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Long-range temporal correlations in the brain distinguish conscious wakefulness from induced unconsciousness

Thomas Thiery, Tarek Lajnef, Etienne Combrisson, Arthur Dehgan, Pierre Rainville, George A. Mashour, Stefanie Blain-Moraes, Karim Jerbi
2018 NeuroImage  
To address this question, we examined long-range temporal correlations (LRTC) of EEG oscillation amplitudes recorded during both wakefulness and anesthetic-induced unconsciousness.  ...  The temporal structure of brain oscillations may provide novel insights into the neural mechanisms underlying consciousness.  ...  In EEG recordings, DFA can be applied to detect long-range temporal correlations (auto-correlations) either in the raw time-domain signals or alternatively in the temporal dynamics of the signal envelope  ... 
doi:10.1016/j.neuroimage.2018.05.069 pmid:29885482 pmcid:PMC6545227 fatcat:aocyba3t7ncevbtkdmgezl7pi4

Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics

Enzo Tagliazucchi, Dante R. Chialvo, Michael Siniatchkin, Enrico Amico, Jean-Francois Brichant, Vincent Bonhomme, Quentin Noirhomme, Helmut Laufs, Steven Laureys
2016 Journal of the Royal Society Interface  
We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints  ...  Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness.  ...  We thank Ben Palanca and two anonymous reviewers for valuable comments on this manuscript, Ed Bullmore and Nicolas Crossley for sharing the DTI data and Patric Hagmann and Olaf Sporns for sharing the DSI  ... 
doi:10.1098/rsif.2015.1027 pmid:26819336 pmcid:PMC4759808 fatcat:kqffz2x6irg7tfw32tkln5qbka

Decoupled temporal variability and signal synchronization of spontaneous brain activity in loss of consciousness: An fMRI study in anesthesia

Zirui Huang, Jun Zhang, Jinsong Wu, Pengmin Qin, Xuehai Wu, Zhiyao Wang, Rui Dai, Yuan Li, Weimin Liang, Ying Mao, Zhong Yang, Jianfeng Zhang (+2 others)
2016 NeuroImage  
Our findings not only extend our current knowledge of the neural correlates of anesthetic-induced unconsciousness, but have implications for both computational neural modeling and clinical practice, such  ...  as in the diagnosis of loss of consciousness in patients with DOC.  ...  Acknowledgments This research was supported by the Natural Science Foundation of China (to Jun Zhang, No. 81171020), the EJLB-Michael Smith Foundation (200809EJL-194083-EJL-CECA-179644), the Canada Institute  ... 
doi:10.1016/j.neuroimage.2015.08.062 pmid:26343319 fatcat:ys3ww4decvhjzidqyrgmkfybpq

Harmonic brain modes: a unifying framework for linking space and time in brain dynamics [article]

Selen Atasoy, Gustavo Deco, Morten L Kringelbach, Joel Pearson
2017 bioRxiv   pre-print
Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal and network-level changes in the brain across different mental states; (wakefulness, sleep, anaesthesia  ...  Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics  ...  GD is supported by the ERC Advanced Grant: DYSTRUCTURE (no 295129), by the Spanish Research Project PSI2016-75688-P (AEI/FEDER), by the European Union's Horizon 2020 research and innovation programme under  ... 
doi:10.1101/162040 fatcat:hihiyoqpbzcina5axi4acczzmm

Making Waves in Consciousness Research

N. D. Schiff
2013 Science Translational Medicine  
A new strategy for quantifying consciousness in human brains may have broad applications in the clinic and in neurobiology research labs (Casali et al., this issue). on March 20, 2014 stm.sciencemag.org  ...  Downloaded from  ...  Brain states that correlate with unconsciousness-including non-rapid eye movement (NREM) sleep, pharmacologically induced coma, and vegetative state (VS) af er structural brain injuries-show either very  ... 
doi:10.1126/scitranslmed.3007004 pmid:23946193 fatcat:eofrwtjymzfztchn6t7lmzcwua

