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Local mechanical properties of white matter structures in the human brain

Curtis L. Johnson, Matthew D.J. McGarry, Armen A. Gharibans, John B. Weaver, Keith D. Paulsen, Huan Wang, William C. Olivero, Bradley P. Sutton, John G. Georgiadis
2013 NeuroImage  
To date, brain MRE investigations have been limited to reporting global mechanical properties, though quantification of the stiffness of specific structures in the white matter architecture may be valuable  ...  in assessing the localized effects of disease.  ...  Kritzer Fund at the University of Illinois at Urbana-Champaign provided support for this work. CLJ acknowledges support from the Beckman Graduate Fellows Program of the Beckman Institute.  ... 
doi:10.1016/j.neuroimage.2013.04.089 pmid:23644001 pmcid:PMC3676712 fatcat:sjt6ogmto5e6tpw2xtoexe5ldm

A dynamic network perspective of chronic pain

Melissa A. Farmer, Marwan N. Baliki, A. Vania Apkarian
2012 Neuroscience Letters  
into persistent pain, and outline the role of mesolimbic learning mechanisms that are likely involved in maintenance of chronic pain.  ...  Based on these observations and recent theoretical advances regarding network architecture properties, we develop a general concept of the dynamic interplay between anatomy and function as the brain progresses  ...  Accordingly, the brain in chronic pain exhibits abnormalities in local grey matter and white matter restructuring, thereby degrading local networks but preserving large scale white matter tracks (Fig.  ... 
doi:10.1016/j.neulet.2012.05.001 pmid:22579823 pmcid:PMC3377811 fatcat:juyv5tmjfvayll6hofdynt3pga

Magnetic resonance elastography for examining developmental changes in the mechanical properties of the brain

Curtis L. Johnson, Eva H. Telzer
2017 Developmental Cognitive Neuroscience  
The measured mechanical properties reflect the microstructural composition and organization of neural tissue, and have shown significant effects in many neurological conditions and normal, healthy aging  ...  The sensitivity of MRE to brain structure, function, and health make it an ideal technique for studying the developing brain; however, brain MRE studies on children and adolescents have only just begun  ...  ) from the National Institutes of Health and the State of Delaware, and from Delaware CTR ACCEL Program with a grant from the National Institutes of General Medical Sciences (U54-GM104941) from the National  ... 
doi:10.1016/j.dcn.2017.08.010 pmid:29239832 pmcid:PMC5832528 fatcat:thhwsdko5zekdjlmupkatak45a

Computational anatomy for studying use-dependant brain plasticity

Bogdan Draganski, Ferath Kherif, Antoine Lutti
2014 Frontiers in Human Neuroscience  
In this article we provide a comprehensive literature review on the in vivo assessment of use-dependant brain structure changes in humans using magnetic resonance imaging (MRI) and computational anatomy  ...  Given the current lack of in-depth understanding of the neurobiological basis of brain structure changes we emphasize the necessity of a paradigm shift in the investigation and interpretation of use-dependent  ...  in underlying white matter architecture.  ... 
doi:10.3389/fnhum.2014.00380 pmid:25018716 pmcid:PMC4072968 fatcat:zutvf57sxjavfibsae6c6tjpbe

Mechanical properties of the in vivo adolescent human brain

Grace McIlvain, Hillary Schwarb, Neal J. Cohen, Eva H. Telzer, Curtis L. Johnson
2018 Developmental Cognitive Neuroscience  
Viscoelastic mechanical properties of the in vivo human brain, measured noninvasively with magnetic resonance elastography (MRE), have recently been shown to be affected by aging and neurological disease  ...  In this work, we characterized global and regional brain stiffness and damping ratio in a sample of 40 adolescents aged 12-14 years, including the lobes of the cerebrum and subcortical gray matter structures  ...  Acknowledgments Support for this study was provided by NSF (SES-1459719), NIH/ NIDA (R01-DA039923), the Delaware INBRE Program (NIH/NIGMS P20-GM103446), the Delaware CTR ACCEL Program (NIH/NIGMS U54-GM104941  ... 
doi:10.1016/j.dcn.2018.06.001 pmid:29906788 pmcid:PMC6289278 fatcat:cpsc47kq7vfdrlgsrffwpd7afy

The role of diffusion MRI in neuroscience

Yaniv Assaf, Heidi Johansen-Berg, Michel Thiebaut de Schotten
2017 NMR in Biomedicine  
Figure 1: First drawings of white matter connection in the human brain. Left, brain dissection from Vieussens 3 and right, brain dissection from Johann Christian Reil 4 .  ...  areas of the brain via their white matter connections.  ...  This work was supported by the 'Agence Nationale de la Recherche' [grants number ANR-10-IAIHU-06 and number ANR-13-JSV4-0001-01].  ... 
doi:10.1002/nbm.3762 pmid:28696013 fatcat:yq23ob4xibhxpfx4txsm664xci

On the Possible Shapes of the Brain

Roberto Toro
2012 Evolutionary biology  
We discuss in particular the mechanisms of cortical folding and the relationship between folding and the structural and functional organisation of the brain.  ...  Based on these phylogenetic and theoretical considerations, we turn to the analysis of the variability trends within humans: regional variations in grey and white matter volume and changes in cortical  ...  Diversity of grey and white matter volumes in the frontal, parietal, occipital and temporal lobes among humans.  ... 
doi:10.1007/s11692-012-9201-8 fatcat:xp5j4b5su5bj7fqw72wvmlpecy

