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Biologie der Zelle. Erich Ries , Manfred Gersh

Hans Ris
1954 The Quarterly review of biology  
By Erich Ries, revised, enlarged, and edited by Manfred Gersch. B. G. Teubner Verlagsgesellschaft, Leipzig. DM. 24.40. viii + 552 pp. + 12 pl; text ill. 1953.  ...  The differences between the Hans Ris  ... 
doi:10.1086/400113 fatcat:niyiwj27drdr7gviqh27ycduwa

A note on MGR methods

Manfred Ries, Ulrich Trottenberg, Gerd Winter
1983 Linear Algebra and its Applications  
RIES, U. TROTTENBERG, AND 6.  ... 
doi:10.1016/0024-3795(83)90091-5 fatcat:pmf4rw3iobhajfnjyfcgez5bae

Secretory meningiomas: A benign subgroup causing life-threatening complications

Jan Regelsberger, Christian Hagel, Pedram Emami, Thorsten Ries, Oliver Heese, Manfred Westphal
2009 Neuro-Oncology  
While meningiomas are known as slow-growing extracerebral neoplasms, the subgroup of secretory meningiomas with histologically benign characteristics tend to cause disproportional peritumoral edema, frequently leading to severe medical and neurological complications in postoperative management. Among 1,484 meningiomas that were resected at our institution between 1990 and 2007, 44 (3%) patients were found to have the histological diagnosis of a secretory meningioma. The clinical course,
more » ... ical appearance, and histopathological features were retrospectively analyzed to examine the specifics of these benign lesions. Meningiomas were located at the convexity (n 5 14), the cranial base (18), and the sphenoid ridge (12). A severe, nearly hemispheric perifocal edema disproportional to tumor size was seen on preoperative MR imaging in 18 (41%) patients. Following surgical resection, the postoperative course was uneventful in 29 patients. In 15 patients, severe peritumoral edema continued or even increased on postoperative CT imaging. Six patients showed midline shift and clinical worsening necessitating respirator-assisted ventilation and intracranial pressure monitoring. An association between the extent of brain edema and number of periodic acid Schiff-positive pseudopsammomas was found (p , 0.02). Further, the size of the edema correlated with the number of immunohistochemically detected cells expressing carcinoembryonic antigen (CEA) and cytokeratin (CK) (p , 0.01). Mean MIB-1 (Ki-67 antigen) proliferation index was 3.0% (range, 0%-17%) and did not correlate with edema or tumor recurrence. Secretory meningiomas are frequently associated with severe peritumoral edema. The extent of edema correlates with immunohistochemically detected expression of CEA and CK. Extended perifocal edema in meningiomas is an unusual finding and should alert the neurosurgeon that surgery may aggravate edema excessively, leading to a life-threatening postoperative situation. Neuro-Oncology 10, 819-824, 2008 (Posted to Neuro-Oncology [serial online], Doc. D08-00240, December 9, 2008
doi:10.1215/15228517-2008-109 pmid:19066343 pmcid:PMC2802401 fatcat:nigcsojtizaqhmejd6thipta7i

Health, health care, and the environment. Econometric evidence from German micro data

Manfred Erbsland, Walter Ried, Volker Ulrich
1995 Health Economics  
Consequently, one arrives at the following specification for the logarithm of the demand for medical care: (l2c) In M ri = k z +u 3 In W,; -u 3 In p';M +u 4 X ti +ust; +u 6 Y ri + In H ri +v ri ' where  ...  and, after replacing In 1t~: (22) drc~( ) M In-a M =In l-u 3 +u 3 lnW ri -u 3 lnP ri +u 4 X ri • Pri Furthermore, the second term on the right hand side of equation (12b) can be transformed as follows  ... 
doi:10.1002/hec.4730040303 pmid:7550768 fatcat:bx5dufbonvcg3mb2hor6hstaku