Assessing levels of consciousness with symbolic analysis

U. Lee, S. Blain-Moraes, G. A. Mashour
2014 Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences  
Consciousness and neural communication In order to distinguish between conscious and unconscious states in individuals who may lack normal responsiveness, we need to understand how the brain generates  ...  Long-range connections were particularly susceptible to decreases in mutual information across brain regions.  ... 
doi:10.1098/rsta.2014.0117 pmid:25548273 fatcat:lfaxctnb6ze5lf4gubeciuhxuq

Consciousness: A Neurological Perspective

Andrea E. Cavanna, Sachin Shah, Clare M. Eddy, Adrian Williams, Hugh Rickards
2011 Behavioural Neurology  
In this article, we explore how a bidimensional model of consciousness involving both level of arousal and subjective awareness of the contents of consciousness can be used to differentiate a range of  ...  In particular, we discuss how arousal and awareness are positively correlated in normal physiological states with the exception of REM sleep, while a disturbance in this relationship is characteristic  ...  In healthy individuals, varying degrees of arousal correspond to a range of conscious states that extend from deep dreamless sleep, through drowsiness to alert wakefulness [64] .  ... 
doi:10.1155/2011/645159 pmid:21447904 pmcid:PMC5378000 fatcat:td5zol5agjgx3gfy5bnwmym4ui

Harmonic Brain Modes: A Unifying Framework for Linking Space and Time in Brain Dynamics

Selen Atasoy, Gustavo Deco, Morten L. Kringelbach, Joel Pearson
2017 The Neuroscientist  
Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal and network-level changes in the brain across different mental states; (wakefulness, sleep, anaesthesia  ...  Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics  ...  In other words, during loss of consciousness neural activity becomes locked to a narrow frequency range, whereas in wakefulness a broad frequency range of the connectome harmonic spectrum constitutes the  ... 
doi:10.1177/1073858417728032 pmid:28863720 fatcat:ll3bahtwxreqbpropmgs7as5jm

Neuropsychology of Consciousness: Some History and a Few New Trends

Giovanni Berlucchi, Carlo Alberto Marzi
2019 Frontiers in Psychology  
However, neuropsychology has been at the forefront in the identification of conscious and unconscious components in the processing of sensory and mnestic information.  ...  Its physiological and pathological mechanisms have been studied in relation to the natural sleep-wake cycle and various forms of normal or morbid unconsciousness, mainly in neurophysiology and clinical  ...  In this connection, Koch et al. (2016) distinguish two neuronal correlates of consciousness, a full correlate, i.e., the neural substrate supporting experience in general, irrespective of its specific  ... 
doi:10.3389/fpsyg.2019.00050 pmid:30761035 pmcid:PMC6364520 fatcat:6lf5zgy7mzdhrmwkisu6hlovmm

Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses

Johan F. Storm, Mélanie Boly, Adenauer G. Casali, Marcello Massimini, Umberto Olcese, Cyriel M.A. Pennartz, Melanie Wilke
2017 Journal of Neuroscience  
The conscious rodent brain: ensemble activity and long-range correlation patterns"; and J.  ...  How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems  ...  The conscious rodent brain: ensemble activity and long-range correlation patterns Animal models provide a unique window to probe the neuronlevel mechanisms of many cognitive processes, including consciousness  ... 
doi:10.1523/jneurosci.1838-17.2017 pmid:29118218 pmcid:PMC5678021 fatcat:sem76lkdq5fgtgbkbfscdflb6u

Slow cortico-cortical connectivity (2-5Hz) is a new robust signature of conscious states [article]

