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Microfluidic Spun Alginate Hydrogel Microfibers and Their Application in Tissue Engineering
2018
Gels
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In this paper, we present an overview of the microfluidic spinning principle of alginate hydrogel microfibers and their application as micro-scaffolds or scaffolding elements for 3D assembly in tissue ...
Tissue engineering is focusing on processing tissue micro-structures for a variety of applications in cell biology and the "bottom-up" construction of artificial tissue. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/gels4020038
pmid:30674814
pmcid:PMC6209268
fatcat:tqxtu2xyyffvhmp2hpz433xsra
3D Bioprinting for Tissue and Organ Fabrication
2016
Annals of Biomedical Engineering
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Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. ...
Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. ...
, R56AI105024), and the Presidential Early Career Award for Scientists and Engineers (PECASE). ...
doi:10.1007/s10439-016-1612-8
pmid:27126775
pmcid:PMC5085899
fatcat:anxu3tmznrbixaya75dwxlrm44
Tissue engineering toward organ-specific regeneration and disease modeling
2017
MRS Communications
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We highlight advances in tissue engineering approaches to enable the regeneration of complex tissue and organ substitutes, and provide tissue-specific models for drug testing and disease modeling. ...
engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for ...
Acknowledgments We acknowledge the financial support of National Institute of Health Grants DP2DK102258, UH2/UH3 TR000504, UH2DK107343, and RO1HL130488. ...
doi:10.1557/mrc.2017.58
pmid:29750131
pmcid:PMC5939579
fatcat:eyuco5opd5gk3fs46qz3c7ztvu
Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects
2021
Micromachines
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In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described. ...
With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed ...
Conflicts of Interest: The authors declare no conflict of interest. Micromachines 2022, 13, 75 ...
doi:10.3390/mi13010075
pmid:35056239
pmcid:PMC8780533
fatcat:koltiylt5ng2fd5hp4fwxtilge
Advanced Bottom-Up Engineering of Living Architectures
2019
Zenodo
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Relevant advances in the bottom-up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular-rich structures or multicomponent cell–biomaterial synergies ...
It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues ...
hydrogels: i) the effective three-dimensionality of the intended patterns that ii) simultaneously enable the compatibility of the 3D-assembled hydrogels with cell encapsulation via cell adhesion, but ...
doi:10.5281/zenodo.6451076
fatcat:2gejvzrlz5hqfecwgnl6vmajgq
Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration
2018
Zenodo
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The application of such principles in the TERM field brings new possibilities for the development of highly complex systems, which holds tremendous promise for tissue regeneration. ...
Lessons afforded with encapsulation systems aiming to treat endocrine diseases seem to be highly valuable for the tissue engineering and regenerative medicine (TERM) systems of today, in which tissue regeneration ...
ERC-2014-ADG-669858-ATLAS) for funding. ...
doi:10.5281/zenodo.6411249
fatcat:it5ucehlhzd4nfhzboirbjfbji
Spatially and temporally controlled hydrogels for tissue engineering
2017
Materials science & engineering. R, Reports
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Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well ...
Spatial control of hydrogels Conventional hydrogels can be employed for fabrication of scaffolds, which provide biomimetic chemical and physical microenvironments for the embedded cells to regulate their ...
For example, Gruene et al. utilized a cell-laden blend bioink composed of fibrinogen-HA to create a vascular-like network using stereolithography bioprinting for 3D assembly of multicellular arrays [180 ...
doi:10.1016/j.mser.2017.07.001
pmid:29200661
pmcid:PMC5708586
fatcat:l45vlsq5dbcilpsw2vbggawvp4
Role of Biological Scaffolds, Hydro Gels and Stem Cells in Tissue Regeneration Therapy
2017
Advances in Tissue Engineering & Regenerative Medicine Open Access
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These engineered MSCs assist in making self-assembling supramolecular hydrogels, which have larger applications in cell therapy of intractable diseases and tissue regeneration. ...
