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Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance

Tamar M. van Veenendaal, Walter H. Backes, Frank C.G. van Bussel, Richard A.E. Edden, Nicolaas A.J. Puts, Albert P. Aldenkamp, Jacobus F.A. Jansen
2018 Magnetic Resonance Imaging  
in the public portal.  ...  purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication  ...  Due to time restrictions, we did not acquire metabolite-nulled macromolecules spectra, to properly account for macromolecules in the LCModel analysis.  ... 
doi:10.1016/j.mri.2017.12.029 pmid:29306050 fatcat:422zgdkwc5ghzkybugghhh5bka

Normalizing data from GABA-edited MEGA-PRESS implementations at 3 Tesla

Ashley D. Harris, Nicolaas A.J. Puts, S. Andrea Wijtenburg, Laura M. Rowland, Mark Mikkelsen, Peter B. Barker, C. John Evans, Richard A.E. Edden
2017 Magnetic Resonance Imaging  
In GABA-edited MEGA-PRESS, two key sources of differences between implementations are: differences in editing efficiency of GABA and the degree of coediting of macromolecules (MM).  ...  In this work, GABA editing efficiency κ and MM-co-editing μ constants are determined for three widely used MEGA-PRESS implementations (on the most common MRI platforms; GE, Philips, and Siemens) by phantom  ...  GABA-edited MEGA-PRESS sequence.  ... 
doi:10.1016/j.mri.2017.04.013 pmid:28479342 pmcid:PMC5581667 fatcat:drmodbeseva35acwlylhu6unt4

MR Spectroscopy and Spectroscopic Imaging of the Brain [chapter]

He Zhu, Peter B. Barker
2010 Msphere  
They are also used in medical practice, although their ultimate clinical value continues to be a source of discussion.  ...  Magnetic resonance spectroscopy (MRS) and the related technique of magnetic resonance spectroscopic imaging (MRSI) are widely used in both clinical and preclinical research for the non-invasive evaluation  ...  Acknowledgments Supported in part by National Institutes of Health grant P41 RR015241.  ... 
doi:10.1007/978-1-61737-992-5_9 pmid:21279603 pmcid:PMC3416028 fatcat:6aomlwmp5jhtdnhbl36y7a474i

Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker

Kelley M. Swanberg, Karl Landheer, David Pitt, Christoph Juchem
2019 Frontiers in Neurology  
The use of 1H-MRS signals as diagnostic biomarkers depends on reproducible and generalizable sensitivity and specificity to disease state that can be confounded by a multitude of influences, including  ...  Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for querying potential diagnostic biomarkers of multiple sclerosis in living central nervous system tissue.  ...  Other short-and long-T E spectral acquisition sequences used have included PRESS with spectral editing (MEscher-GArwood Point-RESolved Spectroscopy or MEGA-PRESS) for GABA (107, 134, 150) , chemical shift  ... 
doi:10.3389/fneur.2019.01173 pmid:31803127 pmcid:PMC6876616 fatcat:mgvogazda5dmtjhqc6d4etcpd4

Corticolimbic hyper-response to emotion and glutamatergic function in people with high schizotypy: a multimodal fMRI-MRS study

G Modinos, A McLaughlin, A Egerton, K McMullen, V Kumari, G J Barker, C Keysers, S C R Williams
2017 Translational Psychiatry  
Examples are in PLOTs 9-11. To use these, you must read Sec 9.3. • MEGA-PRESS: Input SPTYPE = 'mega-press-3' for quantifying GABA [7] using MEGA-PRESS. To use this, you must read Sec 9.4.  ...  S/N is output in the "miscellaneous output" table (Sec 2.4). MEGA-PRESS for GABA This is for the MEGA-PRESS specified in [7] . PLOT 12 in $HOME/.lcmodel/doc/figures.pdf shows an example.  ...  Hints: Check for very poor data or spectral resolution. 7 (info) A regularized analysis in a refinement step has failed to properly converge. The final results should not be seriously affected.  ... 
doi:10.1038/tp.2017.53 pmid:28375210 pmcid:PMC5416694 fatcat:mcztrz7yovbmdj7sgzlm3mafk4

Is it Possible to Extract Metabolic Pathway Information from In Vivo H Nuclear Magnetic Resonance Spectroscopy Data? [article]

Alejandro Chinea Manrique de Lara
2010 arXiv   pre-print
Secondly, the dynamics of the signals are further analyzed using elements from chaos theory in order to understand their underlying structure.  ...  In vivo H nuclear magnetic resonance (NMR) spectroscopy is an important tool for performing non-invasive quantitative assessments of brain tumour glucose metabolism.  ...  González Mora for providing the NMR data used in this work.  ... 
arXiv:1008.2521v2 fatcat:cefjod6ccne3pedwz27qgg4lqq

