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Pictorial review of cardiac sarcomas and their mimickers

Luba Frank, Jadranka Stojanovska
<span title="2014-10-09">2014</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dctwrgcx4zcl3cyxhmp6felxuq" style="color: black;">Cancer Imaging</a> </i> &nbsp;
• Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit this article as: Frank and Stojanovska: Pictorial review of cardiac sarcomas and their  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1470-7330-14-s1-p36">doi:10.1186/1470-7330-14-s1-p36</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7q6lm2vsobgqhf75kmqtrfsrua">fatcat:7q6lm2vsobgqhf75kmqtrfsrua</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191212013335/https://cancerimagingjournal.biomedcentral.com/track/pdf/10.1186/1470-7330-14-S1-P36" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/16/de/16de1928d3c3198952d953365f516430b74357bd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1470-7330-14-s1-p36"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Uterineintravenous leiomyomatosis with cardiac involvement

Irfan Masood, Cihan Duran, Komal Malik, Luba Frank
<span title="2020-06-28">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/axztx4eiozcytcnxzylodwodva" style="color: black;">Radiology Case Reports</a> </i> &nbsp;
Frank).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.radcr.2020.05.053">doi:10.1016/j.radcr.2020.05.053</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32636980">pmid:32636980</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7329926/">pmcid:PMC7329926</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fuwk5wyr7jfnlmlnr4p26nlsxm">fatcat:fuwk5wyr7jfnlmlnr4p26nlsxm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210527084528/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7329926&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a8/90/a89078e0b25b46b4312229839bc1530ed9774d03.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.radcr.2020.05.053"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329926" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Modern technology: lowering the radiation dose for lung cancer screening

Luba Frank, Emmanuel Christodoulou, Ella Kazerooni
<span title="2014-10-09">2014</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dctwrgcx4zcl3cyxhmp6felxuq" style="color: black;">Cancer Imaging</a> </i> &nbsp;
• Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit this article as: Frank et al.: Modern technology: lowering the radiation dose for lung  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1470-7330-14-s1-p39">doi:10.1186/1470-7330-14-s1-p39</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4ogwj7oobnbkda772srxljpsvm">fatcat:4ogwj7oobnbkda772srxljpsvm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191212013227/https://cancerimagingjournal.biomedcentral.com/track/pdf/10.1186/1470-7330-14-S1-P39" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/69/d169c54b1cea72f2407f454b78724a62effe7443.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1470-7330-14-s1-p39"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Diastolic Cardiac Function by MRI—Imaging Capabilities and Clinical Applications

El-Sayed H. Ibrahim, Jennifer Dennison, Luba Frank, Jadranka Stojanovska
<span title="2021-12-08">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ock7fsjjtrc35bouoqdhvl2zda" style="color: black;">Tomography</a> </i> &nbsp;
the ratio of peak sweep rate in earlydiastole to peak sweep rate in atrial systole could possibly be explained by LA dilation and subsequent enhancement of atrial contraction in concordance with the Frank-Starling  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/tomography7040075">doi:10.3390/tomography7040075</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34941647">pmid:34941647</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8706325/">pmcid:PMC8706325</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bq6xpdxdpbeo5nqrjazfqu4kti">fatcat:bq6xpdxdpbeo5nqrjazfqu4kti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220505054351/https://mdpi-res.com/d_attachment/tomography/tomography-07-00075/article_deploy/tomography-07-00075-v2.pdf?version=1639551597" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6a/87/6a8762f476773d05e64dc539c7892a13eb9a61b1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/tomography7040075"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706325" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Chest CT incidentalomas: thyroid lesions, enlarged mediastinal lymph nodes, and lung nodules

