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Short-term effect of changes in smoking behaviour on emphysema quantification by CT

H. Ashraf, P. Lo, S. B. Shaker, M. de Bruijne, A. Dirksen, P. Tonnesen, M. Dahlback, J. H. Pedersen
2010 Thorax  
The effect of smoking cessation and smoking relapse on lung density was studied using low-dose CT.  ...  Methods Spiral, multidetector, low-dose CT was performed on 726 current and former smokers (>20 pack-years) recruited from a cancer screening trial.  ...  Funding The Danish Lung Cancer Screening Trial receives financial support from the Danish Ministry of Interior and Health.  ... 
doi:10.1136/thx.2009.132688 pmid:20978026 fatcat:ntntpzmsczhgjf264kd5blqjdm

Progress in Imaging COPD, 2004 - 2014

David Lynch
2014 Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation  
for lung cancer screening.  ...  Quantitative CT permits evaluation of severity of emphysema, airway wall thickening, and expiratory air trapping, and is now being used for longitudinal evaluation of the progression of COPD.  ...  Longitudinal Evaluation Several studies have evaluated the ability of CT to detect progression of emphysema on longitudinal evaluation ( Figure 7 ).  ... 
doi:10.15326/jcopdf.1.1.2014.0125 pmid:28848813 pmcid:PMC5559143 fatcat:3vkwvlh5cje4bdjtejkmowzoyq

Association of the transfer coefficient of the lung for carbon monoxide with emphysema progression in male smokers

F. A. A. Mohamed Hoesein, P. Zanen, B. van Ginneken, R. J. van Klaveren, J.-W. J. Lammers
2011 European Respiratory Journal  
Heavy smokers, mean¡SD 41.3¡18.7 pack-yrs, participating in a lung cancer screening trial underwent diffusion testing and CT scanning of the lungs.  ...  We evaluated whether in heavy smokers, baseline KCO was associated with the progression of computed tomography (CT)-detected emphysema, and the progression of airflow limitation.  ...  Heavy smokers, mean¡SD 41.3¡18.7 pack-yrs, participating in a lung cancer screening trial underwent diffusion testing and CT scanning of the lungs.  ... 
doi:10.1183/09031936.00050711 pmid:21565924 fatcat:g3a4yaqyjvc6xkvvo7526izobm

Prospective CT Screening for Lung Cancer in a High-Risk Population: HIV-Positive Smokers

Alicia Hulbert, Craig M. Hooker, Jeanne C. Keruly, Travis Brown, Karen Horton, Eliott Fishman, Kristen Rodgers, Beverly Lee, Celis Sam, Salina Tsai, Elizabeth Weihe, Genevieve Pridham (+16 others)
2014 Journal of Thoracic Oncology  
The heterogeneity of emphysema across the entire lung as measured by CT densitometry was significantly higher in HIV-infected subjects with lung cancer compared with the heterogeneity of emphysema in those  ...  On multivariate regression analysis, increased age, higher smoking pack-years, low CD4 nadir, and increased heterogeneity of emphysema on quantitative CT imaging were all significantly associated with  ...  Participants were to have a low-dose helical CT scan at baseline (T0) and up to four scans annually (T1-T4).  ... 
doi:10.1097/jto.0000000000000161 pmid:24828660 pmcid:PMC4023914 fatcat:hukn7j2b5bhrzcfrouvalmnvua

CT Scan Screening for Lung Cancer: Risk Factors for Nodules and Malignancy in a High-Risk Urban Cohort

