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Editorial

Antonio Pedro Costa, Luis Paulo Gonçalves Reis, Pedro Vitor Lemos Cravo, Alexandre Cláudio Botazzo Delbem, Clarimar José Coelho
2015 Fronteiras: Journal of Social, Technological and Environmental Science  
The article Dynamics of Use and Land Cover in Landscape in São Paulo Antonio Pedro Costa 1 Luis Paulo Gonçalves dos Reis 2 Pedro Vitor Lemos Cravo 3 Alexandre Cláudio Botazzo Delbem 4 Clarimar José Coelho  ...  Antonio Pedro Costa 1 Luis Paulo Gonçalves dos Reis 2 Pedro Vitor Lemos Cravo 3 Alexandre Cláudio Botazzo Delbem 4 Clarimar José Coelho 5 (Editores) Editorial Dossier "Technologies, Epistemological  ... 
doi:10.21664/2238-8869.2015v4i3.p11-15 fatcat:hst3fzeiubhx5ijtmuhhhkloau

Pancreatic Stone Protein: Review of a New Biomarker in Sepsis

Pedro Fidalgo, David Nora, Luis Coelho, Pedro Povoa
2022 Journal of Clinical Medicine  
Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection that may evolve rapidly into septic shock and multiple organ failure. Management of sepsis relies on the early recognition and diagnosis of infection and the providing of adequate and prompt antibiotic therapy and organ support. A novel protein biomarker, the pancreatic stone protein (PSP), has recently been studied as a biomarker of sepsis and the available evidence suggests that it has a higher
more » ... diagnostic performance for the identification of infection than the most used available biomarkers and adds prognostic value. This review summarizes the clinical evidence available for PSP in the diagnosis and prognosis of sepsis.
doi:10.3390/jcm11041085 pmid:35207355 pmcid:PMC8880320 fatcat:62yboebzcfcnta5fhkheuhsnhy

FACS: antimicrobial peptide screening in genomes and metagenomes [article]

Celio Dias Santos-Junior, Shaojun Pan, Xing-Ming Zhao, Luis Pedro Coelho
2019 bioRxiv   pre-print
Acknowledgments We thank Hiram He, Fudan University, who helped set up the Macrel website and kindly offered coding support as well as members of the Coelho group for helpful comments on previous versions  ...  For calculating AMP abundance profiles, Macrel uses Paladin (Westbrook et al., 2017) and NGLess (Coelho et al., 2019) .  ...  To ensure realism, the simulated metagenomes contained species abundances estimated from real human gut microbial communities (Coelho et al., 2019) .  ... 
doi:10.1101/2019.12.17.880385 fatcat:llu2s3giinditeznsppekevmfm

Metformin-induced lactic acidosis: a case series

Joana Silvestre, Susana Carvalho, Vitor Mendes, Luis Coelho, Camila Tapadinhas, Pedro Ferreira, Pedro Povoa, Fatima Ceia
2007 Journal of Medical Case Reports  
Unlike other agents used in the treatment of type 2 diabetes mellitus, metformin has been shown to reduce mortality in obese patients. It is therefore being increasingly used in higher doses. The major concern of many physicians is a possible risk of lactic acidosis. The reported frequency of metformin related lactic acidosis is 0.05 per 1000 patient-years; some authors advocate that this rate is equal in those patients not taking metformin. Case presentation: We present two case reports of
more » ... ormin-associated lactic acidosis. The first case is a 77 year old female with a past medical history of hypertension and type 2 diabetes mellitus who had recently been prescribed metformin (3 g/day), perindopril and acetylsalicylic acid. She was admitted to the emergency department two weeks later with abdominal pain and psychomotor agitation. Physical examination revealed only signs of poor perfusion. Laboratory evaluation revealed hyperkalemia, elevated creatinine and blood urea nitrogen and mild leukocytosis. Arterial blood gases showed severe lactic acidemia. She was admitted to the intensive care unit. Vasopressor and ventilatory support was initiated and continuous venovenous hemodiafiltration was instituted. Twenty-four hours later, full clinical recovery was observed, with return to a normal serum lactate level. The patient was discharged from the intensive care unit on the sixth day. The second patient is a 69 year old male with a past medical history of hypertension, type 2 diabetes mellitus and ischemic heart disease who was on metformin (4 g/day), glycazide, acetylsalicylic acid and isosorbide dinitrate. He was admitted to the emergency department in shock with extreme bradycardia. Initial evaluation revealed severe lactic acidosis and elevated creatinine and urea. The patient was admitted to the Intensive Care Unit and commenced on continuous venovenous hemodiafiltration in addition to other supportive measures. A progressive recovery was observed and he was discharged from the intensive care unit on the seventh day. Conclusion: We present two case reports of severe lactic acidosis most probably associated with high doses of metformin in patients with no known contraindications for metformin prescription. In both patients no other condition was identified to cause such severe lactic acidosis. Although controversial, lactic acidosis should be considered in patients taking metformin.
doi:10.1186/1752-1947-1-126 pmid:17974034 pmcid:PMC2169248 fatcat:nlwv2q3ncrgnzntkvw26gmnnjm

