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Predicting Locations of High-Risk Plaques in Coronary Arteries in Patients Receiving Statin Therapy

Ling Zhang, Andreas Wahle, Zhi Chen, John J. Lopez, Tomas Kovarnik, Milan Sonka
2018 IEEE Transactions on Medical Imaging  
Features of high-risk coronary artery plaques prone to major adverse cardiac events (MACE) were identified by intravascular ultrasound (IVUS) virtual histology (VH).  ...  For each segmented and registered VH-IVUS frame pair (n=6341), location-specific (≈0.5mm) vascular features and demographic information at baseline were identified.  ...  The material and software-enabling support from Volcano Corporation is gratefully acknowledged.  ... 
doi:10.1109/tmi.2017.2725443 pmid:28708548 pmcid:PMC5765985 fatcat:72q4gji4x5aqlmrw3udldguzhy

Endovascular Shear Strain Elastography for the Detection and Characterization of the Severity of Atherosclerotic Plaques: In Vitro Validation and In Vivo Evaluation

Younes Majdouline, Jacques Ohayon, Zahra Keshavarz-Motamed, Marie-Hélène Roy Cardinal, Damien Garcia, Louise Allard, Sophie Lerouge, Frédéric Arsenault, Gilles Soulez, Guy Cloutier
2014 Ultrasound in Medicine and Biology  
IVUS images were acquired in vivo in 14 plaques before euthanasia and histology.  ...  This study indicates the feasibility of using SSE to highlight atherosclerotic plaque vulnerability characteristics. (  ...  The specific scan in which the plaque appeared was used for further analysis. The histology slice used for validation was the slice at the same location of the scan.  ... 
doi:10.1016/j.ultrasmedbio.2013.12.008 pmid:24495438 fatcat:adszqafvzrgg7epiqsufgnh2zu

Coronary artery atherectomy reduces plaque shear strains: An endovascular elastography imaging study

Zahra Keshavarz-Motamed, Yoshifumi Saijo, Younes Majdouline, Laurent Riou, Jacques Ohayon, Guy Cloutier
2014 Atherosclerosis  
Mechanical response and properties of the arterial wall can be used to identify the biomechanical instability of plaques and predict their vulnerability to rupture.  ...  This study demonstrates the potential of the IVUS-based SSE technique to detect vulnerable plaques in vivo.  ...  [18, 19] and virtual histology [20, 21] .  ... 
doi:10.1016/j.atherosclerosis.2014.04.022 pmid:24835433 fatcat:huvl75el4ff4vgd6vvgpvkhqbi

Stabilization of atherosclerotic plaques: an update

S. Yla-Herttuala, J. F. Bentzon, M. Daemen, E. Falk, H. M. Garcia-Garcia, J. Herrmann, I. Hoefer, S. Jauhiainen, J. W. Jukema, R. Krams, B. R. Kwak, N. Marx (+7 others)
2013 European Heart Journal  
Funding This study was supported by ESC Working Group of Atherosclerosis and Vascular Biology. Conflict of interest: I.H. has received research grants from NWO, CTMM, BMM, and TI Pharma.  ...  -H has received grants from the Academy of Finland, the Finnish Heart Foundation, and EU FP7 programme grants CliniGene, Baculogenes, BIOMAGSCAR, and BAMI.  ...  of atherosclerosis. 32, 33 Recent studies indicate that it also predicts location of advanced lesions. 34 Repeated measurements indicate that low shear stress is predictive of not only plaque location  ... 
doi:10.1093/eurheartj/eht301 pmid:23966311 fatcat:ftao323mzjdsxa3ss7ujuapgd4

Intracoronary imaging of coronary atherosclerosis: validation for diagnosis, prognosis and treatment

Konstantinos C. Koskinas, Giovanni J. Ughi, Stephan Windecker, Guillermo J. Tearney, Lorenz Räber
2015 European Heart Journal  
ability of various medications to reverse the processes of plaque growth and destabilization.  ...  Future perspectives for in-depth plaque characterization using novel techniques and multimodality imaging approaches are also discussed. ---  ...  Acknowledgements We thank Dr Stefan Stortecky, Bern University Hospital, Switzerland, for providing images for Figure 5A and Drs Takenori Domei and Shoichi Kuramitsu, Kokura Memorial Hospital, Japan,  ... 
doi:10.1093/eurheartj/ehv642 pmid:26655874 fatcat:mtep4mu6lzhzva7smhf6wsqqee

Prediction of cardiovascular outcomes by imaging coronary atherosclerosis

Faraz Pathan, Kazuaki Negishi
2016 Cardiovascular Diagnosis and Therapy  
In this review, we begin with discussing the importance of pre-test probability and quality of outcome measure, followed by specific findings of each modality in relation to prognosis.  ...  tools, as well as invasive modalities including intravascular ultrasound (IVUS), optical coherence tomography (OCT), near infrared spectroscopy and Angioscopy.  ...  Acknowledgements The authors appreciate the courtesy of Dr Hiroko Tsuchiya, for providing Figures 3, 4 . The authors received no specific funding for this work.  ... 
doi:10.21037/cdt.2015.12.08 pmid:27500091 pmcid:PMC4960063 fatcat:fru3mac6zbedpcjl55sl664ndy

Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events

S. Waxman, F. Ishibashi, J. E. Muller
2006 Circulation  
has been termed "virtual histology" (Figure 6) .  ...  In the context of uncertainty about the existence, detection, and timing of plaque vulnerability, it is not possible to recommend routine use of the promising local therapy options discussed below.  ... 
doi:10.1161/circulationaha.105.540013 pmid:17130356 fatcat:nt425tjfpfanxla3kxw5oco3jy

Coronary CT Angiography and the Napkin-ring Sign Indicates High-Risk Atherosclerotic Lesions [chapter]

