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Camos, Ludovic Demoulin de Rochefort, médecin, poète et biblio... ... NOTIZIA ROSANNA GORRIS CAMOS, Ludovic Demoulin de Rochefort, médecin, poète et bibliophile entre Turin et Bâle, in AA. ...doi:10.4000/studifrancesi.3048 fatcat:2o7uxqb2sbgm3a2r6pfrwmmhz4
The range includes all types of handwritten material primarily from the modern period. e-manuscripta.ch est un projet né de la coopération des différentes bibliothèques et archives suisses qui le soutiennent ... La gamme comprend tous les genres de sources manuscrites principalement de l'ère moderne. e-manuscripta.ch è un progetto nato dalla collaborazione delle varie biblioteche e archivi della svizzera ed è ...doi:10.7891/e-manuscripta-23618 fatcat:hbtlmzihh5ey3mslvvi4ea5y3e
Mathematical Biosciences 18, 161 170. 466 URL http://www.sciencedirect.com/science/article/pii/0025556473900278 467  Khalife, M., Rodriguez, D., de Rochefort, L., Durand, E., 2012. ... Die grundform des arteriellen pulses. ...doi:10.1016/j.jbiomech.2014.07.018 pmid:25173919 fatcat:vergrcgnd5axplwckpnoyc744u
NMR in Biomedicine
For optimal image quality in susceptibility-weighted imaging and accurate quantification of susceptibility, it is necessary to isolate the local field generated by local magnetic sources (such as iron) from the background field that arises from imperfect shimming and variations in magnetic susceptibility of surrounding tissues (including air). Previous background removal techniques have limited effectiveness depending on the accuracy of model assumptions or information input. In this article,doi:10.1002/nbm.1670 pmid:21387445 pmcid:PMC3628923 fatcat:viltajddazfaxn6fc4yyeg2z7i
more »... report an observation that the magnetic field for a dipole outside a given region of interest (ROI) is approximately orthogonal to the magnetic field of a dipole inside the ROI. Accordingly, we propose a nonparametric background field removal technique based on projection onto dipole fields (PDF). In this PDF technique, the background field inside an ROI is decomposed into a field originating from dipoles outside the ROI using the projection theorem in Hilbert space. This novel PDF background removal technique was validated on a numerical simulation and a phantom experiment and was applied in human brain imaging, demonstrating substantial improvement in background field removal compared with the commonly used highpass filtering method. Keywords susceptibility; projection; dipole field; background removal * -weighted imaging, susceptibilityweighted imaging (SWI) (1) and quantitative susceptibility mapping (QSM) (2-8). Recently, it has been reported that accurate QSM can be generated by combining information from magnitude and phase images (3). For appropriate phase masking in SWI and accurate susceptibility quantification in QSM (9), it is necessary to separate the local field in a given region of interest (ROI) from the background field. This background field arises from various sources, including imperfect shimming and magnetic susceptibility sources outside the ROI (both inside and outside the imaging volume). For example, in brain imaging, the air-tissue interfaces near the skull and various air cavities induce a strong background field
Einige seltene und zum Teil unedierte Medaillen aus der Sammlung des Ludovic de Rochefort. ... "LOD DEM DE ROCHEFORT L LEO ." Von Perlkreis umgeben. ...doi:10.5169/seals-159696 fatcat:vmshhisdhraito3cg4oiua3hpe
L. de Rochefort acknowledges the France Life Imaging network (Grant ANR-11-INBS-0006) that partially funded the small animal FFC-MRI system. D.J. Lurie, L.M. Broche and P.J. ... FFC-MRI Acquisition system Type field FFC range Bore size Bödenler et al.  Insert coil 2.89 T 2.79-2.99 T Small animal de Rochefort et al.  Table 2 . 2 Comparison of B 0 insert coil specifications ...doi:10.1080/00268976.2018.1557349 fatcat:mattfcooczdz3f4smyjofxd65m
Superparamagnetic iron oxide (SPIO) particles generate signal void regions on gradient echo images due to their strong magnetization. In practice, the signal void region might be indistinguishable from that generated by air. However, the response of SPIO to an externally applied magnetic field is nonlinear. Magnetization of SPIO saturates at around 1 Tesla while magnetization of water and air increase linearly with field strength. Phantom experiment and mice experiments demonstrated thedoi:10.1016/j.mri.2010.06.011 pmid:20688448 pmcid:PMC2963706 fatcat:si25z5y7f5dufcrz7f7ugyl7ii
more »... ity of a non-ambiguous identification of superparamagnetic contrast agents.
Molecular magnetic resonance imaging targeted to an endothelial integrin involved in neoangiogenesis was compared to DCE-US and immunochemistry to assess the early response of three different therapeutic agents in renal cell carcinoma. Human A498 renal cells carcinoma was subcutaneously inoculated into 24 nude mice. Mice received either phosphate-buffered saline solution, sunitinib, everolimus, or bevacizumab during 4 days. DCE-US and molecular MRI targeting αvβ3 were performed at baseline anddoi:10.1155/2017/7498538 pmid:29097936 pmcid:PMC5612742 fatcat:b4kizh5mr5fflfyloq6wr23y5u
more »... days after treatment initiation. PI, AUC, relaxation rate variations ΔR2⁎, and percentage of vessels area quantified on CD31-stained microvessels were compared. Significant decreases were observed for PI and AUC parameters measured by DCE-US for bevacizumab group as early as 4 days, whereas molecular αvβ3-targeted MRI was able to detect significant changes in both bevacizumab and everolimus groups. Percentage of CD31-stained microvessels was significantly correlated with DCE-US parameters, PI (R=0.87, p=0.0003) and AUC (R=0.81, p=0.0013). The percentage of vessel tissue area was significantly reduced (p<0.01) in both sunitinib and bevacizumab groups. We report an early detection of neoangiogenesis modification after induction of targeted therapies, using DCE-US or αvβ3-targeted MRI. We consider these outcomes should encourage clinical trial developments to further evaluate the potential of this molecular MRI technique.