Luba Frank, Leslie E. Quint
<span title="">2012</span> <i title="E-MED LTD"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dctwrgcx4zcl3cyxhmp6felxuq" style="color: black;">Cancer Imaging</a> </i> &nbsp;
A computed tomography (CT) incidentaloma is an incidentally detected and previously unsuspected finding or abnormality that is not related to the indication for obtaining the CT examination. The aim of this article is to review the frequency of incidentalomas on chest CT scans, discuss the potential clinical significance of the findings, and suggest guidelines for reporting, further evaluation, and follow-up, with particular focus on thyroid lesions, enlarged mediastinal lymph nodes and lung nodules.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1102/1470-7330.2012.0006">doi:10.1102/1470-7330.2012.0006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22391408">pmid:22391408</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3335330/">pmcid:PMC3335330</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cvpdqlszdzd4tf3ukyams5pfoa">fatcat:cvpdqlszdzd4tf3ukyams5pfoa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228180721/http://pdfs.semanticscholar.org/966a/518386034b42864297a5bc6222327e52a2fb.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/96/6a/966a518386034b42864297a5bc6222327e52a2fb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1102/1470-7330.2012.0006"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335330" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Safety of CMR in patients with cardiac implanted electronic devices

El-Sayed H Ibrahim, Laura Horwood, Jadranka Stojanovska, Anil Attili, Luba Frank, Hakan Oral, Frank Bogun
<span title="">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jflzecjifjfnzmksqbreqnmoo4" style="color: black;">Journal of Cardiovascular Magnetic Resonance</a> </i> &nbsp;
Safety of CMR in patients with cardiac implanted electronic devices El-Sayed H Ibrahim 1* , Laura Horwood 1 , Jadranka Stojanovska 1 , Anil Attili 1 , Luba Frank 2 , Hakan Oral 1 , Frank Bogun 1 From 19th  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1532-429x-18-s1-o123">doi:10.1186/1532-429x-18-s1-o123</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3vwrzts6hbby3fonvxcwtdrsym">fatcat:3vwrzts6hbby3fonvxcwtdrsym</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719120036/https://jcmr-online.biomedcentral.com/track/pdf/10.1186/1532-429X-18-S1-O123" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3a/6a/3a6ab181e52a4783958fd7ea8db2763ae550406d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1532-429x-18-s1-o123"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Left Ventricular Noncompaction in a Child with Turner Syndrome

Snigdha Bhatia, Amna Qasim, Murad Almasri, Luba Frank, Ashraf M. Aly
<span title="2019-11-11">2019</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gor2ksuanvdxredmhp2uvdvami" style="color: black;">Case Reports in Pediatrics</a> </i> &nbsp;
Congenital heart disease (CHD) may cause a significant comorbidity in patients with Turner syndrome. The commonly reported CHD in these patients includes bicuspid aortic valve and coarctation of the aorta. Left ventricular noncompaction (LVNC) is a rare form of cardiomyopathy that has been reported in literature only three times in adult patients with Turner syndrome. We report the first case of a 6-year-old asymptomatic female with Turner syndrome who was referred for cardiac evaluation after
more &raquo; ... er Turner syndrome diagnosis. Echocardiogram was suspicious for LVNC, which was confirmed on cardiac magnetic resonance imaging.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2019/6824321">doi:10.1155/2019/6824321</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31827964">pmid:31827964</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6881561/">pmcid:PMC6881561</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gqhoztbajrgp5g2symphxvbrr4">fatcat:gqhoztbajrgp5g2symphxvbrr4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207233358/http://downloads.hindawi.com/journals/cripe/2019/6824321.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e3/69/e36980ac922a50f8108e644abc0dbf320d0eea78.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2019/6824321"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881561" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats

William A. Lubas, David W. Frank, Michael Krause, John A. Hanover
<span title="1997-04-04">1997</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
Lubas, D. W. Frank, M. Krause, and J. A. Hanover, unpublished observations.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.272.14.9316">doi:10.1074/jbc.272.14.9316</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/9083068">pmid:9083068</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xfjcnkxlzrhurlwjxbluc64pc4">fatcat:xfjcnkxlzrhurlwjxbluc64pc4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20041102113815/http://minerva.caltech.edu:80/~azurebrd/allpdfs/2840_Lubas97.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b5/04/b504386e742c9d6be97805aeabe6dcd152b7f62f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.272.14.9316"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Value CMR: Towards a Comprehensive, Rapid, Cost-Effective Cardiovascular Magnetic Resonance Imaging [article]

