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Cortisol and 17-Hydroxyprogesterone Levels in Saliva of Healthy Neonates

Ingo Klug, Regina Dressendörfer, Christian Strasburger, Gonne Peter Kühl, Hans-Ludwig Reiter, Andrea Reich, Grit Müller, Kerstin Meyer, Jürgen Kratzsch, Wieland Kiess
2000 Neonatology  
Biol Neonate 2000;78: [22] [23] [24] [25] [26] Klug et al.  ...  75 Midday 295.4B175.8 116.4-983.6 256.4 65 Evening 247.1B131.4 92.3-739.2 205.6 56 Biol Neonate 2000;78: [22] [23] [24] [25] [26] Biol Neonate 2000;78: [22] [23] [24] [25] [26] Klug  ... 
doi:10.1159/000014242 pmid:10878418 fatcat:w7a2in3rena2jnkq7ocos42t5a

Platelet expression and reactivity after BNT162b2 vaccine administration [article]

Melissa Erika Klug, Olga Lazareva, Kilian Kirmes, Marc Rosenbaum, Marina Lukas, Simon Weidlich, Christoph D Spinner, Moritz von Scheidt, Rosanna Gosetti, Jan Baumbach, Juergen Ruland, Gianluigi Condorelli (+4 others)
2021 medRxiv   pre-print
SARS-CoV-2 infection induces a coagulopathy characterized by platelet activation and a hypercoagulable state with an increased incidence of cardiovascular events. The viral spike protein S has been reported to enhance thrombosis formation, stimulate platelets to release pro-coagulant factors and promote the formation of platelet-leukocyte aggregates even in absence of the virus. Although SARS-CoV-2 vaccines induce spike protein overexpression to trigger SARS-CoV-2-specific immune protection,
more » ... ombocyte activity has not been investigated in this context. Here, we provide the first phenotypic platelet characterization of healthy human subjects undergoing BNT162b2 vaccination. Using mass cytometry, we analyzed the expression of constitutive transmembrane receptors, adhesion proteins and platelet activation markers in 12 healthy donors before and at five different timepoints within four weeks after the first BNT162b2 administration. We measured platelet reactivity by stimulating thrombocyte activation with thrombin receptor-activating peptide (TRAP). Activation marker expression (P-Selectin, LAMP-3, LAMP-1, CD40L and PAC-1) did not change after vaccination. All investigated constitutive transmembrane proteins showed similar expressions over time. Platelet reactivity was not altered after BNT162b2 administration. Activation marker expression was significantly lower compared to an independent cohort of mild symptomatic COVID-19 patients analyzed with the same platform. This study reveals that BNT162b2 administration does not alter platelet protein expression and reactivity.
doi:10.1101/2021.05.18.21257324 fatcat:etzb7dl3hzfcrcf2unx4mp25ni

Neutral steroid metabolites in patients with uraemia and after renal transplantation: a quantitative and qualitative study in body fluids

HELGA LUDWIG-KÖHN, H. V. HENNING, ASTRID SZIEDAT, P. KLUG, H. ALEXANDER, F. SCHELER
1985 European Journal of Clinical Investigation  
KLUG, H. ALEXANDER & F.  ...  Ludwig-Koehn H, Henning HV, Sziedat A, Matthaei D, Spi- teller G, Reiner J, Egger H-J.  ... 
doi:10.1111/j.1365-2362.1985.tb00281.x pmid:3938402 fatcat:p3fjoz5blzhy5i3ophkevuvkhu

SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype

Dario Bongiovanni, Melissa Klug, Olga Lazareva, Simon Weidlich, Marina Biasi, Simona Ursu, Sarah Warth, Christian Buske, Marina Lukas, Christoph D. Spinner, Moritz von Scheidt, Gianluigi Condorelli (+4 others)
2021 Cell Death and Disease  
AbstractNovel coronavirus disease 2019 (COVID-19) is associated with a hypercoagulable state, characterized by abnormal coagulation parameters and by increased incidence of cardiovascular complications. With this study, we aimed to investigate the activation state and the expression of transmembrane proteins in platelets of hospitalized COVID-19 patients. We investigated transmembrane proteins expression with a customized mass cytometry panel of 21 antibodies. Platelets of 8 hospitalized
more » ... 9 patients not requiring intensive care support and without pre-existing conditions were compared to platelets of healthy controls (11 donors) with and without in vitro stimulation with thrombin receptor-activating peptide (TRAP). Mass cytometry of non-stimulated platelets detected an increased surface expression of activation markers P-Selectin (0.67 vs. 1.87 median signal intensity for controls vs. patients, p = 0.0015) and LAMP-3 (CD63, 0.37 vs. 0.81, p = 0.0004), the GPIIb/IIIa complex (4.58 vs. 5.03, p < 0.0001) and other adhesion molecules involved in platelet activation and platelet–leukocyte interactions. Upon TRAP stimulation, mass cytometry detected a higher expression of P-selectin in COVID-19 samples compared to controls (p < 0.0001). However, we observed a significantly reduced capacity of COVID-19 platelets to increase the expression of activation markers LAMP-3 and P-Selectin upon stimulation with TRAP. We detected a hyperactivated phenotype in platelets during SARS-CoV-2 infection, consisting of highly expressed platelet activation markers, which might contribute to the hypercoagulopathy observed in COVID-19. In addition, several transmembrane proteins were more highly expressed compared to healthy controls. These findings support research projects investigating antithrombotic and antiplatelet treatment regimes in COVID-19 patients, and provide new insights on the phenotypical platelet expression during SARS-CoV-2 infection.
doi:10.1038/s41419-020-03333-9 pmid:33414384 fatcat:pxxlt3x35bdqzkthbzudf2z5lq

Page 66 of National Union Catalog Vol. 13, Issue [page]

1953 National Union Catalog  
Klug, Alfred, 1883- ed. ee C itz-Cemauti see PT3895.R8B8 56-49130 = E.  ...  Stuttgart, Berliner Union ,1964, 4440p. illus, 24cm, 1 1 Title, TS1890.K54 54-89510 ¢ Kliiber, Johann Ludwig, 1762-1837.  ... 

Inhalt

1987 InfoDaF. Informationen Deutsch als Fremdsprache  
(Sonja Klug, Bonn) 438 Brinker-Gabler, Gisela; Ludwig, Karola; Wöffen, Angela : Lexikon deutschsprachiger Schriftstellerinnen von 1800 bis 1945. München: Deutscher Ta- schenbuch Verlag, 1986.  ...  Ludwig (Hrsg.): Stil: Geschichten und Funktionen eines kultur- wissenschaftlichen Diskurselements.  ... 
doi:10.1515/infodaf-1987-145-601 fatcat:y54f5rdamjhpfdmq4bbgpllzsm

Page 385 of JEGP. Journal of English and Germanic Philology Vol. 27, Issue 3 [page]

1928 JEGP. Journal of English and Germanic Philology  
Beziehungen der Briider Schlegel zu Ludwig Tieck 385 langer man ihn sieht, er ist die Gutmiithigkeit selber, und méchte kein Wasser betriiben, nun aber unternimmt er eine Rolle, die sie eigentlich von  ...  Die Veit ist unbeschreiblich brutal: Musikkennerin, Vertraute der Schlegel, Lucinde in einer Brechpotenz, eine wahre Polychrestpille, zu allen Dingen nutze, und die Schlegel ist auch mehr listig als klug  ... 

Page 604 of Physiological Reviews Vol. 6, Issue 4 [page]

1926 Physiological Reviews  
Stroem’s theory was again revived, however, by Briicke (16), Marshall- Hall, Wittich (129) and received some support from Ludwig.  ...  Klug (57) made an attempt to determine the degree of filling of the coronary system during systole and diastole by histological methods.  ... 

