Filters








1,148 Hits in 7.6 sec

Scalable Bayesian inference of dendritic voltage via spatiotemporal recurrent state space models

Ruoxi Sun, Scott W. Linderman, Ian Kinsella, Liam Paninski
2019 Neural Information Processing Systems  
Our starting point is the cable equation [11] , the partial differential equation that specifies the evolution of membrane potential in space and time.  ...  The model captures potentially different dynamics in each compartment and leverages biophysical knowledge to constrain intra-and inter-compartmental dynamics.  ...  We replace this sum with a simpler, low-dimensional effective model.  ... 
dblp:conf/nips/SunLKP19 fatcat:ut3tzvei7bhj3nmrlvxmtw3qym

Page 608 of The Journal of Neuroscience Vol. 12, Issue 2 [page]

1992 The Journal of Neuroscience  
These unphysiologically long latencies presumably result from the continuous nature of the differential equations used to model the spike and from the absence of noise in the membrane potential (Lecar  ...  Some simulations were done using membrane resistances between these two extremes. The excitatory postsynaptic response was modeled as a conductance increase with a reversal potential of 0 mV.  ... 

Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons

Timothy Rumbell, James Kozloski, Hermann Cuntz
2019 PLoS Computational Biology  
From this population of models, we then discovered low-dimensional controllers for regulating spontaneous firing properties, and gain insight into how currents active in different voltage regimes interact  ...  Here we show robust coordination by linear parameter controllers, discovered through powerful mathematical analyses of data and models, and from which consistent control of DA subthreshold oscillations  ...  Membrane potential equation.  ... 
doi:10.1371/journal.pcbi.1007375 pmid:31545787 pmcid:PMC6776370 fatcat:azb7yzwz4rcn3nzvmzc5dt6gdi

A Novel Form of Compensation in the Tg2576 Amyloid Mouse Model of Alzheimer's Disease

Attila Somogyi, Zoltán Katonai, Alán Alpár, Ervin Wolf
2016 Frontiers in Cellular Neuroscience  
However, little effort has been made to study the potential effects of combined morphological and membrane alterations on signal transfer and synaptic integration in neurons that build up affected neural  ...  Amyloid-related dendritic atrophy and membrane alterations of susceptible brain neurons in AD, and in animal models of AD are widely recognized.  ...  Gary Kish Portsmouth Regional Hospital, Portsmouth NH, USA for English language proofreading and editing of the manuscript.  ... 
doi:10.3389/fncel.2016.00152 pmid:27378850 pmcid:PMC4909742 fatcat:v7kjtjszn5cknpzdqjjg4dfhli

Architectural Correlates of Myocardial Conduction: Changes to the Topography of Cellular Coupling, Intracellular Conductance, and Action Potential Propagation with Hypertrophy in Guinea-Pig Ventricular Myocardium

C. H. Fry, R. P. Gray, P. S. Dhillon, R. I. Jabr, E. Dupont, P. M. Patel, N. S. Peters
2014 Circulation: Arrhythmia and Electrophysiology  
Intercalated disk morphology and connexin 43 immunolabelling were not different in hypertrophy.  ...  Background-We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to  ...  Sources of Funding Thus study was funded by British Heart Foundation grants PG/08/065, RG/10/11/28457, and PG/12/64/29828. Disclosures None.  ... 
doi:10.1161/circep.114.001471 pmid:25313260 fatcat:su7uxlkjrva6zjynzcz3phyr2y

Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro

Thomas Radman, Raddy L. Ramos, Joshua C. Brumberg, Marom Bikson
2009 Brain Stimulation  
Based solely on volume weighted morphology, we developed a parsimonious model of neuronal soma polarization by subthreshold electric fields.  ...  Neuron morphology was reconstructed after intracellular dialysis of biocytin.  ...  Once a stable whole-cell configuration was obtained (resting membrane potential of less than 55 mV, overshooting action potentials, generation of repetitive APs in response to a depolarizing current pulse  ... 
doi:10.1016/j.brs.2009.03.007 pmid:20161507 pmcid:PMC2797131 fatcat:spf6lhpvtzckpl6755u6gorhse

Subthreshold membrane responses underlying sparse spiking to natural vocal signals in auditory cortex

Krista E. Perks, Timothy Q. Gentner
2015 European Journal of Neuroscience  
of the subthreshold response in single cells.  ...  Natural acoustic communication signals, such as speech, are typically high-dimensional with a wide range of co-varying spectro-temporal features at multiple timescales.  ...  Acknowledgements We thank the members of the Gentner laboratory for comments on the manuscript.  ... 
doi:10.1111/ejn.12831 pmid:25728189 pmcid:PMC4347871 fatcat:3rnesbasqngmtnfpvm5zky4oy4

Optimizing computer models of corticospinal neurons to replicate in vitro dynamics

Samuel A. Neymotin, Benjamin A. Suter, Salvador Dura-Bernal, Gordon M. G. Shepherd, Michele Migliore, William W. Lytton
2017 Journal of Neurophysiology  
We used our electrophysiological data to produce a pair of large archives of SPI neuron computer models in two model classes: 1) detailed models with full reconstruction; and 2) simplified models with  ...  EMO selected good models from each of the two model classes to form the two model archives. Archived models showed tradeoffs across fitness functions.  ...  The NIH had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.  ... 
doi:10.1152/jn.00570.2016 pmid:27760819 pmcid:PMC5209548 fatcat:645ire2osbekngz2jzybnm3f5y

