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Radiation-Induced Fibrosarcoma After Radiotherapy for Osteosarcoma in the Mandibular Condyle

Makoto Adachi, Toshinori Iwai, Makoto Hirota, Iwai Tohnai
2012 The Journal of craniofacial surgery (Print)  
With recent improvements in survival duration after cancer treatment, it is becoming increasingly important to study treatment-related morbidity and mortality. Radiation-induced sarcomas in the irradiated field are well-known potential late sequelae of radiotherapy. These tumors are biologically aggressive. In the case described here, a radiation-induced fibrosarcoma appeared at 20 years after initial surgery, radiotherapy, and chemotherapy for an osteosarcoma of the mandibular condyle.
more » ... n-induced fibrosarcoma is relatively rare in the head and neck region. The details of this case are presented, and diagnostic and management considerations are described. Abstract: Parry-Romberg syndrome is a disease characterized by progressive hemifacial atrophy. Multiple surgical procedures have been used to improve the facial volume and contours of patients with this disease, including alloplastic, silicone, or collagen implants; lipofilling; and pedicled or free-flap transplants. The present case describes the successful application of lipostructure to treat a woman with Parry-Romberg syndrome affecting the left side of her face.
doi:10.1097/scs.0b013e31826cf893 pmid:23172499 fatcat:6fi5pgwqzfaurovmpv4tgbkkaq

Catheter placement via the occipital artery to achieve superselective intra-arterial chemotherapy for oral cancer

Toshinori Iwai, Kenji Mitsudo, Takafumi Fukui, Junichi Baba, Masayoshi Uezono, Yoshihito Ohara, Shihomi Shoji, Sachiyo Mitsunaga, Makoto Adachi, Kei Watanuki, Shinsuke Ohta, Hiroshi Chikumaru (+3 others)
2008 Toukeibu Gan  
Fukui, Junichi Baba, Masayoshi Uezono, Yoshihito Ohara, Shihomi Shoji, Sachiyo Mitsunaga, Makoto Adachi, Kei Watanuki, Shinsuke Ohta, Hiroshi Chikumaru, Makoto Hirota, Yoshiro Matsui and Iwai Tohnai Department  ...  キーワード:超選択的動注化学療法,口腔癌,カテーテル留置術,後頭動脈,3D-CT アンギオグラフィー Catheter placement via the occipital artery to achieve superselective intra-arterial chemotherapy for oral cancer : Toshinori Iwai, Kenji Mitsudo, Takafumi  ... 
doi:10.5981/jjhnc.34.508 fatcat:m5beay2a5jhrvc6adqqoumuwwa

Use of methylene blue for precise peripheral ostectomy of keratocystic odontogenic tumour

Toshinori Iwai, Makoto Hirota, Jiro Maegawa, Iwai Tohnai
2011 British Journal of Oral and Maxillofacial Surgery  
All rights reserved. doi:10.1016/j.bjoms.2011.02.Iwai et al. / British Journal of Oral and Maxillofacial Surgery xxx (2011) xxx.e1-xxx.e2 Fig. 2 . 2 Complete removal of the dyed area of the bone.  ...  Iwai). neoplastic tissue, additional peripheral ostectomy is strongly recommended. 3 Incomplete removal after peripheral ostectomy seems to result from technical difficulty when surgeons cannot identify  ... 
doi:10.1016/j.bjoms.2011.02.008 pmid:21450379 fatcat:norhcawagjcqdls22w6g6hgvuu

Isolation of Novel Actinomycetes from Spider Materials

Kimika Iwai, Susumu Iwamoto, Kazuo Aisaka, Makoto Suzuki
2009 Actinomycetologica  
Indeed, new species of the genera Friedmanniella (Iwai et al., in press) and Microlunatus (Iwai et al., submitted) were discovered. (Hayakawa et al., 2000) .  ... 
doi:10.3209/saj.saj230103 fatcat:7bc7hngivzdshbnfvgyqe4tz6a

A Case of Benign Clear Cell Tumor of the Lung
肺のbenign clear cell tumorの1例

Shigetoshi Yoshida, Hideki Kimura, Naomichi Iwai, Makoto Suzuki, Yutaka Yamaguchi, Makoto Matsuzaki
1997 Haigan  
A Case of Benign Clear Cell Tumor of the Lung Shigetoshi Yoshida, Hideki Kimura* , Naomichi Iwai* Makoto Suzuki, Yutaka Yamaguchi and Makoto Matsuzaki** Department of Surgery, Institute  ... 
doi:10.2482/haigan.37.99 fatcat:23hvf7sa45dubm7khqlhe3slbi

Bio-photosensor: Cyanobacterial photosystem I coupled with transistor via molecular wire

