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Novel approaches to imaging epilepsy by MRI

Hoby Hetherington
<span title="">2009</span> <i title="Future Medicine Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gq6wf5jgljav3nrgmqk6bvfcza" style="color: black;">Future Neurology</a> </i> &nbsp;
In this review we will focus on three aspects of MRI: magnetic resonance spectroscopic imaging (MRSI), manganese-enhanced MRI (MEMRI) and functional MRI (fMRI) measures of resting state connectivity.  ...  Recently, studies utilizing magnetic resonance spectroscopic imaging, manganese-enhanced MRI and functional (f)MRI measures of resting state connectivity have demonstrated their ability to detect injury  ...  Executive summary Magnetic resonance spectroscopic imaging • 1 H and 31 P magnetic resonance spectroscopic imaging provide measures of injury and bioenergetic impairment in epilepsy. • Decreases in N-acetylaspartate  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/fnl.09.12">doi:10.2217/fnl.09.12</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20161076">pmid:20161076</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2743439/">pmcid:PMC2743439</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rzgesd6h25hxldhyswt3mcp3pq">fatcat:rzgesd6h25hxldhyswt3mcp3pq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211001556/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2743439&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/72/63/72632188bd7d9c4c9a8a03f97370ca71e61f458f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/fnl.09.12"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743439" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Manganese-Enhanced MRI: Biological Applications in Neuroscience

Jackeline Moraes Malheiros, Fernando Fernandes Paiva, Beatriz Monteiro Longo, Clement Hamani, Luciene Covolan
<span title="2015-07-10">2015</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo.  ...  Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems.  ...  Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy. Epilepsia (2012) 53(7):1225-32. doi:10.1111/j.1528-1167.2012.03521.x 37.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2015.00161">doi:10.3389/fneur.2015.00161</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26217304">pmid:26217304</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4498388/">pmcid:PMC4498388</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/viqrpuwhb5hv3kzjhuztqgwjwu">fatcat:viqrpuwhb5hv3kzjhuztqgwjwu</a> </span>
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Manganese-enhanced MRI reflects seizure outcome in a model for mesial temporal lobe epilepsy

S. Dedeurwaerdere, K. Fang, M. Chow, Y.-T. Shen, I. Noordman, L. van Raay, N. Faggian, M. Porritt, G.F. Egan, T.J. O'Brien
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
Markers of epilepsy such as spontaneous recurrent seizures, hippocampal neuronal loss and mossy fiber sprouting were quantified.  ...  Manganese-enhanced MRI (MEMRI) can potentially aide in this quest as it provides superior tissue contrast, particularly of the hippocampal subregions.  ...  This work was supported by an Early Career Research Grant from the University of Melbourne to Stefanie Dedeurwaerdere, BOF University of Antwerp and FWO.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2012.11.054">doi:10.1016/j.neuroimage.2012.11.054</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23220429">pmid:23220429</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vk3ns3cksrewxpujxnp746r3yu">fatcat:vk3ns3cksrewxpujxnp746r3yu</a> </span>
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The use of manganese-enhanced MRI for the evaluation of neurodegenerative changes in a rat model of kainic acid- induced excitotoxicity

Melda Apaydin, Vedat Evren, Oytun Erbas, Cem Calli, Gonul O. Peker, Dilek Taskiran
<span title="2013-03-11">2013</span> <i title="AVES Publishing Co."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pfr6oi57dbbr7pl33rpo5in6be" style="color: black;">Diagnostic and Interventional Radiology</a> </i> &nbsp;
NEURORADIOLOGY ORIGINAL ARTICLE PURPOSE Manganese-enhanced magnetic resonance imaging (MEM-RI) has been used to detect brain activity based on the ability of active neurons to take up manganese ions through  ...  We used in vivo MEMRI to evaluate neurodegenerative changes in an excitotoxicity model induced by KA in rats.  ...  We observed prominent mossy fiber sprouting and axonal plasticity in the CA1 and CA3 granule cells of hippocampal sections in the KA-induced group, whereas control animals that received MnCl 2 injection  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5152/dir.2013.200">doi:10.5152/dir.2013.200</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23886936">pmid:23886936</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jyq2u3ptrfcf7evicjfq2k76ka">fatcat:jyq2u3ptrfcf7evicjfq2k76ka</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180611114403/http://www.dirjournal.org/sayilar/7/buyuk/pdf_DIR_5502.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8f/f3/8ff3436d3cb42063399b68080a721926a0ca56b9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5152/dir.2013.200"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Manganese-Enhanced MRI of Brain Plasticity in Relation to Functional Recovery after Experimental Stroke

