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Longitudinal modeling of appearance and shape and its potential for clinical use

Guido Gerig, James Fishbaugh, Neda Sadeghi
2016 Medical Image Analysis  
These include spatiotemporal shape modeling and growth trajectories of white matter fiber tracts demonstrated with examples from ongoing longitudinal clinical neuroimaging studies such as analysis of early  ...  Whereas follow-up, monitoring and prediction are natural tasks in clinical diagnosis of disease progression and of assessment of therapeutic intervention, translation of methodologies for calculation of  ...  Longitudinal Analysis of Shape Most longitudinal studies involve extracting clinically relevant measurements from imaging data and fitting a regression model to the discrete values.  ... 
doi:10.1016/j.media.2016.06.014 pmid:27344938 pmcid:PMC5381523 fatcat:ts6v44b6lnedpo6yqwfmxwtmwa

A framework for longitudinal data analysis via shape regression

James Fishbaugh, Stanley Durrleman, Joseph Piven, Guido Gerig, Sébastien Ourselin, David R. Haynor
2012 Medical Imaging 2012: Image Processing  
Finally, we present an example on a shape complex of the brain (left hemisphere, right hemisphere, cerebellum) that demonstrates a potential clinical application for our framework.  ...  In this paper, we propose a consistent framework for the analysis of longitudinal data by estimating the continuous evolution of shape over time as twice differentiable flows of deformations.  ...  Acknowledgments This work was supported by NIH grant RO1 HD055741(ACE, project IBIS) and by NIH grant U54 EB005149 (NA-MIC).  ... 
doi:10.1117/12.911721 pmid:24392201 pmcid:PMC3877317 dblp:conf/miip/FishbaughDPG12 fatcat:qb6asnaaozda5gwivlwiflubiq

029 TEMPORAL STRUCTURAL CHANGES IN HIP OA DETECTED BY SHAPE AND APPEARANCE MODELLING OF DXA IMAGES: A ONE-YEAR PROSPECTIVE LONGITUDINAL STUDY

K. Yoshida, J.S. Gregory, R.J. Barr, S. Alesci, R.M. Aspden, D.M. Reid
2009 Osteoarthritis and Cartilage  
degeneration in clinically normal appearing cartilage.  ...  Techniques for clinical detection of cartilage damage prior to gross tissue failure could lead to identification of new treatment windows for chondroprotective and chondrorestorative therapies that can  ...  Shape and Appearance modelling hold promise as reliable biomarkers in the early diagnosis of hip OA, monitoring its short-term progression and possibly assessing response to disease modifying drugs.  ... 
doi:10.1016/s1063-4584(09)60052-2 fatcat:jbb276risves5ixyeigb5gl3ga

Myoelectrical activity and muscle morphology in a rat model of myofascial trigger points induced by blunt trauma to the vastus medialis

Qiang-Min Huang, Gang Ye, Zhen-Yan Zhao, Jiao-Jiao Lv, Li Tang
2013 Acupuncture in Medicine  
The morphology of MTrPs showed abnormal muscle fibres with large round or ellipse shapes in cross-section and enlarged tapering shapes in longitudinal section.  ...  Active MTrPs are a group of muscle fibres with abnormal shapes and abnormal myoelectrical potentials.  ...  and design of the protocol of the study.  ... 
doi:10.1136/acupmed-2012-010129 pmid:23328717 fatcat:vyjqxcy2qrgr5ag6hbtggoyvz4

Imaging plus X

Neil P. Oxtoby, Daniel C. Alexander
2017 Current Opinion in Neurology  
We argue that this will make disease progression modelling invaluable for recruitment and end-points in future clinical trials, potentially ameliorating the high failure rate in trials of, e.g., Alzheimer's  ...  ; spatiotemporal models have shown that brain shape changes, for example of the hippocampus, can occur before detectable neurodegeneration; and network models have provided some support for prion-like  ...  disease progression modelling.  ... 
doi:10.1097/wco.0000000000000460 pmid:28520598 pmcid:PMC5491241 fatcat:yxaqza7tl5cezch5kdzcpfhreq

Atlas-based ventricular shape analysis for understanding congenital heart disease