Nao Terasaki, Noritaka Yamamoto, Kaoru Tamada, Mineyuki Hattori, Takashi Hiraga, Akihiko Tohri, Ikutaro Sato, Masako Iwai, Michinao Iwai, Shunpei Taguchi, Isao Enami, Yasunori Inoue (+10 others)
2007 Biochimica et Biophysica Acta - Bioenergetics  
We report on the first successful output of electrons directly from photosystem I (PSI) of thermophilic cyanobacteria to the gate of a field-effect transistor (FET) by bypassing electron flow via a newly designed molecular wire, i.e., artificial vitamin K 1 , and a gold nanoparticle; in short, this newly manufactured photosensor employs a bio-functional unit as the core of the device. Photo-electrons generated by the irradiation of molecular complexes composed of reconstituted PSI on the gate
more » ... re found to control the FET. This PSI-bio-photosensor can be used to interpret gradation in images. This PSI-FET system is moreover sufficiently stable for use exceeding a period of 1 year.
doi:10.1016/j.bbabio.2006.11.008 pmid:17184727 fatcat:2jkvxj6ndvberm3xe5shvso5ba

Endoscopic Removal of a Maxillary Third Molar Displaced Into the Maxillary Sinus via the Socket

Toshinori Iwai, Yoshiro Matsui, Makoto Hirota, Iwai Tohnai
2012 The Journal of craniofacial surgery (Print)  
Endoscopic Removal of a Maxillary Third Molar Displaced Into the Maxillary Sinus via the Socket Toshinori Iwai, DDS,* Yoshiro Matsui, DDS, PhD,Þ Makoto Hirota, DDS, PhD,* Iwai Tohnai, DDS, PhD* Abstract  ... 
doi:10.1097/scs.0b013e318252f1cf pmid:22801156 fatcat:jtadcmwch5ebxobp2ob35ml464

Cleavage of specific sites of RNA by designed ribozymes

Makoto Koizumi, Shigenori Iwai, Eiko Ohtsuka
1988 FEBS Letters  
Two ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially paired oligoribonucleotides with chain lengths of 19 and 15. The other ribozyme, which consists of a 19-mer and a 13-mer, recognized a UC sequence at positions 42 and 43 of 5 S rRNA. Synthetic oligoribonucleotide; RNA enzyme; Endonucleolytic activity; RNA sequence recognition
doi:10.1016/0014-5793(88)80935-9 pmid:2460373 fatcat:jnvvuzumpzcjtkpqbjtcgqg5vi

Squamous Cell Carcinoma of the Tongue Dorsum: Incidence and Treatment Considerations

Makiko Okubo, Toshinori Iwai, Hideyuki Nakashima, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Kenji Mitsudo, Iwai Tohnai
2016 Indian Journal of Otolaryngology and Head & Neck Surgery  
Squamous cell carcinoma (SCC) of the tongue is the most common oral cancer. Most cases occur on the lateral border of the tongue and only very rarely on the dorsum. We retrospectively investigated the incidence of SCC of the tongue dorsum in our department between April 2006 and March 2015. Of the 368 patients with tongue cancer, only 3 had SCC of the tongue dorsum (incidence, 0.8 %). All patients with advanced cancer of the tongue dorsum underwent superselective intra-arterial
more » ... for organ preservation. We discuss the present findings in relation to past case reports and series in the English language literature as well as discuss treatments for SCC of the tongue dorsum.
doi:10.1007/s12070-016-0979-z pmid:28239570 pmcid:PMC5305651 fatcat:wqiirvjeuzghre6mvlvt2apwmy

A Case of Maxillary Ossifying Fibroma Treated by Navigation Surgery

2018 Japanese Journal of Oral Diagnosis / Oral Medicine  
IWAI TOHNAI) 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Department of Oral and Maxillofacial Surgery, Yokohama Municipal Citizen' s Hospital (Chief : Dr.  ...  Odontology, 98:181-184, 2010. 12)Iwai, T., Mikami, T., Yasumura, K., et al. : Use of Occlusal Splint for Noninvasive Fixation of a Reference Frame in Orbital Navigation Surgery.  ... 
doi:10.15214/jsodom.31.166 fatcat:bg33un6b6jhxpdzy6w74elvgeu

Ischemic Colitis

1976 Tohoku journal of experimental medicine  
doi:10.1620/tjem.118.suppl_127 fatcat:kkozqfaoendg5jkjaxbd2sbey4

Recognition of 2′-hydroxyl groups byEscherichia coliribonuclease HI

Shigenori Iwai, Shin Kataoka, Makoto Wakasa, Eiko Ohtsuka, Haruki Nakamura
1995 FEBS Letters  
In order to investigate the hydrogen-bonding interactions between Escherichia coli ribonuclease HI and the 2'-hydroxyl functions of the substrate, oligonucleotide duplexes containing 2'-amino-2'-deoxyuridine or 2'-fluoro-2'-deoxyuridine at a specific site were used, and their affinities for the enzyme were determined by kinetic analyses. The results indicate that the hydroxyl groups of the nueleoside 3'-adjacent to the cleaved phosphodiester linkage and the second nucleoside 5' to the cleaved
more » ... osphodiester act as both a proton donor and an acceptor and as a proton acceptor, respectively, in the enzyme-substrate complex. A molecular model was constructed using the interactions derived from the results.
doi:10.1016/0014-5793(95)00683-z pmid:7628629 fatcat:gqxmg7dpjnggpfrnooeskxfn64

