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Age-related alterations in the modulation of intracortical inhibition during stopping of actions

Lize Hermans, Celine Maes, Lisa Pauwels, Koen Cuypers, Kirstin-Friederike Heise, Stephan P. Swinnen, Inge Leunissen
2019 Aging  
We investigated the effect of age on the ability to modulate GABAA-ergic and GABAB-ergic inhibitory activity during stopping of action (reactive inhibition) and preparation to stop (proactive inhibition). Twenty-five young and twenty-nine older adults performed an anticipated response version of the stop-signal task with varying levels of stop-signal probability. Paired-pulse transcranial magnetic stimulation was applied to left primary motor cortex to assess the modulation of GABAA-mediated
more » ... rt-interval intracortical inhibition (SICI) during stopping and GABAB-mediated long-interval intracortical inhibition (LICI) during the anticipation of a stop-signal. At the behavioral level, reactive inhibition was affected by aging as indicated by longer stop-signal reaction times in older compared to young adults. In contrast, proactive inhibition was preserved at older age as both groups slowed down their go response to a similar degree with increasing stop-signal probability. At the neural level, the amount of SICI was higher in successful stop relative to go trials in young but not in older adults. LICI at the start of the trial was modulated as a function of stop-signal probability in both young and older adults. Our results suggest that specifically the recruitment of GABAA-mediated intracortical inhibition during stopping of action is affected by aging.
doi:10.18632/aging.101741 pmid:30670675 pmcid:PMC6366958 fatcat:6tkmmjqbnverfkkt73jkf3kl4y

Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults

Lize Hermans, Inge Leunissen, Lisa Pauwels, Koen Cuypers, Ronald Peeters, Nicolaas A.J. Puts, Richard A.E. Edden, Stephan P. Swinnen
2018 Journal of Neuroscience  
., September 5, 2018 • 38(36):7844 -7851 Hermans et al. • GABA and Motor Inhibition • J. Neurosci., September 5, 2018 • 38(36):7844 -7851 Hermans et al. • GABA and Motor Inhibition  ... 
doi:10.1523/jneurosci.0760-18.2018 pmid:30064995 pmcid:PMC6125814 fatcat:dowodqjtjzecfgjskzeessz5ga

The Belgian health examination survey: objectives, design and methods

Diem Nguyen, Pauline Hautekiet, Finaba Berete, Elise Braekman, Rana Charafeddine, Stefaan Demarest, Sabine Drieskens, Lydia Gisle, Lize Hermans, Jean Tafforeau, Johan Van der Heyden
2020 Archives of Public Health  
In 2018 the first Belgian Health Examination Survey (BELHES) took place. The target group included all Belgian residents aged 18 years and older. The BELHES was organized as a second stage of the sixth Belgian Health Interview Survey (BHIS). This paper describes the study design, recruitment method and the methodological choices that were made in the BELHES. After a pilot period during the first quarter of the BHIS fieldwork, eligible BHIS participants were invited to participate in the BELHES
more » ... ntil a predefined number (n = 1100) was reached. To obtain the required sample size, 4918 eligible BHIS participants had to be contacted. Data were collected at the participant's home by trained nurses. The data collection included: 1) a short set of questions through a face-to-face interview, 2) a clinical examination consisting of the measurement of height, weight, waist circumference, blood pressure and for people aged 50 years and older handgrip strength and 3) a collection of blood and urine samples. The BELHES followed as much as possible the guidelines provided in the framework of the European Health Examination Survey (EHES) initiative. Finally 1184 individuals participated in the BELHES, resulting in a participation rate of 24.1%. Results for all the core BELHES measurements were obtained for more than 90% of the participants. It is feasible to organize a health examination survey as a second stage of the BHIS. The first successfully organized BELHES provides useful information to support Belgian health decision-makers and health professionals. As the BELHES followed EHES recommendations to a large extent, the results can be compared with those from similar surveys in other EU (European Union) member states.
doi:10.1186/s13690-020-00428-9 pmid:32514346 pmcid:PMC7268416 fatcat:fgtd2jkbyfhalnlfs5p5dkhcyy

Domestic violence during the COVID-19 confinement: do victims feel more socially isolated?