El-Sayed H Ibrahim, Luba Frank, Dhiraj Baruah, Jason Rubenstein, V Emre Arpinar, Andrew Nencka, Kevin Koch, L Tugan Muftuler, Orhan Unal, Jadranka Stojanovska, John Charlson, Elizabeth Gore (+1 others)
<span title="2020-10-13">2020</span> <i title="Cold Spring Harbor Laboratory"> medRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
CMR is considered the gold standard for measuring heart function, including cardiac volumes and mass. Further, in a single CMR exam, information about cardiac function, structure, tissue composition, and blood flow could be obtained. Nevertheless, CMR is underutilized due to long scanning times, the need for multiple breath-holds, use of a contrast agent, and relatively higher cost compared to echocardiography. In this study, we propose a rapid CMR exam based on recent developments in imaging
more &raquo; ... quences. The proposed exam is both rapid and provides comprehensive cardiovascular information without the need for a contrast agent or multiple breath-holds. The developed exam includes advanced sequences for evaluating global and regional cardiac functions, myocardial tissue characterization, and flow hemodynamics in the heart, valves, and large vessels. Time-consuming conventional sequences have been replaced by advanced sequences, which resulted in reducing scan time from > 1 hour with conventional CMR exam to <20 minutes with the proposed rapid CMR exam. Specifically, conventional two-dimensional (2D) cine and phase-contrast (PC) sequences have been replaced by optimized three-dimensional (3D)-cine and four-dimensional (4D)-flow sequences, respectively. Compared to 2D cine imaging that requires 12-16 separate breath-holds, the implemented 3D-cine sequence allows for whole heart coverage in 1-2 breath-holds; thus, reducing scan time by 80-90%. Similarly, compared to 2D PC flow imaging that requires multiple breath-holds and the presence of an experienced cardiac operator for precise prescription of the imaging planes, the implemented 4D-flow sequence allows for whole-chest coverage in ~10-minute, free-breathing acquisition without the need for a navigator echo, which makes scan time independent of the patient breathing pattern. Furthermore, conventional myocardial tagging has been replaced by the fast strain-encoding (SENC) sequence, which reduces scan time from one slice per breath-hold to only one slice per heartbeat (~1 second). Finally, T1 and T2 mapping sequences are included in this proposed exam, which allow for myocardial tissue characterization without the need for contrast. The proposed rapid exam has been tested on volunteers and measurements showed good agreement with those from conventional sequences despite the significant reduction in scan time. In conclusion, we propose a rapid, contrast-free, and comprehensive cardiovascular exam that does not require repeated breath-holds or a cardiac experienced operator to run the exam, which would result in improving cost effectiveness of CMR and increasing its adoption in clinical practice.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.09.20204305">doi:10.1101/2020.10.09.20204305</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/aug6azgwgbcp3msacr5uen3o3y">fatcat:aug6azgwgbcp3msacr5uen3o3y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201213194205/https://www.medrxiv.org/content/medrxiv/early/2020/10/13/2020.10.09.20204305.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/db/57/db574bc83da21e213bc9ffe4bbf22b6a8bbf1d97.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.09.20204305"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> medrxiv.org </button> </a>

Computer-Aided Diagnosis of Lung Nodules on CT Scans:

