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MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics [article]

Sean L. Wu, Jared B. Bennett, Hector M. Sanchez C., Andrew J. Dolgert, Tomas M. Leon, John M. Marshall
2020 bioRxiv   pre-print
Example MGDrivE 2 simulations are presented to demonstrate the application of the framework to a CRISPR-based homing gene drive system intended to drive a disease-refractory gene into a population, incorporating  ...  We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): an extension of and development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures  ...  Example MGDrivE 2 simulations for a population replacement gene drive system designed to drive a malaria-refractory gene into an An. gambiae s.l. mosquito population with seasonal population dynamics and  ... 
doi:10.1101/2020.10.16.343376 fatcat:5xnj6hy4affb7n5peqbr5kxsge

MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics

Sean L Wu, Jared B Bennett, Héctor M Sánchez C, Andrew J Dolgert, Tomás M León, John M Marshall
2021 PLoS Computational Biology  
We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): a significant development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures  ...  Example MGDrivE 2 simulations are presented to demonstrate the application of the framework to a CRISPR-based split gene drive system intended to drive a disease-refractory gene into a population in a  ...  Acknowledgments We thank Sandra Hui for discussions on software development and Fausto Bustos for input on the epidemiological model. Author Contributions  ... 
doi:10.1371/journal.pcbi.1009030 pmid:34019537 pmcid:PMC8186770 fatcat:q3ew77lgljdtbgd7baeou73llu

Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

Héctor M Sánchez C, Jared B Bennett, Sean L Wu, Gordana Rašić, Omar S Akbari, John M Marshall
2020 BMC Biology  
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale,  ...  Our analysis supports the use of translocations as a threshold-dependent drive system capable of spreading disease-refractory genes into Ae. aegypti populations in a confineable and reversible manner.  ...  Tomás León, and Ms. Partow Imani for discussions on Aedes aegypti life history and dispersal behavior.  ... 
doi:10.1186/s12915-020-0759-9 pmid:32398005 pmcid:PMC7218562 fatcat:n5e44bupwzbq5i46oxzad5phfi