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By Erich Ries, revised, enlarged, and edited by Manfred Gersch. B. G. Teubner Verlagsgesellschaft, Leipzig. DM. 24.40. viii + 552 pp. + 12 pl; text ill. 1953. ... The differences between the Hans Ris ...doi:10.1086/400113 fatcat:niyiwj27drdr7gviqh27ycduwa
RIES, U. TROTTENBERG, AND 6. ...doi:10.1016/0024-3795(83)90091-5 fatcat:pmf4rw3iobhajfnjyfcgez5bae
While meningiomas are known as slow-growing extracerebral neoplasms, the subgroup of secretory meningiomas with histologically benign characteristics tend to cause disproportional peritumoral edema, frequently leading to severe medical and neurological complications in postoperative management. Among 1,484 meningiomas that were resected at our institution between 1990 and 2007, 44 (3%) patients were found to have the histological diagnosis of a secretory meningioma. The clinical course,doi:10.1215/15228517-2008-109 pmid:19066343 pmcid:PMC2802401 fatcat:nigcsojtizaqhmejd6thipta7i
more »... ical appearance, and histopathological features were retrospectively analyzed to examine the specifics of these benign lesions. Meningiomas were located at the convexity (n 5 14), the cranial base (18), and the sphenoid ridge (12). A severe, nearly hemispheric perifocal edema disproportional to tumor size was seen on preoperative MR imaging in 18 (41%) patients. Following surgical resection, the postoperative course was uneventful in 29 patients. In 15 patients, severe peritumoral edema continued or even increased on postoperative CT imaging. Six patients showed midline shift and clinical worsening necessitating respirator-assisted ventilation and intracranial pressure monitoring. An association between the extent of brain edema and number of periodic acid Schiff-positive pseudopsammomas was found (p , 0.02). Further, the size of the edema correlated with the number of immunohistochemically detected cells expressing carcinoembryonic antigen (CEA) and cytokeratin (CK) (p , 0.01). Mean MIB-1 (Ki-67 antigen) proliferation index was 3.0% (range, 0%-17%) and did not correlate with edema or tumor recurrence. Secretory meningiomas are frequently associated with severe peritumoral edema. The extent of edema correlates with immunohistochemically detected expression of CEA and CK. Extended perifocal edema in meningiomas is an unusual finding and should alert the neurosurgeon that surgery may aggravate edema excessively, leading to a life-threatening postoperative situation. Neuro-Oncology 10, 819-824, 2008 (Posted to Neuro-Oncology [serial online], Doc. D08-00240, December 9, 2008
Consequently, one arrives at the following specification for the logarithm of the demand for medical care: (l2c) In M ri = k z +u 3 In W,; -u 3 In p';M +u 4 X ti +ust; +u 6 Y ri + In H ri +v ri ' where ... and, after replacing In 1t~: (22) drc~( ) M In-a M =In l-u 3 +u 3 lnW ri -u 3 lnP ri +u 4 X ri • Pri Furthermore, the second term on the right hand side of equation (12b) can be transformed as follows ...doi:10.1002/hec.4730040303 pmid:7550768 fatcat:bx5dufbonvcg3mb2hor6hstaku
Additionally, a recently reported variant of MMP-9, MMP-9D, was also investigated (Ries et al., 2007) . ... proMMP-9 and proMMP-2 was performed by exposure to 1 mM 4amino-phenylmercuric acetate for 2 h at 378C, and proMMP-9D was autocatalytically activated by treatment for 1 h at 378C as described previously (Ries ...doi:10.1515/bc.2010.055 pmid:20302517 fatcat:vglxkiszvbe4ln6iqimfqcw6sq
Lecture Notes in Computer Science
iDataCool is an HPC architecture jointly developed by the University of Regensburg and the IBM Research and Development Lab B\"oblingen. It is based on IBM's iDataPlex platform, whose air-cooling solution was replaced by a custom water-cooling solution that allows for cooling water temperatures of 70C/158F. The system is coupled to an adsorption chiller by InvenSor that operates efficiently at these temperatures. Thus a significant portion of the energy spent on HPC can be recovered in the formdoi:10.1007/978-3-642-38750-0_29 fatcat:e4onkkozp5bhtadw3k24ws5t7i
more »... of chilled water, which can then be used to cool other parts of the computing center. We describe the architecture of iDataCool and present benchmarks of the cooling performance and the energy (reuse) efficiency.
