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Maintenance and Manipulation in Spatial Working Memory: Dissociations in the Prefrontal Cortex

D.C. Glahn, J. Kim, M.S. Cohen, V-P. Poutanen, S. Therman, S. Bava, T.G.M. Van Erp, M. Manninen, M. Huttunen, J. Lönnqvist
2002 NeuroImage  
These results support claims that the dorsolateral prefrontal cortex is involved in the manipulation of internal representations and that the superior frontal sulcal region is involved in the maintenance  ...  In the second experiment, manipulation of spatial information held in working memory was contrasted with simple maintenance of that information.  ...  We thank UIla Mustonen, Pirjo Kä ki, and Eila Voipio for their contributions to subject recruitment and evaluation. D.C.G. was funded by a NIMH Postdoctoral Fellowship, NIMH MH14584.  ... 
doi:10.1006/nimg.2002.1161 pmid:12482077 fatcat:tq4pb4d43zfzhh73wxj3c7slgi

Dissociation and convergence of the dorsal and ventral visual working memory streams in the human prefrontal cortex

Emi Takahashi, Kenichi Ohki, Dae-Shik Kim
2013 NeuroImage  
Whether and to what extent dissociation exists in the human prefrontal cortex (PFC) has long been debated.  ...  Visual information is largely processed through two pathways in the primate brain: an object pathway from the primary visual cortex to the temporal cortex (ventral stream) and a spatial pathway to the  ...  This work was supported by National Institutes of Health (NS44825); the Human Frontiers Science Program; and the Uehara Memorial Foundation (Japan).  ... 
doi:10.1016/j.neuroimage.2012.10.002 pmid:23063444 pmcid:PMC4384683 fatcat:3vlte7bgzzecfkpgcrvbslupty

Transcranial Magnetic Stimulation Reveals Executive Control Dissociation in the Rostral Prefrontal Cortex

Weijiang He, Chenggui Fan, Ling Li
2017 Frontiers in Human Neuroscience  
Subjects performed a task-switching paradigm, which included spatial detection (SD), prospective memory (PM) and working memory (WM) tasks, after cTBS.  ...  Although previous studies have shown that the rostral prefrontal cortex (rPFC) plays a crucial role in executive tasks, the various functions of the rPFC in the humans are still understudied.  ...  ACKNOWLEDGMENTS This research was supported by grants from NSFC (61473062) the 111 project (B12027) and the Fundamental Research Funds for the Central Universities.  ... 
doi:10.3389/fnhum.2017.00464 pmid:28970790 pmcid:PMC5609102 fatcat:ssfn7a3irneqljklfccqadphra

Repetitive Transcranial Magnetic Stimulation Dissociates Working Memory Manipulation from Retention Functions in the Prefrontal, but not Posterior Parietal, Cortex

Bradley R. Postle, Fabio Ferrarelli, Massihullah Hamidi, Eva Feredoes, Marcello Massimini, Michael Peterson, Andrew Alexander, Giulio Tononi
2006 Journal of Cognitive Neuroscience  
& Understanding the contributions of the prefrontal cortex (PFC) to working memory is central to understanding the neural bases of high-level cognition.  ...  One question that remains controversial is whether the same areas of the dorsolateral PFC (dlPFC) that participate in the manipulation of information in working memory also contribute to its short-term  ...  in working memory.  ... 
doi:10.1162/jocn.2006.18.10.1712 pmid:17014375 fatcat:mhvtiyg4vncinnph3mptouxyb4

Mapping of the Underlying Neural Mechanisms of Maintenance and Manipulation in Visuo-Spatial Working Memory Using An n-back Mental Rotation Task: A Functional Magnetic Resonance Imaging Study

