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For example in the Sint-Maarten begging party tradition. Which originated from the past, where the poor would go to the doors of farmers to beg for food to survive the winter. ...arXiv:2004.12797v2 fatcat:ajo64rhd3fd6tbrz2nutk6bkey
The European Open Science Cloud (EOSC) enters a next phase of integration and consolidation with the establishment of a common service portal listing underpinning services that enable distributed resources in the areas of computation, data, open access, and above-the-net collaboration services. More than ever before, composition of services within the EOSC ecosystem will create mutual dependencies between service providers –in terms of not only quality management, provisioning, accounting anddoi:10.5281/zenodo.3674676 fatcat:4lstegvmanf5jjz2ez56dtztou
more »... ttlement, but specifically also in managing the attributes of trust: integrity, resilience, availability, and trust in the composition of services and their use. Trust management is enabled by establishing and maintaining essential capabilities providing the appropriate level of integrity, resilience, availability, and confidentiality of the involved services and data.
Many patients seek information online including on social media. To assess the quality of information regarding erectile dysfunction (ED) in YouTube videos. We searched "erectile dysfunction" on YouTube in October 2019 and evaluated the first 100 videos in English sorted by relevance. We recorded the user engagement, video producer, intended audience, and content. Videos containing medical information were evaluated using the Patient Education Materials Assessment Tool (PEMAT) and the DISCERNdoi:10.1016/j.esxm.2020.05.007 pmid:32593674 pmcid:PMC7471071 fatcat:npfl7x55gzg4rb4jv2i2kikvcq
more »... ality criteria for consumer health information. The PEMAT evaluates the understandability and actionability of materials as a percentage. The DISCERN assesses the quality of information by a scale from 1 (serious or extensive shortcomings) to 5 (minimal shortcomings). The median number of total views was 22,450 (range 591-20,255,133) and the median number of views/month was 654 (range 9-723,398). 42 percent of the videos were posted by professional medical institutions, and 21% were posted by individual medical professionals. Most videos were aimed at the general public or patients suffering from ED. The median PEMAT understandability and actionability scores were both 100% (range 50-100% and 33-100%, respectively). The median DISCERN score was 2 (range 1-5) with 80.4% receiving a score of ≤3. Overall, 28% of the videos contained direct misinformation. DISCERN scores were higher in videos produced by medical institutions (P = .0104), not selling specific products (P = .007) and not promoting alternative medicine (P = .0002). The number of subscribers was an independent predictor of views/month (P < .0001). Patients may be exposed to videos of poor quality when searching for information about ED on YouTube. The medical community needs to adapt a strategy to improve the quality of online medical information. Fode M, Nolsøe AB, Jacobsen FM, et al. Quality of Information in YouTube Videos on Erectile Dysfunction. J Sex Med 2020;XX:XXX-XXX.
Materials and Device Characterization in Micromachining II
Micromachined beams are commonly used to measure material properties in MEMS. Such measurements are complicated by the fact that boundary effects at the ends of the beams have a significant effect on the properties being measured. In an effort to improve the accuracy and resolution of such measurements, we are conducting a study of support post compliances in cantilever and fixed-fixed beams. Three different support post designs have been analyzed by finite element modeling. The results aredoi:10.1117/12.360480 fatcat:brflglpbpvhjboskgucj6gpvo4
more »... compared to measurements made on actual devices using interferometry. Using this technique, the accuracy of measurements of Young's modulus has been improved. Continuing work will also improve the measurement of residual stress.
Materials and Device Characterization in Micromachining II
We have designed, fabricated, tested and modeled a first generation small area test structure for MEMS fracture studies by electrostatic rather than mechanical probing. Because of its small area, this device has potential applications as a lot monitor of strength or fatigue of the MEMS structural material. By matching deflection versus applied voltage data to a 3-D model of the test structure, we develop high confidence that the local stresses achieved in the gage section are greater than 1doi:10.1117/12.360459 fatcat:g32gyy6q35bn3ifvj6zkt4dt2m
more »... Brittle failure of the polycrystalline silicon was observed.
words) DNA methylation is a stable covalent epigenetic modification of primarily CpG dinucleotides that has recently gained considerable attention for its use as biomarker in different clinical settings, including disease diagnosis, prognosis and therapeutic response prediction. Although the advent of genomewide DNA methylation profiling in primary disease tissue has provided a manifold resource for biomarker development, only a tiny fraction of DNA methylation-based assays have reacheddoi:10.2217/epi.14.43 pmid:25531255 fatcat:i7e5qrha5fcplkgqzbn2gb6tui
more »... testing. Here, we provide a critical overview of different analytical methods that are suitable for biomarker validation, including general study design considerations, which might help to streamline epigenetic marker development. Furthermore, we highlight some of the recent marker validation studies and established markers that are currently commercially available for assisting in clinical management of different cancers.