Jug: Software for Parallel Reproducible Computation in Python

Luis Pedro Coelho
2017 Journal of Open Research Software  
Pedro Coelho Version published: 1.6.0 Date published: 24 Aug 2017 4.3.2 Code repository Name: Github Persistent identifier: https://github.com/luispedro/jug Licence: MIT  ...  Pedro Coelho designed and implemented Jug.The following individuals have contributed patches (alphabetically): Alex Ford, Andreas Sorge, Breanndán Ó Nualláin, Christian Jauvin, Dominique Geffroy, Elliott  ... 
doi:10.5334/jors.161 fatcat:45nl2ymjybeexarkymrqshyqni

Optimizing Antimicrobial Drug Dosing in Critically Ill Patients

Pedro Póvoa, Patrícia Moniz, João Gonçalves Pereira, Luís Coelho
2021 Microorganisms  
A fundamental step in the successful management of sepsis and septic shock is early empiric antimicrobial therapy. However, for this to be effective, several decisions must be addressed simultaneously: (1) antimicrobial choices should be adequate, covering the most probable pathogens; (2) they should be administered in the appropriate dose, (3) by the correct route, and (4) using the correct mode of administration to achieve successful concentration at the infection site. In critically ill
more » ... nts, antimicrobial dosing is a common challenge and a frequent source of errors, since these patients present deranged pharmacokinetics, namely increased volume of distribution and altered drug clearance, which either increased or decreased. Moreover, the clinical condition of these patients changes markedly over time, either improving or deteriorating. The consequent impact on drug pharmacokinetics further complicates the selection of correct drug schedules and dosing during the course of therapy. In recent years, the knowledge of pharmacokinetics and pharmacodynamics, drug dosing, therapeutic drug monitoring, and antimicrobial resistance in the critically ill patients has greatly improved, fostering strategies to optimize therapeutic efficacy and to reduce toxicity and adverse events. Nonetheless, delivering adequate and appropriate antimicrobial therapy is still a challenge, since pathogen resistance continues to rise, and new therapeutic agents remain scarce. We aim to review the available literature to assess the challenges, impact, and tools to optimize individualization of antimicrobial dosing to maximize exposure and effectiveness in critically ill patients.
doi:10.3390/microorganisms9071401 fatcat:yn7xdxxncfbnlhhed3bsqc5txi

Wine fingerprinting using a bio-geochemical approach

José Ramiro Fernandes, Leonor Pereira, Pedro Jorge, Luis Moreira, Helena Gonçalves, Luis Coelho, Daniel Alexandre, José Eiras-Dias, João Brazão, Pedro Clímaco, Margarida Baleiras-Couto, Sofia Catarino (+3 others)
2015 BIO Web of Conferences  
The wine sector is a billion euro business and therefore subjected to multiple attempts of fraudulent practices. This requires the development of rapid and reliable methods to detect such situations. Several methodologies have been developed based on the chemical profiles of the wines, but they are limited due to the environmental conditions that cannot be controlled. The use of DNA-based detection systems are an emergent research field that have been extended to a wide variety of food products
more » ... and are still the most reliable methods for varietal identification. However these methods are not suitable for geographical determination. Soil related fingerprints have a primary role considering that there is a relationship between the elemental composition of wine and the composition of the provenance soil. WineBioCode is a project aiming to define the best strategy for wine authenticity based on a multidisciplinary approach. Two DNA-based strategies have been developed based on Real-time PCR and a label free optical biosensor platform. Both platforms enabled successful identification of specific DNA-targets when applied to Vitis vinifera L., and can be applied throughout the grape-wine chain. The methods are complementary and can be used in different situations, according to the requirements. The geographical evaluation has been assessed by the strontium 87 Sr/ 86 Sr isotope ratio determination involving soil evaluation in the vineyards followed by its assay in the wine samples. The results are being integrated in order to establish the best procedure to be undertaken for wine fingerprinting, including varietal composition and geographical origin, therefore fulfilling the requirements of the geographical denominations in wine certification.
doi:10.1051/bioconf/20150502021 fatcat:pgivlp3q6ve5fnvwyfmhajmfue