Interdependence of kallikrein-related peptidases in proteolytic networks

Nathalie Beaufort, Karolina Plaza, Daniel Utzschneider, Amelie Schwarz, Julia M. Burkhart, Sabine Creutzburg, Mekdes Debela, Manfred Schmitt, Christian Ries, Viktor Magdolen
2010 Biological chemistry  
Additionally, a recently reported variant of MMP-9, MMP-9D, was also investigated (Ries et al., 2007) .  ...  proMMP-9 and proMMP-2 was performed by exposure to 1 mM 4amino-phenylmercuric acetate for 2 h at 378C, and proMMP-9D was autocatalytically activated by treatment for 1 h at 378C as described previously (Ries  ... 
doi:10.1515/bc.2010.055 pmid:20302517 fatcat:vglxkiszvbe4ln6iqimfqcw6sq

iDataCool: HPC with Hot-Water Cooling and Energy Reuse [chapter]

Nils Meyer, Manfred Ries, Stefan Solbrig, Tilo Wettig
2013 Lecture Notes in Computer Science  
iDataCool is an HPC architecture jointly developed by the University of Regensburg and the IBM Research and Development Lab B\"oblingen. It is based on IBM's iDataPlex platform, whose air-cooling solution was replaced by a custom water-cooling solution that allows for cooling water temperatures of 70C/158F. The system is coupled to an adsorption chiller by InvenSor that operates efficiently at these temperatures. Thus a significant portion of the energy spent on HPC can be recovered in the form
more » ... of chilled water, which can then be used to cool other parts of the computing center. We describe the architecture of iDataCool and present benchmarks of the cooling performance and the energy (reuse) efficiency.
doi:10.1007/978-3-642-38750-0_29 fatcat:e4onkkozp5bhtadw3k24ws5t7i

An Extensible Modeling Language for the Representation of Work Processes in the Chemical and Process Industries [chapter]

Ri Hai, Manfred Theißen, Wolfgang Marquardt
2010 Lecture Notes in Computer Science  
Expressive models of the work processes performed in the chemical and process industries provide a basis for diverse applications like work process documentation, analysis, and enactment. In this contribution, we present a generic modeling language for different types of work processes to allow for their integrated representation in the life cycle of a chemical plant. Further, the generic language allows for extensions specific to certain types of work processes. For two important types -design
more » ... and operational processes -such extensions have been elaborated. These extensions enable the adequate representation of the context of a work process that strongly depends on the process type: for instance, the specification of a chemical plant is a product of a design process, whereas the plant takes the role of a resource during an operational process. This contribution also briefly introduces a modeling tool developed by our group for applying the modeling language in industrial practice.
doi:10.1007/978-3-642-17322-6_28 fatcat:ipabvoxq2rgnzpe6iya5yn4a2q

Re-entering obesity prevention: a qualitative-empirical inquiry into the subjective aetiology of extreme obese adolescents

Matthias Braun, Johanna Schell, Wolfgang Siegfried, Manfred J Müller, Jens Ried
2014 BMC Public Health  
While numerous studies highlight the relevance of socio-cultural factors influencing incidence and prevalence of obesity, only a few address how obese people perceive causes and prevention of or intervention for obesity. This study contributes to a more thorough understanding of subjective aetiologies and framing themes for a mainly understudied but promising field. Thus it may serve for the development of effective public health strategies to combat obesity. Methods: Autobiographically based
more » ... -depth interviews were conducted with 20 patients (adolescents and young adults) institutionalised in the obesity rehabilitation centre INSULA in Bischofswiesen (Germany). The data were analysed with Atlas.ti with regard to two main perspectives: (1) How the interviewees perceive 'their' obesity from a subjective point of view and (2) which conclusions they draw from their own 'story' concerning prevention/ intervention strategies. Results: The interviewees did not indicate a clear starting point for their overweight. Nevertheless, certain life-events (e.g. divorce or illness of parents) were identified as catalysing weight gain. As a consequence of coping with distress, body weight rises rapidly and not continuously. Obesity was generally framed as a problem primarily located within the family and not in the wider environment. Corresponding to this, the family was identified as the main and most important addressee of preventive measures. The interviewees highlighted the importance of personal responsibility as a prerequisite for self-determined action against obesity, but denied any link between responsibility and guilt. Conclusions: This study contributes substantially to a broader perspective on the prevention of obesity. First, more attention has to be paid to the interactions of medical aspects and the social dimension of obesity. Second, prevention efforts should be more aware of the relevance of subjective aetiology when it comes to the definition of reasonable and effective governance strategies in tackling obesity. Third, current assumptions concerning the importance of personal responsibility for obesity prevention might underestimate the relevance of self-determined action of the obese.
doi:10.1186/1471-2458-14-977 pmid:25239081 pmcid:PMC4177709 fatcat:lhadyyrpebholnxt6iv6nxsjcy

