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MRI-based Multi-task Decoupling Learning for Alzheimer's Disease Detection and MMSE Score Prediction: A Multi-site Validation
[article]
2022
arXiv
pre-print
To comprehensively address this challenge, we propose a MRI-based multi-task decoupled learning method for AD detection and MMSE score prediction. ...
Accurately detecting Alzheimer's disease (AD) and predicting mini-mental state examination (MMSE) score are important tasks in elderly health by magnetic resonance imaging (MRI). ...
In this study, we propose a MRI-based multi-task decoupling learning (MTRL) method for AD detection and MMSE score prediction. The framework of our proposed method is shown in Fig. 1 . ...
arXiv:2204.01708v2
fatcat:4d4n2ctdjrbplnr6laqapt5ksa
Learning Multi-Modal Biomarker Representations via Globally Aligned Longitudinal Enrichments
2020
PROCEEDINGS OF THE THIRTIETH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE AND THE TWENTY-EIGHTH INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE CONFERENCE
Alzheimer's Disease (AD) is a chronic neurodegenerative disease that severely impacts patients' thinking, memory and behavior. ...
The learned global and local projections are aligned by a soft constraint and the structured-sparsity norm is used to uncover the multi-modal structure of heterogeneous biomarker measurements. ...
With the fixed-length biomarker representations, we can easily use conventional learning methods to predict the clinical outcomes for early AD detections. ...
doi:10.1609/aaai.v34i01.5426
fatcat:7ijhzfbt3rhg7h6n7g4bn2nvli
Neuro-symbolic Neurodegenerative Disease Modeling as Probabilistic Programmed Deep Kernels
[article]
2021
arXiv
pre-print
We run evaluations on the problem of Alzheimer's disease prediction, yielding results that surpass deep learning in both accuracy and timeliness of predicting neurodegeneration, and with the practical ...
We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. ...
The driving aim for longitudinal modeling Alzheimer's disease is to provide predictions that enable early detection of atrisk subjects and possibly reveal latent disease mechanisms. ...
arXiv:2009.07738v3
fatcat:snzegvlnyzdn3fibg56wsurbki
Abstracts Presented at the Thirty–Third Annual International Neuropsychological Society Conference, February 2–5, 2005, St. Louis, Missouri, USA
2005
Journal of the International Neuropsychological Society
s (2001) proposed validity curoff scores for malingering detection (F > 29, F-K > 18, or Ds2 > 35). ...
Further Validation of the Expanded Auditory Verbal Learning Test for Detecting Poor Effort and Malingering: Data from Temporal Lobectomy Candidates. ...
Subjects were excluded based on Mini-Mental Status Exam (MMSE) scores (<25) consistent with dementia. ...
doi:10.1017/s1355617705059916
fatcat:qu62kn3sqfgnlhda5oxtruv5wq
Final Program, Fortieth Annual Meeting International Neuropsychological Society February 15–18, 2012 Montréal, Québec, Canada
2012
Journal of the International Neuropsychological Society
In this symposium a panel of neuropsychologists will provide direction and insights towards developing a program of sustained externally funded research. ...
Comprised of senior faculty, members of the panel have successfully obtained NIH funding for their research, currently serve as reviewers on NIH grant panels, and have mentored junior scientists towards ...
) task and a color-based flanker task. ...
doi:10.1017/s1355617712000537
fatcat:4p2fkgxxzna3vcf3uxxgac6rsi
Poster Papers
1997
Brain and Cognition
Sensitivity, specificity, and predictive value (positive and negative) tests showed SRT, Trail Making A, and Digit Span to be the most robust differentiators between the two groups. ...
disease (PD) patients' performance in recognition was assessed with different paradigms aimed at detecting specific impairments that would not appear in traditional testing. ...
A., Smith, A. D.,Szatmari, M. et al. 1992. Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. ...
doi:10.1006/brcg.1997.0966
fatcat:tbidfsjdavfcrpvxzennx3wytm
A Novel Virtual Coaching System Based on Personalized Clinical Pathways for Rehabilitation of Older Adults—Requirements and Implementation Plan of the vCare Project
2020
Frontiers in Digital Health
Home-based rehabilitation after an acute episode or following an exacerbation of a chronic disease is often problematic with a clear lack of continuity of care between hospital and home care. ...
In this paper, we are presenting a novel virtual coaching system that will address these challenges by combining recent technological advances with clinical pathways, based on joint research and validation ...
AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. ...
doi:10.3389/fdgth.2020.546562
pmid:34713034
pmcid:PMC8521911
fatcat:2tufodfg4ndsld5wkkszktqld4
Poster Session 2, Monday 27 September
2010
European Journal of Neurology
There were no significant differences in DISC and APS scales. Conclusion: The MMSE-2 might be a good tool for detection and prediction of ICD in Parkinson's disease. ...