実践機械学習システム, Willi Richert, Luis Pedro Coelho著, 斎藤康毅訳, 出版社オライリージャパン, 発行2014年10月, 全ページ288頁, 価格3,200円, ISBN978-4-87311-698-3

Motoyuki SUZUKI
2015 Systems, Control and Information  
書 評 実践 機 械 学 習 シ ス テ ム Willi Richert , Luis Pedro Coelho 著 , 斎 藤 康 毅 訳 。 出 版 社 オ ラ イ リ ー ジ ャ パ ン 。 全 ペ ー ジ 288 頁 oISBN 978 − 487311 − 698 − 3 ・ 発 行 2014年 10 月 。  ... 
doi:10.11509/isciesci.59.9_360 fatcat:iffmktr3dbcu7hcxl7xftxvmie

Macrel: antimicrobial peptide screening in genomes and metagenomes

Célio Dias Santos-Júnior, Shaojun Pan, Xing-Ming Zhao, Luis Pedro Coelho
2020 PeerJ  
ACKNOWLEDGEMENTS We thank Hiram He, Fudan University, who helped set up the Macrel website and kindly offered coding support as well as members of the Coelho group for helpful comments on previous versions  ...  Newly simulated data was similarly archived and is available at Zenodo: Santos-Júnior, Célio Dias, Pan, Shaojun, Zhao, Xing-Ming, & Coelho, Luis Pedro. (2019).  ...  Santos-Júnior Luis Pedro Coelho, Hiram He, & psj1997. (2020, October 28). BigDataBiology/macrel: Version 0.6.1 (Version v0.6.1). Zenodo. DOI 10.5281/zenodo.4147382.  ... 
doi:10.7717/peerj.10555 pmid:33384902 pmcid:PMC7751412 fatcat:qdz27pxfjvbjlar3vyfuqjkdmq

Acupuncture in the treatment of burning mouth syndrome

Mateus Rodrigues Tonetto, Thiago Coelho Bandeca, Flávio Simões, Fábio Luís Miranda Pedro, Monica Barros da Silva, Matheus Coelho Bandéca, Milton Carlos Kuga, Paulo Inácio da Costa
2015 Scientific Journal of Dentistry  
The burning mouth syndrome (BMS) is a chronic orofacial disease characterized by symptoms of burning or burning in the oral mucosa without being able to detect lesions or clinical change. Its etiology is multifactorial and affects mainly women in the postmenopausal periods. Treatment should be multi-disciplinary, but the complexity of the etiology knowledge hinders the establishment of the most appropriate treatment. Therefore, this study evaluated the use of acupuncture in the treatment of
more » ... Through literature review, it can be noticed that the union of the concepts with the teachings of traditional Chinese medicine can provide a new perspective for the treatment of pain/oral burning as acupuncture treats the individual as a whole, in an attempt to restore the balance between the organs. Thus, various pharmacological effects can be achieved, such as analgesic, muscle relaxing, sedative, antidepressant, anti-inflammatory, repair stimulating, and immunity promoter, which might have a great efficacy in the treatment of BMS. Acupuncture in the treatment of burning mouth syndrome. Sci J Dent (2015);2:26-30.
doi:10.15713/ins.sjod.29 fatcat:7j4jeasenba73gcxpcogmaxvoq

The Costly War Against Cancer Treatment: The Example of Metastatic Renal Cell Carcinoma in Portugal

Pedro Coelho Barata, Diogo Alpuim Costa, José Luís Passos Coelho, Ricardo Da Luz
2018 Acta Médica Portuguesa  
doi:10.20344/amp.9969 pmid:30189164 fatcat:i2syctvpazhnvbwmtlahq7cpfu

Prognostic value of CA125 in advanced heart failure patients

Sílvia Monteiro, Fátima franco, Susana Costa, Pedro Monteiro, Henrique Vieira, Lourenço Coelho, Luís Oliveira, Luís A. Providência
2010 International Journal of Cardiology  
Serum levels of CA125 are often high in advanced heart failure (AHF) patients. Aim: To determine the predictive value of CA125 in forecasting the occurrence of death or cardiac transplantation in an AHF population. Methods: 88 AHF patients referred for heart transplantation were divided into 2 groups based on CA125 levels: normal (CA125 b 38 U/mL) and elevated (≥ 38 U/mL). Events (death or heart transplant) were monitored over a period of 13 ± 7 months after CA125 determination. Results:
more » ... s with elevated CA125 (n = 65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher. The combined primary endpoint (death or heart transplant) rate was 39.4% and 62.3% in normal and elevated CA125 groups, respectively (p = 0.029). Multivariate regression analysis showed that CA125 and sodium levels were the only independent predictors of the combined endpoint. Conclusion: In AHF patients, plasma CA125 was an effective prognostic marker. Its determination may contribute to better risk stratification in this population.
doi:10.1016/j.ijcard.2008.11.023 pmid:19285353 fatcat:3bkfsksqdrgovf5jirqrhizs3u