Ted Way, Heang-Ping Chan, Lubomir Hadjiiski, Berkman Sahiner, Aamer Chughtai, Thomas K. Song, Chad Poopat, Jadranka Stojanovska, Luba Frank, Anil Attili, Naama Bogot, Philip N. Cascade (+1 others)
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2dgw6wyfwvb47ow6p4dw5njbrq" style="color: black;">Academic Radiology</a> </i> &nbsp;
Rationale and Objectives-The aim of this study was to evaluate the effect of computer-aided diagnosis (CAD) on radiologists' estimates of the likelihood of malignancy of lung nodules on computed tomographic (CT) imaging. Methods and Materials-A total of 256 lung nodules (124 malignant, 132 benign) were retrospectively collected from the thoracic CT scans of 152 patients. An automated CAD system was developed to characterize and provide malignancy ratings for lung nodules on CT volumetric
more &raquo; ... An observer study was conducted using receiver-operating characteristic analysis to evaluate the effect of CAD on radiologists' characterization of lung nodules. Six fellowshiptrained thoracic radiologists served as readers. The readers rated the likelihood of malignancy on a scale of 0% to 100% and recommended appropriate action first without CAD and then with CAD. The observer ratings were analyzed using the Dorfman-Berbaum-Metz multireader, multicase method. Results-The CAD system achieved a test area under the receiver-operating characteristic curve (A z ) of 0.857 ± 0.023 using the perimeter, two nodule radii measures, two texture features, and two gradient field features. All six radiologists obtained improved performance with CAD. The average A z of the radiologists improved significantly (P < .01) from 0.833 (range, 0.817-0.847) to 0.853 (range, 0.834-0.887). Conclusion-CAD has the potential to increase radiologists' accuracy in assessing the likelihood of malignancy of lung nodules on CT imaging. Keywords Computer-aided diagnosis; pulmonary nodule; observer study; computed tomography The use of computed tomographic (CT) imaging for lung cancer screening is an area of active research. CT imaging has been shown to be more sensitive for lung nodule detection than chest x-ray, especially for smaller nodules (1-4). Henschke et al (5) reported a 92% survival rate among patients who underwent surgical resection for detected stage I lung cancers. Sobue et al (6) reported an almost 100% 5-year survival rate for patients with nodules < 9 mm in size. These data suggest the benefits of earlier intervention with early
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.acra.2009.10.016">doi:10.1016/j.acra.2009.10.016</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20152726">pmid:20152726</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3767437/">pmcid:PMC3767437</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2fvi36hpwrab7mrcmk4beoxxvm">fatcat:2fvi36hpwrab7mrcmk4beoxxvm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200506005821/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3767437&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/74/2e/742ea0c8b7f8d0b02ab42564a61b0aea5c4719c6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.acra.2009.10.016"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767437" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis

Minke M.F. van Mierlo, Luba M. Pardo, Karin B. Fieten, Tim J. van den Broek, Frank H.J. Schuren, Michel van Geel, Suzanne G.M.A. Pasmans
<span title="2022-01-18">2022</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zh5gzb5yubdnfogcobrn4g5wym" style="color: black;">Dermatology</a> </i> &nbsp;
Fieten b, c, d Tim J. van den Broek e Frank H.J. Schuren e Michel van Geel f, g Suzanne G.M.A.  ...  Using a subset analysis to test the effect of FLG mutation status per Luba M. Pardo and Karin B.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000520978">doi:10.1159/000520978</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35042220">pmid:35042220</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bryrym3pxjhjvckuhbcwnooxza">fatcat:bryrym3pxjhjvckuhbcwnooxza</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220123094911/https://www.karger.com/Article/Pdf/520978" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d0/e2/d0e20cd1a249837c6853472b3ed7686297e68fd3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000520978"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

BENZO[a]PYRENE BIOAVAILABILITY FROM PRISTINE SOIL AND CONTAMINATED SEDIMENT ASSESSED USING TWO IN VITRO MODELS

Luba Vasiluk, Linda J. Pinto, Zahra A. Walji, Wing Shan Tsang, Frank A.P.C. Gobas, Curtis Eickhoff, Margo M. Moore
<span title="">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7a3wzdwua5folmp4gbprqnmvie" style="color: black;">Environmental Toxicology and Chemistry</a> </i> &nbsp;
A major route of exposure to hydrophobic organic contaminants (HOCs), such as benzo[a]pyrene (BaP), is ingestion. Matrix-bound HOCs may become bioavailable after mobilization by the gastrointestinal fluids followed by sorption to the intestinal epithelium. The purpose of this research was to measure the bioavailability of [ 14 C]-BaP bound to pristine soils or field-contaminated sediment using an in vitro model of gastrointestinal digestion followed by sorption to human enterocytes (Caco-2
more &raquo; ... ) or to a surrogate membrane, ethylene vinyl acetate (EVA) thin film. Although Caco-2 cells had a twofold higher lipid-normalized fugacity capacity than EVA, [ 14 C]-BaP uptake by Caco-2 lipids and EVA thin film demonstrated a linear relationship within the range of BaP concentrations tested. These results suggest that EVA thin film is a good membrane surrogate for passive uptake of BaP. The in vitro system provided enough sensitivity to detect matrix effects on bioavailability; after 5 h, significantly lower concentrations of [ 14 C]-BaP were sorbed into Caco-2 cells from soil containing a higher percentage of organic matter compared to soil with a lower percentage of organic matter. The [ 14 C]-BaP desorption rate from Caco-2 lipids consistently was twofold higher than from EVA thin film for all matrices tested. The more rapid kinetics observed with Caco-2 cells probably were due to the greater surface area available for absorption/desorption in the cells. After 5 h, the uptake of BaP into Caco-2 lipid was similar in live and metabolically inert Caco-2 cells, suggesting that the primary route of BaP uptake is by passive diffusion. Moreover, the driving force for uptake is the fugacity gradient that exists between the gastrointestinal fluid and the membrane. Keywords-Benzo[a]pyrene Bioavailability Caco-2 cells Soil In vitro tests Environ. Toxicol. Chem. 26, 2007 L. Vasiluk et al. Environ. Toxicol. Chem. 26, 2007
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1897/06-343r.1">doi:10.1897/06-343r.1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17373501">pmid:17373501</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kipkxeaanjdgdbfrkuhxlk7zyi">fatcat:kipkxeaanjdgdbfrkuhxlk7zyi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809122023/http://rem-main.rem.sfu.ca/papers/gobas/ET&amp;C.07.Vasiluk%20et%20al.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4b/06/4b06d97c51676adb769936b042eca21162bdfa49.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1897/06-343r.1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

