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Microfluidic Spun Alginate Hydrogel Microfibers and Their Application in Tissue Engineering

Tao Sun, Xingfu Li, Qing Shi, Huaping Wang, Qiang Huang, Toshio Fukuda
2018 Gels  
In this paper, we present an overview of the microfluidic spinning principle of alginate hydrogel microfibers and their application as micro-scaffolds or scaffolding elements for 3D assembly in tissue  ...  Tissue engineering is focusing on processing tissue micro-structures for a variety of applications in cell biology and the "bottom-up" construction of artificial tissue.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/gels4020038 pmid:30674814 pmcid:PMC6209268 fatcat:tqxtu2xyyffvhmp2hpz433xsra

3D Bioprinting for Tissue and Organ Fabrication

Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell'Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci, Rahmi Oklu (+1 others)
2016 Annals of Biomedical Engineering  
Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues.  ...  Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process.  ...  , R56AI105024), and the Presidential Early Career Award for Scientists and Engineers (PECASE).  ... 
doi:10.1007/s10439-016-1612-8 pmid:27126775 pmcid:PMC5085899 fatcat:anxu3tmznrbixaya75dwxlrm44

Tissue engineering toward organ-specific regeneration and disease modeling

Christian Mandrycky, Kiet Phong, Ying Zheng
2017 MRS Communications  
We highlight advances in tissue engineering approaches to enable the regeneration of complex tissue and organ substitutes, and provide tissue-specific models for drug testing and disease modeling.  ...  engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for  ...  Acknowledgments We acknowledge the financial support of National Institute of Health Grants DP2DK102258, UH2/UH3 TR000504, UH2DK107343, and RO1HL130488.  ... 
doi:10.1557/mrc.2017.58 pmid:29750131 pmcid:PMC5939579 fatcat:eyuco5opd5gk3fs46qz3c7ztvu

Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects

Xiaowen Wang, Zhen Wang, Wenya Zhai, Fengyun Wang, Zhixing Ge, Haibo Yu, Wenguang Yang
2021 Micromachines  
In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described.  ...  With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed  ...  Conflicts of Interest: The authors declare no conflict of interest. Micromachines 2022, 13, 75  ... 
doi:10.3390/mi13010075 pmid:35056239 pmcid:PMC8780533 fatcat:koltiylt5ng2fd5hp4fwxtilge

Advanced Bottom-Up Engineering of Living Architectures

Vítor M. Gaspar, Pedro Lavrador, João Borges, Mariana B. Oliveira, João F. Mano
2019 Zenodo  
Relevant advances in the bottom-up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular-rich structures or multicomponent cell–biomaterial synergies  ...  It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues  ...  hydrogels: i) the effective three-dimensionality of the intended patterns that ii) simultaneously enable the compatibility of the 3D-assembled hydrogels with cell encapsulation via cell adhesion, but  ... 
doi:10.5281/zenodo.6451076 fatcat:2gejvzrlz5hqfecwgnl6vmajgq

Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration

Clara R. Correia, Rui L. Reis, João F. Mano
2018 Zenodo  
The application of such principles in the TERM field brings new possibilities for the development of highly complex systems, which holds tremendous promise for tissue regeneration.  ...  Lessons afforded with encapsulation systems aiming to treat endocrine diseases seem to be highly valuable for the tissue engineering and regenerative medicine (TERM) systems of today, in which tissue regeneration  ...  ERC-2014-ADG-669858-ATLAS) for funding.  ... 
doi:10.5281/zenodo.6411249 fatcat:it5ucehlhzd4nfhzboirbjfbji

Spatially and temporally controlled hydrogels for tissue engineering

Jeroen Leijten, Jungmok Seo, Kan Yue, Grissel Trujillo-de Santiago, Ali Tamayol, Guillermo U. Ruiz-Esparza, Su Ryon Shin, Roholah Sharifi, Iman Noshadi, Mario Moisés Álvarez, Yu Shrike Zhang, Ali Khademhosseini
2017 Materials science & engineering. R, Reports  
Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well  ...  Spatial control of hydrogels Conventional hydrogels can be employed for fabrication of scaffolds, which provide biomimetic chemical and physical microenvironments for the embedded cells to regulate their  ...  For example, Gruene et al. utilized a cell-laden blend bioink composed of fibrinogen-HA to create a vascular-like network using stereolithography bioprinting for 3D assembly of multicellular arrays [180  ... 
doi:10.1016/j.mser.2017.07.001 pmid:29200661 pmcid:PMC5708586 fatcat:l45vlsq5dbcilpsw2vbggawvp4

Role of Biological Scaffolds, Hydro Gels and Stem Cells in Tissue Regeneration Therapy