Ultrafast large-scale simulations of biophysically realistic neurons using deep learning [article]

Viktor Janos Olah, Nigel P Pedersen, Matthew JM Rowan
2021 bioRxiv   pre-print
We identified a single ANN that accurately predicted both subthreshold and action potential firing, and correctly generalized its responses to previously unobserved synaptic input.  ...  When scaled, processing times were orders of magnitude faster compared with traditional approaches, allowing for rapid parameter-space mapping in a circuit model of Rett syndrome.  ...  Acknowledgements Partial support (NPP) provided by CURE Epilepsy and the National Institutes of Health K08NS105929.  ... 
doi:10.1101/2021.02.22.432356 fatcat:6p2v5skoxrcxjmlvlhfwylykwu

Model Order Reduction in Neuroscience [article]

Bülent Karasözen
2020 arXiv   pre-print
The aim of model reduction of large-scale neuronal networks is an accurate and fast prediction of patterns and their propagation in different areas of the brain.  ...  It has been observed that the neuronal activity evolves on low-dimensional subspaces.  ...  The reduced order model in [16] preserves the spatial precision of synaptic input, captures accurately the subthreshold and spiking behaviors.  ... 
arXiv:2003.05133v2 fatcat:3gwvjzh5czdkxj3rfhcrrnxjcm

Threshold Firing Frequency–Current Relationships of Neurons in Rat Somatosensory Cortex: Type 1 and Type 2 Dynamics

T. Tateno, A. Harsch, H. P. C. Robinson
2004 Journal of Neurophysiology  
amplitude and subthreshold oscillations.  ...  Very close to threshold, FS cells switch irregularly between bursts of periodic firing and subthreshold oscillations.  ...  Because higher-dimensional spiking models may often be accurately reduced into fast and slow systems of variables, such type 1 and 2 threshold bifurcations may apply quite generally to biological neurons  ... 
doi:10.1152/jn.00109.2004 pmid:15381746 fatcat:h3fjds3i6zdbfh2vwbpshkuk2y

Weak electric fields promote resonance in neuronal spiking activity: Analytical results from two-compartment cell and network models

Josef Ladenbauer, Klaus Obermayer, Lyle J. Graham
2019 PLoS Computational Biology  
due to the morphology of pyramidal cells.  ...  While their influence on the subthreshold membrane voltage can be biophysically well explained using spatially extended neuron models, mechanistic analyses of neuronal spiking and network activity have  ...  Acknowledgments We thank Srdjan Ostojic for an inspiring discussion on modeling aspects, and we thank Joshua Goldwyn and the two anonymous reviewers for their constructive comments and useful suggestions  ... 
doi:10.1371/journal.pcbi.1006974 fatcat:a75knz6grnhgtpns4ydwoejvv4

Weak electric fields promote resonance in neuronal spiking activity: analytical results from two-compartment cell and network models [article]

Josef Ladenbauer, Klaus Obermayer
2018 bioRxiv   pre-print
While their influence on the subthreshold membrane voltage can be biophysically well explained using spatially extended neuron models, mechanistic analyses of neuronal spiking and network activity have  ...  due to the morphology of pyramidal cells.  ...  The funders had no role in study design, analysis, decision to publish, or preparation of the manuscript.  ... 
doi:10.1101/379560 fatcat:u6qtnpu6j5ehblwg637htpsxdi

BluePyOpt: Leveraging Open Source Software and Cloud Infrastructure to Optimise Model Parameters in Neuroscience

Werner Van Geit, Michael Gevaert, Giuseppe Chindemi, Christian Rössert, Jean-Denis Courcol, Eilif B. Muller, Felix Schürmann, Idan Segev, Henry Markram
2016 Frontiers in Neuroinformatics  
At many scales in neuroscience, appropriate mathematical models take the form of complex dynamical systems.  ...  Parametrising such models to conform to the multitude of available experimental constraints is a global nonlinear optimisation problem with a complex fitness landscape, requiring numerical techniques to  ...  Stable subthreshold oscillations in the IO can facilitate accurate timing by phase-locking spikes to the peaks of the oscillation.  ... 
doi:10.3389/fninf.2016.00017 pmid:27375471 pmcid:PMC4896051 fatcat:n5ejvfz4crhxtbszkjvzydxg5e

Automated High-Throughput Characterization of Single Neurons by Means of Simplified Spiking Models

Christian Pozzorini, Skander Mensi, Olivier Hagens, Richard Naud, Christof Koch, Wulfram Gerstner, Jonathan W. Pillow
2015 PLoS Computational Biology  
The model is capable of predicting both the spiking activity and the subthreshold dynamics of different cell types, and can be used for online characterization of neuronal properties.  ...  Here we demonstrate that, using a convex optimization procedure we previously introduced, a Generalized Integrateand-Fire model can be accurately fitted with a limited amount of data.  ...  Among others, this finding highlights the need of spiking neuron models that accurately capture the subthreshold membrane potential dynamics.  ... 
doi:10.1371/journal.pcbi.1004275 pmid:26083597 pmcid:PMC4470831 fatcat:n2sna4rjxndujdvaa3mhl2bxne
« Previous Showing results 1 — 15 out of 1,148 results