from both protocols and sampling protocol doesn't influence CL statistically.  ...  A strong relationship between the CL of the day 1-3 obtained from the original protocol and the simplified protocol is observed (R 2 =0.9985).  ...  Methods: Donor samples were retrieved from the Collaborative Biobank (Dresden, Germany) and mapped to patient outcome data extracted from the EBMT and CIBMTR.  ... 
doi:10.1038/s41409-019-0559-4 pmid:31270396 pmcid:PMC7091813 fatcat:glrpibmqtjem3ms5buhwjafzjm

Abstract Book of the XXIII Congresso Nazionale della Società Scientifica FADOI, Bologna, 12-15 maggio 2018

Presidente: A. Fontanella
2018 Italian Journal of Medicine  
: Hepatitis C Virus (HCV) eradication and remission of concomitant lymphoproliferative disorders (LPD) with antiviral treatment interferon-based highlight the etiologic link between the LPD and HCV infection  ...  reducing management costs and it is a map of critical issues.  ...  between a medical intervention and a health outcome.  ... 
doi:10.4081/itjm.2018.s2 fatcat:7oaydpf5nbhutok5pyyhdocqgq
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