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Low-Dimensional Maps Encoding Dynamics in Entorhinal Cortex and Hippocampus

Dmitri D. Pervouchine, Theoden I. Netoff, Horacio G. Rotstein, John A. White, Mark O. Cunningham, Miles A. Whittington, Nancy J. Kopell
2006 Neural Computation  
The results obtained in the dynamic clamp experiments are in a good agreement with the analytical framework.  ...  In this article, we use models and dynamic clamp experiments to investigate the synchronization properties Neural Computation 18, 2617-2650 (2006) C 2006 Massachusetts Institute of Technology hibitory  ...  Acknowledgments We acknowledge Jozsi Jalics and Corey Acker for insightful discussions.  ... 
doi:10.1162/neco.2006.18.11.2617 pmid:16999573 fatcat:x3wg36dvtjcgfhf5maujaxvbrq

Bayesian Integration of Multi-resolutional Grid Codes for Spatial Cognition [article]

Taiping Zeng, XiaoLi Li, Bailu Si
2019 arXiv   pre-print
dynamics work in the entorhinal-hippocampal circuit.  ...  To understand the information transform across between neocortex, entorhinal cortex, and hippocampus, we propose spatial memory indexing theory from hippocampal indexing theory to investigate how neural  ...  neocortex (visual cortex and vestibular cortex), entorhinal cortex (medial entorhinal cortex and lateral entorhinal cortex), and hippocampus (CA3 and CA1).  ... 
arXiv:1910.05881v1 fatcat:vz235oqkujcqfkqad7sx4ve6dy

Place cells, spatial maps and the population code for memory

Stefan Leutgeb, Jill K Leutgeb, May-Britt Moser, Edvard I Moser
2005 Current Opinion in Neurobiology  
The code is based on inputs from a topographically organized, path-integrationdependent spatial map that lies upstream in the medial entorhinal cortex.  ...  The study of population dynamics in hippocampal place cells has emerged as one of the most powerful tools for understanding the encoding, storage and retrieval of declarative memory.  ...  Frank LM, Brown EN, Wilson M: Trajectory encoding in the hippocampus and entorhinal cortex. Neuron 2000, 27:169-178. 21.  ... 
doi:10.1016/j.conb.2005.10.002 pmid:16263261 fatcat:cuxrsxddnzbbxcns7ssrqjhst4

Navigating cognition: Spatial codes for human thinking

Jacob L. S. Bellmund, Peter Gärdenfors, Edvard I. Moser, Christian F. Doeller
2018 Science  
In our framework, place and grid cell population codes provide a representational format to map variable dimensions of cognitive spaces.  ...  Action sequences result in trajectories through cognitive space, which can be simulated via sequential coding in the hippocampus.  ...  (B) Firing of a place cell (left) and a grid cell (right) recorded from the hippocampus and entorhinal cortex, respectively.  ... 
doi:10.1126/science.aat6766 pmid:30409861 fatcat:uwu3jgxuxbhh5pkxoigt4kvrpe

Knowledge Across Reference Frames: Cognitive Maps and Image Spaces

Roberto Bottini, Christian F. Doeller
2020 Trends in Cognitive Sciences  
In human and non-human animals, conceptual knowledge is partially organized according to low-dimensional geometries that rely on brain structures and computations involved in spatial representations.  ...  We also suggest that cognitive maps and image spaces may be two manifestations of a more general propensity of the mind to create low-dimensional internal models.  ...  Acknowledgments We thank Jacob Bellmund, Talia Brandman, Kyle Jasmin, Léo Dutriaux, and Yangwen Xu for comments on an earlier draft.  ... 
doi:10.1016/j.tics.2020.05.008 pmid:32586649 fatcat:b6dl7uhpubhb3axtqoy56f6asy

MRI hippocampal and entorhinal cortex mapping in predicting conversion to Alzheimer's disease

D.P. Devanand, Ravi Bansal, Jun Liu, Xuejun Hao, Gnanavalli Pradhaban, Bradley S. Peterson
2012 NeuroImage  
Objective-Using MRI surface morphometry mapping, to evaluate local deformations of the hippocampus, parahippocampal gyrus, and entorhinal cortex in predicting conversion from mild cognitive impairment  ...  Methods-Baseline brain MRI with surface morphological analysis was performed in 130 outpatients with MCI, broadly defined, and 61 healthy controls followed for an average of 4 years in a single site study  ...  Acknowledgments Supported in part by grants AG17761 and P30 AG08051 from the National Institute of Aging.  ... 
doi:10.1016/j.neuroimage.2012.01.075 pmid:22289801 pmcid:PMC3320768 fatcat:kamwgivw5nbhbafaj7rxa5kghe

Four-Dimensional Consciousness

Richard Sieb
2017 Activitas Nervosa Superior  
Conscious experience is an orientation in space and time, an understanding of the position of the observer in space and time.  ...  A neural correlate for four-dimensional conscious experience can be found in the human brain and is modelled by Einstein's special theory of relativity.  ...  Utilizing a reference grid set up by entorhinal cortex grid cells, the hippocampus differentially encodes key events in space and time and represents spacetime interval inequalities.  ... 
doi:10.1007/s41470-017-0008-x fatcat:ok7qkk63sjftbhqmbrrvy5yox4