Human white matter and knowledge representation

Franco Pestilli
2018 PLoS Biology  
and local cortical circuitry) to the macroscale (brain cortical folding and white matter tracts) [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] .  ...  Understanding how knowledge is represented in the human brain is a fundamental challenge in neuroscience.  ...  McPherson for comments on early versions of this manuscript.  ... 
doi:10.1371/journal.pbio.2005758 pmid:29698391 pmcid:PMC5940236 fatcat:ttspqrukkvfk5cft4wd3abbygi

Time-harmonic magnetic resonance elastography of the normal feline brain

A.J. Pattison, S.S. Lollis, P.R. Perriñez, I.M. Perreard, M.D.J. McGarry, J.B. Weaver, K.D. Paulsen
2010 Journal of Biomechanics  
the recovered properties of grey and white matter.  ...  Imaging of the mechanical properties of in vivo brain tissue could eventually lead to non-invasive diagnosis of hydrocephalus, Alzheimer's disease and other pathologies known to alter the intracranial  ...  Grey and white matter is also better distinguished in the feline brain relative to other small animals, appearing more similarly to the human brain.  ... 
doi:10.1016/j.jbiomech.2010.06.008 pmid:20655045 pmcid:PMC2963725 fatcat:oo3a7ylxtjfr3bt5b2t2enzzvm

Combining the Finite Element Method with Structural Connectome-based Analysis for Modeling Neurotrauma: Connectome Neurotrauma Mechanics

Reuben H. Kraft, Phillip Justin Mckee, Amy M. Dagro, Scott T. Grafton, Olaf Sporns
2012 PLoS Computational Biology  
We relate localized mechanical brain damage predicted from biofidelic finite element simulations of the human head subjected to impact with degradation in the structural connectome for a single individual  ...  In the future, this computational framework could help inform functional networks from physics-based structural brain biomechanics to obtain not only a biomechanics-based understanding of injury, but also  ...  are related to a decrease in localized white matter integrity.  ... 
doi:10.1371/journal.pcbi.1002619 pmid:22915997 pmcid:PMC3420926 fatcat:xpmfjcax6rf63oulz2v2atksaq

Correction: Combining the Finite Element Method with Structural Connectome-based Analysis for Modeling Neurotrauma: Connectome Neurotrauma Mechanics

Reuben H. Kraft, Phillip Justin Mckee, Amy M. Dagro, Scott T. Grafton, Olaf Sporns
2012 PLoS Computational Biology  
We relate localized mechanical brain damage predicted from biofidelic finite element simulations of the human head subjected to impact with degradation in the structural connectome for a single individual  ...  In the future, this computational framework could help inform functional networks from physics-based structural brain biomechanics to obtain not only a biomechanics-based understanding of injury, but also  ...  are related to a decrease in localized white matter integrity.  ... 
doi:10.1371/annotation/fd39b102-fb25-4ff2-9907-07af01ea6801 fatcat:jbxua5tbjne6xa2kmvo6ftnuym

Imaging structural co-variance between human brain regions

Aaron Alexander-Bloch, Jay N. Giedd, Ed Bullmore
2013 Nature Reviews Neuroscience  
Brain structure varies between people in a markedly organized fashion. Communities of brain regions co-vary in their morphological properties.  ...  This Review discusses the state of current research into brain structural co-variance, its underlying mechanisms and its potential value in the understanding of various neurological and psychiatric conditions  ...  white matter links, owing to indirect or emergent properties of white matter networks 34,35,218,219 .  ... 
doi:10.1038/nrn3465 pmid:23531697 pmcid:PMC4043276 fatcat:k2iuznauebdw3ibxu7f7l67co4

The Role Of Diffusion MRI In Neuroscience [article]

Yaniv Assaf, Heidi Johansen-Berg, Michel Thiebaut de Schotten
2017 bioRxiv   pre-print
Diffusion weighted imaging has further pushed the boundaries of neuroscience by allowing us to peer farther into the white matter microstructure of the living human brain.  ...  We will briefly summarise key questions, that have historically been raised in neuroscience, concerning the brain's white matter.  ...  This work was supported by the 'Agence Nationale de la Recherche' [grants number ANR-10-IAIHU-06 and number ANR-13-JSV4-0001-01].  ... 
doi:10.1101/140459 fatcat:jjianciqojbtpmafzpkxkkqivm

Advances in multimodal magnetic resonance imaging of vascular mild cognitive impairment

Zhi-Qi Wang, Yan-Qing Han
2019 Journal of Hainan Medical University  
As a widely used imaging method, multimode magnetic resonance imaging can evaluate the brain structure and function of patients with VaMCI noninvasively and explore the relationship between brain structure  ...  It is beneficial to provide an idea for early diagnosis of VaMCI and to further understand the neuropathologic mechanism of its occurrence, which has broad application prospects.In this paper, the research  ...  Topological structure of brain network based on graph theory In recent years, humans have found that the brain has extraordinary topological properties, such as small-world attributes and short path length  ... 
doaj:8362f89dd33d48d2abc6e8a07c608b8f fatcat:3x3tsryp6jdyvpyyrtxlrrj6pi

Hemispheric Asymmetry of Human Brain Anatomical Network Revealed by Diffusion Tensor Tractography

Ni Shu, Yaou Liu, Yunyun Duan, Kuncheng Li
2015 BioMed Research International  
Furthermore, local structural connections were also investigated to examine the local asymmetries of some specific white matter tracts.  ...  The topological architecture of the cerebral anatomical network reflects the structural organization of the human brain.  ...  Moreover, the structural properties of some local white matter tracts also exhibit hemispheric asymmetries, which indicated the asymmetries of local connections.  ... 
doi:10.1155/2015/908917 pmid:26539535 pmcid:PMC4619913 fatcat:npcfpqe7mzemrhib6pwt5gj6ze
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