Lucia Agoston-Coldea, Carmen Cionca, Silvia Lupu
2015 Coronary Artery Disease - Assessment, Surgery, Prevention  
and positive predictive value for the presence of advanced lesions.  ...  Recent research provides CCTA descriptions of vulnerable plaques and a particular radiological sign shows promising perspectives.  ...  A more detailed analysis of coronary plaque composition has been provided by virtual histology (VH)-IVUS studies [39, 40, 41] .  ... 
doi:10.5772/61393 fatcat:xtoaccwxqbgj7pcx6dosa4brcu

Machine Learning Model Comparison for Automatic Segmentation of Intracoronary Optical Coherence Tomography and Plaque Cap Thickness Quantification

Caining Zhang, Xiaopeng Guo, Xiaoya Guo, David Molony, Huaguang Li, Habib Samady, Don P. Giddens, Lambros Athanasiou, Dalin Tang, Rencan Nie, Jinde Cao
2020 CMES - Computer Modeling in Engineering & Sciences  
Since OCT has limited penetration, virtual histology IVUS was combined with OCT data to improve reliability. A 3-fold cross-validation method was used for model training and validation.  ...  The aim of this study was to develop automatic techniques to characterize plaque components and quantify plaque cap thickness using 3 machine learning methods including convolutional neural network (CNN  ...  plaque rupture risk and predict rupture location.  ... 
doi:10.32604/cmes.2020.09718 fatcat:mgudw6blqvgi3n44kch7nv3o4y

Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography

Atsushi Tanaka, Guillermo J. Tearney, Brett E. Bouma
2010 Journal of Biomedical Optics  
Because of its high resolution, OCT may also be used to identify macrophages in vivo. In this paper we review recent developments in OCT for measuring macrophages in atherosclerotic plaques.  ...  Cellularity of the fibrous caps of coronary atheromas, manifested by the infiltration of macrophages ͑average size, 20 to 30 m͒, is thought to weaken the structural integrity of the cap and predispose  ...  reflectivity at a specific spatial position is detected.  ... 
doi:10.1117/1.3290810 pmid:20210430 fatcat:2d3cjmnmhrdcjbywtxtflw23k4

Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives

Christodoulos Stefanadis, Christos‐Konstantinos Antoniou, Dimitrios Tsiachris, Panagiota Pietri
2017 Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease  
to predict events used IVUS-based approaches in their definition of vulnerability  ...  Virtual histology IVUS, iMAP IVUS, and integrated backscatter IVUS are examples of this, with high reproducibility although they remain proprietary and use different color-coding for the same structures  ... 
doi:10.1161/jaha.117.005543 pmid:28314799 pmcid:PMC5524044 fatcat:crumj6mi2zbcvi3xftdn7gke3e

Imaging Biomarkers in Atherosclerosis Trials

J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, J. Pressacco
2011 Circulation Cardiovascular Imaging  
Indexes have been created to characterize plaques with standard IVUS images. 43, 46 More recently, an algorithm (called virtual histology) that provides information on the types of plaques present based  ...  (Ն50%) in a patient-based analysis. 66 In another multicenter study, a specificity of 90%, a positive predictive value of 91%, and a negative predictive value of 83% were reported. 67 These results  ...  World Wide Web at: The online version of this article, along with updated information and services, is located on the  ... 
doi:10.1161/circimaging.110.962001 pmid:21586743 fatcat:a7qoxpdccvcbzhvxevczfwcosu

Prognostic Value and Therapeutic Perspectives of Coronary CT Angiography: A Literature Review

Patrizia Carità, Andrea Igoren Guaricci, Giuseppe Muscogiuri, Nazario Carrabba, Gianluca Pontone
2018 BioMed Research International  
In this review we summarize the current evidence regarding vulnerable plaque and effects of lipid lowering therapy on morphological features of CAD.  ...  Research in this field may also advance towards an era of personalized risk prediction and individualized medical therapy.  ...  Gianluca Pontone received institutional grant and fee from GE Healthcare, Medtronic, Bracco, Heartflow.  ... 
doi:10.1155/2018/6528238 pmid:30306089 pmcid:PMC6165606 fatcat:afxquocwprc6vhkw4qvbcit6my

Current Concepts of Vulnerable Plaque on Coronary CT Angiography

Seung Min Yoo, Hwa Yeon Lee, Kwang Nam Jin, Eun Ju Chun, Frazier Aletta Ann, Charles S White
2017 Cardiovascular Imaging Asia  
Thus, noninvasive identification and modification of vulnerable plaque are of paramount important to reduce cardiac events.  ...  This review article discusses what we know and what remains unclear in the CT evaluation of vulnerable plaque.  ...  Widespread use of intravascular ultrasound (IVUS) or IVUS virtual histology (IVUS-VH), optical coherence tomography (OCT), and angioscopy in evaluating vulnerable plaque is limited by the invasive nature  ... 
doi:10.22468/cvia.2016.00073 fatcat:l6g535tt5rbopdns3xllis5s44

Fundamentals and role of intravascular ultrasound in percutaneous coronary intervention

James Xu, Sidney Lo
2020 Cardiovascular Diagnosis and Therapy  
Clinical applications of IVUS in PCI include assessment of lesion severity, characterizing plaque morphology, optimization of acute stent results and clarification of mechanisms of stent failure.  ...  The current review provides a summary of the fundamental aspects and current clinical roles of IVUS in coronary intervention.  ...  Although predominantly done in the research setting, radiofrequency plaque analysis with virtual histology IVUS can aid in the detection of thin-cap fibroatheromas (TCFA).  ... 
doi:10.21037/cdt.2020.01.15 pmid:33224762 pmcid:PMC7666933 fatcat:qvp5k2ltzngotl7rboo6mkkzke
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