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Engineering Living Functional Materials

Allen Y. Chen, Chao Zhong, Timothy K. Lu
2015 ACS Synthetic Biology  
Natural materials, such as bone, integrate living cells composed of organic molecules together with inorganic components.  ...  Thus, tools from synthetic biology, such as those for artificial gene regulation, can be used to engineer the spatiotemporal characteristics of living systems and to interface living systems with inorganic  ...  The authors declare the following competing financial interest(s): T.K.L. and A.Y.C. have filed a patent application with the U.S. Patent and Trademark Office.  ... 
doi:10.1021/sb500113b pmid:25592034 pmcid:PMC4304442 fatcat:qccbq32fsbd3nnqxrj24riwvpm

Vaccine manufacturing: challenges and solutions

Jeffrey B Ulmer, Ulrich Valley, Rino Rappuoli
2006 Nature Biotechnology  
Gene-based vaccines, virus-like particles, plant-derived vaccines and novel adjuvants and delivery systems represent promising approaches to creating safer, more potent vaccines.  ...  However, the increased cost of producing new vaccines and regulatory uncertainty remain challenges for vaccine manufacturers.  ...  Manufacturing processes for killed organism-based vaccines are similar to those for live, attenuated vaccines.  ... 
doi:10.1038/nbt1261 pmid:17093488 fatcat:abgogtafivcarjt7qx6bejivdq

Trends of Manufacturing Systems with Distributed Computing

Abedalhakeem Issa
2017 Oriental journal of computer science and technology  
This fact has made the manufacturing systems to be totally dependent on ICT and therefore these systems have to keep pace with the advancement in ICT.  ...  The industry developed dramatically in the second half of the 20th century, And with it developed and manufacturing systems ranging from manual to fully computerized systems employing information and communication  ...  Similarly the organisms in the living thing are performing their own function in unison with other organs in the body.  ... 
doi:10.13005/ojcst/10.02.02 fatcat:ovad77ndhjh2velsbvxktpo7om

3-D Printing in Organ Transplantation

Goeun Lim, Dongho Choi, Eric B. Richardson
2014 Hanyang Medical Reviews  
Computer-aided bio-additive manufacturing of 3-D tissue and organs, involves the highly accurate deposition of living cells with an associated hydrogel scaffold of biomaterials mimicking vascular structure  ...  Recently several bio-printing methods have been developed that accumulate organized 3D structures of living cells by inkjet, extrusion, and laser based printing systems.  ... 
doi:10.7599/hmr.2014.34.4.158 fatcat:yhgs2fhsa5gs5ji65birbq4zni

Risk analysis for veterinary biologicals released into the environment

S V Silva, B S Samagh, R S Morley
1995 Rev Sci Tech Off Int Epizoot  
The other pathway involving direct human exposure to baits containing live recombinant vaccine, concerns the potential for immunosuppressed individuals to react systemically to the TK-vaccine organism.  ...  , the potential for the establishment of a TK + reservoir in animals, and finally human contact with such infected animals and reservoirs resulting in systemic reactions to the vaccine organism or the  ... 
pmid:8639945 fatcat:rm2iae6wi5bd7dtqcef2ne3lam

Regenerative medicine as a disruptive technology: implications for manufacturing & clinical adoption

Geoffrey Banda, Joyce Tait, James Mittra
2019 Cell and Gene Therapy Insights  
We discuss the challenges of dealing with inherent variability in living systems and how this necessitates co-evolution of technologies and innovations.  ...  This paper, based on ten cases in the UK, analyses the nature of disruption for allogeneic and autologous therapies in terms of manufacturing, distribution and adoption in clinical settings.  ...  The cell obviously is a living system in its own right … it's a living system in vitro and then it's also a living system when you put it into the patient.  ... 
doi:10.18609/cgti.2019.135 fatcat:h4eowcjnbzhs5i5kodf7lmhzhu

Innovation 2.0 as a Paradigm Shift: Comparative Analysis of Three Innovation Modes

Gang Song, Nan Zhang, Qingguo Meng
2009 2009 International Conference on Management and Service Science  
The traditional boundary of organization is dissolving as well as the traditional innovation and R&D boundaries.  ...  of innovation 2.0 as a paradigm shift from manufacturing paradigm to service paradigm in a knowledge-based society.  ...  Organizations nowadays need to take full advantage of modern ICT as well as dealing with the fluidity of the interaction with the mobile society.  ... 
doi:10.1109/icmss.2009.5303100 fatcat:ge37meaeczgq3ni3a2idxhzcj4

Extending Life Concepts to Complex Systems

Jean Le Fur
2013 Interdisciplinary Description of Complex Systems  
This approach is developed within a general classification of systems, with complex systems considered as a general 'living things' category and living organisms as a specialised class within this category  ...  This article explores, as a heuristic approach, the possibility of using notions associated with life as transversal concepts for defining complex systems.  ...  immaterial systems and manufactured complex systems.  ... 
doi:10.7906/indecs.11.1.4 fatcat:ntkn567nczaydk3etow52k7nra