Alissa K. Greenberg, Feng Lu, Judith D. Goldberg, Ellen Eylers, Jun-Chieh Tsay, Ting-An Yie, David Naidich, Georgeann McGuinness, Harvey Pass, Kam-Meng Tchou-Wong, Doreen Addrizzo-Harris, Abraham Chachoua (+3 others)
2012 PLoS ONE  
Low-dose computed tomography (CT) for lung cancer screening can reduce lung cancer mortality. The National Lung Screening Trial reported a 20% reduction in lung cancer mortality in high-risk smokers.  ...  Methods: We performed a longitudinal lung cancer biomarker discovery trial (NYU LCBC) that included low-dose CTscreening of high-risk individuals over 50 years of age, with more than 20 pack-year smoking  ...  In contrast, as mentioned, the NLST found that screening with low-dose chest CTs can identify early lung cancers and decrease lung cancer mortality, but at the cost of large numbers of non-specific NCN  ... 
doi:10.1371/journal.pone.0039403 pmid:22768300 pmcid:PMC3388074 fatcat:egq4e6jwwfaa5nxwyxvxd4okci

CT-quantified emphysema in male heavy smokers: association with lung function decline

F. A. A. Mohamed Hoesein, B. de Hoop, P. Zanen, H. Gietema, C. L. J. J. Kruitwagen, B. van Ginneken, I. Isgum, C. Mol, R. J. van Klaveren, A. E. Dijkstra, H. J. M. Groen, H. M. Boezen (+3 others)
2011 Thorax  
Methods Current and former heavy smokers participating in a lung cancer screening trial were recruited to the study and all underwent CT. Spirometry was performed at baseline and at 3-year follow-up.  ...  Conclusion Greater baseline severity of CT-detected emphysema is related to lower baseline lung function and greater rates of lung function decline, even in those without airway obstruction.  ...  of emphysema are frequently found on CT scans performed in lung cancer screening trials studying heavy smokers who are also at a great risk of developing COPD, but this CT-detected emphysema is often  ... 
doi:10.1136/thx.2010.145995 pmid:21474499 fatcat:6ppjdymfpne7njfeaiox3eac6m

Maintaining lung health with longstanding HIV

Paul Collini, Alison Morris
2016 Current Opinion in Infectious Diseases  
Recent Findings-Diagnoses of COPD are now up to 50% more prevalent in HIV-seropositive individuals than HIV-uninfected controls, and prospective pulmonary function studies find significant impairment in  ...  Although host factors such as age and smoking have a role, HIV is an independent contributor to the pathogenesis of COPD, PAH and lung cancer.  ...  Initial reports from the French HIV CHEST study, targeting HIV-seropositive individuals over 40 years of age with significant recent smoking history, suggest that using low dose CT thorax for early lung  ... 
doi:10.1097/qco.0000000000000221 pmid:26555039 pmcid:PMC4689652 fatcat:jv5hwgplvzcxldizcwvolstbuq

Association of incidental emphysema with annual lung function decline and future development of airflow limitation

Hyeon-Kyoung Koo, Kwang Nam Jin, Deog Kyeom Kim, Hee Soon Chung, Chang-Hoon Lee
2016 International Journal of COPD  
of emphysema scoring calculated from our low radiation dose CT protocol without modification, which is fitted for lung cancer screening  ...  mortality in cases with %LAA −950 .10%. 5,6 Since minimal differences were reported in the quantification of emphysema between standard radiation dose and low radiation dose CT techniques, we used values  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/copd.s96809 pmid:26893550 pmcid:PMC4745855 fatcat:hzefzqskqjehnd3tmvonvotfw4

Early detection of COPD is important for lung cancer surveillance

Yasuo Sekine, Hideki Katsura, Eitetsu Koh, Kenzo Hiroshima, Takehiko Fujisawa
2011 European Respiratory Journal  
Low-dose computed tomography (LDCT) is an effective procedure for the early detection of lung cancer in high-risk patients.  ...  We propose that, for the prevention of both diseases, COPD screening in smokers should be initiated as early as possible, so they can stop smoking and so that candidates for an efficient lung cancer screening  ...  From a 20-yr follow-up study of 448,600 lifelong nonsmokers, TURNER et al.  ... 
doi:10.1183/09031936.00126011 pmid:22088970 fatcat:ifp4vpkytja63b2av4z3pdlns4

