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MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics
[article]
2020
bioRxiv
pre-print
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Example MGDrivE 2 simulations are presented to demonstrate the application of the framework to a CRISPR-based homing gene drive system intended to drive a disease-refractory gene into a population, incorporating ...
We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): an extension of and development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures ...
Example MGDrivE 2 simulations for a population replacement gene drive system designed to drive a malaria-refractory gene into an An. gambiae s.l. mosquito population with seasonal population dynamics and ...
doi:10.1101/2020.10.16.343376
fatcat:5xnj6hy4affb7n5peqbr5kxsge
MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics
2021
PLoS Computational Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
We present MGDrivE 2 (Mosquito Gene Drive Explorer 2): a significant development from the MGDrivE 1 simulation framework that investigates the population dynamics of a variety of gene drive architectures ...
Example MGDrivE 2 simulations are presented to demonstrate the application of the framework to a CRISPR-based split gene drive system intended to drive a disease-refractory gene into a population in a ...
Acknowledgments We thank Sandra Hui for discussions on software development and Fausto Bustos for input on the epidemiological model.
Author Contributions ...
doi:10.1371/journal.pcbi.1009030
pmid:34019537
pmcid:PMC8186770
fatcat:q3ew77lgljdtbgd7baeou73llu
Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations
2020
BMC Biology
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A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, ...
Our analysis supports the use of translocations as a threshold-dependent drive system capable of spreading disease-refractory genes into Ae. aegypti populations in a confineable and reversible manner. ...
Tomás León, and Ms. Partow Imani for discussions on Aedes aegypti life history and dispersal behavior. ...
doi:10.1186/s12915-020-0759-9
pmid:32398005
pmcid:PMC7218562
fatcat:n5e44bupwzbq5i46oxzad5phfi