Functional 1H MR spectroscopic investigations of pain processing in the human brain [article]

Marianne Cleve, Universitäts- Und Landesbibliothek Sachsen-Anhalt, Martin-Luther Universität, Jochen Balbach, Jürgen R. Reichenbach, Peter Bachert
being held responsible to cause disease, such as chronic pain.  ...  Beyond, functional 1H MRS (fMRS) is increasingly used to investigate changes in stimulation-induced metabolite concentrations with the aim to gain knowledge about the regulation of neurochemical processes  ...  In particular, when using 1 H MEGA-PRESS, drifts between the two initial different MR scans have to be accounted for to enable sufficient GABA quantitation.  ... 
doi:10.25673/2160 fatcat:nulz4hjt6nctvakbmwkblr6euu

Panel and Study Groups

2013 Neuropsychopharmacology  
Similarly, the switch from GABA being excitatory to inhibitory is mediated by relative ratios that favor NKCC1 prenatally to ones that favor KCC2 postnatally.  ...  GABA signaling abnormalities have been reported frequently in postmortem schizophrenia studies.  ...  For detection of GABA, spectra were acquired from the same voxel using macromolecule suppressed MEGA-PRESS: TR/TE=2000/68 ms, 14 ms editing pulses applied at 1.9 and 1.5 ppm, and 256 averages.  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

Investigation of the human brain neurochemistry in pain related cortical areas and brainstem

Nuno Miguel Prates De Matos
In the second study, we strived to make structures of the human brainstem accessible to functional 1 H-MRS investigations for the first time.  ...  The results revealed reduced concentrations in the total N-acetylaspartate and GABA signal during orofacial stimulation in the trigeminal nuclear complex.  ...  In addition, we would like to thank all volunteers who participated in the current study. Conflicts of Interest The authors declare that they have no conflict of interest.  ... 
doi:10.5167/uzh-168842 fatcat:bfr7tlidtrbvjfusbs24zcqmcm

Oral Presentations: Dietary interventions including probiotics, prebiotics and synbiotics

2017 Neurogastroenterology and Motility  
A water-suppressed MEGA-PRESS sequence (kindly provided by R.Edden, Johns Hopkins University) was used with a voxel (4.5×2.0×3.0 cm 3 ) placed in bilateral AIns.  ...  Methods: Metabolite concentrations for group comparisons of 35 female IBS patients with 20 age-matched healthy women were measured using a 3 T scanner and a MEGA-PRESS sequence with a 4.5×2×3 cm 3 voxel  ...  Similarly, the centrally expressed growth hormone secretagogue receptor 1a (GHSR1a) has been shown to be involved in appetite regulation and food intake, and more recently implicated in stress, anxiety  ... 
doi:10.1111/nmo.13180 pmid:28804938 fatcat:szg4wlshlzdatc5oiwsbrcazfu

Abstracts of the XXXIX Congress of the Spanish Society of Physiological Sciences (SECF), 18-21 September 2018, Cádiz, Spain

2018 Journal of physiology and biochemistry  
These studies will be presented in the form of plenary lectures, symposia, oral communications and posters including, for the first time, a special session for End-of-Degree projects of contrasted quality  ...  an environment in which to wake up the interest of the newly graduates in research.  ...  Neurogenesis, stem cells, PKC, brain injury P3-13 I N H I B I T I O N O F P R O T E I N K I N A S E C P R O M O T E S NEUROGENESIS IN INJURED BRAIN CORTEX N. , F. , S. Domínguez-García (1) , M.  ... 
doi:10.1007/s13105-018-0656-7 fatcat:3w2ixa34zzbxrdbm5hy6xyag5e

The stress-protectants and chemical chaperones ectoine and hydroxyectoine: enzymes, importer, exporter and transcriptional regulation

Laura Czech, Biologie, Bremer, Erhard (Prof. Dr.)
Ectoines are not only major stress protective compounds for microorganisms but their physicochemical attributes and function-preserving features also entailed their industrial production and use in the  ...  In the following paragraph the research subjects and major results of my PhD thesis will be briefly summarized: • Bioinformatical analysis focusing on the phylogenetic distribution of the genes for ectoine  ...  We are grateful to Vickie Koogle for her help in the language editing of our manuscript and to our colleague Lutz Schmitt (Institute of Biochemistry, Heinrich-Heine University Düsseldorf) for his kind  ... 
doi:10.17192/z2019.0527 fatcat:4crdba4ggrejzjuv2vkgrlk32i