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

György Buzsáki, Edvard I Moser
2013 Nature Neuroscience  
We review experimental data in support of this hypothesis and discuss how specific firing patterns and oscillatory dynamics in the entorhinal cortex and hippocampus can support both navigation and memory  ...  Theories on the functions of the hippocampal system are based largely on two fundamental discoveries: the amnestic consequences of removing the hippocampus and associated structures in the famous patient  ...  among modules of the entorhinal cortex grid map.  ... 
doi:10.1038/nn.3304 pmid:23354386 pmcid:PMC4079500 fatcat:flxypijmt5bmhkm26aiyqtwjsi

A single microcircuit with multiple functions: state dependent information processing in the hippocampus

Margaret F Carr, Loren M Frank
2012 Current Opinion in Neurobiology  
Many neural circuits process information in multiple distinct modes. For example, the hippocampus is involved in memory encoding, retrieval, and consolidation processes.  ...  These different mnemonic computations require processing of differing balances of current sensory input and previously stored associations.  ...  Microstructure of a spatial map in the entorhinal cortex. Nature. 2005; 436:801-806. [PubMed: 15965463] 21. Sargolini F, Fyhn M, Hafting T, McNaughton BL, Witter MP, Moser MB, Moser EI.  ... 
doi:10.1016/j.conb.2012.03.007 pmid:22480878 pmcid:PMC3438355 fatcat:xf257oheobb7tdgok6w2vlnelm

A processing architecture for associative short-term memory in electronic noses

G Pioggia, M Ferro, F Di Francesco, D De Rossi
2006 Measurement science and technology  
Starting from the base models available in the architecture core, dedicated models for neurons, maps and connections were tailored to an artificial olfactory system devoted to analysing olive oil.  ...  To overcome these problems this paper presents an architecture for dynamic and efficient management of multi-transducer data processing techniques and for saving an associative short-term memory of the  ...  The input entorhinal cortex and the output entorhinal cortex maps represent the input and the output of the net, respectively.  ... 
doi:10.1088/0957-0233/17/11/027 fatcat:qri3gntvyjcjxix7snadrpgmey

A Controlled Attractor Network Model of Path Integration in the Rat

John Conklin, Chris Eliasmith
2005 Journal of Computational Neuroscience  
Cells in several areas of the hippocampal formation show place specific firing patterns, and are thought to form a distributed representation of an animal's current location in an environment.  ...  Experimental results suggest that this representation is continually updated even in complete darkness, indicating the presence of a path integration mechanism in the rat.  ...  This work is supported by the National Science and Engineering Research Council of Canada (261453-03), the Canadian Foundation for Innovation (3358401), and the Ontario Innovation Trust (3358501).  ... 
doi:10.1007/s10827-005-6558-z pmid:15714269 fatcat:7lpa7s4ujfcfdfconjmu6usmqa

A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability

Haggai Agmon, Yoram Burak
2020 eLife  
Here we develop a theory of joint attractor dynamics in the hippocampus and the MEC.  ...  Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments.  ...  Impaired Spatial Representation in CA1 after Lesion of Direct Input from Entorhinal Burak, Y. (2014). Spatial coding and attractor dynamics of grid cells in the entorhinal cortex. 820 Curr. Opin.  ... 
doi:10.7554/elife.56894 fatcat:jwsqcykz6nda3chkojrsnkyibe

Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map

S. Leutgeb, J. K. Leutgeb
2007 Learning & memory (Cold Spring Harbor, N.Y.)  
entorhinal cortex.  ...  The hippocampal CA3 subregion is critical for rapidly encoding new memories, which suggests that neuronal computations are implemented in its circuitry that cannot be performed elsewhere in the hippocampus  ...  McNaughton, and M. Witter for their helpful comments. The work was supported by a Centre of Excellence and a NevroNor grant from the Norwegian Research Council.  ... 
doi:10.1101/lm.703907 pmid:18007018 fatcat:vrc75lph25bcddcbbnt37b7ese

Parametric Anatomical Modeling: A method for modeling the anatomical layout of neurons and their projections

Pyka Martin, Cheng Sen
2014 Frontiers in Neuroinformatics  
The low-dimensional, but yet biologically plausible, parameter space renders PAM suitable to analyse allometric and evolutionary factors in networks and to model the complexity of real networks with comparatively  ...  function of the hippocampus.  ...  This low-dimensional encoding has two practical advantages.  ... 
doi:10.3389/conf.fninf.2014.18.00020 fatcat:d3sobrur3vaknf3ar6qgovclja

A Role for the Longitudinal Axis of the Hippocampus in Multiscale Representations of Large and Complex Spatial Environments and Mnemonic Hierarchies [chapter]

Bruce Harland, Marcos Contreras, Jean-Marc Fellous
2018 The Hippocampus - Plasticity and Functions  
The hippocampus is involved in spatial navigation and memory in rodents and humans.  ...  during navigation in large and complex environments or when encoding complex memories.  ...  Acknowledgements We wish to thank Blaine Harper and Sahana Srivathsa for comments which improved the manuscript.  ... 
doi:10.5772/intechopen.71165 fatcat:iv2o7wtz5jhjrov7cdtszvfwpq
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