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Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging☆

P. Kochunov, A.E. Ramage, J.L. Lancaster, D.A. Robin, S. Narayana, T. Coyle, D.R. Royall, P. Fox
2009 NeuroImage  
Relationships between structural MRI-based markers of declining cerebral integrity, and regional PET measurements of 18 FDG uptake have not been studied well in normal aging.  ...  Our findings suggest that the age-related decline in white matter integrity, observed as increases in HWM lesions, intergyral spans and reduction in FA, correlated with a decline in the global and regional  ...  Acknowledgments This work has been supported by the National Institute of Biomedical Imaging and Bioengineering (K01 EB006395) grant to P.  ... 
doi:10.1016/j.neuroimage.2008.11.010 pmid:19095067 pmcid:PMC2734283 fatcat:yo64lrezkna5tndoeg2nyvg6f4

Neurodevelopmental and Neurodegenerative Models of Schizophrenia: White Matter at the Center Stage

P. Kochunov, L. E. Hong
2014 Schizophrenia Bulletin  
GM as the "primary" tissue of interest, often overlooking the importance of intact cerebral white matter (WM) in maintaining normal cerebral connectivity.  ...  We develop this perspective by reviewing normal lifetime trajectories of white and gray matter changes.  ...  cerebral white matter (WM) in maintaining normal cerebral connectivity.  ... 
doi:10.1093/schbul/sbu070 pmid:24870447 pmcid:PMC4059450 fatcat:zcqtxnyabfdnxebkaaq772mami

Staging Alzheimer's disease progression with multimodality neuroimaging

Michael Ewers, Giovanni B. Frisoni, Stefan J. Teipel, Lea T. Grinberg, Edson Amaro, Helmut Heinsen, Paul M. Thompson, Harald Hampel
2011 Progress in Neurobiology  
We integrate recent findings on changes in cortical gray matter volume, white matter fiber tracts, neuropathological alterations, and brain metabolism assessed with molecular positron emission tomography  ...  The association between in vivo and post mortem findings will clarify the temporal dynamics of pathophysiological alterations in the development of preclinical AD.  ...  Gray matter loss also progresses at a rate of 3-4% per year in most of these regions .  ... 
doi:10.1016/j.pneurobio.2011.06.004 pmid:21718750 pmcid:PMC3223355 fatcat:th2njrtlmvabpgwyzd6ysw5j2m

Multispectral Quantitative MR Imaging of the Human Brain: Lifetime Age-related Effects

Memi Watanabe, Joseph H. Liao, Hernán Jara, Osamu Sakai
2013 Radiographics  
, followed by (b) volume loss, myelin breakdown, and axonal degradation, leading to the disruption of neural integrity later in life.  ...  Quantitative magnetic resonance (MR) imaging allows visualization of agerelated changes in the normal human brain from functional, biochemical, and morphologic perspectives.  ...  In an MR spectroscopic study of relative concentration, the NAA/choline ratio of cerebral white matter increased rapidly in the 1st decade of life, reached relative maximum in young adulthood, and declined  ... 
doi:10.1148/rg.335125212 pmid:24025926 fatcat:hgtngzel2bhwlj2aicccyl64sq

Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease

Farzaneh A. Sorond, Philip B. Gorelick
2019 Brain Sciences  
In this chapter, we specifically focus on WMH of vascular origin and explore white matter development, plasticity, and enduring processes of myelination across the health span in the context of experimental  ...  Age-related brain white matter disease is a form of small vessel disease (SVD) that may be associated with lacunar and other small subcortical infarcts, cerebral microbleeds, and perivascular spaces.  ...  We now know that in individuals with small vessel disease, normal-appearing white matter deteriorates with the presence of increasing WMHs and age, confirming that normal-appearing white matter in the  ... 
doi:10.3390/brainsci9080193 pmid:31398858 pmcid:PMC6721396 fatcat:lggwqexeb5ds7lxtddubeuqprq

Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

Mark B Vestergaard, Mette LF Jensen, Nanna Arngrim, Ulrich Lindberg, Henrik BW Larsson
2018 Journal of Cerebral Blood Flow and Metabolism  
Brain functions were examined in 81 healthy humans (aged 18-62 years) by acquisitions of gray and white matter volumes, cerebral blood flow, cerebral oxygen consumption, and concentrations of lactate,  ...  In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vivo.  ...  The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Acknowledgments We would like to thank Poul Jennum for providing  ... 
doi:10.1177/0271678x18818291 pmid:30540217 fatcat:viacjscbm5g5vlx64v6fmg76lu

P1-318: Correlations between regional cerebral blood flow and cognitive alterations in patients with Alzheimer's disease after 4 to 5 years of follow-up

Diana M. Bezerra, Fábio L.S. Duran, Carlos A. Buchpiguel, Geraldo F. Busatto, Cássio M.C. Bottino
2008 Alzheimer's & Dementia  
While much of structural imaging has focused on gray matter, the quantification of white matter integrity is of interest not only because of the noted white matter pathology seen in Alzheimer's disease  ...  Conclusions: While the similar rate of white matter loss across groups may reflect aging, this would not provide an explanation for the initial significantly smaller white matter volume seen in the high-risk  ...  We hypothesized that limbic system white matter projections would show the earliest changes on DTI measures, producing a functional decline in FDG metabolism by PET in the PC.  ... 
doi:10.1016/j.jalz.2008.05.909 fatcat:fr2u4sbrefal3grjute6ubpwnq

Neuroimaging Biomarkers for Alzheimer's Disease

Freddie Márquez, Michael A. Yassa
2019 Molecular Neurodegeneration  
These approaches offer tremendous versatility in terms of targeting distinct age-related and pathophysiological mechanisms such as structural decline (e.g. volumetry, cortical thinning), functional decline  ...  In the absence of a cure, this number could increase to 13.8 million by 2050.  ...  Availability of data and materials Not applicable Ethics approval and consent to participate Not applicable Consent for publication Both authors consent to publication Competing interests The authors  ... 
doi:10.1186/s13024-019-0325-5 pmid:31174557 pmcid:PMC6555939 fatcat:xr6dap7dqvg4fhnnyujvkfor4y

Pathways to Brain Aging and Their Modifiers: Free-Radical-Induced Energetic and Neural Decline in Senescence (FRIENDS) Model - A Mini-Review

Naftali Raz, Ana M. Daugherty
2017 Gerontology  
We examine these findings in the context of current biological theories of aging and propose the means of integrating noninvasive measures -spectroscopic indices of brain energy metabolism and regional  ...  We assess the impact of vascular, metabolic, and inflammatory risk factors on the trajectories of change in regional brain volumes and white matter properties, as well as the relationships between neuroanatomical  ...  Acknowledgements The work on this review was supported by a grant (R01-AG011230) from the National Institute on Aging to N.R. and a Beckman Institute Postdoctoral Fellowship (University of Illinois at  ... 
doi:10.1159/000479508 pmid:28858861 pmcid:PMC5828941 fatcat:n47n773f5zg6xeo6vrxnm5x4ye

Diffusion tensor imaging of the brain: review of clinical applications

P. C. Sundgren, Q. Dong, D. G�mez-Hassan, S. K. Mukherji, P. Maly, R. Welsh
2004 Neuroradiology  
We also review its potential use in diseases such as epilepsy, multiple sclerosis, and Alzheimer's disease. The value of DTI in the investigation of brain tumors and metabolic disorders is assessed.  ...  We review the theoretical background to diffusion tensor imaging (DTI) and some of its commoner clinical applications, such as cerebral ischemia, brain maturation and traumatic brain injury.  ...  Acknowledgements We wish to say a special thank you to Professor Thomas Chenevert, Department of Radiology, University of Michigan Hospitals, for valuable comments and support in the preparation of this  ... 
doi:10.1007/s00234-003-1114-x pmid:15103435 fatcat:dylmx6wbcbfo7jd2qdaaxu6p3q