It also explains different scaffold types, polymer hydrogels which are necessary for formation of microstructure, cell attachment, differentiation, tissue vascularization and integration. ...
(2D) coating and three-dimensional (3D) hydrogel platforms for culture and transplantation of primary hepatocytes. ...
doi:10.15406/atroa.2017.02.00020
fatcat:2ncta5zrmff7febj5diy4swoji
Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs
2019
Journal of Clinical Medicine
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Engineering three-dimensional (3D) scaffolds for functional tissue and organ regeneration is a major challenge of the tissue engineering (TE) community. ...
The second part of this review article illustrates layer-by-layer modular scaffolds fabrication based on discontinuous, where layers' fabrication and assembly are split, and continuous processes. ...
Morphological and histological analysis demonstrated the possibility to create a complete branching vascular network and direct SMCs growth into fiber-like bundles inside the microstructured channels. ...
doi:10.3390/jcm8111816
pmid:31683796
pmcid:PMC6912533
fatcat:fpg2u5vnefeflj2yunqwh3ec7i
Three-Dimensional Cell Culture Matrices: State of the Art
2008
Tissue engineering. Part B, Reviews
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We also outline key challenges in this field and most likely directions for future development of 3D cell culture over the period of 5-10 years. ...
Traditional methods of cell growth and manipulation on 2-dimensional (2D) surfaces have been shown to be insufficient for new challenges of cell biology and biochemistry, as well as in pharmaceutical assays ...
the channels, which remodeled and matured the nascent vascular networks. ...
doi:10.1089/teb.2007.0150
pmid:18454635
fatcat:vk3f6tupsvagfatwhuisxy6h3q
Progress of 3D Bioprinting in Organ Manufacturing
2021
Polymers
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Three-dimensional (3D) bioprinting is a family of rapid prototyping technologies, which assemble biomaterials, including cells and bioactive agents, under the control of a computer-aided design model in ...
The unique advantages of 3D bioprinting technologies for organ manufacturing have improved the traditional medical level significantly. ...
They assembled a PEDOT nanostructure layer on the channel surface of the porous Cs-Gel scaffold to make a conductive PEDOT-Cs-Gel scaffold. ...
doi:10.3390/polym13183178
pmid:34578079
fatcat:yrwgihjkknctnikrwezk7linyq
3D Bioprinting for Organ Regeneration
2016
Advanced Healthcare Materials
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Three-dimensional (3D) bioprinting is evolving into an unparalleled bio-manufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities ...
We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. ...
Acknowledgements This work is supported by NIH Director's New Innovator Award 1DP2EB020549-01, NSF BME program grant # 1510561, NSF MME program grant # 1642186 and March of Dimes Foundation's Gene Discovery ...
doi:10.1002/adhm.201601118
pmid:27995751
pmcid:PMC5313259
fatcat:5zeul6s3fvft3ew4iyicifyaqa
Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives
2022
Pharmaceuticals
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Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques. ...
Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/ph15060678
pmid:35745597
pmcid:PMC9229198
fatcat:ub64hs572jdt5np63kz4vntos4
From Shape to Function: The Next Step in Bioprinting
2020
Advanced Materials
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Nevertheless, it remains largely unknown which materials and technical parameters are essential for the fabrication of intrinsically hierarchical cell-material constructs that truly mimic biologically ...
At that time, the lack of printable materials that could serve as cell-laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint. ...
, as demonstrated, for instance on hepatic constructs ...
doi:10.1002/adma.201906423
pmid:32045053
fatcat:hpwjy6takvfxvcp5c3gjy4prsu
Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
2021
Micromachines
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This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS. ...
The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system). ...
Schematic of modular microphysiological system. (a) Three-dimensional heart chip with cardiomyocytes (CMs) and stromal cells suspended in hydrogel between posts. ...
doi:10.3390/mi12020139
pmid:33525451
fatcat:d2gibw3eqvcj5e6qgawmdmgtea
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