Sabine Drieskens, Elise Braekman, Karin De Ridder, Lydia Gisle, Rana Charafeddine, Lize Hermans, Stefaan Demarest
2022 Archives of Public Health  
Background Since March 13th 2020, confinement measures have been introduced in Belgium to curb the spread of the coronavirus (COVID-19). These measures also have an impact on people's daily life (closure of school/businesses, teleworking, recommendation to stay at home). This can cause stress on social, economic and psychological levels and thereby can trigger domestic violence. Besides, confinement also fosters social isolation, which can complicate help seeking behaviour. The aim of this
more » ... is to determine the prevalence of domestic violence during the coronavirus crisis and to assess whether there is an association between domestic violence and social isolation. Methods Several online COVID-19 Health Surveys were organised among Belgian residents aged 18+ via snowball sampling. This study is based on the second (April 2020) and the sixth survey (March 2021). After excluding 1-person households and missing data, the sample size was respectively 25,251 and 12,589. Weighted prevalence of domestic violence was evaluated for the two surveys. The association (OR; 95% CI; p-value) between domestic violence and subjective social isolation was assessed with logistic regression stratified by survey and adjusted for covariates. Results In April 2020, 4.0% of the adult population reported being a victim of domestic violence (1.2% in the Health Interview Survey 2018); in March 2021, this was 6.2%. In April 2020, victims of domestic violence had higher odds of being unsatisfied with their social contacts (OR = 1.25; 95% CI: 1.08–1.44; p < .05), weak social support (OR = 2.26; 95% CI: 1.97–2.58; p < .0001) and having less confidence in health care services (OR = 1.38; 95% CI: 1.13–1.71; p < .05). In March 2021, victims had higher odds of being unsatisfied with their social contacts (OR = 1.30; 95% CI: 1.08–1.56; p < .05) and weak social support (OR = 2.41; 95% CI: 2.04–2.84; p < .0001), and social (OR = 2.64; 95% CI: 2.23–3.13; p < .0001) and emotional loneliness (OR = 2.22; 95% CI: 1.80–2.73; p < .0001). Conclusions More people have reported domestic violence since the start of the coronavirus crisis than did in 2018. An association between domestic violence and social isolation was determined. Although confinement is needed to counteract the virus, it can put people in a dangerous situation since they do not get the help they need. Therefore, adequate support is essential.
doi:10.1186/s13690-021-00765-3 pmid:35078519 pmcid:PMC8787181 fatcat:72yqhkc4ybedfjkhxb325bcmqq

Mental health, compliance with measures and health prospects during the COVID-19 epidemic: the role of health literacy