ORCID iD Maarten Wensink http://orcid.org/0000-0001-6518-1015 ...doi:10.1136/bmjopen-2021-053946 pmid:35354621 pmcid:PMC8968542 fatcat:p3sdtkernrbntgdfgqjyvb3ezi
Background. In urban Guinea-Bissau, adults with a vaccinia scar had better survival but also a higher prevalence of HIV-2 infection. We therefore investigated the association between vaccinia scar and survival and HIV infection in a rural area of Guinea-Bissau. Methodology/Principal Findings. In connection with a study of HIV in rural Guinea-Bissau, we assessed vaccinia and BCG scars in 193 HIV-1 or HIV-2 infected and 174 uninfected participants. Mortality was assessed after 2K-3 years ofdoi:10.1371/journal.pone.0000101 pmid:17183634 pmcid:PMC1762358 fatcat:xiufuld4vreupovse3hf6m22ne
more »... -up. The analyses were adjusted for age, sex, village, and HIV status. The prevalence of vaccinia scar was associated with age, village, and HIV-2 status but not with sex and schooling. Compared with individuals without any scar, individuals with a vaccinia scar had better survival (mortality rate ratio (MR) = 0.22 (95% CI 0.08-0.61)), the MR being 0.19 (95% CI 0.06-0.57) for women and 0.40 (95% CI 0.04-3.74) for men. Estimates were similar for HIV-2 infected and HIV-1 and HIV-2 uninfected individuals. The HIV-2 prevalence was higher among individuals with a vaccinia scar compared to individuals without a vaccinia scar (RR = 1.57 (95% CI 1.02-2.36)). Conclusion. The present study supports the hypothesis that vaccinia vaccination may have a non-specific beneficial effect on adult survival.
During the COVID-19 crisis there have been many difficult decisions governments and other decision makers had to make. E.g. do we go for a total lock down or keep schools open? How many people and which people should be tested? Although there are many good models from e.g. epidemiologists on the spread of the virus under certain conditions, these models do not directly translate into the interventions that can be taken by government. Neither can these models contribute to understand thearXiv:2004.12809v1 fatcat:vs7goyis4zayxby34ebrcc7xsm
more »... and/or social consequences of the interventions. However, effective and sustainable solutions need to take into account this combination of factors. In this paper, we propose an agent-based social simulation tool, ASSOCC, that supports decision makers understand possible consequences of policy interventions, bu exploring the combined social, health and economic consequences of these interventions.
Kongsfjorden, a fjord in north-western Svalbard, is characterized by large environmental gradients driven by meltwater processes along the margins of tidewater glaciers and the inflow of relatively warm Atlantic Water, the main heat source for the European Arctic. These factors make Kongsfjorden a key area to investigate changes in the polar climate-ocean-glacier system and to examine the resulting effects on the marine environment. The aim of this paper is to synthesize knowledge about thedoi:10.33265/polar.v38.3380 fatcat:p6u4q4k56vhfhek4hpfjpga2nu
more »... ne sedimentary environment in Kongsfjorden since the last deglaciation. Fjords act as natural sedimentary traps, archiving information about past and present environmental conditions and changes. Geological studies of Kongsfjorden have demonstrated a good potential for reconstructing palaeoenvironments and establishing baselines values for the natural climate changes in the Arctic. Palaeoceanographic reconstructions reveal rising water temperatures similar to modern temperatures ca. 12 000 years ago. The extent of warm Atlantic Water entering the fjords influences processes at, and the stability of, the margins of the tidewater glaciers. Enhanced inflow may cause accelerated glacial melting that, in consequence, leads to an increase in the sediment flux from the glacial catchments into the fjord, as observed ca. 12 000 years ago and at present. However, responses of sediment flux to modern environmental changes remain poorly understood, hence long-term and monitoring studies are needed to quantify and model the effects of climate warming on the sedimentary environment of Kongsfjorden.
Journal of Virology
We present the results of a 6-year study of 131 human immunodeficiency virus (HIV) type 2 (HIV-2)-infected individuals from a rural population in Guinea-Bissau. Proviral DNA sequences 1.3 kb in length were obtained from each individual and, together with clinical data, including proviral load and CD4 and CD8 levels, were used to assess whether viral genotype influences clinical outcome. With a phylogenetic model, a correlation was found between viral genotype and mortality; this correlation wasdoi:10.1128/jvi.72.10.7895-7899.1998 fatcat:uwtxzj52hja6bo7tbmjv7v3dzu
more »... not due to confounding factors, such as age-specific viral strains or cohabitation of patients. The data provide strong evidence for the involvement of viral genetic factors in determining HIV disease progression in vivo. The pattern of association found suggests that virulence factors are multiple and scattered throughout the HIV-2 genome and can be rapidly gained or lost by the virus through a combination of mutation and recombination. These findings may lead to the identification of viral determinants of HIV disease progression.
We present an implementation of analytical quantum mechanical molecular gradients within the polarizable embedding (PE) model to allow for efficient geometry optimizations and vibrational analysis of molecules embedded in large, geometrically frozen environments. We consider a variational ansatz for the quantum region, covering (multiconfigurational) self-consistent-field and Kohn-Sham density functional theory. As the first application of the implementation, we consider the internaldoi:10.1063/1.4905909 pmid:25612701 fatcat:mdeoidgamzey3el25agqgqyvum
more »... Stark effect of the C==O group of acetophenone in different solvents and derive its vibrational linear Stark tuning rate using harmonic frequencies calculated from analytical gradients and computed local electric fields. Comparisons to PE calculations employing an enlarged quantum region as well as to a non-polarizable embedding scheme show that the inclusion of mutual polarization between acetophenone and water is essential in order to capture the structural modifications and the associated frequency shifts observed in water. For more apolar solvents, a proper description of dispersion and exchange-repulsion becomes increasingly important, and the quality of the optimized structures relies to a larger extent on the quality of the Lennard-Jones parameters. C 2015 AIP Publishing LLC. [http://dx.
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