Lecture Notes in Computer Science
Expressive models of the work processes performed in the chemical and process industries provide a basis for diverse applications like work process documentation, analysis, and enactment. In this contribution, we present a generic modeling language for different types of work processes to allow for their integrated representation in the life cycle of a chemical plant. Further, the generic language allows for extensions specific to certain types of work processes. For two important types -designdoi:10.1007/978-3-642-17322-6_28 fatcat:ipabvoxq2rgnzpe6iya5yn4a2q
more »... and operational processes -such extensions have been elaborated. These extensions enable the adequate representation of the context of a work process that strongly depends on the process type: for instance, the specification of a chemical plant is a product of a design process, whereas the plant takes the role of a resource during an operational process. This contribution also briefly introduces a modeling tool developed by our group for applying the modeling language in industrial practice.
BMC Public Health
While numerous studies highlight the relevance of socio-cultural factors influencing incidence and prevalence of obesity, only a few address how obese people perceive causes and prevention of or intervention for obesity. This study contributes to a more thorough understanding of subjective aetiologies and framing themes for a mainly understudied but promising field. Thus it may serve for the development of effective public health strategies to combat obesity. Methods: Autobiographically baseddoi:10.1186/1471-2458-14-977 pmid:25239081 pmcid:PMC4177709 fatcat:lhadyyrpebholnxt6iv6nxsjcy
more »... -depth interviews were conducted with 20 patients (adolescents and young adults) institutionalised in the obesity rehabilitation centre INSULA in Bischofswiesen (Germany). The data were analysed with Atlas.ti with regard to two main perspectives: (1) How the interviewees perceive 'their' obesity from a subjective point of view and (2) which conclusions they draw from their own 'story' concerning prevention/ intervention strategies. Results: The interviewees did not indicate a clear starting point for their overweight. Nevertheless, certain life-events (e.g. divorce or illness of parents) were identified as catalysing weight gain. As a consequence of coping with distress, body weight rises rapidly and not continuously. Obesity was generally framed as a problem primarily located within the family and not in the wider environment. Corresponding to this, the family was identified as the main and most important addressee of preventive measures. The interviewees highlighted the importance of personal responsibility as a prerequisite for self-determined action against obesity, but denied any link between responsibility and guilt. Conclusions: This study contributes substantially to a broader perspective on the prevention of obesity. First, more attention has to be paid to the interactions of medical aspects and the social dimension of obesity. Second, prevention efforts should be more aware of the relevance of subjective aetiology when it comes to the definition of reasonable and effective governance strategies in tackling obesity. Third, current assumptions concerning the importance of personal responsibility for obesity prevention might underestimate the relevance of self-determined action of the obese.
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector inducing invasion and metastasis of tumor cells that express the Met tyrosine kinase receptor. One of the effectors of HGF/SF is the urokinase-type plasminogen activator, a serine protease that facilitates tumor progression and metastasis by controlling the synthesis of the extracellular matrix degrading plasmin. Stimulation of NIH 3T3 cells that were stably transfected with the human Met receptor (NIH 3T3-Met hum ) withdoi:10.1074/jbc.274.23.16377 pmid:10347197 fatcat:u56xj2ubx5gxpktgcg4b6kqk6a
more »... HGF/SF induced a trans-activation of the urokinase promoter and urokinase secretion. Induction of the urokinase promoter by HGF/SF via the Met receptor was blocked by co-expression of a dominant-negative Grb2 and Sos1 expression construct. Further, the expression of the catalytically inactive mutants of Ha-Ras, RhoA, c-Raf, and Erk2 or addition of the Mek1-specific inhibitor PD 098059 abrogated the stimulation of the urokinase promoter by HGF/SF. A sequence residing between ؊2109 and ؊1870 base pairs (bp) was critical for stimulation of the urokinase gene by HGF/SF. Mobility shift assays with oligonucleotides spanning an AP-1 site at ؊1880 bp or a combined PEA3/AP-1 site at ؊1967 bp showed binding of nuclear factors from NIH 3T3-Met hum cells. Expression of an expression plasmid that inhibits DNA binding of AP-1 proteins (A-Fos) abrogated inducible and basal activation of the urokinase promoter. Nuclear extract from unstimulated NIH 3T3-Met hum cells contained more JunD and showed a stronger JunD supershift with the AP-1 oligonucleotides, compared with HGF/SF-stimulated cells. Consistent with the levels of JunD expression being functionally important for basal expression of the urokinase promoter, we found that overexpression of wild type JunD inhibited the induction of the urokinase promoter by HGF/SF. These data suggest that the induction of urokinase by HGF/SF is regulated by a Grb2/Sos1/Ha-Ras/c-Raf/RhoA/Mek1/ Erk2/c-Jun-dependent mitogen-activated protein kinase pathway.