N-myc Downstream-Regulated Gene 1 Is Mutated in Hereditary Motor and Sensory Neuropathy–Lom

Luba Kalaydjieva, David Gresham, Rebecca Gooding, Lisa Heather, Frank Baas, Rosalein de Jonge, Karin Blechschmidt, Dora Angelicheva, David Chandler, Penelope Worsley, Andre Rosenthal, Rosalind H.M. King (+1 others)
<span title="">2000</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ho5llzhlhzhmrlusxzz4j2bery" style="color: black;">American Journal of Human Genetics</a> </i> &nbsp;
Hereditary motor and sensory neuropathies, to which Charcot-Marie-Tooth (CMT) disease belongs, are a common cause of disability in adulthood. Growing awareness that axonal loss, rather than demyelination per se, is responsible for the neurological deficit in demyelinating CMT disease has focused research on the mechanisms of early development, cell differentiation, and cell-cell interactions in the peripheral nervous system. Autosomal recessive peripheral neuropathies are relatively rare but
more &raquo; ... clinically more severe than autosomal dominant forms of CMT, and understanding their molecular basis may provide a new perspective on these mechanisms. Here we report the identification of the gene responsible for hereditary motor and sensory neuropathy-Lom (HMSNL). HMSNL shows features of Schwann-cell dysfunction and a concomitant early axonal involvement, suggesting that impaired axonglia interactions play a major role in its pathogenesis. The gene was previously mapped to 8q24.3, where conserved disease haplotypes suggested genetic homogeneity and a single founder mutation. We have reduced the HMSNL interval to 200 kb and have characterized it by means of large-scale genomic sequencing. Sequence analysis of two genes located in the critical region identified the founder HMSNL mutation: a premature-termination codon at position 148 of the N-myc downstream-regulated gene 1 (NDRG1). NDRG1 is ubiquitously expressed and has been proposed to play a role in growth arrest and cell differentiation, possibly as a signaling protein shuttling between the cytoplasm and the nucleus. We have studied expression in peripheral nerve and have detected particularly high levels in the Schwann cell. Taken together, these findings point to NDRG1 having a role in the peripheral nervous system, possibly in the Schwann-cell signaling necessary for axonal survival.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1086/302978">doi:10.1086/302978</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/10831399">pmid:10831399</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1287101/">pmcid:PMC1287101</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pjjwph4fdzdpbbm4yoewdqa4fm">fatcat:pjjwph4fdzdpbbm4yoewdqa4fm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190328194522/https://core.ac.uk/download/pdf/82361593.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9a/b3/9ab34129cdb055f207e03d08d58a6ee780dcbf19.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1086/302978"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287101" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: study protocol for a randomized controlled trial (MAAS trial)