Acknowledgment 388 The authors would like to thank Alain De Cesares with the Laboratoire d'Imagerie Fonctionnelle, U678, 389 Paris, France, for his contribution to a part of data processing. ...doi:10.1016/j.medengphy.2014.11.004 pmid:25500196 fatcat:ws7dugn22jdgpkys5z6evyofhy
Purpose-To investigate the effectiveness of flow signal suppression of a motion-sensitizing magnetization preparation (MSPREP) sequence and to optimize a 2D MSPREP steady-state free precession (SSFP) sequence for black blood imaging of the heart. Materials and Methods-Using a flow phantom, the effect of varying field of speed (FOS), bvalue, voxel size, and flow pattern on the flow suppression was investigated. In seven healthy volunteers, black blood images of the heart were obtained at 1.5Tdoi:10.1002/jmri.21568 pmid:18972350 pmcid:PMC2666444 fatcat:wg4x44rzujdnjngtxk4rtlggqi
more »... h MSPREP-SSFP and double inversion recovery fast spin echo (DIR-FSE) techniques. Myocardium and blood signal-to-noise ratio (SNR) and myocardium-to-blood contrast-to-noise ratio (CNR) were measured. The optimal FOS that maximized the CNR for MSPREP-SSFP was determined. Results-Phantom data demonstrated that the flow suppression was induced primarily by the velocity encoding effect. In humans, FOS = 10-20 cm/s was found to maximize the CNR for shortaxis (SA) and four-chamber (4C) views. Compared to DIR-FSE, MSPREP-SSFP provided similar blood SNR efficiency in the SA basal and mid views and significantly lower blood SNR efficiency in the SA apical (P = 0.02) and 4C (P = 0.01) views, indicating similar or better blood suppression. Conclusion-Velocity encoding is the primary flow suppression mechanism of the MSPREP sequence and 2D MSPREP-SSFP black blood imaging of the heart is feasible in healthy subjects.
Seeking out and identifying imaging biomarkers for early cancer diagnosis and the evaluation of patient response to therapy requires an improvement in the specificity of imaging techniques. This study explores in vivo neo-angiogenesis assessment using molecular mechanisms through target molecular Magnetic Resonance (MR) and Ultrasound (US). In this context, our study examines and compares the use of both imaging technics, targeting the same integrin in a mouse xeno graft tumor model. Followingdoi:10.23937/2572-3235/1510027 fatcat:bbrksz5jxfhbjlbgkoblooa2mi
more »... eno transplantation of human renal cell carcinoma (Human A498), thirteen nude mice were injected with ανβ3-targeted and non-targeted Contrast Agents (CA) for MR and US use, respectively. CA binding to the targeted receptor was measured through Dynamic Susceptibility Contrast MR imaging and Differential Targeted Enhancement (DTE) US imaging. The specificities and co location of both targeted CAs were studied throughout the tumor, in both hypoand hyper-vascularized areas. One hour postinjection, a significant difference was observed between the signals of targeted and non-targeted MR CA (p = 0.03). The DTE-US targeted CA was significantly enhanced compared to non-targeted CA (p = 0.002). In the hypo-and hyper-vascularized regions of interest, a strong correlation was observable between both modalities, with values of r 10min = 0.86 (p = 0.0003), r 30min = 0.85 (p = 0.0004) and r 60min = 0.87 (p = 0.0001). This study highlights the specificity of each targeted CA. A high correlation was noted between MR and US molecular imaging for angiogenesis assessment. These two molecular imaging modalities may be used interchangeably to monitor patient response to anti-angiogenic treatment.
The core for the latter experiments is supported by 2 "Investissements d'avenir" (ANR-10-IAIHU-06 and ANR-11-INBS-0011-NeurATRIS) and the "DIM-NeRF Ile de France". ...doi:10.1016/j.ebiom.2019.08.026 pmid:31447395 pmcid:PMC7033528 fatcat:gerbgkjgbvhfpj7cg5biwy4v24
Introduction Quantitatively measuring the magnetic susceptibility of brain tissue has recently received increased scientific and clinical attention (de Rochefort et al., 2008a; de Rochefort et al., 2010 ... Materials and methods Magnetic susceptibility and field In MRI, the tissue local magnetic field can be approximated as the convolution of the dipole kernel with the susceptibility distribution (de Rochefort ...doi:10.1016/j.neuroimage.2011.08.082 pmid:21925276 pmcid:PMC3254812 fatcat:xks6mznokzenloty5iiah23yyq
NMR in Biomedicine
The minimum-norm method was first proposed by de Rochefort et al. 2  who also replaced the mask M′ in Eq. (16) with a weighting function that masked the external region and additionally accounted ... algorithms to the total field within the brain: HARPERELLA and iHARPERELLA (W.L.), LBV, iSMV, and PDF (Dong Zhou from Yi Wang's group), direct solution, SHARP and V-SHARP (F.S.), minimum norm solution (L. de ...doi:10.1002/nbm.3604 pmid:27717080 pmcid:PMC5587182 fatcat:oqeue5quqfbujnot4ptgein5kq
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