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Longitudinal modeling of appearance and shape and its potential for clinical use
2016
Medical Image Analysis
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These include spatiotemporal shape modeling and growth trajectories of white matter fiber tracts demonstrated with examples from ongoing longitudinal clinical neuroimaging studies such as analysis of early ...
Whereas follow-up, monitoring and prediction are natural tasks in clinical diagnosis of disease progression and of assessment of therapeutic intervention, translation of methodologies for calculation of ...
Longitudinal Analysis of Shape Most longitudinal studies involve extracting clinically relevant measurements from imaging data and fitting a regression model to the discrete values. ...
doi:10.1016/j.media.2016.06.014
pmid:27344938
pmcid:PMC5381523
fatcat:ts6v44b6lnedpo6yqwfmxwtmwa
A framework for longitudinal data analysis via shape regression
2012
Medical Imaging 2012: Image Processing
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Finally, we present an example on a shape complex of the brain (left hemisphere, right hemisphere, cerebellum) that demonstrates a potential clinical application for our framework. ...
In this paper, we propose a consistent framework for the analysis of longitudinal data by estimating the continuous evolution of shape over time as twice differentiable flows of deformations. ...
Acknowledgments This work was supported by NIH grant RO1 HD055741(ACE, project IBIS) and by NIH grant U54 EB005149 (NA-MIC). ...
doi:10.1117/12.911721
pmid:24392201
pmcid:PMC3877317
dblp:conf/miip/FishbaughDPG12
fatcat:qb6asnaaozda5gwivlwiflubiq
029 TEMPORAL STRUCTURAL CHANGES IN HIP OA DETECTED BY SHAPE AND APPEARANCE MODELLING OF DXA IMAGES: A ONE-YEAR PROSPECTIVE LONGITUDINAL STUDY
2009
Osteoarthritis and Cartilage
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degeneration in clinically normal appearing cartilage. ...
Techniques for clinical detection of cartilage damage prior to gross tissue failure could lead to identification of new treatment windows for chondroprotective and chondrorestorative therapies that can ...
Shape and Appearance modelling hold promise as reliable biomarkers in the early diagnosis of hip OA, monitoring its short-term progression and possibly assessing response to disease modifying drugs. ...
doi:10.1016/s1063-4584(09)60052-2
fatcat:jbb276risves5ixyeigb5gl3ga
Myoelectrical activity and muscle morphology in a rat model of myofascial trigger points induced by blunt trauma to the vastus medialis
2013
Acupuncture in Medicine
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The morphology of MTrPs showed abnormal muscle fibres with large round or ellipse shapes in cross-section and enlarged tapering shapes in longitudinal section. ...
Active MTrPs are a group of muscle fibres with abnormal shapes and abnormal myoelectrical potentials. ...
and design of the protocol of the study. ...
doi:10.1136/acupmed-2012-010129
pmid:23328717
fatcat:vyjqxcy2qrgr5ag6hbtggoyvz4
Imaging plus X
2017
Current Opinion in Neurology
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We argue that this will make disease progression modelling invaluable for recruitment and end-points in future clinical trials, potentially ameliorating the high failure rate in trials of, e.g., Alzheimer's ...
; spatiotemporal models have shown that brain shape changes, for example of the hippocampus, can occur before detectable neurodegeneration; and network models have provided some support for prion-like ...
disease progression modelling. ...
doi:10.1097/wco.0000000000000460
pmid:28520598
pmcid:PMC5491241
fatcat:yxaqza7tl5cezch5kdzcpfhreq
Atlas-based ventricular shape analysis for understanding congenital heart disease
2016
Progress in pediatric cardiology
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Shape analysis-derived model properties, and myocardial wall motions between end-diastole and end-systole, were compared with physician observations of clinical functional parameters. ...
Atlas-based parametric shape analysis was used to analyze ventricular geometries of eight adolescent or adult single-ventricle CHD patients with tricuspid atresia and Fontans. ...
Modeling tool for atlas-based ventricular shape modeling using cMRI. ...
doi:10.1016/j.ppedcard.2016.07.010
pmid:28082823
pmcid:PMC5222611
fatcat:mdnykpbzp5a55l6truyufborbe
Multidimensional ultrasound imaging of the wrist: Changes of shape and displacement of the median nerve and tendons in carpal tunnel syndrome
2015
Journal of Orthopaedic Research
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Transversal and longitudinal displacement and shape (changes) were calculated for the median nerve, tendons and surrounding tissue. ...
Binary logistic modeling to diagnose CTS using ultrasound showed a sensitivity of 70-71% and specificity of 80-84%. ...
Acknowledgements This study was funded by NIH/NIAMS grant AR049823/AR062613 and the Erasmus MC Grants. ...
doi:10.1002/jor.22909
pmid:25865180
pmcid:PMC4529801
fatcat:qoqpph6mqnb4havb3iudsr7vhy
A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease
2018
Alzheimer s & Dementia Translational Research & Clinical Interventions
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Methods: Longitudinal change from baseline (14-item version of Alzheimer's Disease Assessment Scale-Cognitive Subscale) was simulated for treatment/placebo from multivariate normal distributions with the ...
In clinical trials of Alzheimer's disease, a mixed-model repeated measure approach often serves as the primary analysis when evaluating disease progression; a slope model may be secondary. ...