Activation Mechanisms of the Urokinase-type Plasminogen Activator Promoter by Hepatocyte Growth Factor/Scatter Factor

Sabine Ried, Claudia Jäger, Michael Jeffers, George F. Vande Woude, Henner Graeff, Manfred Schmitt, Ernst Lengyel
1999 Journal of Biological Chemistry  
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector inducing invasion and metastasis of tumor cells that express the Met tyrosine kinase receptor. One of the effectors of HGF/SF is the urokinase-type plasminogen activator, a serine protease that facilitates tumor progression and metastasis by controlling the synthesis of the extracellular matrix degrading plasmin. Stimulation of NIH 3T3 cells that were stably transfected with the human Met receptor (NIH 3T3-Met hum ) with
more » ... HGF/SF induced a trans-activation of the urokinase promoter and urokinase secretion. Induction of the urokinase promoter by HGF/SF via the Met receptor was blocked by co-expression of a dominant-negative Grb2 and Sos1 expression construct. Further, the expression of the catalytically inactive mutants of Ha-Ras, RhoA, c-Raf, and Erk2 or addition of the Mek1-specific inhibitor PD 098059 abrogated the stimulation of the urokinase promoter by HGF/SF. A sequence residing between ؊2109 and ؊1870 base pairs (bp) was critical for stimulation of the urokinase gene by HGF/SF. Mobility shift assays with oligonucleotides spanning an AP-1 site at ؊1880 bp or a combined PEA3/AP-1 site at ؊1967 bp showed binding of nuclear factors from NIH 3T3-Met hum cells. Expression of an expression plasmid that inhibits DNA binding of AP-1 proteins (A-Fos) abrogated inducible and basal activation of the urokinase promoter. Nuclear extract from unstimulated NIH 3T3-Met hum cells contained more JunD and showed a stronger JunD supershift with the AP-1 oligonucleotides, compared with HGF/SF-stimulated cells. Consistent with the levels of JunD expression being functionally important for basal expression of the urokinase promoter, we found that overexpression of wild type JunD inhibited the induction of the urokinase promoter by HGF/SF. These data suggest that the induction of urokinase by HGF/SF is regulated by a Grb2/Sos1/Ha-Ras/c-Raf/RhoA/Mek1/ Erk2/c-Jun-dependent mitogen-activated protein kinase pathway.
doi:10.1074/jbc.274.23.16377 pmid:10347197 fatcat:u56xj2ubx5gxpktgcg4b6kqk6a

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases

Valentin Rausch, Andreas Krieg, Jordi Camps, Bianca Behrens, Manfred Beier, Darawalee Wangsa, Kerstin Heselmeyer-Haddad, Stephan E. Baldus, Wolfram T. Knoefel, Thomas Ried, Nikolas H. Stoecklein
2017 BMC Research Notes  
Improper oligonucleotides were removed in quality control using the same flags as in the Agilent Feature Extraction tool: oligonucleotides were removed if gIsSaturated = 1 or rIs-Saturated = 1 to exclude  ... 
doi:10.1186/s13104-017-2886-0 pmid:29110683 pmcid:PMC5674747 fatcat:tcpvt2dvunceln5o3cm74dtqxe

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

Kornelius Kerl, David Ries, Rebecca Unland, Christiane Borchert, Natalia Moreno, Martin Hasselblatt, Heribert Jürgens, Marcel Kool, Dennis Görlich, Maria Eveslage, Manfred Jung, Michael Meisterernst (+1 others)
2013 BMC Cancer  
Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Methods: Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin in
more » ... tumor cell lines. Results: HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Conclusion: Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors.
doi:10.1186/1471-2407-13-286 pmid:23764045 pmcid:PMC3693872 fatcat:7uamj3bqczdmbnbyx6lngzgovu

Prevalence of corneal arcus and associated factors in a German population—Results from the Gutenberg Health Study