A Case of Sialendoscope Removal of a Parenchymal Sialolith of the Submandibular Gland

2018 Japanese Journal of Oral Diagnosis / Oral Medicine  
AND IWAI TOHNAI Abstract:Recently, endoscopic removal of sialoliths has been introduced to avoid invasive surgery including submandibular sialoadenectomy.  ...  IWAI TOHNAI) 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. * Oral and Maxillofacial Surgery, The Nippon Dental University in Niigata Hospital(Chief : Dr.  ...  Ann Otol Rhinol Laryngol, 119:155-164, 2010. 15) Iwai, T., Matsui, Y., Yamagishi, M., et al. : Simple technique for dilatation of the papilla in sialoendoscopy.  ... 
doi:10.15214/jsodom.31.225 fatcat:l3gka7g325ghfdr5xeyrknwhr4

Chemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer

Toshiyuki Koizumi, Kenji Mitsudo, Senri Oguri, Toshinori Iwai, Sachiyo Mitsunaga, Tomohiro Iisaka, Mitomu Kioi, Makoto Hirota, Daichi Chikazu, Iwai Tohnai
2013 Toukeibu Gan  
Concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion demonstrates good local control and overall survival rates due to the advantage of simultaneous infusion of anticancer agent with the synergistic effects of chemotherapy and radiotherapy. This study was conducted to evaluate the therapeutic results of 17 patients with locally advanced squamous cell carcinoma of the upper gingiva (T3, T4) treated with definitive concurrent chemoradiotherapy using retrograde
more » ... selective intra-arterial infusion. Treatment consisted of superselective intra-arterial infusions (docetaxel, total 60mg/m 2 ; cisplatin, total 150mg/m 2 ) and daily concurrent radiotherapy (total 60 Gy) for 6 weeks. Patients underwent biopsy of the primary lesion and radiological examinations 4 weeks after the completion of all treatments. Complete response (CR) of the primary site was achieved in 14 (82.4%) patients. Among them, 1 patient showed local recurrence and 1 patient showed cervical and pulmonary metastases. Four patients died, 1 of pulmonary metastases, 1 of cervical metastases, and 2 of uncontrolled local lesion during follow-up. Two-year cumulative local control and overall survival rates by the Kaplan-Meier method were 76.5% and 81.4%, respectively. Key words: Squamous cell carcinoma of the upper gingiva, Retrograde superselective intra-arterial infusion, Chemoradiotherapy, Local control rate, Overall survival rate
doi:10.5981/jjhnc.39.443 fatcat:nxwdy2ydebehrmiul7xcc2ow3u

Evaluation of Influence Factors to Reduce Mechanical Stress on the Marginally Resected Mandibular Bone Against Dental Implant-supported Occlusion

Naohito Tamai, Makoto Hirota, Toshinori Iwai, Mitomu Kioi, Kenji Mitsudo, Iwai Tohnai
2018 Journal of Hard Tissue Biology  
This study aimed to evaluate the mechanical stress on resected mandibular bone against occlusal force using dental implant without any bone grafting by fi nite element analysis to reduce the risk of the bone fracture. A model of marginal resection of the symphysis of the mandible, in which the bone height of the region was 5, 10 or 15 mm, was prepared. Two, four, or six implant-supported fi xed prostheses (superstructure) or overdenture were set up in the model and loaded with 500N of occlusal
more » ... orce. The von Mises stress on the resected region was the highest when two implants were bilaterally placed at positions closest to the resected region. The von Mises stress value on the resected region could be high enough to induce the bone fracture. The mechanical stress was reduced up to < 50 % by adding implant at posterior position and connecting all implants. The presence of superstructure on 4 or 6 implants signifi cantly decreased the von Mises stress when the residual bone height was 10 or 15 mm. Use of 6 implants showed no signifi cant advantage at the stress reduction compared to use of 4 implants. When the residual bone height was 5 mm, reinforcement of the residual bone or bone graft should be considered to avoid the bone fracture. Although the present results were obtained under restrictive conditions, the number of implant, implant position, and prostheses style could reduce the von Mises stress and the risk of bone fracture on the resected region.
doi:10.2485/jhtb.27.11 fatcat:rrq4qdzeovbijktcb5gstcipey
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