Hypecoum der Flora von Kroatien

Ludwig Farkas-Vukotinovic
1860 Plant Systematics and Evolution  
Yon Ludwig v. Farkas-Vukotinovic. Auf ttrn. hT eil r e i e h's Aufforderung hinsichtlich des ltypecoum antworte ich Folgendes: ~Im Jahre 1852 als ich mit Dr.  ...  unbrauchbaren Zustande far die weitere Pr~iparation angekommen, nnd wird eine wiederbolte Excursion in diese herrlichen-Gebirgsgegenden hoffentlicb ein besseres Resultat liefern, da man (lurch Schaden klug  ... 
doi:10.1007/bf01962733 fatcat:bdmmonzttzd7bml7gnv3pqx224

Page 550 of National Union Catalog Vol. 29, Issue [page]

1963 National Union Catalog  
Cty NUC67-28104 Klliber, Johann Ludwig, 1762-1837, ed, see Vienna, Congress, 1814-1815, Acten des Wiener Congresses...  ...  MH NUC63-42859 Klug, Harold Philip, 1902- The elements and compounds of group IVA rby) Harold P. Klug and Robert C. Brasted.  ... 

Page 126 of Biological Chemistry Vol. 50, Issue [page]

1906 Biological Chemistry  
Einige Forscher aber erkennen die Gastrolipase nieht an (Klemperer und Schleuerlen, Klug, Contejan, Kunkel, Inouye und Ludwig v.  ... 

Page 41 of Monatshefte Vol. 47, Issue 1 [page]

1955 Monatshefte  
Profs.: Ludwig Kahn, Ph.D.; Bennet Olli, Ph.D.; Samuel L. Sumberg, Ph.D.; Max Wein- reich, Ph.D. Asst.  ...  Condoyannis, Ph.D.; Herman Klug- man, Ph.D. Prof.: Melaine R. Rosborough.* Assoc. Prof.: Robert S. Whitehouse; Albert Ivanoff. Asst. Prof.: Lee Butterfield. Profs.: J. R. Breitenbucher,* Ph.D.; G. L.  ... 

Page 41 of Monatshefte Vol. 47, Issue 1 [page]

1955 Monatshefte  
Profs.: Ludwig Kahn, Ph.D.; Bennet Olli, Ph.D.; Samuel L. Sumberg, Ph.D.; Max Wein- reich, Ph.D. Asst.  ...  Condoyannis, Ph.D.; Herman Klug- man, Ph.D. Prof.: Melaine R. Rosborough.* Assoc. Prof.: Robert S. Whitehouse; Albert Ivanoff. Asst. Prof.: Lee Butterfield. Profs.: J. R. Breitenbucher,* Ph.D.; G. L.  ... 

Heike Hartmann, Lars Eckstein, Helmut Peitsch, Anja Schwarz und Steffen Krestin, Hrsg.: Der Australienforscher Ludwig Leichhardt: Spuren eines Verschollenen

Gerhard Stilz
2014 Zeitschrift für Australienstudien / Australian Studies Journal  
Leichhardts Journale erscheinen damit als kunstvolle, in ihrer Wirkung klug kalkulierte literarische Texte.  ...  -Das Werk von Finger ist übrigens jüngst in Kylie Cranes flüssiger Übersetzung nunmehr auch auf Englisch erschienen (Ludwig Leichhardt: Lost in the Outback.  ... 
doi:10.35515/zfa/asj.28/2014.08 fatcat:xdggp4d7brhb3ebcyk2cm2f3m4

Contents, Vol. 20, Supplement 2, 1980

1980 Gynäkologisch-Geburtshilfliche Rundschau  
Ergebnisse 1977-1980 135 Tatra, G. und Ludwig, H.: Fetale und plazentare Proteine beim Ovarialkarzinom . 138 Szalay, S.; Tatra, G. und Janisch, H.: Erste Erfahrungen mit dem «Cancer-Serum-Index» bei gynäkologischen  ...  Blasenentleerungsstörungen aus der Sicht des Urologen 161 Vorträge Hetzel, H.; Manzl, J. und Dapunt, O.: Röntgenologische und urodynamische Untersuchungsergebnisse vor und nach Schlingenoperation 173 Mayer, H.G.K. und Klug  ... 
doi:10.1159/000269010 fatcat:7wkc6dl5tjhrdir6srcsoo7pqa
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