Gemma Lamp, Bonnie Alexander, Robin Laycock, David P. Crewther, Sheila G. Crewther
2016 Frontiers in Behavioral Neuroscience  
Mapping of the underlying neural mechanisms of visuo-spatial working memory (WM) has been shown to consistently elicit activity in right hemisphere dominant fronto-parietal networks.  ...  However, when the task involved maintaining and manipulating the same stimuli through 90 • rotation, activation was primarily seen in the bilateral parietal lobe and left fusiform gyrus.  ...  The authors also acknowledge the MRI department of the Brain Research Institute, Florey Institute of Neuroscience and Mental Health.  ... 
doi:10.3389/fnbeh.2016.00087 pmid:27199694 pmcid:PMC4858518 fatcat:6blhze6rx5b25nm5siycd7ojee

Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning

E. Koechlin, G. Corrado, P. Pietrini, J. Grafman
2000 Proceedings of the National Academy of Sciences of the United States of America  
Specifically, the posterior prefrontal cortex, in association with the premotor cortex, was found to subserve basic executive processes including the maintenance of information in mind over time (working  ...  In contrast, the anterior prefrontal cortex was shown to be engaged selectively in processes integrating working memory and task switching, i.e., holding temporarily in mind an ongoing task to complete  ...  Specifically, the posterior prefrontal cortex, in association with the premotor cortex, was found to subserve basic executive processes including the maintenance of information in mind over time (working  ... 
doi:10.1073/pnas.130177397 pmid:10852964 pmcid:PMC16600 fatcat:a34w7zg3szbeholpgmmu2lidhq

Dissociable Roles of the Medial Prefrontal Cortex and Nucleus Accumbens Core in Goal-Directed Actions for Differential Reward Magnitude

T. Michael Gill, Paulo J. Castaneda, Patricia H. Janak
2010 Cerebral Cortex  
The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) are 2 structures within a larger corticolimbic network mediating goal-directed actions, especially when the procurement of different goals  ...  In contrast, NAc-core lesions decreased the total amount of responding and total volume of reward earned without altering choice impulsivity across differing nosepoke durations and reward sizes.  ...  The authors wish to acknowledge and thank William Schairer for expert technical assistance with data program analysis and Dr Gemma Guillazo-Blanch for professional assistance with surgery and behavioral  ... 
doi:10.1093/cercor/bhq036 pmid:20308201 fatcat:uxqy2h6z7vgoxh665e7f7dkp5q

Content- and Task-Specific Dissociations of Frontal Activity during Maintenance and Manipulation in Visual Working Memory

H. M. Mohr
2006 Journal of Neuroscience  
Working memory, the short-term maintenance and manipulation of information, relies strongly on neural activity in the frontal cortex.  ...  Functional imaging studies in human participants have attempted to reveal neural correlates of the subdivision of visual working memory into different processes (maintenance vs manipulation) and according  ...  In the left frontal cortex, this dissociation followed a dorsoventral gradient, with dorsal premotor cortex more active during spatial and a region along the IFS during color working memory, regardless  ... 
doi:10.1523/jneurosci.5232-05.2006 pmid:16641225 pmcid:PMC6674080 fatcat:ptrioxlimbc53lsozdq7nfkxou

Neuroimaging analyses of human working memory

E. E. Smith, J. Jonides
1998 Proceedings of the National Academy of Sciences of the United States of America  
A first set of studies indicates that verbal working memory includes a storage component, which is implemented neurally by areas in the left-hemisphere posterior parietal cortex, and a subvocal rehearsal  ...  We focus on the executive process of inhibition as it is used in verbal working memory.  ...  Working memory (WM) allows humans (and other species) to maintain a limited amount of information in an active state for a brief period of time and to manipulate that information (1) .  ... 
doi:10.1073/pnas.95.20.12061 pmid:9751790 pmcid:PMC21765 fatcat:xyittwxajbg7zpz5gni4b6oydm

Double dissociation in neural correlates of visual working memory: A PET study

J. Ventre-Dominey, A. Bailly, F. Lavenne, D. LeBars, H. Mollion, N. Costes, P.F. Dominey
2005 Cognitive Brain Research  
cortex and the dorsal prefrontal cortex, and (2) The non spatial task activated a ventral stream network distributed in the left hemisphere in the temporo-occipital cortex, the ventral prefrontal cortex  ...  These results support the existence of a domain-specific dissociation with dorsal and ventral cortical systems involved respectively in spatial and non spatial working memory functions.  ...  assistance.This work has been funded by a CNRS grant (Cognition et Traitement de l'Information) and by LAFMI project.  ... 
doi:10.1016/j.cogbrainres.2005.09.004 pmid:16242922 fatcat:smndlqqlqrh33pgv2s6b3bncna