BMC Research Notes
Improper oligonucleotides were removed in quality control using the same flags as in the Agilent Feature Extraction tool: oligonucleotides were removed if gIsSaturated = 1 or rIs-Saturated = 1 to exclude ...doi:10.1186/s13104-017-2886-0 pmid:29110683 pmcid:PMC5674747 fatcat:tcpvt2dvunceln5o3cm74dtqxe
Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Methods: Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin indoi:10.1186/1471-2407-13-286 pmid:23764045 pmcid:PMC3693872 fatcat:7uamj3bqczdmbnbyx6lngzgovu
more »... tumor cell lines. Results: HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Conclusion: Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors.
Purpose We aimed to determine the prevalence of corneal arcus and to identify associated factors in the general population of Germany. Methods The Gutenberg Health Study (GHS) is a population-based cohort study in Germany, which includes an ophthalmological assessment. Refraction, distance-corrected visual acuity, non-contact tonometry and anterior segment imaging were performed for the five-year follow-up examination. Anterior segment photographs were graded for the presence of corneal arcus.doi:10.1371/journal.pone.0255893 pmid:34547023 pmcid:PMC8454945 fatcat:cjpfaa27yff5diuqqedpn62xtm
more »... revalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. Results A total of 9,850 right and 9,745 left eyes of 9,858 subjects (59.2±10.8 years), 49.0% females were included in this cross-sectional analysis. 21.1% of men (95%-CI: 20.0%– 22.3%) had a corneal arcus in at least one eye, and 16.9% (95%-CI: 15.9%– 18.0%) of women. In multivariable analyses, the presence of corneal arcus was associated with male gender (OR = 0.54 for female, p<0.0001), higher age (OR = 2.54 per decade, p<0.0001), smoking (OR = 1.59, p<0.0001), hyperopia (OR = 1.05 per diopter, p<0.0001), thinner cornea (OR = 0.994 per μm, p<0.0001), higher IOP (OR = 1.02, p = 0.039), higher HDL-C-level (OR = 2.13, p<0.0001), higher LDL-C-level (OR = 1.21, p<0.0001), and intake of lipid modifying agents (OR = 1.26, p = 0.0001). Arcus was not associated with socio-economic status, BMI, arterial blood pressure, and HbA1c. Conclusions Corneal arcus is a frequent alteration of the cornea in Germany and is associated with ocular parameters and systemic parameters of dyslipidemia.
Exposed XAD-2 cartridges (were Soxhlet-extracted by using a mixture of nhexane/acetone (3:1) after spiking with 13 C-chloropesticide standards (pentachlorobenzene 13 C 6 , α-HCH 13 C 6 , γ-HCH 13 C 6 , β-HCH 13 C 6 , δ-HCH 13 C 6 , PCA 13 C 6 , HCB 13 C 6 , heptachlor 13 C 10 , aldrin 13 C 12 , OCS 13 C 6 , oxy-chlordane 13 C 10 , cis-heptachloroepoxide 13 C 10 , 2,4'-DDE 13 C 12 , 4,4'-DDE 13 C 12 , trans-chlordane 13 C 12 , endosulfan-I 13 C 9 , endosulfan-II 13 C 9 ,doi:10.4209/aaqr.2015.04.0213 fatcat:pgo2j44b3jgodpfjxvspfxvfku
Expression of one of the upregulated genes encoding the matrix metalloproteinase MMP-9 was further analyzed at the protein level (Ries et al. , 2007 ) . ...doi:10.1515/hsz-2012-0206 pmid:23667902 fatcat:phc7632idbdxxd74zv2xk2qiaa
While the international nEDM collaboration at the Paul Scherrer Institut (PSI) took data in 2017 that covered a considerable fraction of the parameter space of claimed potential signals of hypothetical neutron (n) to mirror-neutron (n′) transitions, it could not test all claimed signal regions at various mirror magnetic fields. Therefore, a new study of n−n′ oscillations using stored ultracold neutrons (UCNs) is underway at PSI, considerably expanding the reach in parameter space of mirrordoi:10.3390/sym14030503 fatcat:xi6mika6bvegbooxywveujuqrq
more »... tic fields (B′) and oscillation time constants (τnn′). The new apparatus is designed to test for the anomalous loss of stored ultracold neutrons as a function of an applied magnetic field. The experiment is distinguished from its predecessors by its very large storage vessel (1.47 m3), enhancing its statistical sensitivity. In a test experiment in 2020 we have demonstrated the capabilities of our apparatus. However, the full analysis of our recent data is still pending. Based on already demonstrated performance, we will reach sensitivity to oscillation times τnn′/cos(β) well above a hundred seconds, with β being the angle between B′ and the applied magnetic field B. The scan of B will allow the finding or the comprehensive exclusion of potential signals reported in the analysis of previous experiments and suggested to be consistent with neutron to mirror-neutron oscillations.
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