Dotted Suffix Trees A Structure for Approximate Text Indexing [chapter]

Luís Pedro Coelho, Arlindo L. Oliveira
2006 Lecture Notes in Computer Science  
In this work, the problem we address is text indexing for approximate matching. Given a text T which undergoes some preprocessing to generate an index, we can later query this index to identify the places where a string occurs up to a certain number of errors k (edition distance). The indexing structure occupies space O(n log k n) in the average case, independent of alphabet size. This structure can be used to report the existence of a match with k errors in O(3 k m k+1 ) and to report the
more » ... rences in O(3 k m k+1 +ed) time, where m is the length of the pattern and ed and the number of matching edit scripts. The construction of the structure has time bound by O(kN|Σ|), where N is the number of nodes in the index and |Σ| the alphabet size.
doi:10.1007/11880561_27 fatcat:3r6tjnxgi5apdpmciz6zgme2g4

Development of a Long Period Fiber Grating Interrogation System Using A Multimode Laser Diode

Luís Henrique Silva, Paulo Santos, Luís C. C. Coelho, Pedro Jorge, José Manuel Baptista
2021 Sensors  
Optical fiber gratings have long shown their sensing capabilities. One of the main challenges, however, is the interrogation method applied, since typical systems tend to use broadband light sources with optical spectrum analyzers, laser scanning units or CCD (Charged Coupled Device) spectrometers. The following paper presents the development of an interrogation system, which explores the temperature response of a multimode laser diode, in order to interrogate long period fiber gratings. By
more » ... orming a spectral sweep along one of its rejection bands, a discrete attenuation spectrum is created. Through a curve fitting technique, the original spectrum is restored. The built unit, while presenting a substantially reduced cost compared with typical interrogation systems, is capable of interrogating along a 10 nm window with measurement errors reaching minimum values as low as 0.4 nm, regarding the grating central wavelength, and 0.4 dB for its attenuation. Given its low cost and reduced dimensions, the developed system shows potential for slow-changing field applications.
doi:10.3390/s21030749 pmid:33499358 pmcid:PMC7865967 fatcat:4ljxbcriofglnmt3z64wn4dnvy

Usefulness of C-reactive protein in monitoring the severe community-acquired pneumonia clinical course

Luís Coelho, Pedro Póvoa, Eduardo Almeida, Antero Fernandes, Rui Mealha, Pedro Moreira, Henrique Sabino
2007 Critical Care  
The aim of the present study was to evaluate the C-reactive protein level, the body temperature and the white cell count in patients after prescription of antibiotics in order to describe the clinical resolution of severe community-acquired pneumonia. Methods A cohort of 53 consecutive patients with severe community-acquired pneumonia was studied. The C-reactive protein levels, body temperature and white cell count were monitored daily. Results By day 3 a C-reactive protein level 0.5 times the
more » ... nitial level was a marker of poor outcome (sensitivity, 0.91; specificity, 0.59). Patients were divided according to their C-reactive protein patterns of response to antibiotics, into fast response, slow response, nonresponse, and biphasic response. About 96% of patients with a C-reactive protein pattern of fast response and 74% of patients with a slow response pattern survived, whereas those patients with the patterns of nonresponse and of biphasic response had a mortality rate of 100% and 33%, respectively (P < 0.001). On day 3 of antibiotic therapy, a decrease in C-reactive protein levels by 0.31 or more from the previous day's level was a marker of good prognosis (sensitivity, 0.75; specificity, 0.85). Conclusion Daily C-reactive protein measurement after antibiotic prescription is useful in identification, as early as day 3, of severe community-acquired pneumonia patients with poor outcome. The identification of the C-reactive protein pattern of response to antibiotic therapy was useful in the recognition of the individual clinical course, either improving or worsening, as well as the rate of improvement, in patients with severe community-acquired pneumonia.
doi:10.1186/cc6105 pmid:17723153 pmcid:PMC2206486 fatcat:m6wowzqgwfcr3clwkfw5iesqta
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