Jet P van der Zijden, Mark J R J Bouts, Ona Wu, Tom A P Roeling, Ronald LAW Bleys, Annette van der Toorn, Rick M Dijkhuizen
<span title="2007-11-07">2007</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zh7dem5jnfbevczyfq7zr6yhme" style="color: black;">Journal of Cerebral Blood Flow and Metabolism</a> </i> &nbsp;
We performed in vivo magnetic resonance imaging (MRI)-based neuronal tract tracing with manganese in combination with immunohistochemical detection of the neuronal tracer wheatgerm agglutinin horseradish  ...  This study shows that manganese-enhanced MRI can provide unique in vivo information on the spatiotemporal pattern of neuroanatomical plasticity after stroke.  ...  We and others have recently shown that changes in neuronal connectivity after experimental stroke can be assessed in vivo with manganese-enhanced magnetic resonance imaging (MEMRI) (Allegrini and Wiessner  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.jcbfm.9600576">doi:10.1038/sj.jcbfm.9600576</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17987047">pmid:17987047</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bkmfwy37dfenbngthxgjztry4m">fatcat:bkmfwy37dfenbngthxgjztry4m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223111303/http://pdfs.semanticscholar.org/4e83/d8e50ef79e5066d01eed7243608ac85c830f.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4e/83/4e83d8e50ef79e5066d01eed7243608ac85c830f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.jcbfm.9600576"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy

Sandesh Reddy, Iyan Younus, Vidya Sridhar, Doodipala Reddy
<span title="2019-01-08">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3loumxx7kzamnlu4h6x3xoz6ay" style="color: black;">International Journal of Molecular Sciences</a> </i> &nbsp;
Magnetic resonance imaging (MRI) is a sensitive method for detecting structural and functional changes in the brain, especially to identify region-specific neuronal damage patterns in epilepsy.  ...  Recently, several in vivo biomarkers for epileptogenesis have been investigated for characterizing neuronal loss, inflammation, blood-brain barrier alterations, changes in neurotransmitter density, neurovascular  ...  Magnetic Resonance Spectroscopy for Detecting Metabolites Magnetic resonance spectroscopy (MRS) can be used to analyze different metabolites in the brain tissue.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms20010220">doi:10.3390/ijms20010220</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/baikpmau5zekhlgkotohzftvxi">fatcat:baikpmau5zekhlgkotohzftvxi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190307005343/http://pdfs.semanticscholar.org/ced0/c9fa979a89b1910537bc9bf5fe4e29be2b6d.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ce/d0/ced0c9fa979a89b1910537bc9bf5fe4e29be2b6d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ijms20010220"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI)

Satoko Hattori, Hideo Hagihara, Koji Ohira, Ichio Aoki, Tsuneo Saga, Tetsuya Suhara, Makoto Higuchi, Tsuyoshi Miyakawa
<span title="2013-11-11">2013</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ocihcbhrsvefji6tmqvzm24pfm" style="color: black;">Frontiers in Integrative Neuroscience</a> </i> &nbsp;
In this study, we performed in vivo manganese-enhanced magnetic resonance imaging (MEMRI) to assess the regional cellular activity in the brains of αCaMKII HKO mice.  ...  role in synaptic plasticity, learning and memory. αCaMKII heterozygous knockout (HKO) mice exhibit abnormal emotional and aggressive behaviors and cognitive impairments and have been proposed as an animal  ...  In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI) INTRODUCTION The alpha isoform of calcium/calmodulin-dependent  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnint.2013.00076">doi:10.3389/fnint.2013.00076</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24273499">pmid:24273499</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3822296/">pmcid:PMC3822296</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/arkpcbiayrhkvcjg7ob2n7i6yi">fatcat:arkpcbiayrhkvcjg7ob2n7i6yi</a> </span>
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Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Jun Yang, Qinqing Li
<span title="2020-02-25">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn2+. Mn2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels.  ...  In this article, we provide a brief review of MEMRI use in CNS diseases ranging from neurodegenerative diseases to brain injury and spinal cord injury.  ...  Manganese enhanced magnetic resonance imaging (MEMRI) is a special MR functional imaging method, which is different from other imaging methods.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2020.00143">doi:10.3389/fneur.2020.00143</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32161572">pmid:32161572</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7052353/">pmcid:PMC7052353</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hypuo4utcfhufdmqi5ovdhhs5y">fatcat:hypuo4utcfhufdmqi5ovdhhs5y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200229201216/https://fjfsdata01prod.blob.core.windows.net/articles/files/495047/pubmed-zip/.versions/1/.package-entries/fneur-11-00143/fneur-11-00143.pdf?sv=2015-12-11&amp;sr=b&amp;sig=D2vIulsWM6Ofc8NnM%2FCsgjyu0nj4uptyh1awQlr2wj0%3D&amp;se=2020-02-29T20%3A12%3A46Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fneur-11-00143.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9f/f5/9ff54340aa44760fcf4ef9a16174e452ebe4dd0f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2020.00143"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052353" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration

Ryan A. Cloyd, Shon A. Koren, Jose F. Abisambra
<span title="2018-12-13">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xyafp6gbr5et3ghi4kqddnyolm" style="color: black;">Frontiers in Aging Neuroscience</a> </i> &nbsp;
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging.  ...  Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans.  ...  Nairismägi et al. (2006) showed in vivo MEMRI evidence of mossy fiber sprouting following drug-induced SE in rats, which was later confirmed via histopathology.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2018.00403">doi:10.3389/fnagi.2018.00403</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30618710">pmid:30618710</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6300587/">pmcid:PMC6300587</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gno7h566cja2rbkc3lrhewj7wm">fatcat:gno7h566cja2rbkc3lrhewj7wm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200318155244/https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1135&amp;context=physiology_facpub" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/63/c8/63c837f892a19b286e7f0159883536a548625d68.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2018.00403"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300587" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Current Status and Potential Challenges of Cell-Based Therapy for Treating Status Epilepticus and Chronic Epilepsy [chapter]

Huifang Zhao, Zhiyuan Li
<span title="2020-10-29">2020</span> <i title="IntechOpen"> Epilepsy [Working Title] </i> &nbsp;
Various stem cell types were used for treatment of epilepsy in basic and experimental researches.  ...  The goal of this chapter is to evaluate the progress made hitherto in this area and to discuss the prospect for cell-based therapy for epilepsy.  ...  Conflict of interest The authors declare that they have no competing interests. Nomenclature ROS reactive oxygen species  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.93811">doi:10.5772/intechopen.93811</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y4gjhseu5jbm5fbc4zzl5qa2ja">fatcat:y4gjhseu5jbm5fbc4zzl5qa2ja</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201112005740/https://api.intechopen.com/chapter/pdf-download/73296.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/90/a7/90a7a71fc9696979bf03e162608943467705d9e1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/intechopen.93811"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

Taekwan Lee, Xiao-an Zhang, Shanta Dhar, Henryk Faas, Stephen J. Lippard, Alan Jasanoff
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/v6fzdolajra2detrgb2pojrdpm" style="color: black;">Chemistry and Biology</a> </i> &nbsp;
Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects.  ...  Membrane permeability, optical activity, and high relaxivity of porphyrin-based contrast agents offer exceptional functionality for in vivo imaging.  ...  ACKNOWLEDGMENTS This work was funded by NIH grant DP2-OD2441 (New Innovator Award) and Department of Defense grant DAMD17-03-1-0413 to A.J., and by NIH grant R01-GM065519 to S.J.L.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.chembiol.2010.05.009">doi:10.1016/j.chembiol.2010.05.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20609416">pmid:20609416</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2906115/">pmcid:PMC2906115</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4bq2l75wrracpnzrklk2i6y2ry">fatcat:4bq2l75wrracpnzrklk2i6y2ry</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170930065946/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/89f/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMTA3NDU1MjExMDAwMTcxNw%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/24/fa/24fa0292f3d64f19c04d61e9e39cfe033a1cac30.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.chembiol.2010.05.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906115" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

Clarissa F. Cavarsan, Jackeline Malheiros, Clement Hamani, Imad Najm, Luciene Covolan
<span title="2018-11-30">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
In this review, we highlight the role of mossy fiber sprouting in seizure generation and hippocampal excitability and discuss the response of alternative treatment strategies in terms of MFS and spontaneous  ...  Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting (granular cell axons) into the dentate gyrus inner molecular layer.  ...  ACKNOWLEDGMENTS The authors would like to thank Katharina Quinlan (University of Rhode Island) for her assistance proof reading the article. This work was supported by CNPq (200970/2015-1) (Brazil).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2018.01023">doi:10.3389/fneur.2018.01023</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30555406">pmid:30555406</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6284045/">pmcid:PMC6284045</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wxscazykkzf4pd6jrvagyjumpi">fatcat:wxscazykkzf4pd6jrvagyjumpi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222161035/http://pdfs.semanticscholar.org/3a3e/c7a9f54d4f40466d5e452d5b2da87e5e43de.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3a/3e/3a3ec7a9f54d4f40466d5e452d5b2da87e5e43de.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2018.01023"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284045" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neuroimaging in animal models of epilepsy

