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Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images

Jiangyang Zhang, Qi Peng, Qing Li, Neda Jahanshad, Zhipeng Hou, Mali Jiang, Naoki Masuda, Douglas R. Langbehn, Michael I. Miller, Susumu Mori, Christopher A. Ross, Wenzhen Duan
2010 NeuroImage  
This is the first report of longitudinal characterization of brain atrophy in a mouse model of Huntington's disease by using automatic morphological analysis.  ...  In this paper, we describe a tool for automated segmentation and voxel-based morphological analyses of the mouse brains.  ...  This research was supported by a grant from the CHDI Inc Foundation (to W. Duan), NINDS NS16375 (to CAR), NIH EB003543 and NIH ES012665 (to S. Mori), and NIH NS065306 (to J. Zhang).  ... 
doi:10.1016/j.neuroimage.2009.10.027 pmid:19850133 pmcid:PMC2929697 fatcat:ot4a63rycrc5bp5fxh2w3lxhxe

Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging

Manisha Aggarwal, Wenzhen Duan, Zhipeng Hou, Neal Rakesh, Qi Peng, Christopher A. Ross, Michael I. Miller, Susumu Mori, Jiangyang Zhang
2012 NeuroImage  
In this study, three dimensional in vivo magnetic resonance imaging (MRI) and automated longitudinal deformation-based morphological analysis was used to elucidate the spatial and temporal patterns of  ...  Mouse models of Huntington's disease (HD) that recapitulate some of the phenotypic features of human HD, play a crucial role in investigating disease mechanisms and testing potential therapeutic approaches  ...  Acknowledgments This research was supported by grants from the CHDI Inc. foundation (to W. Duan), NINDS NS16375 (to CAR), NIH EB003543, RR15241, and ES012665 (to S. Mori), and NIHNS065306 (to J.  ... 
doi:10.1016/j.neuroimage.2012.01.141 pmid:22342677 pmcid:PMC3321064 fatcat:2gxqhc3as5bkvm7af45qzp6izy

Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease

H. D. Rosas, A. S. Feigin, Steven M. Hersch
2004 Neurotherapeutics  
Trangenic mouse models and other screens are being used to identify potential therapeutic agents for use in clinical trials in Huntington's disease (HD).  ...  Because HD is relatively uncommon and only a portion of available subjects meet inclusion and exclusion criteria, therapeutic trials are limited by the availability of potential subjects as well as the  ...  MAGNETIC RESONANCE IMAGING Morphometric analyses Basal ganglia pathology has been the focus of much work using magnetic resonance imaging (MRI) methods to quantitate brain volumes and has been central  ... 
doi:10.1007/bf03206610 fatcat:por2foq72rfazjvtjafseznuhm

Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease

H. D. Rosas, A. S. Feigin, Steven M. Hersch
2004 NeuroRx  
Trangenic mouse models and other screens are being used to identify potential therapeutic agents for use in clinical trials in Huntington's disease (HD).  ...  Because HD is relatively uncommon and only a portion of available subjects meet inclusion and exclusion criteria, therapeutic trials are limited by the availability of potential subjects as well as the  ...  MAGNETIC RESONANCE IMAGING Morphometric analyses Basal ganglia pathology has been the focus of much work using magnetic resonance imaging (MRI) methods to quantitate brain volumes and has been central  ... 
doi:10.1602/neurorx.1.2.263 pmid:15717027 pmcid:PMC534942 fatcat:wyjruwdprvarbix2fcagnqrq3u

Magnetic resonance imaging of Huntington's disease: preparing for clinical trials

S. Klöppel, S.M. Henley, N.Z. Hobbs, R.C. Wolf, J. Kassubek, S.J. Tabrizi, R.S.J. Frackowiak
2009 Neuroscience  
The known genetic mutation causing Huntington's disease (HD) makes this disease an important model to study links between gene and brain function.  ...  This review summarizes recent magnetic resonance imaging (MRI)-based findings in HD with a focus on the requirements if imaging is to be used in treatment trials.  ...  This selective review will restrict itself to magnetic resonance imaging (MRI).  ... 
doi:10.1016/j.neuroscience.2009.01.045 pmid:19409230 pmcid:PMC2771270 fatcat:ilnyxbbtuvbc5db6v3kap6qbmm

