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Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19

Shisong Fang, Lin Zhang, Yingzhi Liu, Wenye Xu, Weihua Wu, Ziheng Huang, Xin Wang, Hui Liu, Ying Sun, Renli Zhang, Bo Peng, Xiaodong Liu (+14 others)
2021 Briefings in Bioinformatics  
We performed transcriptome analysis of peripheral blood mononuclear cells (PBMCs) from COVID-19 patients and identified the aberrant upregulation of genes in the lysosome pathway.  ...  In conclusion, lysosome function is deregulated in PBMCs isolated from COVID-19 patients, and the related biomarker LC3B may serve as a novel tool for stratifying patients with moderate-to-severe COVID  ...  Consent for publication All the authors are aware of and agree to the content of the paper, copyright assignment and authorship responsibility.  ... 
doi:10.1093/bib/bbab043 pmid:33620066 pmcid:PMC7929326 fatcat:bi4p76la7za6jbrdaov2eabbwi

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients

Sergej Tomić, Jelena Đokić, Dejan Stevanović, Nataša Ilić, Alisa Gruden-Movsesijan, Miroslav Dinić, Dušan Radojević, Marina Bekić, Nebojša Mitrović, Ratko Tomašević, Dragan Mikić, Dragoš Stojanović (+1 others)
2021 Frontiers in Immunology  
Here we analyzed ~140 parameters of cellular and humoral immune response in peripheral blood of 41 COVID-19 patients and 16 age/gender-matched healthy donors by flow-cytometry, quantitative PCR, western  ...  Unlike increased activation of ICOS-1+ CD4+ T cells in mild COVID-19 patients (n=21), T cells in severe patients showed impaired activation, low IFN-γ production and high functional exhaustion, which correlated  ...  ACKNOWLEDGMENTS The authors are grateful to Ljiljana Sofronic-Milosavljevic( INEP) and Danica C ́ujić(INEP) for generous help in serological diagnostics and critical revision of the manuscript.  ... 
doi:10.3389/fimmu.2021.614599 pmid:33692788 pmcid:PMC7937809 fatcat:bpmy2zbljbbyznpsdkta7vwksu

ISEV2021 Abstract Book

2021 Journal of Extracellular Vesicles  
Here, we investigate the role of X-rays, alpha, Auger and beta particles in triggering systemic effects through the activation of cGAS-STING pathway in tumor and host immune cells and assessed the role  ...  GO enrichment for biological processes revealed that EXO samples were enriched in proteins related to exopeptidase activity, whereas MV samples in those related to cell redox homeostasis and intrinsic  ...  Introduction: In an earlier study, we showed that under vasculogenic conditioning, pro-inflammatory cell subsets of peripheral blood mononuclear cells (PBMCs) such as macrophages type 1 (M1ɸ), T cells,  ... 
doi:10.1002/jev2.12083 fatcat:6m2b3nhzozac7fgsy7n2gtt2pq

16th International Congress on Neuromuscular Diseases, 21 - 22 & 28 - 29 May 2021 Virtual, Worldwide

2021 Journal of Neuromuscular Diseases  
Infection was observed in approximately 30% of the patients, and acute infl ammatory demyelinating polyneuropathy (AIDP) as the most prevalent type of GBS in 48.8%.  ...  The secondary effi cacy endpoints included the changes from baseline to the end of study of adjusted INCAT disability score, grip strength in the dominant and non-dominant hand, Rasch-built overall disability  ...  Results: The study has recently been completed and the data will be analyzed to evaluate the presence and relationship of TEMRA cells in circulating blood of IBM patients with disease phenotype, NT5c1A  ... 
doi:10.3233/jnd-219006 pmid:34334417 fatcat:5ixajewia5d3hhpkwj4yqyb32a