Daniele Bertoglio, Jeroen Verhaeghe, Stefanie Dedeurwaerdere, Olli Gröhn
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/l52eh66fdzhhbmbsefbbyzwkaq" style="color: black;">Neuroscience</a> </i> &nbsp;
Here we review the advances of different in vivo imaging techniques, including magnetic resonance-based and nuclear imaging-based modalities, in animal models of epilepsy.  ...  Altogether, it is not surprising that MRI has been increasingly used in in vivo assessment of epileptogenesis and epilepsy both in animal models and in clinical settings.  ...  Acknowledgements References Acknowledgements DB has a PhD fellowship from the Research Foundation Flanders (FWO, 11W2516N) , OG is supported by Academy of Finland.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroscience.2017.06.062">doi:10.1016/j.neuroscience.2017.06.062</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28688882">pmid:28688882</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/44465e34sfh5ndcwt6s6aqki7i">fatcat:44465e34sfh5ndcwt6s6aqki7i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200309132617/https://erepo.uef.fi/bitstream/handle/123456789/4418/1-s2.0-S0306452217304670-main.pdf;jsessionid=1EEDA7C9D0B2946066C738F58B87C41D?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ec/23/ec235a1e94d5804bf80efd325a2f408fd2165fe6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroscience.2017.06.062"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline

Marcelo Febo, Thomas C. Foster
<span title="2016-06-29">2016</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xyafp6gbr5et3ghi4kqddnyolm" style="color: black;">Frontiers in Aging Neuroscience</a> </i> &nbsp;
Studies employing magnetic resonance imaging and spectroscopy (MRI and MRS, respectively) in animal models have emerged as an integrative set of techniques bridging localized cellular/molecular phenomenon  ...  and broader in vivo neural network alterations.  ...  Functional and anatomical imaging techniques find strong complementation with in vivo magnetic resonance spectroscopy (MRS), which describes biochemical correlates in memory regions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2016.00158">doi:10.3389/fnagi.2016.00158</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27468264">pmid:27468264</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4942756/">pmcid:PMC4942756</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4vkoz3kdrbfqbc2x4wu775o3pa">fatcat:4vkoz3kdrbfqbc2x4wu775o3pa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171006061756/http://publisher-connector.core.ac.uk/resourcesync/data/Frontiers/pdf/14e/aHR0cDovL2pvdXJuYWwuZnJvbnRpZXJzaW4ub3JnL2FydGljbGUvMTAuMzM4OS9mbmFnaS4yMDE2LjAwMTU4L3BkZg%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8e/b7/8eb7ebfe20b3acaa4b8edc626ffb5464a7cf2d6d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2016.00158"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942756" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice

Sandra Dieni, Sigrun Nestel, Mirjam Sibbe, Michael Frotscher, Sabine Hellwig
<span title="2015-10-23">2015</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5j7w5nihpbdjxp6k7que2k24au" style="color: black;">Frontiers in Synaptic Neuroscience</a> </i> &nbsp;
activation or plasticity; (iii) subtle changes to microglial structure; and (iv) morphological alterations to the mossy fiber (MF) synapse.  ...  plasticity.  ...  KG and the Medical Faculty of the University of Freiburg.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnsyn.2015.00018">doi:10.3389/fnsyn.2015.00018</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26557085">pmid:26557085</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4615824/">pmcid:PMC4615824</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/un6jtyphgvd3xotu2jzbqp735e">fatcat:un6jtyphgvd3xotu2jzbqp735e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830133118/https://fjfsdata01prod.blob.core.windows.net/articles/files/167135/pubmed-zip/.versions/1/.package-entries/fnsyn-07-00018/fnsyn-07-00018.pdf?sv=2015-12-11&amp;sr=b&amp;sig=scviHadpC0IIJnOEP%2FDjC%2BHVfWMB7hF5PaW1pN%2FEbMs%3D&amp;se=2017-08-30T13%3A31%3A22Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnsyn-07-00018.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/92/d7/92d74033eccad0f4c9c299c014b9bc8e4522e72d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnsyn.2015.00018"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615824" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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