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MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures

M. Saha, M. Levitt, W. Chiu
2010 Bioinformatics  
We present a new, first-of-its-kind, fully automated computational tool MOTIF-EM for identifying regions or domains or motifs in cryoEM maps of large macromolecular assemblies (such as chaperonins, viruses  ...  MOTIF-EM takes cryoEM volumetric maps as inputs. The technique used by MOTIF-EM to detect conserved sub-structures is inspired by a recent breakthrough in 2D object recognition.  ...  In this article we present a new fully automated first-of-its-kind computational tool MOTIF-EM, which is meant to solve an important structural comparison problem P.  ... 
doi:10.1093/bioinformatics/btq195 pmid:20529921 pmcid:PMC2881380 fatcat:gitcpe66erexvojwbac7wt6jpq

Three dimensional electron microscopy and in silico tools for macromolecular structure determination

Subhomoi Borkotoky, Chetan Kumar Meena, Mohammad Wahab Khan, Ayaluru Murali
2013 EXCLI Journal : Experimental and Clinical Sciences  
Combining the 3DTEM data with in silico tools, one can have better refined structure of a desired complex.  ...  Recently, structural biology witnessed a major tool - electron microscopy - in solving the structures of macromolecules in addition to the conventional techniques, X-ray crystallography and nuclear magnetic  ...  ACKNOWLEDGEMENT Ayaluru Murali thanks University Grants Commission, New Delhi (India) for financial support.  ... 
pmid:27092033 pmcid:PMC4827587 fatcat:sny5lwvfnbckhpk3n2anh7dx7q

Three dimensional electron microscopy and in silico tools for macromolecular structure determination

Subhomoi Borkotoky, Mohammad Wahab Khan, Chetan Kumar Meena, Ayaluru Murali, Technische Universität Dortmund, Technische Universität Dortmund
2013
Combining the 3DTEM data with in silico tools, one can have better refined structure of a desired complex.  ...  Recently, structural biology witnessed a major tool – electron microscopy – in solving the structures of macromolecules in addition to the conventional techniques, X-ray crystallography and nuclear magnetic  ...  ACKNOWLEDGEMENT Ayaluru Murali thanks University Grants Commission, New Delhi (India) for financial support.  ... 
doi:10.17877/de290r-10753 fatcat:3o5c25gnjnaofbffaca7f72e5m