Genevieve Farrar, Avan Suinesiaputra, Kathleen Gilbert, James C. Perry, Sanjeet Hegde, Alison Marsden, Alistair A. Young, Jeffrey H. Omens, Andrew D. McCulloch
2016 Progress in pediatric cardiology  
Shape analysis-derived model properties, and myocardial wall motions between end-diastole and end-systole, were compared with physician observations of clinical functional parameters.  ...  Atlas-based parametric shape analysis was used to analyze ventricular geometries of eight adolescent or adult single-ventricle CHD patients with tricuspid atresia and Fontans.  ...  Modeling tool for atlas-based ventricular shape modeling using cMRI.  ... 
doi:10.1016/j.ppedcard.2016.07.010 pmid:28082823 pmcid:PMC5222611 fatcat:mdnykpbzp5a55l6truyufborbe

Multidimensional ultrasound imaging of the wrist: Changes of shape and displacement of the median nerve and tendons in carpal tunnel syndrome

Anika Filius, Marjan Scheltens, Hans G. Bosch, Pieter A. van Doorn, Henk J. Stam, Steven E. R. Hovius, Peter C. Amadio, Ruud W. Selles
2015 Journal of Orthopaedic Research  
Transversal and longitudinal displacement and shape (changes) were calculated for the median nerve, tendons and surrounding tissue.  ...  Binary logistic modeling to diagnose CTS using ultrasound showed a sensitivity of 70-71% and specificity of 80-84%.  ...  Acknowledgements This study was funded by NIH/NIAMS grant AR049823/AR062613 and the Erasmus MC Grants.  ... 
doi:10.1002/jor.22909 pmid:25865180 pmcid:PMC4529801 fatcat:qoqpph6mqnb4havb3iudsr7vhy

A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease

Yun-Fei Chen, Xiao Ni, Adam S. Fleisher, Wei Zhou, Paul Aisen, Richard Mohs
2018 Alzheimer s & Dementia Translational Research & Clinical Interventions  
Methods: Longitudinal change from baseline (14-item version of Alzheimer's Disease Assessment Scale-Cognitive Subscale) was simulated for treatment/placebo from multivariate normal distributions with the  ...  In clinical trials of Alzheimer's disease, a mixed-model repeated measure approach often serves as the primary analysis when evaluating disease progression; a slope model may be secondary.  ...  ., and W.Z. are full-time employees and minor shareholders of Eli Lilly and Company.  ... 
doi:10.1016/j.trci.2017.12.002 pmid:29955651 pmcid:PMC6021263 fatcat:ptwprqe2ajapdnjagtaayanixu

3D shape visualization of curved needles in tissue from 2D ultrasound images using RANSAC

Michael Waine, Carlos Rossa, Ronald Sloboda, Nawaid Usmani, Mahdi Tavakoli
2015 2015 IEEE International Conference on Robotics and Automation (ICRA)  
Then, a Random Sample and Consensus (RANSAC) algorithm is used to filter out false positives and fit the remaining points to a polynomial model.  ...  To test this method, a set of 21 transverse ultrasound images of a brachytherapy needle embedded within a transparent tissue phantom are obtained and used to reconstruct the needle shape.  ...  Estimate Model Parameters: Given a data set S of N points and a model M that requires k < N points for complete parameterization, a random selection of k points is used to identify the model parameters  ... 
doi:10.1109/icra.2015.7139855 dblp:conf/icra/WaineRSUT15 fatcat:ja7jqyg7kje37hssgv7hweodya

Validation of an active shape model-based semi-automated segmentation algorithm for the analysis of thigh muscle and adipose tissue cross-sectional areas

Jana Kemnitz, Felix Eckstein, Adam G. Culvenor, Anja Ruhdorfer, Torben Dannhauer, Susanne Ring-Dimitriou, Alexandra M. Sänger, Wolfgang Wirth
2017 Magnetic Resonance Materials in Physics, Biology and Medicine  
Conclusion The semi-automated approach showed high agreement with manual segmentation of thigh muscle and adipose tissue CSAs and showed longitudinal training effects similar to that observed using manual  ...  a significant gain in quadriceps, hamstring and adductor CSAs. With endurance training, a significant reduction in adipose tissue CSAs was observed with both methods.  ...  We would like to thank the OAI participants, the participants of the training intervention study, OAI study investigators and OAI Clinical Center staff for generating this publicly available image sets  ... 
doi:10.1007/s10334-017-0622-3 pmid:28455629 pmcid:PMC5608793 fatcat:c2feozofonc45mhothrpp47gia