., and W.Z. are full-time employees and minor shareholders of Eli Lilly and Company. ...
doi:10.1016/j.trci.2017.12.002
pmid:29955651
pmcid:PMC6021263
fatcat:ptwprqe2ajapdnjagtaayanixu
3D shape visualization of curved needles in tissue from 2D ultrasound images using RANSAC
2015
2015 IEEE International Conference on Robotics and Automation (ICRA)
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Then, a Random Sample and Consensus (RANSAC) algorithm is used to filter out false positives and fit the remaining points to a polynomial model. ...
To test this method, a set of 21 transverse ultrasound images of a brachytherapy needle embedded within a transparent tissue phantom are obtained and used to reconstruct the needle shape. ...
Estimate Model Parameters: Given a data set S of N points and a model M that requires k < N points for complete parameterization, a random selection of k points is used to identify the model parameters ...
doi:10.1109/icra.2015.7139855
dblp:conf/icra/WaineRSUT15
fatcat:ja7jqyg7kje37hssgv7hweodya
Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas
2017
Magnetic Resonance Materials in Physics, Biology and Medicine
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Conclusion The semi-automated approach showed high agreement with manual segmentation of thigh muscle and adipose tissue CSAs and showed longitudinal training effects similar to that observed using manual ...
a significant gain in quadriceps, hamstring and adductor CSAs. With endurance training, a significant reduction in adipose tissue CSAs was observed with both methods. ...
We would like to thank the OAI participants, the participants of the training intervention study, OAI study investigators and OAI Clinical Center staff for generating this publicly available image sets ...
doi:10.1007/s10334-017-0622-3
pmid:28455629
pmcid:PMC5608793
fatcat:c2feozofonc45mhothrpp47gia
Linear clinical progression, independent of age of onset, in Niemann-Pick disease, type C
2009
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
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This scale may prove useful in the characterization of potential biomarkers, and as an outcome measure to monitor disease progression in NPC patients. ...
Longitudinal chart review of historical data demonstrated that although age of onset varied significantly, the rate of progression appeared linear, independent of age of onset, and similar in all patients ...
Steven Walkley and Daniel Ory for critical review of the manuscript and Christopher Zalewski for assistance with audiological evaluations. ...
doi:10.1002/ajmg.b.30969
pmid:19415691
pmcid:PMC2798912
fatcat:lu23wpy22jbypkvsuho4yyvyji
"Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Tendon Repair in Horses: Experimental Study"
2021
Journal of Biotechnology & Bioresearch
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Results proved the potential of autologous MSCs to accelerating tendon repair in terms of quality and time. ...
The horses were clinically, ultrasonography and morpho-histology evaluated at 2, 4, 8, 12 &16 weeks. Horses were euthanized after 16 weeks. ...
Materials and Methods Five adult athletic clinically normal horses (3 males and 2 females) of a median weight 350Kg (4 to 10 years old) of mixed breeds were used in this model. ...
doi:10.31031/jbb.2021.03.000559
fatcat:jkyhs6hxa5hwxcyqoufqjlbly4
Analysis of Longitudinal Shape Variability via Subject Specific Growth Modeling
[chapter]
2012
Lecture Notes in Computer Science
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We evaluate our method on a synthetic shape database and clinical data from a study that seeks to quantify brain growth differences in infants at risk for autism. ...
Statistical analysis of longitudinal imaging data is crucial for understanding normal anatomical development as well as disease progression. ...
This work was supported by NIH grant RO1 HD055741 (ACE, project IBIS) and by NIH grant U54 EB005149 (NA-MIC). ...
doi:10.1007/978-3-642-33415-3_90
fatcat:5b2ffmvtnrcbnefxsmccwtblcu
Development and validation of a new algorithm model for differential diagnosis between Crohn's disease and intestinal tuberculosis: a combination of laboratory, imaging and endoscopic characteristics
2021
BMC Gastroenterology
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Background Sometimes in clinical practice, it is a great challenge to distinguish Crohn's disease (CD) and intestinal tuberculosis (ITB), we conducted this study to identify simple and useful algorithm ...
We used multivariate analysis to identify the potential variables, and then we used R package rpart to build the classification and regression tree (CART), and validated the newly developed model. ...
Hence, models that can be used at the bedside for easy and accurate differential diagnosis would be extremely useful in clinical practice. ...
doi:10.1186/s12876-021-01838-x
fatcat:z3kgy7fajna4dblv3oom56yd6q
440 LONGITUDINAL ANALYSIS OF PROGRESSION IN HIP OSTEOARTHRITIS OVER 6 YEARS, USING A COMPUTATIONAL, AUTOMATED ALGORITHM
2009
Osteoarthritis and Cartilage
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Association of the D-repeat of asporin in patients with congenital dysplasia of the hip in a Han Chinese population after stratification Groups compared D14 vs Others D13 vs Others D14 vs D13 ...
We evaluated longitudinal change of mJSW of all patients and examined potential risk factors for progressive narrowing of mJSW, including CE angle, Sharp angle, initial K/L grading. ...
A General Linear Model was used to test the effect of group membership and OA (KL>1) on the various shape aspects. Results: Two shape aspects were associated with impingement status. ...
doi:10.1016/s1063-4584(09)60461-1
fatcat:lhz6qsjct5eanh433xd3uvca3q
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