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MARK1 - A Decision Support System for the Early Detection of Malignant Melanoma

Konstantinos Perakis, Thanassis Bouras, Spiros Kostopoulos, Konstantinos Sidiropoulos, Lior Wayn, Hagit Timor
2014 Proceedings of the 4th International Conference on Wireless Mobile Communication and Healthcare - "Transforming healthcare through innovations in mobile and wireless technologies"   unpublished
Early stage detection of melanoma (one of the most common cancers today) is of major significance for increasing chances of long term survival of affected patients.  ...  The main objective of the present paper is to present the conceptual architecture of a platform that can address the need for early and accurate detection of skin lesion through a screening solution that  ...  Israel Call for Proposals for Joint R&D Projects, the main objective of which is to launch projects with joint participation from the two countries.  ... 
doi:10.4108/icst.mobihealth.2014.257247 fatcat:dqit5fxa2rfpdb5ndlr3mischi

Design of a decision support system, trained on GPU, for assisting melanoma diagnosis in dermatoscopy images

Dimitris Glotsos, Spiros Kostopoulos, Stella Lalissidou, Konstantinos Sidiropoulos, Pantelis Asvestas, Christos Konstandinou, George Xenogiannopoulos, Eirini Konstantina Nikolatou, Konstantinos Perakis, Thanassis Bouras, Dionisis Cavouras
2015 Journal of Physics, Conference Series  
The purpose of this study was to design a decision support system for assisting the diagnosis of melanoma in dermatoscopy images.  ...  This could assist towards early detection of melanoma cases, if suspicious moles were to be captured on smartphone by patients and be transferred to the physician together with an assessment of the mole's  ...  (NSRF) 2007-2013, concerning the project "MARK1" with ref. number (ISR_3233) within the Bilateral Cooperation between Greece & Israel action.  ... 
doi:10.1088/1742-6596/633/1/012079 fatcat:fxvzcdpu4naqvgnkqxqc2tkbpu


Spiros Kostopoulos, Dimitris Glotsos, Pantelis Asvestas, Christos Konstandinou, George Xenogiannopoulos, Konstantinos Sidiropoulos, Eirini-Konstantina Nikolatou, Konstantinos Perakis, Spyros Mantzouratos, Theophilos Sakkis, George Sakellaropoulos, George Nikiforidis (+1 others)
2016 Image Analysis and Stereology  
Malignant melanoma represents the most dangerous type of skin cancer.  ...  In this study we present an ensemble classification scheme, employing the mutual information, the cross-correlation and the clustering based on proximity of image features methods, for early stage assessment  ...  In this study, we present a decision support system for melanoma detection, which attempts to guide patients to meaningful alerts regarding the urgency for a physician visit and safeguard physicians' decisions  ... 
doi:10.5566/ias.1446 fatcat:ucwah2dbpjh2xgzvdxbg34iwne

Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer

Linda D. Mellby, Andreas P. Nyberg, Julia S. Johansen, Christer Wingren, Børge G. Nordestgaard, Stig E. Bojesen, Breeana L. Mitchell, Brett C. Sheppard, Rosalie C. Sears, Carl A.K. Borrebaeck
2018 Journal of Clinical Oncology  
Conclusion This serum biomarker signature might represent a tenable approach to detecting early-stage, localized PDAC if these findings are supported by a prospective validation study.  ...  Therefore, we used multiparametric analysis of blood samples to obtain a novel biomarker signature of early-stage PDAC.  ...  Hospital, for blood samples (Danish BIOPAC Biobank and the Copenhagen General Population Study).  ... 
doi:10.1200/jco.2017.77.6658 pmid:30106639 pmcid:PMC6161836 fatcat:df3ti5d34rdt7k3xaydmcjipee

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

J. Xia, P. Jia, K. E. Hutchinson, K. B. Dahlman, D. Johnson, J. Sosman, W. Pao, Z. Zhao
2014 Molecular Cancer Therapeutics  
This meta-analysis provides a road map for the study of additional potentially actionable genes in both driver mutation-positive and pan-negative melanomas. Mol Cancer Ther; 13(7); 1918-28.  ...  Next generation sequencing (NGS) has been used to characterize the overall genomic landscape of melanomas.  ...  Acknowledgments The authors thank the members of the Bioinformatics and Systems Medicine Laboratory for their valuable discussion in this project.  ... 
doi:10.1158/1535-7163.mct-13-0804 pmid:24755198 pmcid:PMC4090262 fatcat:ujywyulqljbthpdh32lwcxrhc4

miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment

Conti, Varano, Simioni, Laface, Milani, Rimondi, Neri
2020 Cells  
Cancer cells cooperate with stromal cells and elements of the extracellular matrix (ECM) to establish a comfortable niche to grow, to evade the immune system, and to expand.  ...  We also review growing evidence suggesting the use of miRNAs as novel targets or potential tools for therapeutic applications.  ...  Acknowledgments: The authors are grateful to Eva Costanzi and Cinzia Brenna for the helpful collaboration. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cells9010220 pmid:31952362 pmcid:PMC7016744 fatcat:22siafqf2nhxndwla5yj5hafg4

Tumor-Derived Exosomes in Tumor-Induced Immune Suppression

Qiongyu Hao, Yong Wu, Yanyuan Wu, Piwen Wang, Jaydutt V. Vadgama
2022 International Journal of Molecular Sciences  
Herein, we provide a review of the latest research progress on TEX in the context of tumor-mediated immune suppression and discuss the potential as well as challenges of TEX as a target of immunotherapy  ...  The immune system defenses, which may initially restrict tumor progression, are progressively blunted by the broad array of TEX molecules that activate suppressive pathways in different immune cells.  ...  cells and supports the functional effects of TEX as a means for the tumor to manipulate its environs [114] .  ... 
doi:10.3390/ijms23031461 pmid:35163380 pmcid:PMC8836190 fatcat:mmwhxlvb55axdpydoqufn5vw7u

Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling

Martim Dias Gomes, Sandra Iden
2021 EMBO Journal  
Recent findings on the role of polarity signalling for tissue mechanics, micro-environmental functions and fate choices in health and disease will be summarized.  ...  While polarity-dependent fate decisions in mammals utilize molecular machineries similar to invertebrates, the hierarchies and effectors can differ widely.  ...  Acknowledgements We thank all members of the Iden laboratory for stimulating discussions and Sina Knapp for critical reading of the review draft.  ... 
doi:10.15252/embj.2020106787 pmid:33998017 pmcid:PMC8204866 fatcat:awwvdbrahzbp5ekgl65ifb5dha

Cancer models inCaenorhabditis elegans

Natalia V. Kirienko, Kumaran Mani, David S. Fay
2010 Developmental Dynamics  
Aided by the conservative nature of evolution and the persistence of a cohort of devoted researchers, the role of model organisms as a key tool in solving the cancer problem has, however, become widely  ...  Specifically, we discuss findings in the worm that address a well-defined set of processes known to be deregulated in cancer cells including cell cycle progression, growth factor signaling, terminal differentiation  ...  and supportive environment for the pursuit of basic science.  ... 
doi:10.1002/dvdy.22247 pmid:20175192 pmcid:PMC4098942 fatcat:urx66f5nlnf6xi3rwg2o2hw4li

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

Chunyong Ding, Zilan Song, Ancheng Shen, Tingting Chen, Ao Zhang
2020 Acta Pharmaceutica Sinica B  
use as a new immune stimulatory therapy.  ...  However, the majority of cancers have low clinical response rates to these ICIs due to poor tumor immunogenicity.  ...  A more serious This work was supported by grants from Natural Science Foundation of China (Grant Supporting grants from the Key Program of the Frontier Science (Grant No. 160621, China) of the Chinese  ... 
doi:10.1016/j.apsb.2020.03.001 pmid:33354501 pmcid:PMC7745059 fatcat:dmpbx235g5bqbp3c465rhptiwu

Graves' ophthalmopathy: current concepts regarding pathogenesis and management

H. B. Burch
1993 Endocrine reviews  
within a class of the NO SPECS classification system.  ...  Unifying concepts in each of these modified classification systems have been a need for greater objectivity, and a need for specification of an activity level of the inflammatory process, both of which  ... 
doi:10.1210/er.14.6.747 pmid:8119236 fatcat:ossvhlyoifbnxjy5dlv4xh5qny

Graves' Ophthalmopathy: Current Concepts Regarding Pathogenesis and Management*

1993 Endocrine reviews  
within a class of the NO SPECS classification system.  ...  Unifying concepts in each of these modified classification systems have been a need for greater objectivity, and a need for specification of an activity level of the inflammatory process, both of which  ... 
doi:10.1210/edrv-14-6-747 pmid:8119236 fatcat:243ifc2nnjh7dhcbjocanzh3jy

Global Transcriptional Profiling of Neural and Mesenchymal Progenitors Derived from Human Embryonic Stem Cells Reveals Alternative Developmental Signaling Pathways

Jérôme Alexandre Denis, Christelle Rochon-Beaucourt, Benoite Champon, Geneviève Pietu
2011 Stem Cells and Development  
Moreover, SIX1 a developmental gene encoding for a homeodomain transcription factor was the most up-regulated transcription regulator in MPC.  ...  We first performed a subtractive analysis of gene profiles of each of these lineages as compared to the undifferentiated stage.  ...  For one decade, human embryonic stem cells (hES) have been recognized as a valuable model for studies of early steps of human development since the acquisition of a defined phenotype in vitro follows sequential  ... 
doi:10.1089/scd.2010.0331 pmid:21142452 fatcat:fixun4qgbvf2xjbvx2mn65twn4

Cold Shock Domain Proteins in Normal and Leukemic Hematopoiesis

Cheng Li
Western blotting was performed as previously described.3,4 The horseradish peroxidase signal was detected by an ECL detection system (Bio-Rad, Hercules, CA).TAT-cre induction of floxingAfter red blood  ...  In a cell-free system, it has been shown that the binding of YBX1 to this sequence will suppress the translation of YBX1 mRNA 66 , while the binding of Poly (A)-binding protein (PABP) will activate the  ...  p.G815W 353 0 0 183 89 32.72 Ax2-16 18 37129340 37129340 G A SNP Pcdha6 missense p.R644H 449 0 0 286 47 14.07 Ax2-16 19 6931605 6931605 A G SNP Ccdc88b missense p.L148P  ... 
doi:10.7936/k71n7z44 fatcat:lctgrp3hmrcxvdsrhk3j3fsg3y

Using the RISCI Genetic Screening Platform for Elucidating Apoptosis Signalling Network

Kuan Chee Bevan Lin, Stefan Grimm, John Wharton, Johnson & Johnson ; Medical Research Council (Great Britain)
The integration of a pro-apoptosis treatment to screen for inhibitors and sensitizers is a novel aspect of the current experimental setup, along with the low redundancy library.  ...  A high throughput genetic screening platform, RISCI (robotic single cDNA investigation), was previously established for the systematic evaluation of single gene activities.  ...  Transgenic Zebrafish were also established as excellent cancer models for melanoma and leukaemia [264] [265] [266] and the study of the nervous system [267] .  ... 
doi:10.25560/11662 fatcat:iua3yk6uxnb57mtrpwatlkzt54
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