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Dear Editor In response to the comments [1, 2] regarding the article by Cicalese et al., "An Ecological Study of the Association between Air Pollution and Hepatocellular Carcinoma Incidence in Texas" [ ... Dear Editor In response to the comments [1, 2] regarding the article by Cicalese et al., "An Ecological Study of the Association between Air Pollution and Hepatocellular Carcinoma Incidence in Texas" ...doi:10.1159/000486433 pmid:30319990 pmcid:PMC6167695 fatcat:mtfdcnpzqrfrdpk3yloie7p4by
Reviews Pyruvate in Organ Transplantation Luca Cicalese, MD From the Division of Transplantation Surgery, University of Illinois at Chicago, Illinois ABSTRACT. ... Correspondence: Luca Cicalese, MD, Assistant Professor of Surgery, Director Intestinal Transplant Program, Division of Transplantation Surgery, University of Illinois at Chicago, 840 South Wood Street, ...doi:10.1177/0148607101025004216 pmid:11434653 fatcat:xlsyiyb2lbgpfm4diefek7lzum
De Luca are members of the Gruppo Nazionale per l'Analisi Matematica, la Probabilità e le loro Applicazioni (GNAMPA) of the Istituto Nazionale di Alta Matematica (INdAM). A. ... Cicalese was supported by the DFG Collaborative Research Center TRR 109, "Discretization in Geometry and Dynamics". the Jacobian Jv of v is the L 1 function defined as follows Jv := det∇v. ...arXiv:2012.12559v1 fatcat:q236jth3prdrvcrqi2hbj365na
We consider a variational model for two interacting species (or phases), subject to cross and self attractive forces. We show existence and several qualitative properties of minimizers. Depending on the strengths of the forces, different behaviors are possible: phase mixing or phase separation with nested or disjoint phases. In the case of Coulomb interaction forces, we characterize the ground state configurations.arXiv:1507.08446v1 fatcat:jij4xmjwhzbjhmn7dz64uivicy
Rhabdomyosarcoma (RMS) is a primary malignancy that arises from the embryonic mesenchyme with the potential to differentiate into skeletal muscle. RMS of the biliary tree is extremely rare. We report a case of an undifferentiated pleomorphic RMS involving the liver and pancreas. A 62 year old Caucasian woman with rapidly growing abdominal mass and a history of endometrial adenocarcinoma underwent laparotomy due to compression symptoms and concerns of malignancy. A large mass arising from thedoi:10.1016/j.ijscr.2015.05.029 pmid:26092712 pmcid:PMC4529633 fatcat:7xahmzpdxfghtpa5ghpkyomn3m
more »... creas and extending into the liver was identified and resected with a distal pancreatectomy associated with a left lateral liver segmentectomy. A diagnosis of pleomorphic RMS was made from the pathology specimen. Chemotherapy and radiotherapy were also performed. Unfortunately the patient died 2 years following treatment due to recurrence of the disease. P-RMS in the biliary tree is extremely rare (0.5%) and mostly seen in infants and children. Preoperative diagnosis is challenging since the symptoms are unspecific. Preoperative imaging rarely contributes to the final diagnosis. The only possible treatment for adult RMS is surgical resection of the tumor followed by chemotherapy and radiotherapy. Long-term prognosis of P-RMS reported (predominantly of limbs) is poor. To our knowledge, no previous cases of RMS originating from the pancreas have been reported. However RMS is an extremely rare tumor in adults, it should be included in the differential diagnosis of patients with atypical pancreatic and liver lesions.
The incidence of hepatocellular carcinoma (HCC), the most common primary liver cancer, is increasing in the US and tripled during the past two decades. The reasons for such phenomenon remain poorly understood. Texas is among continental states with the highest incidence of liver cancer with an annual increment of 5.7%. Established risk factors for HCC include Hepatitis B and C (HBV, HCV) viral infection, alcohol, tobacco and suspected risk factors include obesity and diabetes. Whiledoi:10.1371/journal.pone.0185610 pmid:29016628 pmcid:PMC5634561 fatcat:afaw7asbpvh5pme4qmrbt7soca
more »... of these risk factors in the state of Texas is similar to the national data and homogeneous, the incidence of HCC in this state is exceptionally higher than the national average and appears to be dishomogeneous in various areas of the state suggesting that other non-recognized risk factors might play a role. No population-based studies are currently available investigating the effect of exposure to Hazardous Air Pollutants (HAPs) as a contributing risk factor for liver cancer. Incidence rate of liver cancer in Texas by counties for the time period between 2002 and 2012 was obtained from the Texas Cancer Registry (TCR). Through Principal Component Analysis (PCA) a subgroup of pollutants, explaining almost all the dataset variability, were identified and used to cluster Texas counties. The analysis generated 4 clusters showing liver cancer rate either higher or lower than national average in association with either high or low levels of HAPs emission in the environment. The study shows that the selected relevant HAPs, 10 among 253 analyzed, produce a significant correlation (P = 0.01-0.05) and some of these have been previously identified as carcinogens. An association between the increased production and consequent exposure to these HAPs and a higher presence of liver cancer in certain counties is suggested. This study provides a new insight on this complex multifactorial disease suggesting that environmental substances might play a role in the etiology of this cancer. Fig 4. Map of current Texas counties with boundaries as of January 1, 1990 showing all 4 clusters: Cluster 1-blue; Cluster 2-green; Cluster 3-orange; Cluster 4 -red. https://doi.org/10.1371/journal.pone.0185610.g004 Fig 3. Age-adjusted liver cancer incidence rate for Texas State over time. https://doi.org/10.1371/journal.pone.0185610.g003 Pollutants in Texas and primary liver cancer PLOS ONE | https://doi.org/10.1371/journal.pone.