Lize Hermans, Stephan Van den Broucke, Lydia Gisle, Stefaan Demarest, Rana Charafeddine
2021 BMC Public Health  
Background The importance of health literacy in dealing with the COVID-19 epidemic has been emphasized but scarcely addressed empirically. In this study, the association of health literacy with mental health, compliance with COVID-19 preventive measures and health prospects was assessed in a Belgian context. Methods Data were extracted from the third of a series of cross-sectional online COVID-related surveys (n = 32,794). Data collection took place for 1 week starting the 28th of May 2020.
more » ... le residing in Belgium and aged 18 years or older could participate. Data were collected on sociodemographic background, health literacy, multimorbidity, mental health (depression, anxiety, sleeping disorder, vitality), knowledge about COVID-19, compliance with COVID-19 measures (hygiene, physical distance, covering mouth and nose on public transport and in places where physical distance cannot be respected), and health prospects (risk for health when returning to normal life and possibility of infection). Prevalence Ratio (PR) of poor mental health, non-compliance with the measures and health prospects in relation to health literacy were calculated using Poisson regressions. Results People showing sufficient health literacy were less likely to suffer from anxiety disorders (PR = 0.47, 95% CI = [0.42–0.53]), depression (PR = 0.46, 95% CI = [0.40–0.52]) and sleeping disorders (PR = 0.85, 95% CI = [0.82–0.87]), and more likely to have optimal vitality (PR = 2.41, 95% CI = [2.05–2.84]) than people with low health literacy. They were less at risk of not complying with the COVID-19 measures (PR between 0.60 and 0.83) except one (covering mouth and nose in places where physical distance cannot be respected). Finally, they were less likely to perceive returning to normal life as threatening (PR = 0.70, 95% CI = [0.65–0.77]) and to consider themselves at risk of an infection with COVID-19 (PR = 0.75, 95% CI = [0.67–0.84]). The associations remained significant after controlling for COVID-19 knowledge and multimorbidity. Conclusions These results suggest that health literacy is a crucial factor in managing the COVID-19 epidemic and offer a perspective for future studies that target health literacy in the context of virus outbreaks.
doi:10.1186/s12889-021-11437-w pmid:34243741 fatcat:l4et6mfxfzes3kouqaoobgojue

Anxiety and Depression in Belgium during the First 15 Months of the COVID-19 Pandemic: A Longitudinal Study

Helena Bruggeman, Pierre Smith, Finaba Berete, Stefaan Demarest, Lize Hermans, Elise Braekman, Rana Charafeddine, Sabine Drieskens, Karin De Ridder, Lydia Gisle
2022 Behavioral Sciences  
The COVID-19 pandemic and policy measures enacted to contain the spread of the coronavirus have had nationwide psychological effects. This study aimed to assess the impact of the first 15 months of the COVID-19 pandemic on the level of anxiety (GAD-7 scale) and depression (PHQ-9 scale) of the Belgian adult population. A longitudinal study was conducted from April 2020 to June 2021, with 1838 respondents participating in 6 online surveys. Linear mixed models were used to model the associations
more » ... tween the predictor variables and the mental health outcomes. Results showed that the prevalence of symptoms of anxiety and depression was higher in times of stricter policy measures. Furthermore, after the initial stress from the outbreak, coping and adjustment were observed in participants, as symptoms of anxiety and depression decreased during times of lower policy restrictions to almost the same level as in pre-COVID times (2018). Though time trends were similar for all population subgroups, higher levels of both anxiety and depression were generally found among women, young people, people with poor social support, extraverts, people having pre-existing psychological problems, and people who were infected/exposed to the COVID-19 virus. Therefore, investment in mental health treatment programs and supports, especially for those risk groups, is crucial.
doi:10.3390/bs12050141 fatcat:onxukoyc2jf4hb62cyusbas45e

Neurometabolic correlates of reactive and proactive motor inhibition in young and older adults: evidence from multiple regional 1H-MR spectroscopy

Akila Weerasekera, Oron Levin, Amanda Clauwaert, Kirstin-Friederike Heise, Lize Hermans, Ronald Peeters, Dante Mantini, Koen Cuypers, Inge Leunissen, Uwe Himmelreich, Stephan P Swinnen
2020 Cerebral Cortex Communications  
and colleagues (Hermans et al. 2018) .  ...  Briefly, participants performed an anticipated response version of the SST Hermans et al. 2018; Hermans et al. 2019) .  ... 
doi:10.1093/texcom/tgaa028 fatcat:vxdudch37vfpxnclljvu3ylnxe

The 15th Biannual National Congress of the South African Society of Psychiatrists, 10-14 August 2008, Fancourt, George, W Cape

