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MR-Less High Dimensional Spatial Normalization of 11C PiB PET Images on a Population of Elderly, Mild Cognitive Impaired and Alzheimer Disease Patients [chapter]

Jurgen Fripp, Pierrick Bourgeat, Parnesh Raniga, Oscar Acosta, Victor Villemagne, Gareth Jones, Graeme O'keefe, Christopher Rowe, Sébastien Ourselin, Olivier Salvado
2008 Lecture Notes in Computer Science  
The approach was compared with MR NRR using data from healthy elderly, mild cognitive impaired and Alzheimer disease participants.  ...  We designed and evaluated a high dimensional spatial normalization approach that only uses the 11 C PiB PET image.  ...  Fig. 1 . 1 Four example spatially normalized 11 C PiB PET cases overlaid on the Colin atlas left Healthy elderly middle left mild cognitive impaired middle and far right Alzheimer's Fig. 2 . 2 Example  ... 
doi:10.1007/978-3-540-85988-8_53 fatcat:5rmq3x6tffdlnnew3xc577iy4a

Alzheimer Disease: New Concepts on Its Neurobiology and the Clinical Role Imaging Will Play

Clifford R. Jack
2012 Radiology  
Jack CR Jr, Lowe VJ, Senjem ML, et al. 11C PiB and structural MRI provide complemen- tary information in imaging of Alzheimer's disease and amnestic mild cog- nitive impairment.  ...  [11C]PIB in a nondemented population: po- tential antecedent marker of Alzheimer disease. Neurology 2006;67(3):446-452. 49. Aizenstein HJ, Nebes RD, Saxton JA, et al.  ... 
doi:10.1148/radiol.12110433 pmid:22517954 pmcid:PMC3329271 fatcat:kxtmmttn5bfzhlwd4gyklsvkxy

Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints

Kim JW, Byun MS, Yi D, Lee JH, Ko K, Jung G, Lee DY
2019 Neuropsychiatric Disease and Treatment  
brain imaging including [11C] Pittsburgh compound B positron emission tomography (PET), [18F] fluorodeoxyglucose-PET, and magnetic resonance imaging.  ...  (Aβ) deposition and neurodegeneration (ND) with subjective memory complaints (SMCs) in cognitively normal (CN) individuals, focusing specially on the modulating effects of vascular risk (VR) on those  ...  three-dimensional (3D) PiB-PET and 3D T1-weighted magnetic resonance (MR) imaging using a 3.0T Biograph mMR scanner (PET-MR scanner; Siemens, Washington DC, USA) according to the manufacturer’s approved  ... 
doaj:a3f5271276614b6c868fb322c92ed35b fatcat:hc7nlelaszbmrljxjn4mjhyafy

Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals

Ira Driscoll, Yun Zhou, Yang An, Jitka Sojkova, Christos Davatzikos, Michael A. Kraut, Weiguo Ye, Luigi Ferrucci, Chester A. Mathis, William E. Klunk, Dean F. Wong, Susan M. Resnick
2011 Neurobiology of Aging  
Amyloid-β plaques (Aβ) are a hallmark of Alzheimer's disease (AD), begin deposition decades before the incipient disease, and are thought to be associated with neuronal loss, brain atrophy and cognitive  ...  We examine associations between 11 C-PiB-PET measurement of Aβ burden and brain volume changes in the preceding years in 57 non-demented individuals (age 64-86; M = 78.7).  ...  Acknowledgments We thank the staff of the PET facility at Johns Hopkins University and the neuroimaging staff of the BLSA project National Institute on Aging (NIA) for their assistance. Dr.  ... 
doi:10.1016/j.neurobiolaging.2009.12.008 pmid:20176414 pmcid:PMC2908199 fatcat:w564legac5dj3f6fcbq745l3fe

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

S. F. Carter, M. Scholl, O. Almkvist, A. Wall, H. Engler, B. Langstrom, A. Nordberg
2012 Journal of Nuclear Medicine  
No other potential conflict of interest relevant to this article was reported. 4. Regional cortical and subcortical 18 F-FDG uptake in the MCI 11 C-PIB-, 11 C-MCI PIB1, and AD patients.  ...  Foundation, Karolinska Institutet foundations, the Swedish Brain Foundation, and the Alzheimer Foundation in Sweden.  ...  The current investigation is the first, to our knowledge, to use 11 C-DED, 11 C-PIB, and 18 F-FDG PET in a group of mild cognitive impairment (MCI) patients and mild AD patients.  ... 
doi:10.2967/jnumed.110.087031 pmid:22213821 fatcat:zfdblva4snczdmmjbpboz4np5i