Ravi Kant Upadhyay
2017 Advances in Tissue Engineering & Regenerative Medicine Open Access  
These engineered MSCs assist in making self-assembling supramolecular hydrogels, which have larger applications in cell therapy of intractable diseases and tissue regeneration.  ...  It also explains different scaffold types, polymer hydrogels which are necessary for formation of microstructure, cell attachment, differentiation, tissue vascularization and integration.  ...  (2D) coating and three-dimensional (3D) hydrogel platforms for culture and transplantation of primary hepatocytes.  ... 
doi:10.15406/atroa.2017.02.00020 fatcat:2ncta5zrmff7febj5diy4swoji

Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs

Aurelio Salerno, Giuseppe Cesarelli, Parisa Pedram, Paolo Antonio Netti
2019 Journal of Clinical Medicine  
Engineering three-dimensional (3D) scaffolds for functional tissue and organ regeneration is a major challenge of the tissue engineering (TE) community.  ...  The second part of this review article illustrates layer-by-layer modular scaffolds fabrication based on discontinuous, where layers' fabrication and assembly are split, and continuous processes.  ...  Morphological and histological analysis demonstrated the possibility to create a complete branching vascular network and direct SMCs growth into fiber-like bundles inside the microstructured channels.  ... 
doi:10.3390/jcm8111816 pmid:31683796 pmcid:PMC6912533 fatcat:fpg2u5vnefeflj2yunqwh3ec7i

Three-Dimensional Cell Culture Matrices: State of the Art

Jungwoo Lee, Meghan J. Cuddihy, Nicholas A. Kotov
2008 Tissue engineering. Part B, Reviews  
We also outline key challenges in this field and most likely directions for future development of 3D cell culture over the period of 5-10 years.  ...  Traditional methods of cell growth and manipulation on 2-dimensional (2D) surfaces have been shown to be insufficient for new challenges of cell biology and biochemistry, as well as in pharmaceutical assays  ...  the channels, which remodeled and matured the nascent vascular networks.  ... 
doi:10.1089/teb.2007.0150 pmid:18454635 fatcat:vk3f6tupsvagfatwhuisxy6h3q

Progress of 3D Bioprinting in Organ Manufacturing

Dabin Song, Yukun Xu, Siyu Liu, Liang Wen, Xiaohong Wang
2021 Polymers  
Three-dimensional (3D) bioprinting is a family of rapid prototyping technologies, which assemble biomaterials, including cells and bioactive agents, under the control of a computer-aided design model in  ...  The unique advantages of 3D bioprinting technologies for organ manufacturing have improved the traditional medical level significantly.  ...  They assembled a PEDOT nanostructure layer on the channel surface of the porous Cs-Gel scaffold to make a conductive PEDOT-Cs-Gel scaffold.  ... 
doi:10.3390/polym13183178 pmid:34578079 fatcat:yrwgihjkknctnikrwezk7linyq

3D Bioprinting for Organ Regeneration

Haitao Cui, Margaret Nowicki, John P. Fisher, Lijie Grace Zhang
2016 Advanced Healthcare Materials  
Three-dimensional (3D) bioprinting is evolving into an unparalleled bio-manufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities  ...  We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver.  ...  Acknowledgements This work is supported by NIH Director's New Innovator Award 1DP2EB020549-01, NSF BME program grant # 1510561, NSF MME program grant # 1642186 and March of Dimes Foundation's Gene Discovery  ... 
doi:10.1002/adhm.201601118 pmid:27995751 pmcid:PMC5313259 fatcat:5zeul6s3fvft3ew4iyicifyaqa

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

Awaji Y. Safhi
2022 Pharmaceuticals  
Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques.  ...  Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ph15060678 pmid:35745597 pmcid:PMC9229198 fatcat:ub64hs572jdt5np63kz4vntos4

From Shape to Function: The Next Step in Bioprinting

Riccardo Levato, Tomasz Jungst, Ruben G. Scheuring, Torsten Blunk, Juergen Groll, Jos Malda
2020 Advanced Materials  
Nevertheless, it remains largely unknown which materials and technical parameters are essential for the fabrication of intrinsically hierarchical cell-material constructs that truly mimic biologically  ...  At that time, the lack of printable materials that could serve as cell-laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint.  ...  , as demonstrated, for instance on hepatic constructs  ... 
doi:10.1002/adma.201906423 pmid:32045053 fatcat:hpwjy6takvfxvcp5c3gjy4prsu

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

Leslie Donoghue, Khanh T. Nguyen, Caleb Graham, Palaniappan Sethu
2021 Micromachines  
This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS.  ...  The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system).  ...  Schematic of modular microphysiological system. (a) Three-dimensional heart chip with cardiomyocytes (CMs) and stromal cells suspended in hydrogel between posts.  ... 
doi:10.3390/mi12020139 pmid:33525451 fatcat:d2gibw3eqvcj5e6qgawmdmgtea
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