Neuroimaging studies of working memory:

Tor D. Wager, Edward E. Smith
2003 Cognitive, Affective, & Behavioral Neuroscience  
Analyses of material type showed the expected dorsal-ventral dissociation between spatial and nonspatial storage in the posterior cortex, but not in the frontal cortex.  ...  Working memory (WM), a system for actively maintaining and manipulating information, has been one of the most studied topics in cognitive psychology and cognitive neuroscience.  ...  In contrast, as has been described above, what emerged clearly from our analyses was a double dissociation between spatial maintenance in the parietal cortex (dorsal stream) and object maintenance in the  ... 
doi:10.3758/cabn.3.4.255 pmid:15040547 fatcat:cqvgmwt44zgipcbbk4hhloeawe

Distinguishing the Functional Roles of Multiple Regions in Distributed Neural Systems for Visual Working Memory

James V. Haxby, Laurent Petit, Leslie G. Ungerleider, Susan M. Courtney
2000 NeuroImage  
Moreover, the working memory regions could be distinguished from each other based on the relative strength of their participation in spatial and face working memory and on the relative strength of sustained  ...  Distinctions between functions, such as perception versus memory maintenance, or spatial versus face working memory, are a matter of the degree of participation of different regions, not the discrete parcellation  ...  Similarly, the distributions of cells in monkey prefrontal cortex that participate in spatial working memory, object working memory, or both spatial and object working memory overlap, and the degree of  ... 
doi:10.1006/nimg.2000.0592 pmid:10806025 fatcat:4k65femw35dnreajkwcj5giprq

Functional MRI studies of spatial and nonspatial working memory

M D'Esposito, G.K Aguirre, E Zarahn, D Ballard, R.K Shin, J Lease
1998 Cognitive Brain Research  
Single-unit recordings in monkeys have revealed neurons in the lateral prefrontal cortex that increase their firing during a delay between the presentation of information and its later use in behavior.  ...  A group and subgroup analysis revealed similarly located activation in right middle frontal gyrus Brodmann's area 46 in w x w both spatial and nonspatial working memory-control subtractions.  ...  Acknowledgements Supported by the McDonnell-Pew Program in Cognitive Neuroscience, the Charles A. Dana Foundation and NIH grants NS 01762 and AG13483.  ... 
doi:10.1016/s0926-6410(98)00004-4 pmid:9714705 fatcat:exik4loosvh67bf4yke6docbfm

The prefrontal cortex and working memory: physiology and brain imaging

Dick Passingham, Katsuyuki Sakai
2004 Current Opinion in Neurobiology  
Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys.  ...  We suggest that the key to prefrontal cortex lies not in the maintenance of sensory information but in the prospective use of that information for behaviour.  ...  Acknowledgements Our work is supported by the Wellcome Trust. K Sakai is supported by the Human Frontiers Science Programme. This paper is written in memory of Patricia Goldman-Rakic .  ... 
doi:10.1016/j.conb.2004.03.003 pmid:15082320 fatcat:iplkpq5gone3bhzozszrqegs2i

The primate working memory networks

2004 Cognitive, Affective, & Behavioral Neuroscience  
The neural mechanisms of memory maintenance and the integrative role of the prefrontal cortex are also discussed.  ...  Anatomical and physiological evidence suggests, however, that the prefrontal cortex is part of a broader network of interconnected brain areas involved in working memory.  ...  Lesion studies in humans and nonhuman primates reveal no clear deficits in working memory tasks after OFC lesions and, thereby, a strong functional dissociation between the OFC and the lateral prefrontal  ... 
doi:10.3758/cabn.4.4.444 pmid:15849890 pmcid:PMC3885185 fatcat:2avdapvlqzechgztmyslvihfpi
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