Inflammation after trauma: Microglial activation and traumatic brain injury

Anil F. Ramlackhansingh, David J. Brooks, Richard J. Greenwood, Subrata K. Bose, Federico E. Turkheimer, Kirsi M. Kinnunen, Steve Gentleman, Rolf A. Heckemann, Karen Gunanayagam, Giorgio Gelosa, David J. Sharp
2011 Annals of Neurology  
Effective management demands a greater understanding of the changes taking place at a neuronal level.  ...  of Objectives: Neurodegeneration is an important pathological component hallmark of many neurological illnesses.  ...  Five patients at risk of, or affected by, prion disease underwent [11C]-PIB PET studies including one patient with vCJD who had a post-mortem examination 6 months following imaging.  ... 
doi:10.1002/ana.22455 pmid:21710619 fatcat:lrrjyvf5tnfjfl43fkmhnqed5e

New Molecular Targets for PET and SPECT Imaging in Neurodegenerative Diseases

Marcel Benadiba, Gert Luurtsema, Lauro Wichert-Ana, Carlos Alberto Buchpigel, Geraldo Busatto Filho
2012 Revista Brasileira de Psiquiatria  
computed tomography (SPECT) now allow the non-invasive tracking of such molecular targets of known relevance to ND in vivo. applications in regard to differential diagnosis of ND and monitoring of disease  ...  However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display -synuclein, positron emission tomography (PET) and single photon emission  ...  Acknowledgements We thank Janine Doorduin, PhD, Inês Farinha Antunes, PhD, and Andor Glaudemans, MD, for making available 11 C]PK11195, [ 18 F]FEAnGA and PIB PET Scans, respectively.  ... 
doi:10.1016/j.rbp.2012.07.002 pmid:23429844 fatcat:karjqbpq6bawroh5dwnwhya2fi

Amyloid and vascular cognitive impairment: A pilot study of frequency and impact

Elizabeth Dao, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Teresa Liu-Ambrose
2013 Alzheimer's & Dementia  
Twenty-four participants -18 participants with VCI and 6 normal controlscompleted PET imaging using Pittsburgh Compund-B (PiB) to quantify amyloid burden.  ...  To determine the effect of amyloid pathology on cognitive function we collected the following cognitive measures: 1) ADAS-Cog; 2) EXIT-25; and 3) Three executive processes including a) Digits Forward and  ...  Briefly, a series of healthy PiB-PET scans were normalized to one-another and then an average image was created. This PiB-PET image template was then normalized to the T1-MRI template.  ... 
doi:10.1016/j.jalz.2013.05.745 fatcat:q4xqhtmipbdtzcbxze526nwdre

Imaging the Alzheimer Brain

J. Wesson Ashford, Ahmad Salehi, Ansgar Furst, Peter Bayley, Giovanni B. Frisoni, Clifford R. Jack Jr, Osama Sabri, Maheen M. Adamson, Kerry L. Coburn, John Olichney, Norbert Schuff, Daniel Spielman (+14 others)
2011 Journal of Alzheimer's Disease  
., Principles of classification analyses in mild cognitive impairment (MCI) and Alzheimer Disease [189].  ...  ., Multiple diffusion indices reveals white matter degeneration in Alzheimer's disease and mild cognitive impairment: A tract-based spatial statistics [162] .  ... 
doi:10.3233/jad-2011-0073 pmid:21971448 pmcid:PMC3760773 fatcat:ppczzkpe6rb5tanbygwnzgyr3m

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Johan Luthman, John C. Morris (+7 others)
2015 Alzheimer's & Dementia  
The initial study, ADNI-1, enrolled 400 subjects with early mild cognitive impairment (MCI), 200 with early AD, and 200 cognitively normal elderly controls.  ...  fluid (CSF) biomarkers in a multicenter setting; (2) elucidation of the patterns and rates of change of imaging and CSF biomarker measurements in control subjects, MCI patients, and AD patients.  ...  Weiner has served on the scientific advisory boards for Lilly, Araclon and Institut Catala de Neurociencies Aplicades, Gulf War Veterans Illnesses Advisory Committee, VACO, Biogen Idec, and Pfizer; has  ... 
doi:10.1016/j.jalz.2014.11.001 pmid:26073027 pmcid:PMC5469297 fatcat:2k7ag6astffy5gphqxf5lodkdq

Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images

Shengwen Guo, Chunren Lai, Congling Wu, Guiyin Cen
2017 Frontiers in Aging Neuroscience  
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI).  ...  Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI).  ...  FUNDING This study was partly supported by the National Natural Science Foundation of China (31371008), Science and Technology Planning Project of Guangdong Province (2015A02024006), Guangzhou Bureau of  ... 
doi:10.3389/fnagi.2017.00146 pmid:28572766 pmcid:PMC5435825 fatcat:txc3t7f5nvctpcjtaiv5p2t77e

A review of β-amyloid neuroimaging in Alzheimer's disease

Paul A. Adlard, Bob A. Tran, David I. Finkelstein, Patricia M. Desmond, Leigh A. Johnston, Ashley I. Bush, Gary F. Egan
2014 Frontiers in Neuroscience  
In this review we summarize the main efforts of neuroimaging in AD in humans and in mouse models, with a specific focus on β-amyloid, and discuss the potential of new applications and novel approaches.  ...  Neuroimaging has enabled in vivo visualization of pathological changes in the brain associated with the disease, providing a greater understanding of its pathophysiological development and progression.  ...  Furthermore, it is now evident that patients who will develop AD may present as a subset of people with mild cognitive impairment (MCI).  ... 
doi:10.3389/fnins.2014.00327 pmid:25400539 pmcid:PMC4215612 fatcat:265nreraargevcyzu4cvjaikvq

The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations

E Cavedo, S Lista, Z Khachaturian, P Aisen, P Amouyel, K Herholz, C R Jack, R Sperling, J Cummings, K Blennow, S O'Bryant, G B Frisoni (+19 others)
2014 The journal of prevention of Alzheimer's disease  
of AD dementia, mild cognitive impairment (MCI) due to AD, prodromal AD and preclinical AD.  ...  The revised diagnostic criteria for "prodromal AD" and "mild cognitive impairment due to AD" include hippocampal atrophy (as the fourth validated biomarker), which is considered an indicator of regional  ...  Hospital ; the International Genomics of Alzheimer's Project (IGAP) is supported by the French National Foundation on Alzheimer's disease and related disorders and the Alzheimer's Association.  ... 
doi:10.14283/jpad.2014.32 pmid:26478889 pmcid:PMC4606938 fatcat:fwioj6jy2ved7eq4ggacwe56mm

Early and Presenting Symptoms of Dementia with Lewy Bodies

Eirik Auning, Arvid Rongve, Tormod Fladby, Jan Booij, Tibor Hortobágyi, Françoise J. Siepel, Clive Ballard, Dag Aarsland
2011 Dementia and Geriatric Cognitive Disorders  
Emission Tomography (FDG-PET) in patient with subjective (SCI) and mild (MCI) cognitive impairment.  ...  Using PET scanning with the 11C-labeled Pittsburg compound B (PiB-PET), a benzothiazole derivative of Thioflavin T, allows for the estimation of amyloid levels in the living brain.  ... 
doi:10.1159/000333072 pmid:22095040 fatcat:madmb22wh5csblnu2wxzy4vyfa

Arizona battery of communication disorders of dementia for evaluation of cognitive impairment in PD and early diagnosis of PDD. [Proceeding]

Dionysios Tafiadis, Messinis Labros, Chondrogiorgi Maria, Konitsiotis Spyridon, Nasios Grigorios
2017 Figshare  
Proceeding @ 10th Panhellenic Conference on Alzheimer's Disease and Related Disorders and 2nd Mediterranean Conference on Neurodegenerative Diseases  ...  Bibliography Acknowledgements Athens Alzheimer Association of Alzheimer's Disease and Related Disorders appreciate the information that the innovAge WP3 consortium has provided for this article.  ...  Cortical and cognitive development in 4th, 8th and 12th grade students. The contribution of speed of processing and executive functioning to cognitive development. Biol Psychol 1992; 48: 37-56.  ... 
doi:10.6084/m9.figshare.5260198.v2 fatcat:74dsspsfejcfvaed472xnoid7y
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