Identification of the key role of white matter alteration in the pathogenesis of Huntington's Disease [article]

Jean-Baptiste Perot, Marina Celestine, Marco Palombo, Marc Dhenain, Sandrine Humbert, Emmanuel Brouillet, Julien Flament
2021 bioRxiv   pre-print
imaging, in order to assess white matter integrity over the life of this very progressive mouse model.  ...  Pathogenesis of the inherited neurodegenerative disorder Huntington s Disease (HD) is complex and progressive, with a long presymptomatic phase in which subtle changes occur in the brain of gene carriers  ...  Introduction Huntington's disease (HD) is an inherited neurodegenerative disease characterized by a triad of symptoms.  ... 
doi:10.1101/2021.06.21.449242 fatcat:55jvlpejufdmzdvuhl36blyq7e

Porcine Model of Huntington's Disease [chapter]

Petra Rausova, Petra Vochozkova, Daniela Vidinska, Eva Hrnciarova, Bozena Bohuslavova, Monika Macakova, Ivona Valekova, Stefan Juhas, Taras Ardan, Petr Solc, Jan Motlik, Zdenka Ellederova
2017 Huntington's Disease - Molecular Pathogenesis and Current Models  
At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD).  ...  Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies.  ...  Acknowledgements This study was supported by National Sustainability Programme, project number LO1609 (Czech Ministry of Education, Youth and Sports). Author details  ... 
doi:10.5772/66353 fatcat:6h3ewepj4nem7jiziw7ujyqngu

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease

Jérémy Pépin, Laetitia Francelle, Maria-Angeles Carrillo-de Sauvage, Lucie de Longprez, Pauline Gipchtein, Karine Cambon, Julien Valette, Emmanuel Brouillet, Julien Flament
2016 NeuroImage  
Huntington's disease (HD) is an inherited neurodegenerative disease characterized by motor, cognitive and psychiatric symptoms.  ...  In this study, we used Chemical Exchange Saturation Transfer imaging of glutamate (gluCEST) in order to map glutamate distribution in the brain of a knock-in mouse model (Ki140CAG) with a precise anatomical  ...  Humbert for their help in getting the breeders for starting our Ki140CAG mouse colony. We are grateful J. Mitja for taking care of the animal and helping with behavioral studies.  ... 
doi:10.1016/j.neuroimage.2016.06.023 pmid:27318215 fatcat:burejlh4mbednd777yjafcj5qi

Huntington's Disease Mouse Models Online: High-Resolution MRI Images with Stereotaxic Templates for Computational Neuroanatomy

Stephen J. Sawiak, Nigel I. Wood, T. Adrian Carpenter, A. Jennifer Morton, Grainne M. McAlonan
2012 PLoS ONE  
Here we used MRI to make a dataset of ex vivo brains from two different rodent models of Huntington's disease (HD), the R6/2 line and the YAC 128 mouse.  ...  Magnetic resonance imaging (MRI) has proved to be an ideal modality for non-destructive and highly detailed assessment of structural morphology in biological tissues.  ...  Historically, magnetic resonance imaging (MRI) findings for individual patients were diagnostic only in later stages of HD, for example where caudate atrophy contributed to the characteristically large  ... 
doi:10.1371/journal.pone.0053361 pmid:23300918 pmcid:PMC3534048 fatcat:hb6c3cw66bggbpy6miqwfjhipa