ESR/ERS white paper on lung cancer screening

Hans-Ulrich Kauczor, Lorenzo Bonomo, Mina Gaga, Kristiaan Nackaerts, Nir Peled, Mathias Prokop, Martine Remy-Jardin, Oyunbileg von Stackelberg, Jean-Paul Sculier
2015 European Radiology  
Annual low-dose computed tomography has shown a survival benefit in screening individuals at high risk for lung cancer.  ...  Key points • Lung cancer screening using low dose computed tomography reduces mortality. • Leading US medical societies recommend large scale screening for high-risk individuals. • There are no lung cancer  ...  Acknowledgments We acknowledge the support from the ESR office, in particular Chiara Manavella.  ... 
doi:10.1007/s00330-015-3697-0 pmid:25929939 pmcid:PMC4529446 fatcat:23arpid6wvbsvjavneioo5uh3m

ESR/ERS white paper on lung cancer screening

Hans-Ulrich Kauczor, Lorenzo Bonomo, Mina Gaga, Kristiaan Nackaerts, Nir Peled, Mathias Prokop, Martine Remy-Jardin, Oyunbileg von Stackelberg, Jean-Paul Sculier
2015 European Respiratory Journal  
Annual low-dose computed tomography has shown a survival benefit in screening individuals at high risk for lung cancer.  ...  Key points • Lung cancer screening using low dose computed tomography reduces mortality. • Leading US medical societies recommend large scale screening for high-risk individuals. • There are no lung cancer  ...  Acknowledgments We acknowledge the support from the ESR office, in particular Chiara Manavella.  ... 
doi:10.1183/09031936.00033015 pmid:25929956 pmcid:PMC4486375 fatcat:urpejc7hfjertismmqgbftkzea

New developments in the assessment of COPD: early diagnosis is key

Eric Gartman, Nicholas Csikesz
2014 International Journal of COPD  
However, there is strong evidence to suggest that the majority of patients with objective COPD are not aware of their condition, and this leads to a significant delay in diagnosis, more aggressive smoking-cessation  ...  a rapid decline in lung function occurs and may be prevented if acted upon.  ...  emphysema, air trapping, and bronchial wall thickening to pre-bronchodilator spirometry in 1,140 male lung-cancer screening participants using low-dose CT with inspiratory and expiratory sequences.  ... 
doi:10.2147/copd.s46198 pmid:24600220 pmcid:PMC3942111 fatcat:nvb3inr23zddrpxkmho5jpqtry

Lung Cancer Screening: Evidence, Risks, and Opportunities for Implementation
Lungenkrebs-Screening: Evidenz, Risiken und Möglichkeiten der Implementierung

Giulia Tringali, Gianluca Milanese, Roberta Eufrasia Ledda, Ugo Pastorino, Nicola Sverzellati, Mario Silva
2021 RöFo. Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (Print)  
Several trials with different screening approaches have recognized the role of lung cancer screening with low-dose CT for reducing lung cancer mortality.  ...  The efficacy of lung cancer screening depends on many factors and implementation is still pending in most European countries.  ...  low-dose CT.  ... 
doi:10.1055/a-1382-8648 pmid:33772489 fatcat:wikizkfohrfxxootmzpmwauzau

Chemotherapy for advanced lung cancer: is the glass half full or half empty?

G Silvestri
2004 Thorax  
to follow the progression of emphysema in vivo.  ...  Cohort studies can be divided into cross sectional studies and follow up studies.  ... 
doi:10.1136/thx.2004.025916 pmid:15454643 pmcid:PMC1746839 fatcat:nflyno5xrjclnefkfhzfzeo4fu

Pi MZ and COPD: will we ever know?

N Seersholm
2004 Thorax  
to follow the progression of emphysema in vivo.  ...  Cohort studies can be divided into cross sectional studies and follow up studies.  ... 
doi:10.1136/thx.2004.024810 pmid:15454645 pmcid:PMC1746850 fatcat:f367qap7c5a65pnn2e375iz3lm
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