Eugene Allers, U A Botha, O A Betancourt, B Chiliza, Helen Clark, J Dill, Robin Emsley, Mike Ewart Smith, Alan J Flisher, Christoffel Grobler, S M Hawkridge, Volker Hitzeroth (+41 others)
2008 South African Journal of Psychiatry  
Approaching the dual diagnosis dilemma</strong></p><p>Lize Weich</p><p><strong>64.  ...  What every psychiatrist needs to know about scans</strong></p><p>Herman van Vuuren</p><p><strong>61.  ...  APPROACHING THE DUAL DIAGNOSIS DILEMMA Lize Weich University of Stellenbosch and Stikland Hospital, W Cape Co-morbid substance disorders are very prevalent among psychiatric patients and produce a  ... 
doi:10.4102/sajpsychiatry.v14i3.165 fatcat:pfbtpj7pljasnnporw4ulvxt5e

Page 602 of Guernsey Breeders' Journal Vol. 114, Issue 9 [page]

1964 Guernsey Breeders' Journal  
Bou¬ ton and Sons; 2, Cogniac’s Miss Lize, Hazel H. Beach and Robert D. Som¬ mers; 3, Mississinewa Farms M Tenna, Herman Stocksdale and Family. Futurity 1, Mississinewa Farms M.  ...  Muehle- bach; 2, Lapo Chal’s Lize, C. R. John¬ ston; 3, Lapo Chal’s Lizzie, C. R. John¬ ston. Cow, 2 Years and Under 3 1, Lapo Leader’s Memoir, C. R.  ... 

Page 242 of JAMA Ophthalmology Vol. 46, Issue 2 [page]

1951 JAMA Ophthalmology  
Herman M. Jahr. 16 pages. 15 cents. What Does Your Baby Put in His Mouth? Chevalier Jackson and Chevalier L. Jackson.  ...  Fur- nished with Stainless Steel steri- lizing rack which holds 6 knives or other handle type instruments, and two felt covered and elastic banded trays for scissors, forceps New Eye Instrument Catalog  ... 

Page 473 of Journal of Polymer Science Vol. 5, Issue 4 [page]

1950 Journal of Polymer Science  
The solvent is said to be partly immobi- lized in the central part of the coil.  ...  Hermans‘ for sedimentation and by Peterlin® for the viscosity.  ... 

Conceptual causal framework to assess the effect of SARS-CoV-2 variants on COVID-19 disease severity among hospitalized patients

Nina Van Goethem, Ben Serrien, Mathil Vandromme, Chloé Wyndham-Thomas, Lucy Catteau, Ruben Brondeel, Sofieke Klamer, Marjan Meurisse, Lize Cuypers, Emmanuel André, Koen Blot, Herman Van Oyen
2021
Competing interests Herman Van Oyen is editor of Archives of Public Health. The other authors declare that they have no competing interests.  ... 
doi:10.1186/s13690-021-00709-x pmid:34696806 fatcat:vgpjo3vmerfe7ltaab7qfejxyy

Page 53 of American Sportswear & Knitting Times Vol. 35, Issue 46 [page]

1966 American Sportswear & Knitting Times  
Beitling Leaves Lee Herman — Merl Beitling has resigned his post as a designer for Lee Herman. Mr.  ...  Miss Basta who had her own boutique in Stockholm, is uti- lizing a Scandinavian look and new fabrics in her swim suit line. Price range is from $18.35-30.00.  ... 

Page 162 of Psychological Abstracts Vol. 34, Issue 1 [page]

1960 Psychological Abstracts  
rceptual and conceptual Staudt lox] Spits, Herman H., & Blackman, Leonard S.  ...  A comparison of mental retardates and nor- nals on visual figural aftereffects and reversible figures 1 rm ychol 1959 58, 105-110 rroul ’ ' lized hi 4) | mentally boys was compan ed j y ite !  ... 

Page 130 of SMPTE Motion Imaging Journal Vol. 95, Issue 1 [page]

1986 SMPTE Motion Imaging Journal  
Herman Badler is vice-president of operations, CBS-TV, in Washington, D.C., where he is in charge of the Washington Broadcast Center (radio and TV).  ...  He was associated with the develop- ment and application of color TV sys- tems for use in the medical/surgery field; developed photo-electric mea- suring systems and techniques uti- lized in monitor level  ... 
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