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Momo – Multi-Objective Metabolic mixed integer Optimization: application to yeast strain engineering [article]

Ricardo Andrade, Mahdi Doostmohammadi, João L. Santos, Marie-France Sagot, Nuno P. Mira, Susana Vinga
2018 biorxiv/medrxiv   pre-print
AbstractIn this paper, we explore the concept of multi-objective optimization in the field of metabolic engineering when both continuous and integer decision variables are involved in the model.  ...  The multi-objective programming framework we developed, called Momo, is open-source and uses PolySCIP‡ as underlying multi-objective solver. Momo is available at http://momo-sysbio.gforge.inria.fr  ...  Ethics approval and consent to participate Not applicable. Consent for publication  ... 
doi:10.1101/476689 fatcat:da4wmo6wlngwboxtnqute7o3gm

MOMO - multi-objective metabolic mixed integer optimization: application to yeast strain engineering

Ricardo Andrade, Mahdi Doostmohammadi, João L. Santos, Marie-France Sagot, Nuno P. Mira, Susana Vinga
2020 BMC Bioinformatics  
In this paper, we explore the concept of multi-objective optimization in the field of metabolic engineering when both continuous and integer decision variables are involved in the model.  ...  requirements in microbial metabolic engineering.  ...  Ethics approval and consent to participate Not applicable. Consent for publication  ... 
doi:10.1186/s12859-020-3377-1 pmid:32093622 pmcid:PMC7041195 fatcat:vhwjsffogrfc7jrpurna2nu7xi

Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006)

2006 Neuroscience research  
To measure "value", we have developed a probability matching paradigm for monkeys in which the animal's valuation is revealed through the proportion of choices allocated to alternative behaviors.  ...  In neurophysiological recordings, we have found that neurons in the lateral intraparietal area (LIP) code value, although LIP is unlikely to be the site where value is originally computed.  ...  Acknowledgments We wish to thank Professor Miyashita for valuable advice.  ... 
doi:10.1016/j.neures.2006.04.004 fatcat:mja5yvu2tbcjrmfx3a7abvvicm

On-demand Presentation

2022 Nippon Saikingaku Zasshi  
However, some Escherichia coli strains, including Shiga toxinproducing E. coli O157:H7, are known to be resistant to tellurite. This resistance is involved in ter operon.  ...  To clarify the characteristics of the ter operon, we examined 106 E. coli strains carrying the ter operon from various animals.  ...  Integ. Sci. Life., Hiroshima Univ.) analysis of multi-drug resistance genes in M. tuberculosis using CRISPR interference ○Nao 3, ○Tadashi Shimamoto 2 ( 1 Lab. Food Microbiol. Hyg., Sch. Appl. Biol.  ... 
doi:10.3412/jsb.77.58 pmid:35185075 fatcat:eulr5inwjfd4blqkzhuokpdhey

抄録

2017 Regulation of Plant Growth & Development  
To elucidate targeted genes, the screening for yeast mutants resistant against momilactones is underway using a set of fi ssion yeast strains that overexpress each gene in the whole genome.  ...  Thus, modifying the application of NMN can be used to optimize the defence signalling pathways activated in response to F. graminearum and facilitates the control of disease injury and mycotoxin accumulation  ...  To investigate oxidative stress signal transduction mechanism by 2-hexenal, we used pharmacological and reverse genetics analysis.  ... 
doi:10.18978/jscrp.52.supplement_15 fatcat:nynhe4hwcff3joarxbyihbwhbi