The Shrinking Brain: Cerebral Atrophy Following Traumatic Brain Injury

Taylor C. Harris, Rijk de Rooij, Ellen Kuhl
2018 Annals of Biomedical Engineering  
Here we attempt to fill this gap in our current knowledge by integrating the current literature into a cohesive theory of preferential brain tissue loss and by identifying common risk factors for accelerated  ...  Computational modeling of brain atrophy could open new strategies for physicians to make informed decisions for whom, how, and when to administer pharmaceutical treatment to manage the chronic loss of  ...  Disease Longitudinal magnetic resonance imaging of an Alzheimer’s patient reveals the characteristic pattern of progressive A number of diseases that impact the brain also atrophy in the hippocampus  ... 
doi:10.1007/s10439-018-02148-2 pmid:30341741 pmcid:PMC6757025 fatcat:56vgrfaen5fmndsn62yncqoqw4

MR Imaging of SCA3/MJD

Na Wan, Zhao Chen, Linlin Wan, Beisha Tang, Hong Jiang
2020 Frontiers in Neuroscience  
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is a progressive autosomal dominantly inherited cerebellar ataxia characterized by the aggregation of polyglutamine-expanded protein within  ...  Magnetic resonance imaging (MRI) techniques such as morphometric MRI, diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and magnetic resonance spectroscopy (MRS) have gained  ...  / licenses/by/3.0/).  ... 
doi:10.3389/fnins.2020.00749 pmid:32848545 pmcid:PMC7417615 fatcat:majiso7curh6hpuulozo3meo6y

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD

Ivan Rattray, Edward Smith, Richard Gale, Kaoru Matsumoto, Gillian P. Bates, Michel Modo, Emmanuel Planel
2013 PLoS ONE  
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene.  ...  The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy.  ...  Donna Smith for providing R6/2 males for breeding, Maik Stille for assistance with semi-automated image analysis and Prof. Jon Cooper for help with histological procedures. Author Contributions  ... 
doi:10.1371/journal.pone.0060012 pmid:23593159 pmcid:PMC3617160 fatcat:7pptdcew5vcydcnbgqll66ijye

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington's Disease

Ivan Rattray, Edward J. Smith, William R. Crum, Thomas A. Walker, Richard Gale, Gillian P. Bates, Michel Modo, Emmanuel Planel
2017 PLoS ONE  
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease.  ...  A hypothesis-free analysis using tensor-based morphometry highlighted further regions undergoing atrophy by contrasting brain growth and regional neurodegeneration.  ...  Magnetic resonance imaging In vivo longitudinal MRI. WT and HdhQ150 mice were scanned in vivo, serially, a total of seven times at 8, 15, 23, 36, 52, 81 and 94 weeks of age.  ... 
doi:10.1371/journal.pone.0168556 pmid:28099507 pmcid:PMC5242535 fatcat:ipi2hmozsjelplbpzktro5g4ja

Magnetic resonance imaging for detection and analysis of mouse phenotypes

Brian J. Nieman, Nicholas A. Bock, Jonathon Bishop, X. Josette Chen, John G. Sled, Janet Rossant, R. Mark Henkelman
2005 NMR in Biomedicine  
With the enormous and growing number of experimental and genetic mouse models of human disease, there is a need for efficient means of characterizing abnormalities in mouse anatomy and physiology.  ...  Adaptation of magnetic resonance imaging (MRI) to the scale of the mouse promises to address this challenge and make major contributions to biomedical research by non-invasive assessment in the mouse.  ...  Brian Nieman is the recipient of a Canada Graduate Scholarship. Mark Henkelman is the recipient of a Canada Research Chair in Imaging.  ... 
doi:10.1002/nbm.981 pmid:16206127 fatcat:xym33bpwgfhnhk2q66yu6a6kri

Abstracts from the 2013 WORLD CONGRESS ON HUNTINGTON'S DISEASE

2013 Journal of Huntington's Disease  
face stimuli using functional magnetic resonance (MR) imaging.  ...  Background: Huntington's disease (HD) is a disorder characterized by involuntary movement characterized by chorea.  ...  diseases such as Huntington's disease (HD).  ... 
doi:10.3233/jhd-139005 fatcat:abojdnosczb6dmo4circmjtcim
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