Linear clinical progression, independent of age of onset, in Niemann-Pick disease, type C

Nicole M. Yanjanin, Jorge I. Vélez, Andrea Gropman, Kelly King, Simona E. Bianconi, Sandra K. Conley, Carmen C. Brewer, Beth Solomon, William J. Pavan, Mauricio Arcos-Burgos, Marc C. Patterson, Forbes D. Porter
2009 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
This scale may prove useful in the characterization of potential biomarkers, and as an outcome measure to monitor disease progression in NPC patients.  ...  Longitudinal chart review of historical data demonstrated that although age of onset varied significantly, the rate of progression appeared linear, independent of age of onset, and similar in all patients  ...  Steven Walkley and Daniel Ory for critical review of the manuscript and Christopher Zalewski for assistance with audiological evaluations.  ... 
doi:10.1002/ajmg.b.30969 pmid:19415691 pmcid:PMC2798912 fatcat:lu23wpy22jbypkvsuho4yyvyji

"Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Tendon Repair in Horses: Experimental Study"

Shokry MM
2021 Journal of Biotechnology & Bioresearch  
Results proved the potential of autologous MSCs to accelerating tendon repair in terms of quality and time.  ...  The horses were clinically, ultrasonography and morpho-histology evaluated at 2, 4, 8, 12 &16 weeks. Horses were euthanized after 16 weeks.  ...  Materials and Methods Five adult athletic clinically normal horses (3 males and 2 females) of a median weight 350Kg (4 to 10 years old) of mixed breeds were used in this model.  ... 
doi:10.31031/jbb.2021.03.000559 fatcat:jkyhs6hxa5hwxcyqoufqjlbly4

Analysis of Longitudinal Shape Variability via Subject Specific Growth Modeling [chapter]

James Fishbaugh, Marcel Prastawa, Stanley Durrleman, Joseph Piven, Guido Gerig
2012 Lecture Notes in Computer Science  
We evaluate our method on a synthetic shape database and clinical data from a study that seeks to quantify brain growth differences in infants at risk for autism.  ...  Statistical analysis of longitudinal imaging data is crucial for understanding normal anatomical development as well as disease progression.  ...  This work was supported by NIH grant RO1 HD055741 (ACE, project IBIS) and by NIH grant U54 EB005149 (NA-MIC).  ... 
doi:10.1007/978-3-642-33415-3_90 fatcat:5b2ffmvtnrcbnefxsmccwtblcu

Development and validation of a new algorithm model for differential diagnosis between Crohn's disease and intestinal tuberculosis: a combination of laboratory, imaging and endoscopic characteristics

Yi Lu, Yonghe Chen, Xiang Peng, Jiayin Yao, Weijie Zhong, Chujun Li, Min Zhi
2021 BMC Gastroenterology  
Background Sometimes in clinical practice, it is a great challenge to distinguish Crohn's disease (CD) and intestinal tuberculosis (ITB), we conducted this study to identify simple and useful algorithm  ...  We used multivariate analysis to identify the potential variables, and then we used R package rpart to build the classification and regression tree (CART), and validated the newly developed model.  ...  Hence, models that can be used at the bedside for easy and accurate differential diagnosis would be extremely useful in clinical practice.  ... 
doi:10.1186/s12876-021-01838-x fatcat:z3kgy7fajna4dblv3oom56yd6q

440 LONGITUDINAL ANALYSIS OF PROGRESSION IN HIP OSTEOARTHRITIS OVER 6 YEARS, USING A COMPUTATIONAL, AUTOMATED ALGORITHM

T. Shiomi, T. Nishii, T. Sakai, M. Takao, T. Hananouchi, I. Nakahara, K. Tsuda, H. Yoshikawa, N. Sugano
2009 Osteoarthritis and Cartilage  
Association of the D-repeat of asporin in patients with congenital dysplasia of the hip in a Han Chinese population after stratification Groups compared D14 vs Others D13 vs Others D14 vs D13  ...  We evaluated longitudinal change of mJSW of all patients and examined potential risk factors for progressive narrowing of mJSW, including CE angle, Sharp angle, initial K/L grading.  ...  A General Linear Model was used to test the effect of group membership and OA (KL>1) on the various shape aspects. Results: Two shape aspects were associated with impingement status.  ... 
doi:10.1016/s1063-4584(09)60461-1 fatcat:lhz6qsjct5eanh433xd3uvca3q
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