Joanna Wasielica-Poslednik, Ulrike Hampel, Lisa Ries, Ruah Faysal, Andreas Schulz, Jürgen H. Prochaska, Philipp S. Wild, Irene Schmidtmann, Thomas Münzel, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer (+2 others)
2021 PLoS ONE  
Purpose We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. Methods The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus.
more » ... revalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. Results A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%– 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%– 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per μm, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Conclusions Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.
doi:10.1371/journal.pone.0255893 pmid:34547023 pmcid:PMC8454945 fatcat:cjpfaa27yff5diuqqedpn62xtm

Ambient Air Levels of Organochlorine Pesticides at Three High Alpine Monitoring Stations: Trends and Dependencies on Geographical Origin

Manfred Kirchner, Gert Jakobi, Wolfgang Körner, Walkiria Levy, Wolfgang Moche, Bernhard Niedermoser, Marcus Schaub, Ludwig Ries, Peter Weiss, Felix Antritter, Norbert Fischer, Bernhard Henkelmann Bernhard Henkelmann (+1 others)
2016 Aerosol and Air Quality Research  
Exposed XAD-2 cartridges (were Soxhlet-extracted by using a mixture of nhexane/acetone (3:1) after spiking with 13 C-chloropesticide standards (pentachlorobenzene 13 C 6 , α-HCH 13 C 6 , γ-HCH 13 C 6 , β-HCH 13 C 6 , δ-HCH 13 C 6 , PCA 13 C 6 , HCB 13 C 6 , heptachlor 13 C 10 , aldrin 13 C 12 , OCS 13 C 6 , oxy-chlordane 13 C 10 , cis-heptachloroepoxide 13 C 10 , 2,4'-DDE 13 C 12 , 4,4'-DDE 13 C 12 , trans-chlordane 13 C 12 , endosulfan-I 13 C 9 , endosulfan-II 13 C 9 ,
doi:10.4209/aaqr.2015.04.0213 fatcat:pgo2j44b3jgodpfjxvspfxvfku

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes

Bettina Grismayer, Sumito Sato, Charlotte Kopitz, Christian Ries, Susanne Soelch, Manfred Schmitt, Gustavo Baretton, Achim Krüger, Thomas Luther, Matthias Kotzsch, Viktor Magdolen
2012 Biological chemistry  
Expression of one of the upregulated genes encoding the matrix metalloproteinase MMP-9 was further analyzed at the protein level (Ries et al. , 2007 ) .  ... 
doi:10.1515/hsz-2012-0206 pmid:23667902 fatcat:phc7632idbdxxd74zv2xk2qiaa

Improved Search for Neutron to Mirror-Neutron Oscillations in the Presence of Mirror Magnetic Fields with a Dedicated Apparatus at the PSI UCN Source

Nicholas J. Ayres, Zurab Berezhiani, Riccardo Biondi, Georg Bison, Kazimierz Bodek, Vira Bondar, Pin-Jung Chiu, Manfred Daum, Reza Tavakoli Dinani, Cornelis B. Doorenbos, Solange Emmenegger, Klaus Kirch (+13 others)
2022 Symmetry  
While the international nEDM collaboration at the Paul Scherrer Institut (PSI) took data in 2017 that covered a considerable fraction of the parameter space of claimed potential signals of hypothetical neutron (n) to mirror-neutron (n′) transitions, it could not test all claimed signal regions at various mirror magnetic fields. Therefore, a new study of n−n′ oscillations using stored ultracold neutrons (UCNs) is underway at PSI, considerably expanding the reach in parameter space of mirror
more » ... tic fields (B′) and oscillation time constants (τnn′). The new apparatus is designed to test for the anomalous loss of stored ultracold neutrons as a function of an applied magnetic field. The experiment is distinguished from its predecessors by its very large storage vessel (1.47 m3), enhancing its statistical sensitivity. In a test experiment in 2020 we have demonstrated the capabilities of our apparatus. However, the full analysis of our recent data is still pending. Based on already demonstrated performance, we will reach sensitivity to oscillation times τnn′/cos(β) well above a hundred seconds, with β being the angle between B′ and the applied magnetic field B. The scan of B will allow the finding or the comprehensive exclusion of potential signals reported in the analysis of previous experiments and suggested to be consistent with neutron to mirror-neutron oscillations.
doi:10.3390/sym14030503 fatcat:xi6mika6bvegbooxywveujuqrq
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