A New Model For E-Crm In E-Commerce Using Live-Operator

Samin Jirehbandei, Alireza Nemaney Pour
2011 Zenodo  
Live-operator is a system which is involved both with the customers and the organization.In this system the customers feelthatthey receive the service directly from the organization.  ...  Therefore, it is important to keep good relationship with the customers. This paper proposes a new model to increase the customer satisfaction by introducing live-operator.  ...  Live-operator is a system which is involved both with the customer and the organization.  ... 
doi:10.5281/zenodo.1063372 fatcat:swylvqta5jasppjlolvmowge4i

Non-destructive quality monitoring of 3D printed tissue scaffolds via dielectric impedance spectroscopy and supervised machine learning

Shohanuzzaman Shohan, Jordan Harm, Mahmud Hasan, Binil Starly, Rohan Shirwaiker
2021 Procedia Manufacturing  
The outcomes of this study demonstrate the approach of using DIS and supervised ML in conjunction for assessment of TEMPs in an automated manufacturing system.  ...  The outcomes of this study demonstrate the approach of using DIS and supervised ML in conjunction for assessment of TEMPs in an automated manufacturing system.  ...  Acknowledgments This study was supported by a grant from Advanced Regenerative Manufacturing Institute (ARMI) BioFabUSA.  ... 
doi:10.1016/j.promfg.2021.06.063 fatcat:soeegt5uwbcylnd4a557raiscq

The Design of Integrated Logistics Management System of an Industrial Company

Martin Hart, Ondrej Stopka
2017 MATEC Web of Conferences  
The article deals with brief description of the issues on company management, company information management systems and logistics management.  ...  Further it's stated the methodology to created integrated logistics management system, which is containing the methodics to design logistics management sub-systems of purchasing, manufacturing, distribution  ...  with the forecasting systems of the other companies, organizations or the retailers within the scope of given supply chains.  ... 
doi:10.1051/matecconf/201713400018 fatcat:mlpoywuhqbay5f65tg7pynxm7q

Enabling out-of-body experiences for living organs

Donald E. Ingber
2021 Journal of Experimental Medicine  
Med. described a technique for culturing whole living organs outside the body.  ...  We began with a very similar goal to that of Carrel; however, we attempted to engineer small functional parts of living organs from the bottom up.  ...  article describing how to culture whole living organs ex vivo (Carrel, 1937) .  ... 
doi:10.1084/jem.20201756 pmid:33710255 fatcat:2pqdhqxe2vhrpnw2emafk3z53m

An Analysis of Quality Management in Vaccine Manufacturers of China Based on the New Vaccine Administration Law

Min Xue Ji, Xiang Qun Li, Cui Liu
2020 Journal of Applied Virology  
With the application of new technologies in development and production, the quality of vaccines in China had been constantly improved, and vaccines manufactured in China were being supplied to international  ...  Meanwhile, the quality management performance of vaccine manufacturers in China was continually improving.  ...  FDA Guidance for the Evaluation of Combination Vaccines, a combination vaccine was defined as a combination of two or more live organisms, inactivated organisms or purified antigens combined either by  ... 
doi:10.21092/jav.v9i2.88 fatcat:gfqhgpfqdjcntosjdkmoioevpm

Basic Semiosis as Code-Based Control

Stefan Artmann
2009 Biosemiotics  
Barbieri took a first step towards such a conception by distinguishing three types of semiosis in living systems: manufacturing, signalling, and interpretive semiosis.  ...  This paper integrates Barbieri's distinction into Roman Jakobson's systematization of possible functions of messages in order to propose a general conception of possible types of semiosis in living systems  ...  He distinguishes three types of semiosis in living systems: manufacturing, signalling, and interpretive semiosis.  ... 
doi:10.1007/s12304-008-9037-x fatcat:s3bgllblw5e6pozrupyhtx2wtm

Simulation Framework for Cyber-Physical Production System: Applying Concept of LVC Interoperation

Byeong Soo Kim, Seunghoon Nam, Yooeui Jin, Kyung-Min Seo, Hang Su
2020 Complexity  
With the LVC interoperation, we propose a systematic and efficient architecture for smart manufacturing.  ...  Various kinds of simulations, depending on system levels, such as assembly line, logistics, worker, and process, are utilized for smart manufacturing.  ...  Figure 1 :Figure 2 : 12 Concept Concept of live simulation in smart manufacturing. Figure 3 : 3 Application of live simulation in smart manufacturing.  ... 
doi:10.1155/2020/4321873 fatcat:ptgj7burtrho5p7mp375n35cxu
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