Cardiovascular Risk Factors and Brain Health: Impact on Long-Range Cortical Connections and Cognitive Performance

Barbara K Marebwa, Robert J Adams, Gayenell S Magwood, Alexandra Basilakos, Martina Mueller, Chris Rorden, Julius Fridriksson, Leonardo Bonilha
2018 Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease  
Conclusions Cardiovascular risk factors may mediate negative effects on brain health via loss of energy-dependent long-range white matter fibers, which in turn leads to disruption of the topological organization  ...  Multivariate analyses were used to evaluate the relationship between cardiovascular risk factor burden, physical activity, age, education, white matter integrity, and verbal IQ .  ...  white matter has lower metabolic needs, it is significantly more vulnerable to ischemic damage compared with gray matter.  ... 
doi:10.1161/jaha.118.010054 pmid:30520672 pmcid:PMC6405561 fatcat:fwodzfugfbdzlmmtu7p4ogke74

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

Freddy J. Alfaro, Anna Gavrieli, Patricia Saade-Lemus, Vasileios-Arsenios Lioutas, Jagriti Upadhyay, Vera Novak
2018 Metabolism: Clinical and Experimental  
This review analyzes the impact of metabolic syndrome on white matter microstructural integrity, brain structure abnormalities and their relationship to cognitive function.  ...  Each of the metabolic syndrome components exerts a specific signature of white matter microstructural abnormalities.  ...  The keywords used were "diffusion tensor imaging", "DTI", "microstructural white matter", "white matter disease", "cerebral small vessel disease", "magnetic resonance imaging", "MRI", "metabolic syndrome  ... 
doi:10.1016/j.metabol.2017.08.009 pmid:28920863 pmcid:PMC5732847 fatcat:edd5ea66wbf2va7piin2h3hb5u

Tracking Alzheimer's Disease

2007 Annals of the New York Academy of Sciences  
Population-based brain mapping provides great insight into the trajectory of aging and dementia, as well as brain changes that normally occur over the human life-span.  ...  We report the first time-lapse maps of cortical atrophy spreading dynamically in the living brain, based on averaging data from populations of subjects with Alzheimer's disease and normal subjects imaged  ...  This research was supported by the National Institute on Aging, the National Library of Medicine, the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging

Farzaneh A. Sorond, Shawn Whitehead, Ken Arai, Douglas Arnold, S. Thomas Carmichael, Charles De Carli, Marco Duering, Myriam Fornage, Rafael E. Flores-Obando, Jonathan Graff-Radford, Edith Hamel, David C. Hess (+11 others)
2019 GeroScience  
of white matter injury and age-related cognitive decline.  ...  injury and age-related cognitive decline.  ...  In the aging brain, myelin is lost in both white matter and gray matter, and this atrophy tracks closely with aging and cognitive decline (Bartzokis et al. 2001; Braak and Braak 1996) .  ... 
doi:10.1007/s11357-019-00141-8 pmid:31811528 pmcid:PMC7031447 fatcat:fs5vnbnfkvcrzcixg3pv3qkc2q

Brain Changes Underlying Cognitive Dysfunction in Diabetes: What Can We Learn From MRI?

G. J. Biessels, Y. D. Reijmer
2014 Diabetes  
Advanced imaging techniques detect microstructural lesions in the cerebral gray and white matter of patients with diabetes that affect structural and functional connectivity.  ...  Challenges are to further unravel the etiology of these cerebral complications by integrating findings from different imaging modalities and detailed clinical phenotyping and by linking structural MRI  ...  Advanced imaging techniques detect microstructural lesions in the cerebral gray and white matter of patients with diabetes that affect structural and functional connectivity.  ... 
doi:10.2337/db14-0348 pmid:24931032 fatcat:v4v2jsnbyzbszdg6gbvy4t6tmm
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