Joan Totté, Jill de Wit, Luba Pardo, Frank Schuren, Martijn van Doorn, Suzanne Pasmans
<span title="2017-08-31">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/elawdhnd7neuxgmzbrr6efzkgu" style="color: black;">Trials</a> </i> &nbsp;
Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory results. Long-term interventions against S. aureus might be needed to restore the microbial balance, but carry the risk of bacterial resistance induction. Staphefekt, an engineered
more &raquo; ... hage endolysin, specifically kills S. aureus leaving other skin commensals unharmed. Bacterial resistance towards endolysins has not been reported, nor is it expected, which allows us to study its effect as long-term anti-staphylococcal treatment in non-infected AD. Methods: This is a multi-centre, placebo-controlled, double-blinded and randomized superiority trial with a parallel group design. A total of 100 participants, aged 18 years or older, diagnosed with moderate to severe AD and using a topical corticosteroid in the weeks before enrolment are included in the study. The study is executed in the Erasmus MC University Medical Centre Rotterdam in collaboration with the Havenziekenhuis Rotterdam. After a 2-week run-in period to standardize the corticosteroid use with triamcinolone acetonide 0.1% cream, participants will be randomized to either treatment with Staphefekt in a cetomacrogol-based cream or a placebo for 12 weeks, followed by an 8-week follow-up period. The primary objective is to assess the difference in the need for corticosteroid co-therapy between the Staphefekt and the placebo group, measuring the number of days per week of corticosteroid cream (triamcinolone) use. Secondary outcomes include the difference in use of corticosteroid cream measured in grams, differences in clinical efficacy, quality of life (QoL), microbial composition (includi23ng S. aureus) between the Staphefekt and the placebo group, and the safety and tolerability. Discussion: The results of this trial will provide data about the effect of long-term anti-staphylococcal therapy with Staphefekt on corticosteroid use, clinical symptoms and QoL in patients with moderate to severe AD. Additional data about growth characteristics of the skin microbiome, including S. aureus, will give insight into the role of the microbiome as a factor in the pathophysiology of AD. Trial registration: ClinicalTrials.gov, NCT02840955. Registered on 11 July 2016.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13063-017-2118-x">doi:10.1186/s13063-017-2118-x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28859690">pmid:28859690</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5580294/">pmcid:PMC5580294</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z2p26jmyezbfnbd6b4jplma6sa">fatcat:z2p26jmyezbfnbd6b4jplma6sa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719001033/https://repub.eur.nl/pub/101715/REPUB_101715-OA.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a5/0c/a50c17e94c10ec17da6122c63aef4c0756fd6c90.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13063-017-2118-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580294" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cardiovascular disease in women: insights from magnetic resonance imaging

Chiara Bucciarelli-Ducci, Ellen Ostenfeld, Lauren A. Baldassarre, Vanessa M. Ferreira, Luba Frank, Kimberly Kallianos, Subha V. Raman, Monvadi B. Srichai, Elisa McAlindon, Sophie Mavrogeni, Ntobeko A. B. Ntusi, Jeanette Schulz-Menger (+2 others)
<span title="2020-09-28">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jflzecjifjfnzmksqbreqnmoo4" style="color: black;">Journal of Cardiovascular Magnetic Resonance</a> </i> &nbsp;
The presentation and identification of cardiovascular disease in women pose unique diagnostic challenges compared to men, and underrecognized conditions in this patient population may lead to clinical mismanagement. This article reviews the sex differences in cardiovascular disease, explores the diagnostic and prognostic role of cardiovascular magnetic resonance (CMR) in the spectrum of cardiovascular disorders in women, and proposes the added value of CMR compared to other imaging modalities.
more &raquo; ... n addition, this article specifically reviews the role of CMR in cardiovascular diseases occurring more frequently or exclusively in female patients, including Takotsubo cardiomyopathy, connective tissue disorders, primary pulmonary arterial hypertension and peripartum cardiomyopathy. Gaps in knowledge and opportunities for further investigation of sex-specific cardiovascular differences by CMR are also highlighted.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12968-020-00666-4">doi:10.1186/s12968-020-00666-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32981527">pmid:32981527</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fgtk3hedkfdodbmkmvzcicju5q">fatcat:fgtk3hedkfdodbmkmvzcicju5q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428010805/https://research-information.bris.ac.uk/ws/files/252916239/s12968_020_00666_4.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/63/e0/63e06001e379f12b4d9267062776c768b9c01f1d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12968-020-00666-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>
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