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The Ensembl COVID-19 resource: Ongoing integration of public SARS-CoV-2 data [article]

Nishadi H. De Silva, Jyothish Bhai, Marc Chakiachvili, Bruno Contreras-Moreira, Carla Cummins, Adam Frankish, Astrid Gall, Thiago Genez, Kevin L. Howe, Sarah E. Hunt, Fergal J. Martin, Benjamin Moore (+15 others)
2020 bioRxiv   pre-print
The Ensembl COVID-19 browser (covid-19.ensembl.org) was launched in May 2020 in response to the ongoing pandemic. It is Ensembl's contribution to the global efforts to develop treatments, diagnostics and vaccines for COVID-19, and it supports research into the genomic epidemiology and evolution of the SARS-CoV-2 virus. This freely available resource incorporates a new Ensembl gene set, multiple sets of variants, and alignments of annotation from several resources against the reference assembly
more » ... or SARS-CoV-2. It represents the first virus to be encompassed within the Ensembl platform. Additional data are being continually integrated via our new rapid release protocols alongside tools such as the Ensembl Variant Effect Predictor. Here we describe the data and infrastructure behind the resource and discuss future work.
doi:10.1101/2020.12.18.422865 fatcat:4bz3upbr3vdjlpvukhes5x55ai

[Front cover]

2020 2020 International Conference on Emerging Trends in Information Technology and Engineering (ic-ETITE)  
S 153.Design, Implementation & Functional Aspects of the Control & Instrumentation System for Real Time Computer Based Safety Grade Decay Heat Removal System of PFBR P Manoj, M Kasinathan, M Sakthivel,  ...  Soundra Pandian Scientist, O/o CCA Ministry of Electronics & Information Technology. Government of India.  ... 
doi:10.1109/ic-etite47903.2020.9077683 fatcat:iwmz2md26bhavjllkvvao3co7i

Madurai Formula Films: Caste Pride and Politics in Tamil Cinema

Karthikeyan Damodaran, Hugo Gorringe
2017 South Asia Multidisciplinary Academic Journal  
Pandian 2015) .  ...  Pandian 2000) .  ... 
doi:10.4000/samaj.4359 fatcat:vnvtk7erhrcjdkcadlgizkyplu

Impact of Evidence‐Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study

Paula Muñoz Venturelli, Xian Li, Sandy Middleton, Caroline Watkins, Pablo M. Lavados, Verónica V. Olavarría, Alejandro Brunser, Octavio Pontes‐Neto, Taiza E. G. Santos, Hisatomi Arima, Laurent Billot, Maree L. Hackett (+631 others)
2019 Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease  
The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence-based processes of care for acute ischemic stroke ( AIS ) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke
more » ... it care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0-2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or "defect-free" care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18-1.65) and better survival (odds ratio, 2.23; 95% CI , 1.62-3.09). Defect-free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0-1) (odds ratio, 1.22; 95% CI , 1.04-1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions Use of evidence-based care is associated with improved clinical outcome in AIS . Strategies are required to address regional variation in the use of proven AIS treatments. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique Identifier: NCT02162017.
doi:10.1161/jaha.119.012640 pmid:31237173 pmcid:PMC6662356 fatcat:6vzble3fbbcx7img577x25y6nu