Pierre Bourdillon, Bertrand Hermann, Marc Guénot, Hélène Bastuji, Jean Isnard, Jean-Rémi King, Jacobo Sitt, Lionel Naccache
2019 bioRxiv   pre-print
We discovered that long-range FC in the 2-5Hz frequency band was a specific marker of conscious states that could discriminate CW and REM from SWS and PA.  ...  from patients in the minimally conscious state.  ...  CW = conscious wakefulness; SWS = N3 Slow Wave Sleep; REM = Rapid Eye Movement Sleep; In coherence with our original study, wSMI computed in the 4-10Hz succeeded to distinguish CW from SWS in 8 out of  ... 
doi:10.1101/692970 fatcat:2jmj5sawnnadjpnd62qibv6qou

Human consciousness is supported by dynamic complex patterns of brain signal coordination

A. Demertzi, E. Tagliazucchi, S. Dehaene, G. Deco, P. Barttfeld, F. Raimondo, C. Martial, D. Fernández-Espejo, B. Rohaut, H. U. Voss, N. D. Schiff, A. M. Owen (+3 others)
2019 Science Advances  
Our results establish that consciousness rests on the brain's ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious  ...  Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness.  ...  Kirsch (GIGA-Consciousness, Anesthesia and Intensive Care laboratories, CHU Liège) for assistance in performing anesthesia in patients. We thank L.  ... 
doi:10.1126/sciadv.aat7603 pmid:30775433 pmcid:PMC6365115 fatcat:cqyva76yqbhn5c6gs7x4cu5pl4

Functional diversity of brain networks supports consciousness and verbal intelligence

Lorina Naci, Amelie Haugg, Alex MacDonald, Mimma Anello, Evan Houldin, Shakib Naqshbandi, Laura E. Gonzalez-Lara, Miguel Arango, Christopher Harle, Rhodri Cusack, Adrian M. Owen
2018 Scientific Reports  
With a novel 28 approach, we brought together for the first time, data from the same paradigm-a highly 29 engaging auditory-only narrative-in three independent domains: anesthesia-induced 30 unconsciousness  ...  , unconsciousness after brain injury, and individual differences in 31 intellectual abilities during conscious cognition.  ...  (A) Loss of long-range connectivity between different networks; (B) Loss of 940 long-range connectivity within a specific network, e.g., between frontal and parietal 941 regions; (C) A combination of patterns  ... 
doi:10.1038/s41598-018-31525-z pmid:30185912 pmcid:PMC6125486 fatcat:nxftbq7xyvawros5pe4ftaxwhe

Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness

Yonatan Sanz Perl, Carla Pallavicini, Ignacio Pérez Ipiña, Athena Demertzi, Vincent Bonhomme, Charlotte Martial, Rajanikant Panda, Jitka Annen, Agustin Ibañez, Morten Kringelbach, Gustavo Deco, Helmut Laufs (+4 others)
2021 PLoS Computational Biology  
We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness.  ...  (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness.  ...  Acknowledgments The authors thank the patients and their families for participation in the study, as well as the whole staff from the Radiodiagnostic department at University Hospital of Liège.  ... 
doi:10.1371/journal.pcbi.1009139 pmid:34314430 pmcid:PMC8315553 fatcat:22ktesiesvdlxaqahpxhnmzuwy

BOLD temporal variability differentiates wakefulness from anesthesia-induced unconsciousness

Alexis T. Baria, Maria V. Centeno, Mariam E. Ghantous, Pei C. Chang, Daniele Procissi, A. Vania Apkarian
2018 Journal of Neurophysiology  
NEW & NOTEWORTHY Multiple metrics previously suggested to be able to distinguish between states of consciousness were compared, within and across rats in awake and isoflurane anesthesia-induced unconsciousness  ...  Here, we investigated the brain activity and functional connectivity changes that occur in the isoflurane-anesthetized unconscious state in contrast to the awake state in rats (awake and/or anesthetized  ...  We found that variability was the single most robust measurement that distinguished anesthesia-induced unconsciousness from awake brains.  ... 
doi:10.1152/jn.00714.2017 pmid:29212921 fatcat:3vi6gbrtc5edphfxkkihaxgrbm
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