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver and particularly in the tumor proximity. The present study investigated primary human hepatocyte cultures obtained from liver specimens of patients affected by cirrhosis and HCC, their proliferation anddoi:10.3892/ijo.2015.3312 pmid:26717856 fatcat:gx2ege5vifeqdfn2k7kcchhxea
more »... transformation. Liver samples were obtained from seven HCC cirrhotic patients and from three patients with normal liver (NL). Immediately after surgery, cell outgrowth and primary cultures were obtained from the HCC lesion, the cirrhotic tissue proximal (CP, 1-3 cm) and distal (CD, >5 cm) to the margin of the neoplastic lesion, or from NL. Cells were kept in culture for 16 weeks. Morphologic analyses were performed and proliferation rate of the different cell populations compared over time. Glypican-3, Heppar1, Arginase1 and CD-44 positivity were tested. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a Transwell migration assay. We observed that HCC cells maintained their morphology and unmodified neoplastic characteristics when cultured. Cells isolated from CP, showed a progressive morphologic transformation in HCC-like cells accompanied by modification of markers expression with signs of invasiveness. Absence of HCC contamination in the CP isolates was confirmed. In CD samples some of these characteristics were present and at significantly lower levels. With the present study, we are the first to have identified and describe the existence of human hepatocytes near the cancerous lesion that can transform in HCC in vitro.
S628 survival (LPFS) rate was 75.8% at median follow-up of 19 months, and 1-and 2-year LPFS was 93.8%, 73.2% respectively. Overall survival was relatively worse, 90.8% at 1 year and 51.9% at 2 year, because most of patients had a medical problem in lung or heart. While all patients developed grade 1 radiation pneumonitis within 3 months of SRS treatment, none developed symptomatic or serious late complications. Conclusions: The results demonstrate that fractionated SRS on consecutive days wasdoi:10.1097/01.jto.0000283807.63177.8f fatcat:zarxdinucvdd5gwwoviovnqtnq
more »... th effective and convenient for treating technically operable, but medically inoperable patients with early stage NSCLC. This treatment appears to offer comparable local disease control without serious complications.
Cicalese et al  utilized an acellularized matrix of connective tissue obtained from the dermis of cadaveric donors to develop "acellular dermal matrix" (ADM) with preserved proteins of basement membrane ...doi:10.5500/wjt.v6.i1.1 pmid:27011901 pmcid:PMC4801784 fatcat:34qxvkbx2nhbjjrvwszuw52yjm
Experimental evidence suggests that the protein phosphatase calcineurin mediates the action of amyloid-␤ (A␤) oligomers, the most toxic amyloid species thought to drive initial cognitive decline in Alzheimer's disease (AD). However, there is currently no evidence that inhibition of calcineurin could prevent the onset of AD in humans. Here, we report for the first time that individuals chronically treated with calcineurin inhibitors to prevent solid organ transplant rejection have adoi:10.3233/jad-150065 pmid:26401556 pmcid:PMC4923720 fatcat:pbh4rsrfxjepje3sonch43mpyy
more »... lower incidence of AD/dementia as compared to the general population. This result prompts further clinical development of calcineurin inhibition as a viable treatment for AD.
We consider a variational model for two interacting species (or phases), subject to cross and self attractive forces. We show existence and several qualitative properties of minimizers. Depending on the strengths of the forces, different behaviors are possible: phase mixing or phase separation with nested or disjoint phases. In the case of Coulomb interaction forces, we characterize the ground state configurations. 12 2.2. The strongly attractive case c 11 + c 22 ≤ −2 13 2.3. The weaklydoi:10.1137/15m1033976 fatcat:jm7xafvbvnecbdxylrfh6tagzu
more »... ve case c 11 + c 22 > −2 16 3. The Coulomb kernel 17 3.1. Consequences of the first variation 17 3.2. The strongly attractive case c 11 + c 22 ≤ −2 18 3.3. The weakly attractive case c 11 + c 22 > −2 (preliminary results) 18 3.4. The weakly attractive case c 11 + c 22 > −2 (in dimension N = 1) 20 3.5. The weakly attractive case c 11 + c 22 > −2 (the case N ≥ 2) 21 Conclusions and perspectives 27 References 29
doi:10.1016/j.jtcvs.2006.06.035 pmid:17059959 fatcat:rlbhx2rsuzb27iukfs737huh5u
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