Discussion: Current risk stratification tools such as the ABCD2 and RRE-90 scores reliably predict stroke risk 14 and 90 days following a TIA but there is currently no validated tool for risk stratifying ...
Patients with incontinence symptom had lower MMSE-K scores than those with continent symptom. The QoL score showed a high correlation with the total IPSS score (p< 0.05). ...
doi:10.1111/j.1468-1331.2010.03233.x
fatcat:lsellp2xyvc77c7gr7qbzu6coi
1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints
2018
Journal of Proteome Research
of disease pathogenesis. ...
SF was aspirated from knee joints of 10 OA and 14 RA patients. 100 μL SF was analyzed using a 700 MHz Avance IIIHD Bruker NMR spectrometer with a TCI cryoprobe. ...
Jouko Vepsäläinen for his skillful guidance and his invaluable help in making this thesis finally rise from the lyophilized remains of CSF. Thank you. Additionally, I thank my other supervisors, Dr. ...
doi:10.1021/acs.jproteome.8b00455
pmid:30229649
pmcid:PMC6220363
fatcat:rh2c4czluzecza7bg7jevfivmq
CARS 2016—Computer Assisted Radiology and Surgery Proceedings of the 30th International Congress and Exhibition Heidelberg, Germany, June 21–25, 2016
2016
International Journal of Computer Assisted Radiology and Surgery
'', and Amazon Inc., for providing valuable computing resources through an ''AWS in Education Research'' grant. ...
Acknowledgments The authors wish to thank Fundación CEIBA and Alcaldía Mayor de Bogotá, for the financial support of Ricardo Mendoza's PhD studies through the scholarship program ''Becas Rodolfo Llinás ...
processes such as Alzheimer's disease and Multiple Sclerosis (MS). ...
doi:10.1007/s11548-016-1412-5
pmid:27206418
fatcat:uk5r46n2xvhedkfjzmeiweyneq
Design of large polyphase filters in the Quadratic Residue Number System
2010
2010 Conference Record of the Forty Fourth Asilomar Conference on Signals, Systems and Computers
We report the results of this analysis on 313 subjects from the Mild Cognitive Impairment group in the Alzheimer's Disease Neuroimaging Initiative (ADNI). ...
In this paper, we consider a macrocell site underlaid with self-organized stand-alone femtocells and propose a mechanism for macro-to-femtocell handover, inspired by multi-stage Dutch auction. ...
doi:10.1109/acssc.2010.5757589
fatcat:ccxnu5owr5fyrcjcqukumerueq
Poster Session I
2015
Neuropsychopharmacology
In this study, we evaluated whether ELS severity predicted GBC in subjects with a spectrum of ELS exposure. Methods: MRI images from 46 right-handed participants were used for this study. ...
predicted GBC. ...
Scans began with bolus injection of 475±210 MBq, and PET data were acquired for 120 min on a high resolution research tomograph (HRRT), featuring arterial blood sampling for measurement of the input function ...
doi:10.1038/npp.2015.325
pmid:26632286
pmcid:PMC4672310
fatcat:cqqyl6zydfeuxltv6zkqhn7qry
Poster Session II
2012
Neuropsychopharmacology
Z-scores ranging from n ¼ 228/481 (47%) for the visual learning task to n ¼ 393/481 (82%) for the verbal learning task. ...
They had MMSE scores 4 ¼ 24 and did not meet Petersen's criteria for MCI. ...
In recognition of this, we sought to develop an ecologically valid objective measure of motivation using virtual reality (VR) technology coupled with a progressive ratio task, where subjects work for reward ...
doi:10.1038/npp.2012.220
fatcat:coblfrtlujc6hdycjbnrdwzslm
ACRT-SCTS Scholar Abstracts
2010
Clinical and Translational Science
Control for potential confounding will be attempted using multi-variable adjustment, propensity score methods, and instrumental variable analysis. ...
For polymorphisms without a published meta-analysis we performed one de novo, using allele-based random effects models. ...
The objective of this study is to derive and validate a clinical prediction rule to identify patients at high risk for these events. ...
doi:10.1111/j.1752-8062.2010.00181_2.x
fatcat:lwvd6nteozgezazejeqpjupawu
Abstracts of the 4th World Parkinson Congress, September 20–23, 2016, Portland, OR, USA
2016
Journal of Parkinson's Disease
PD is a multi-system disorder and although dopaminergic replacement therapies are highly effective for ameliorating motor symptoms, other features of the disease require a more holistic approach. ...
Evidence-based treatments for speech changes in early PD, such as the Lee Silverman Voice Treatment (LSVT LOUD), exist. ...
obtained in a Phase 2a clinical trial for Alzheimer's disease (ANAVEXTM Life Science Corp). ...
doi:10.3233/jpd-169900
pmid:27589541
fatcat:ld522ggsvvceriigc4fi7e5g7q
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